Role of anastrozole across the breast cancer continuum: from advanced to early disease and prevention.

abstract：OBJECTIVES:It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients. METHODS:Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of...

journal_title：Oncology

authors： Herrmann E,Bierer S,Gerss J,Köpke T,Hertle L,Wülfing C

更新日期：2008-01-01 00:00:00

abstract：:Using a Gompertzian pharmacodynamic model, we have studied the changes induced by graded doses of adriamycin (AM) on the growth of intramuscular Lewis lung carcinoma (3LL) and its lung metastases in C57Bl/6 mice. An interpretation of the drug's effects on free growth of the tumor cells is given in the Appendix. Unlike...

journal_title：Oncology

authors： Madonna M,Colombo T,Donelli MG,Dagnino G

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Osteosarcoma is a rare malignancy, and patients with this disease benefit from adjuvant chemotherapy. While cisplatin, anthracyclines and ifosfamide are the most commonly used agents in the treatment of osteosarcoma, a search for the best combination with higher efficacy and minimal toxicity continues. We pl...

journal_title：Oncology

authors： Basaran M,Bavbek ES,Saglam S,Eralp L,Sakar B,Atalar AC,Bilgic B,Ozger H,Onat H

更新日期：2007-01-01 00:00:00

abstract：:The mode of growth of tumour cells from primary breast carcinoma in the axillary nodes is shown to be related to the oestrogen receptor (ER) status of the primary tumour. ER-positive primaries are described as tending to show sinophilic growth, the tumour cells spreading along the nodal sinuses; while the ER-negative ...

journal_title：Oncology

authors： Hartveit F,Thorsen T,Tangen M,Maehle BO,Thoresen S,Halvorsen JF

更新日期：1983-01-01 00:00:00

abstract：:We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this serie...

journal_title：Oncology

authors： Vider M,Kashmiri R,Hunter L,Moses B,Meeker WR,Utley JF,Maruyama Y

更新日期：1974-01-01 00:00:00

abstract：BACKGROUND/AIM:Erlotinib and chemotherapy have shown similar efficacy for pretreated non-small cell lung cancer (NSCLC) patients, but none of the large studies have selected patients based on histology. We present a retrospective single-center series of advanced non-squamous NSCLC patients treated with erlotinib or pem...

journal_title：Oncology

authors： Zugazagoitia J,Puente J,González-Larriba JL,Manzano A,Sotelo M,Hernández S,Sanz J,Pérez P,Díaz-Rubio E

更新日期：2013-01-01 00:00:00

abstract：:23 patients received cis-platinum, doxorubicin and cyclophosphamide for gynecologic malignancy between December 1, 1980 and December 1, 1982. Each patient was randomized with each course of chemotherapy to receive intravenous droperidol or the combination of promethazine and chlorpromazine rectal suppositories as an a...

journal_title：Oncology

authors： Roberts WS,Wisniewski BJ,Cavanagh D,Marsden DE

更新日期：1985-01-01 00:00:00

abstract：:The Abelson-virus-induced murine lymphosarcoma cell line RAW117-P and its in vivo selected highly malignant and metastatic variant RAW117-H10 have been studied for their growth in vivo, in vitro and in semi-solid agar. The highly malignant metastatic variant RAW117-H10 cells killed syngeneic Balb/c mice rapidly and fo...

journal_title：Oncology

authors： Joshi SS,Sharp JG,Brunson KW

更新日期：1987-01-01 00:00:00

abstract：:Thirteen samples of gastric tumors that had developed in the remnant stomach (remnant gastric cancer) were compared with 63 samples of primary gastric tumors located in the upper third of the stomach (primary gastric cancer) by both clinicopathologic and flow cytometric analysis. The depths of invasion of all these tu...

journal_title：Oncology

authors： Ikeguchi M,Kondou A,Oka A,Tsujitani S,Maeta M,Kaibara N

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:The RUNX proteins are a family of transcriptional factors that have essential functions during embryogenesis and development, whereas deregulation in expression of RUNXs is often linked to tumor formation. To date, there has been no study describing the precise expression, prognostic impact and methylation s...

journal_title：Oncology

authors： Tonomoto Y,Tachibana M,Dhar DK,Onoda T,Hata K,Ohnuma H,Tanaka T,Nagasue N

