Abstract:
OBJECTIVE:Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). PATIENTS AND METHODS:We analyzed TrkB expression in 161 GC patients by immunohistochemistry and Western blot analysis. The correlation of TrkB mRNA and protein expression levels was examined in 10 patients by RT-PCR assay. RESULTS:TrkB expression was of level 1 in 97 (60.2%) and level 2 in 64 (39.8%) patients. Patients with level 2 expression had a significantly higher incidence of distant metastases (p < 0.0001), well-differentiated tumors (p < 0.005), deeper depth of invasion (p < 0.005) and poorer disease-free and overall survival (p < 0.0001 each) compared to patients with level 1. Multivariate analysis identified the level of TrkB expression as an independent prognostic factor for both disease-free and overall survival (p < 0.01 and p < 0.0001, respectively). Both lymph node metastasis (odds ratio = 10.7) and TrkB expression (odds ratio = 9.3) were independent predictors of distant metastases. CONCLUSION:A high level of TrkB expression was observed in well-differentiated GC subtypes and is a predictor for distant metastases and prognosis in GC.
journal_name
Oncologyjournal_title
Oncologyauthors
Zhang Y,Fujiwara Y,Doki Y,Takiguchi S,Yasuda T,Miyata H,Yamazaki M,Ngan CY,Yamamoto H,Ma Q,Monden Mdoi
10.1159/000151615subject
Has Abstractpub_date
2008-01-01 00:00:00pages
17-26issue
1-2eissn
0030-2414issn
1423-0232pii
000151615journal_volume
75pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::The present study was undertaken to detect the spontaneous mammary tumor-associated antigen ( MTAA ), and to find the cross-reacting antigen in chemically-induced mammary tumor. The antisera against spontaneous mammary tumor were raised in the WAF1 rats of the same strain and tested for the detection of tumor-associat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225824
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:To define the cyclophosphamide (CTX) maximal tolerated dose when combined with fixed doses of gemcitabine, fluorouracil (5-FU) and folinic acid (leucovorin, LFA) in metastatic breast cancer patients pretreated with anthracyclines and taxanes. METHODS:Metastatic breast cancer patients aged < or = 75 years, with...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000048243
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression by regulating DNA repair, cell division and apoptosis. One major function of wild-type p53 is to control the onset of DNA replication at the G1-S boundary by inducing p21 protein, which promotes cell cycle arrest b...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000066223
更新日期:2002-01-01 00:00:00
abstract::Nucleophosmin/B23 is a nucleolar phosphoprotein which redistributes from nucleoli to nucleoplasm (B23-translocation) when cells are exposed to certain anticancer drugs, particularly intercalators. The B23-translocation assay has been demonstrated in cell culture to correlate with drug effects and to detect drug-resist...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227043
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Brain metastases develop frequently in patients with non-small cell lung cancer (NSCLC), and the prognosis for these patients is very poor. We evaluated the role of chemotherapy for patients with brain metastases from NSCLC. METHODS:We analyzed 30 patients who were discovered to have brain metastases during...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012185
更新日期:2000-11-01 00:00:00
abstract::362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227550
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Wernicke's encephalopathy (WE) is a neurological emergency which presents with symptoms of confusion, ophthalmoplegia, and ataxia. Cancer patients are at high risk of this acute encephalopathy due to chronic malnutrition, chemotherapy-induced nausea and vomiting, and consumption of thiamine by rapidly growin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000174951
更新日期:2009-01-01 00:00:00
abstract::Coagulation disorders are frequently detected in patients affected by different tumours even though clinical symptoms occur in a very small percentage of such subjects. Coagulation processes are probably involved in the mechanism of metastatic spread. We assayed the plasma levels of thrombin-antithrombin III (TAT) com...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227086
更新日期:1992-01-01 00:00:00
abstract::A multidrug-resistant (MDR) cell line isolated from HOB1 lymphoma cells was characterized. The MDR phenotype in this cell line was typified by resistance to vincristine with varying degrees of cross-resistance to Adriamycin, colcemid and actinomycin D. Decreased intracellular [3H]vincristine with concurrent increase i...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227300
更新日期:1994-01-01 00:00:00
abstract::Expression of ras p21 in human gastric cancers, benign lesions and normal tissues was immunohistochemically evaluated by the avidin-biotin peroxidase complex (ABC) method with anti-ras p21 monoclonal antibody rp-28. Positive p21 immunoreactivity was shown in 23 (77%) of 30 gastric cancers, in 13 (48%) of 27 benign les...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226728
更新日期:1989-01-01 00:00:00
