Chemoradiotherapy alone as the standard treatment of epidermoid esophageal carcinoma.

Abstract:

OBJECTIVES:Surgery has traditionally been the treatment of choice for patients with potentially resectable esophageal carcinoma. Recently, however, definitive chemoradiotherapy (CRT) has been suggested as a preferred treatment modality. In this study, CRT results with or without surgery are compared. METHODS:A total of 986 patients of esophageal carcinoma were categorized into two groups depending on the treatment: surgery (675 patients) or CRT (311 patients). These two groups were compared based on age, sex, weight loss, tumor location and length, tumor shape, grade, stage, delay in receiving treatment, event-free survival (EFS) and overall survival (OS). RESULTS:Patients in the CRT arm were significantly older (p = 0.01), had a more significant adenocarcinoma histology (p = 0.015), upper esophageal carcinoma (p = 0.0001) and more advanced stages of the disease (p = 0.0001). The median EFS for the surgery group was 24.5 months [95% confidence interval (CI), 17-32] versus 22.5 months (95% CI, 16.7-28.2) for the CRT arm (p = 0.56). The mean OS was 59.25 months (95% CI, 53.8-64.7) for the surgery group compared to 58.77 months (95% CI, 50.9-66.6) for the CRT group (p = 0.78). CONCLUSION:Definitive CRT is effective enough so as to consider omitting surgery and could be used as a standard treatment for patients with esophageal carcinoma.

journal_name

Oncology

journal_title

Oncology

authors

Salek R,Tabrizi FV,Bezenjani SE,Saedi HS,Ashkiki MH,Hosainzadeh SM,Mohtashami S

doi

10.1159/000333448

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

214-9

issue

3-4

eissn

0030-2414

issn

1423-0232

pii

000333448

journal_volume

81

pub_type

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