Abstract:
:Sodium cyanate, a drug that selectively suppresses amino acid incorporation for protein synthesis in tumor tissue, was given to patients with advanced colorectal carcinoma who had failed to conventional therapy, with the purpose of assessing a maximum tolerable oral dose. At 35 mg/kg p.o. daily, the drug had to be stopped in approximately half (4) of the patients because of gastrointestinal toxicity (nausea, vomiting) and neurologic toxicity (hallucinations, disorientation). However, in 5 other patients, at the same dose, the drug was well tolerated for up to 147 days and for a total cumulative dose of 308 g. In this group of patients, sodium cyanate was stopped because of evidence of tumor progression. No hematologic toxicity was observed. We observed no therapeutic effects. We therefore recommend a starting dose of 30 mg/kg p.o. if a phase-II study is considered.
journal_name
Oncologyjournal_title
Oncologyauthors
Herrera-Ornelas L,Petrelli NJ,Madajewicz S,Mittelman A,Allfrey VGdoi
10.1159/000226038subject
Has Abstractpub_date
1985-01-01 00:00:00pages
236-41issue
4eissn
0030-2414issn
1423-0232journal_volume
42pub_type
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