Effects of cycloheximide on chromatin-bound and -unbound PCNA in HeLa cells.

Abstract:

:We examined the effects of cycloheximide on the amount of chromatin-bound and -unbound PCNA subpopulations in HeLa cells. The chromatin-bound PCNA content decreased rapidly in the presence of cycloheximide, whereas the reduction of the total amount of PCNA was minimal even 24 h after the treatment with cycloheximide. From these data, the half-life of PCNA was estimated to be 31.0 h for chromatin-bound PCNA and 276.8 h for the total.

journal_name

Oncology

journal_title

Oncology

authors

Sasaki K,Kurose A,Uesugi N,Kato A

doi

10.1159/000227500

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

419-21

issue

5

eissn

0030-2414

issn

1423-0232

journal_volume

52

pub_type

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