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...

journal_title：Oncology

authors： Kotsori AA,Dolly S,Sheri A,Parton M,Shaunak N,Ashley S,Walsh G,Johnston S,Smith IE

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Adenocarcinoma is the most frequent pathological type of stomach cancer. Hodgkin's lymphoma is a lymphoproliferative disease arising from lymphoid tissue which is characterized by Reed-Sternberg cells. Synchronous occurrence of these two malignancies has not been reported in the English literature so far. C...

journal_title：Oncology

authors： Comez G,Pehlivan Y,Kalender ME,Sevinc A,Sari I,Camci C

更新日期：2007-01-01 00:00:00

abstract：:Twenty-five patients with cutaneous melanoma were imaged with F(ab')2 fragments of antimelanoma monoclonal antibody (MoAb) 225.28S labeled with 99mTc and 131I or 111In. Out of 16 patients without evidence of metastatic lesions, 6 false-positive cases were observed. Only 4 out of 9 patients with known lesions showed po...

journal_title：Oncology

authors： Repetto L,Scopinaro G,Michelotti A,Claudiani F,Fusco V,Grimaldi A,Sertoli MR,Rosso R

更新日期：1988-01-01 00:00:00

abstract：:Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...

journal_title：Oncology

authors： Watson DS,Brotherick I,Shenton BK,Wilson RG,Angus B,Varma JS,Campbell FC

更新日期：1999-01-01 00:00:00

abstract：:Ifosfamide is relatively well tolerated but it can be associated occasionally with life-threatening complications such as arrhythmias and heart failure, severe encephalopathy and hemorrhagic cystitis. Mesna administration can control the urothelial toxicity of ifosfamide, but it is without effect on the other complica...

journal_title：Oncology

authors： Klastersky J

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS:The analysis enrolled 117 patients and the variables...

journal_title：Oncology

authors： Miyake M,Morizawa Y,Hori S,Marugami N,Iida K,Ohnishi K,Gotoh D,Tatsumi Y,Nakai Y,Inoue T,Anai S,Torimoto K,Aoki K,Tanaka N,Shimada K,Konishi N,Fujimoto K

更新日期：2017-01-01 00:00:00

abstract：:Pancreatic intraepithelial neoplasia (PanIN) is a microscopic papillary noninvasive lesion arising from the pancreatic ductal epithelium. However, the natural history and time to progression of high-grade PanIN remain unclear. Herein, we report 2 cases of high-grade PanIN without morphological changes of the main panc...

journal_title：Oncology

authors： Yamao K,Takenaka M,Nakai A,Omoto S,Kamata K,Minaga K,Miyata T,Imai H,Sakurai T,Watanabe T,Nishida N,Matsumoto I,Takeyama Y,Chikugo T,Kudo M

更新日期：2017-01-01 00:00:00

abstract：:A loss of heterozygosity (LOH) at the DCC gene locus was detected in colorectal tumors, and this LOH might be related to metastasis. The aim of this study was to determine DCC protein expression in colorectal cancer and to evaluate its prognostic value. Allelic loss of the DCC locus was observed in 16 of the 23 patien...

journal_title：Oncology

authors： Saito M,Yamaguchi A,Goi T,Tsuchiyama T,Nakagawara G,Urano T,Shiku H,Furukawa K

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:Primary chemoradiotherapy for locally advanced pancreatic cancer (LAPC) may improve local control, curative resection rate and long-term survival. We performed a phase II study to evaluate toxicity and activity of primary radiation therapy and concurrent chemotherapy with gemcitabine (GEM) twice weekly in pa...

journal_title：Oncology

authors： Magnino A,Gatti M,Massucco P,Sperti E,Faggiuolo R,Regge D,Capussotti L,Gabriele P,Aglietta M

更新日期：2005-01-01 00:00:00

abstract：:The serum detection of S100B, a new melanoma marker, has shown clinical significance in early studies. The aim of our study of 1, 339 serum samples from 412 different melanoma patients and 107 control patients was to prove the prognostic value of serum S100B levels in melanoma patients at different stages of disease a...