abstract::The value of a screening test for sytoxic chemotherapeutic agents in the treatment of advanced malignant disease is assessed by comparing the performances of 32 patients whose treatment followed closely the test recommendations with that of 31 patients whose treatment did not follow the predictions. The significant im...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000224977
更新日期:1974-01-01 00:00:00
abstract::Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer. Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225692
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Adenocarcinoma is the most frequent pathological type of stomach cancer. Hodgkin's lymphoma is a lymphoproliferative disease arising from lymphoid tissue which is characterized by Reed-Sternberg cells. Synchronous occurrence of these two malignancies has not been reported in the English literature so far. C...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000136799
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:New effective therapy is desirable for patients with non-small cell lung cancer (NSCLC) who have failed previous treatments. Fractionated administration of paclitaxel may be less toxic and more active against NSCLC. The aim of this study was to evaluate the activity and toxicity of weekly paclitaxel therapy f...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000079481
更新日期:2004-01-01 00:00:00
abstract::In squamous cell carcinoma of the head and neck (SCCHN), hypoxia is considered a crucial physiological modulator for malignant progression, wherebythe plasminogen activation system is involved in overlapping functions such as moulding of the extracellular matrix, cell proliferation and signal transduction. Little is k...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000106789
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. METHODS:We retro...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000327222
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Elevated histone deacetylase (HDAC) isoenzyme levels have been described in patients with carcinomas and leukemias. HDAC inhibitors (HDACi) have shown promise in the treatment of carcinomas and are currently under intense research. To make better use of HDACi in treating chronic lymphocytic leukemia (CLL), H...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000334577
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply in...
journal_title:Oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000486338
更新日期:2018-01-01 00:00:00
abstract::The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011850
更新日期:1998-03-01 00:00:00
abstract::Canthaxanthin, a carotenoid with no vitamin A activity, was evaluated for its efficacy in the prevention of chemically induced mammary cancers. Canthaxanthin was administered in the diet at two dose levels (3,390 or 1,130 mg/kg diet). In the dimethylbenzanthracene-induced mammary cancer model, diet supplementation wit...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226935
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:We investigated the efficacy of risk-adapted adjuvant paclitaxel/carboplatin chemotherapy in early-stage ovarian carcinoma. METHODS:Fifty-three patients were treated according to the risk of relapse: patients with stages IA or IB or with grade 1 (low risk) received 4 cycles of paclitaxel and carboplatin; pat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000334230
更新日期:2011-01-01 00:00:00
abstract::Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000478703
更新日期:2017-01-01 00:00:00
abstract::The mode of growth of tumour cells from primary breast carcinoma in the axillary nodes is shown to be related to the oestrogen receptor (ER) status of the primary tumour. ER-positive primaries are described as tending to show sinophilic growth, the tumour cells spreading along the nodal sinuses; while the ER-negative ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225735
更新日期:1983-01-01 00:00:00
abstract::Breast conservation treatment followed, if useful, by adjuvant therapy is the treatment of choice in early breast cancer. Late cosmetic outcome and toxicity are important in comparing conservative treatment to mastectomy. We reviewed the records of 225 patients treated from 1981 to 1988 with a median follow-up of 74 m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227454
更新日期:1995-05-01 00:00:00
abstract::Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333279
更新日期:2011-01-01 00:00:00
abstract::Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226855
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000323175
更新日期:2010-01-01 00:00:00
abstract::A sulfur-containing amino acid compound, S-allyl cysteine (SAC), derived from garlic extract inhibited proliferation of nine human and murine melanoma cell line in a dose-dependent manner (1.2-10 mM) assessed by a [3H]thymidine incorporation assay. Three control human lymphoblastoid cell lines were not inhibited by SA...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227149
更新日期:1993-01-01 00:00:00
abstract::The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227347
更新日期:1994-05-01 00:00:00
abstract::We examined the expression of p16, the CDKN2A gene product, in EBV-associated gastric carcinomas (EBV-GCs). EBV-GCs were identified by detecting EBV-encoded small RNA (EBER) using an in situ hybridization assay of paraffin-embedded tissue. Two non-EBV-GC cases for each EBV-GC case were selected, matched for age, sex, ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000080290
更新日期:2004-01-01 00:00:00