Abstract:
:An increase in serum iron levels and a decrease in serum unsaturated iron binding capacity (uIBC) were noted following the administration of cisplatinum to 9 children with malignancies. The mean serum iron concentration increased from a pretreatment level of 75.7 +/- 30.5 micrograms/ml to a posttreatment level of 162.1 +/- 65.3 micrograms/ml with the first cisplatinum treatment course (p less than 0.004). The uIBC concomitantly decreased from 181.9 +/- 33.7 micrograms/ml to 86.4 +/- 44.6 micrograms/ml (p less than 0.0005). A cumulative effect was noted following subsequent courses. The levels returned to baseline values within 2-4 months following cessation of therapy in 6 children in whom follow-up data were available. It is possible that this reversal of the iron/uIBC ratio is the result of cisplatinum competition for iron binding sites to proteins.
journal_name
Oncologyjournal_title
Oncologyauthors
Kletter G,Parks BR Jr,Bhatnagar A,Iyer RVdoi
10.1159/000226657subject
Has Abstractpub_date
1988-01-01 00:00:00pages
421-3issue
6eissn
0030-2414issn
1423-0232journal_volume
45pub_type
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