journal_title：Oncology

authors： Hauschild A,Engel G,Brenner W,Gläser R,Mönig H,Henze E,Christophers E

更新日期：1999-01-01 00:00:00

abstract：:The role of estrogen and estrogen-related growth factors in the mechanism of hormone dependency of endometrial adenocarcinoma cells was investigated. The proliferation of hormone-responsive human endometrial adenocarcinoma cells (Ishikawa cells), which possess both estrogen and progesterone receptors, was optimally st...

journal_title：Oncology

authors： Hata H,Hamano M,Watanabe J,Kuramoto H

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVES:It was the aim of this study to evaluate clinicopathological characteristics and prognostic factors of uterine leiomyosarcomas (LMS). METHODS:Twenty-eight patients with uterine LMS were evaluated in this retrospective study. Their features and survival were analyzed by Kaplan-Meier and log-rank tests. RESU...

journal_title：Oncology

authors： Loizzi V,Cormio G,Nestola D,Falagario M,Surgo A,Camporeale A,Putignano G,Selvaggi L

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 cen...

journal_title：Oncology

authors： Esposito F,Cecere SC,Magazzino F,Katsaros D,Ottaiano A,Gadducci A,Pisano C,Scalone S,Rabaiotti E,Salutari V,Cormio G,Canuto EM,Greggi S,Savarese A,Marinaccio M,Scollo P,Santeufemia DA,Sacco C,Facchini G,Pignata S

更新日期：2014-01-01 00:00:00

abstract：:High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...

journal_title：Oncology

authors： Cruz JM,Muss HB,Russell G

更新日期：1992-01-01 00:00:00

abstract：:C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM stagin...

journal_title：Oncology

authors： Drahovsky D,Dunzendorfer U,Ziegenhagen G,Drahovsky M,Kellen JA

更新日期：1981-01-01 00:00:00

abstract：:The aim of this study is to compare the levels of carcinoembryonic antigen (CEA) in the gastric juice, stomach mucosa and plasma of gastrectomy patients at risk of developing cancer with those in normal controls and gastric cancer subjects. Blood samples, gastric juices and biopsy material were taken from 52 patients ...

journal_title：Oncology

authors： Castelli M,Guadagni S,Bagnato A,Pistoia MA,Carboni M,Sega E

更新日期：1986-01-01 00:00:00

abstract：:Immunoperoxidase methods permit the demonstration of a variety of antigens in routinely processed tissues. The morphological detail obtained by this procedure is comparable to orthodox haematoxylin and eosin stained sections, and so offers the diagnostic pathologist the opportunity of simultaneously identifying normal...

journal_title：Oncology

authors： Taylor CR

更新日期：1978-01-01 00:00:00

abstract：:Macroscopic morphology, histology and ultrastructure of BK virus (BKV)-induced hamster and mouse tumors were investigated. Groups of animals were immunosuppressed to study the relationship between immune system and BKV oncogenesis. Ependymomas had the highest incidence, followed by tumors of pancreatic islets, osteosa...

journal_title：Oncology

authors： Altavilla G,Carrà L,Alberti S,Corallini A,Cavazzini L,Fabris G,Aleotti A,Barbanti-Brodano G

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Patients with localized gastric adenocarcinoma (LGAC), who get pre-operative therapy, have heterogeneous/unpredictable outcomes. Predictive clinical variables/biomarkers are not established. METHODS:We analyzed 107 LGAC patients who had chemoradiation and surgery. LGACs were grouped for (1) presence/absence...

journal_title：Oncology

authors： Charalampakis N,Nogueras González GM,Elimova E,Wadhwa R,Shiozaki H,Shimodaira Y,Blum MA,Rogers JE,Harada K,Matamoros A Jr,Sagebiel T,Das P,Minsky BD,Lee JH,Weston B,Bhutani MS,Estrella JS,Badgwell BD,Ajani JA

更新日期：2016-01-01 00:00:00

abstract：:Expression of ras p21 in human gastric cancers, benign lesions and normal tissues was immunohistochemically evaluated by the avidin-biotin peroxidase complex (ABC) method with anti-ras p21 monoclonal antibody rp-28. Positive p21 immunoreactivity was shown in 23 (77%) of 30 gastric cancers, in 13 (48%) of 27 benign les...

journal_title：Oncology

authors： Nakajima K,Kuzumaki N,Oda A,Kobayashi H,Katoh H,Tanabe T

更新日期：1989-01-01 00:00:00