Abstract:
:Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both in the cytoplasm and the nucleus of cells and in numerous organs. The noncarcinogenic compound dibenz(a,c)anthracene was undetectable. This work suggests that the differences in carcinogenicity may result in the possibility of the compounds to penetrate the nucleus of target cells.
journal_name
Oncologyjournal_title
Oncologyauthors
Stora Cdoi
10.1159/000225395subject
Has Abstractpub_date
1980-01-01 00:00:00pages
23-6issue
1eissn
0030-2414issn
1423-0232journal_volume
37pub_type
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