Abstract:
:Expression of ras p21 in human gastric cancers, benign lesions and normal tissues was immunohistochemically evaluated by the avidin-biotin peroxidase complex (ABC) method with anti-ras p21 monoclonal antibody rp-28. Positive p21 immunoreactivity was shown in 23 (77%) of 30 gastric cancers, in 13 (48%) of 27 benign lesions and in 10 (22%) of 46 normal mucosa cases. Among them, strong staining was demonstrated only in 11 (37%) of 30 gastric cancers, but not in benign lesions and normal tissues. Cases showing more than 20% positive cell ratio were observed in 22 (73%) gastric cancers, in 11 (41%) benign lesions and 6 (13%) normal mucosa cases. Further, intracellular distribution of ras p21 is heterogeneous in gastric cancers, while it is homogeneous in benign lesions or normal tissues. The ABC method with rp-28 could be helpful for clinical differential diagnosis between gastric cancers and benign lesions by investigating three factors: staining intensity, positive cell ratio and intracellular distribution of ras p21.
journal_name
Oncologyjournal_title
Oncologyauthors
Nakajima K,Kuzumaki N,Oda A,Kobayashi H,Katoh H,Tanabe Tdoi
10.1159/000226728subject
Has Abstractpub_date
1989-01-01 00:00:00pages
260-5issue
4eissn
0030-2414issn
1423-0232journal_volume
46pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000485322
更新日期:2018-01-01 00:00:00
abstract::Ifosfamide is relatively well tolerated but it can be associated occasionally with life-threatening complications such as arrhythmias and heart failure, severe encephalopathy and hemorrhagic cystitis. Mesna administration can control the urothelial toxicity of ifosfamide, but it is without effect on the other complica...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000073351
更新日期:2003-01-01 00:00:00
abstract::The chemosensitivities of 62 human colon cancer tissues, 67 rectal cancer tissues and 31 tumor-adjacent normal mucosal tissues were determined using the in vitro succinate dehydrogenase inhibition (SDI) test. These tissues obtained at the time of surgery were exposed to carboquone (CQ), adriamycin (ADM), mitomycin C (...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226917
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:In order to improve the prognosis of pancreatic cancer patients, it is crucial to explore novel tools for its early diagnosis. Here, we attempted to screen serum biomarkers to distinguish pancreatic cancer from non-cancer individuals. METHODS:47 serum samples from pancreatic cancer patients, 39 of whom had s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000084824
更新日期:2005-01-01 00:00:00
abstract::The activities of established and experimental antitumor drugs were tested against the BRO and MeWo human melanomas transplanted in the subrenal capsule of phenotypically immunocompetent (CBA x C57BL/6)F1 mice. Immunosuppression was achieved with preliminary whole-body radiation, and cytological examination showed tha...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227400
更新日期:1994-11-01 00:00:00
abstract::Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225395
更新日期:1980-01-01 00:00:00
abstract::The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227347
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression by regulating DNA repair, cell division and apoptosis. One major function of wild-type p53 is to control the onset of DNA replication at the G1-S boundary by inducing p21 protein, which promotes cell cycle arrest b...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000066223
更新日期:2002-01-01 00:00:00
abstract::Lymph node and distant metastasis were comparatively studied in 225 oral carcinomas, and factors predisposing toward metastasis were investigated using clinical and immunohistopathological approaches. Neither the sites of tumors nor T-stage was correlated with either type of metastasis. Tumor cell differentiation was ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012090
更新日期:2000-02-01 00:00:00
abstract:PURPOSE:To confirm the safety and effectiveness of techniques to assist radiofrequency ablation (RFA) for difficult cases, we retrospectively evaluated successful treatment rates, early complications and local tumor progressions. PATIENTS AND METHODS:Between June 1999 and April 2009, a total of 341 patients with 535 n...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000315236
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. METHODS:We retro...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000327222
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:This study reports the percentage of breast cancer survivors receiving ongoing benzodiazepines and the circumstances surrounding their usage. METHODS:The medical records of 1,000 consecutive breast cancer survivors who were no longer receiving adjuvant chemotherapy were reviewed. RESULTS:Among those patient...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000330814
更新日期:2011-01-01 00:00:00
abstract::The effects of the gamma-amino-n-butyric acid (GABA)A receptor agonist muscimol, and the GABAB receptor agonist baclofen, on colon carcinogenesis induced by azoxymethane in Wistar rats were tested. Administration of either muscimol or baclofen had no influence on the incidence of colon tumors at week 30. However, almo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227048
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Hormone receptor-positive breast cancer accounts for nearly two-thirds of breast cancer cases; it ultimately acquires resistance during endocrine treatment and becomes more aggressive. This study evaluated the role of developmental endothelial locus (Del)-1 in tamoxifen-resistant (TAM-R) breast cancer. METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000501340
更新日期:2019-01-01 00:00:00
abstract::From January 1991 to August 1993, 237 women with metastatic breast cancer were recruited into a multicentric phase II clinical trial designed to assess the cardioprotective activity of Cardioxane (ICRF-187). All patients were treated with 5-fluorouracil 500 mg/m2, doxorubicin 50 mg/m2, cyclophosphamide 500 mg/m2 (FDC)...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227467
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:There is much evidence for the detrimental effect of treatment interruptions on tumor control, particularly in head and neck cancer. In order to determine the outcome of the treatment interruptions in postoperative irradiation of breast cancer, 853 female patients treated between 1990 and 1999 inclusive were ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000087909
更新日期:2005-01-01 00:00:00
abstract::72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225162
更新日期:1976-01-01 00:00:00
abstract::The encouraging results that have been reported for cisplatin combination chemotherapy in a minority of patients with cancer of unknown primary (CUP) together with the previously shown equal activity of carboplatin in this setting, prompted us to investigate the effectiveness of a carboplatin-containing regimen in a p...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000011890
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:Serrated adenoma (SA) consists of glands both with intraluminal projection of tall columnar cells, which resemble the terminally differentiated cells in the surface epithelium, and with concave short cells, which resemble progenitor crypt cells of the colon. The aim of this study was to clarify the relationsh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151359
更新日期:2008-01-01 00:00:00
abstract::The registry of digestive cancer set up for the French department of Côte d'Or (455, 727) enables a morbidity study about esophageal cancer to be made among residents. The crude animal incidence rate was 16.7/100,000 for males and 1.2/100,000 for females. Corresponding age-standardized rates were 13.2 and 0.5. The sex...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225510
更新日期:1981-01-01 00:00:00
abstract::In 29 patients (48 courses of chemotherapy), a randomized double-blind crossover study was undertaken to establish the antiemetic effectiveness of a combination of metoclopramide at a moderately high dose (5 mg/kg body weight) with 1 g methylprednisolone (treatment A) as compared with metoclopramide monotherapy (5 mg/...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000226063
更新日期:1985-01-01 00:00:00
abstract::Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer. Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225692
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000458531
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:We investigated the efficacy of risk-adapted adjuvant paclitaxel/carboplatin chemotherapy in early-stage ovarian carcinoma. METHODS:Fifty-three patients were treated according to the risk of relapse: patients with stages IA or IB or with grade 1 (low risk) received 4 cycles of paclitaxel and carboplatin; pat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000334230
更新日期:2011-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is common in Asia, and there were no effective chemotherapeutic agents for advanced HCC. Sorafenib, an oral multikinase inhibitor, has set a milestone in the management of HCC in that it is the first agent to significantly improve the overall survival in patients with advanced HCC in a d...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000315246
更新日期:2010-07-01 00:00:00
abstract::Using a Gompertzian pharmacodynamic model, we have studied the changes induced by graded doses of adriamycin (AM) on the growth of intramuscular Lewis lung carcinoma (3LL) and its lung metastases in C57Bl/6 mice. An interpretation of the drug's effects on free growth of the tumor cells is given in the Appendix. Unlike...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225709
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Transcatheter arterial chemoembolization (TACE) is a standard therapy used in the treatment of intermediate hepatocellular carcinoma (HCC). Recently, balloon-occluded TACE (B-TACE) has been developed. PURPOSE:This study aimed to clarify the effects of B-TACE in patients with HCC, with a focus on which drug ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492822
更新日期:2019-01-01 00:00:00
abstract::The best treatment for primary gastric lymphomas (PGL) has not yet been defined. Eighty-three patients with stage I/II PGL are documented, focusing on prognostic factors, treatment-related morbidity and mortality, and therapeutic outcome. Chemotherapy improved survival in comparison to local treatments, i.e. gastrecto...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011978
更新日期:1999-01-01 00:00:00
abstract::Mice of four different inbred strains (CBA, Balb/c, C57Bl/6 and DBA/2), bearing different transplanted tumours (methylcholanthrene-induced sarcomas, B16 melanoma and P-815 mastocytoma), were tested for cellular immune reactivity to the synthetic encephalitogenic peptide of human myelin basic protein by the leucocyte a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225732
更新日期:1983-01-01 00:00:00
abstract::Anticipatory nausea and vomiting (ANV) are learned responses to chemotherapy that develop in up to 25% of patients by the fourth treatment cycle. Post-treatment nausea and emesis must occur before development of ANV can take place. Certain patient characteristics and other responses to chemotherapy can also be used to...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227633
更新日期:1996-06-01 00:00:00