Effects of cycloheximide on chromatin-bound and -unbound PCNA in HeLa cells.

abstract：:The prognosis of brain glioblastoma is still very poor and the median survival time is generally less than 6 months. At present, no chemotherapy has appeared to influence its prognosis. On the other hand, recent advances in brain tumor biology have suggested that brain tumor growth is at least in part under a neuroend...

journal_title：Oncology

authors： Lissoni P,Meregalli S,Nosetto L,Barni S,Tancini G,Fossati V,Maestroni G

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP...

journal_title：Oncology

authors： Ulusoy G,Adali O,Tumer TB,Sahin G,Gozdasoglu S,Arinç E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Cancer patients have a higher risk for thrombosis that is usually related to advanced stage and poor prognosis. This study aimed to identify the clinical picture and outcome of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients with pulmonary embolism (PE). PATIENTS AND METHODS:Fr...

journal_title：Oncology

authors： Chuang YM,Yu CJ

更新日期：2009-01-01 00:00:00

abstract：:Recent studies have demonstrated that nitroso chemical carcinogens activate guanylate cyclase (EC 4.6.1.2) which catalyzes the production of guanosine 3',5'-monophosphate. This nucleotide is thought to be involved in normal and abnormal cell growth. We examined the effect of 3 major classes of anticancer chemotherapeu...

journal_title：Oncology

authors： Vesely DL,Levey GS

更新日期：1979-01-01 00:00:00

abstract：:This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...

journal_title：Oncology

authors： Chi KH,Chang YC,Chan WK,Liu JM,Law CK,Lo SS,Shu CH,Yen SH,Whang-Peng J,Chen KY

更新日期：1997-05-01 00:00:00

abstract：:Breast conservation treatment followed, if useful, by adjuvant therapy is the treatment of choice in early breast cancer. Late cosmetic outcome and toxicity are important in comparing conservative treatment to mastectomy. We reviewed the records of 225 patients treated from 1981 to 1988 with a median follow-up of 74 m...

journal_title：Oncology

authors： Amichetti M,Busana L,Caffo O

更新日期：1995-05-01 00:00:00

abstract：:Two randomized controlled trials identified that transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) shows a significant survival benefit compared with controls, after a long-term controversy. Thus, TACE is the current standard of care for patients presenting with multinodular HCC. Monit...

journal_title：Oncology

authors： Minami Y,Kudo M

更新日期：2013-01-01 00:00:00

abstract：:The role of p53, retinoblastoma (RB) and c-erbB-2 gene proteins in the pathogenesis of anal carcinomas has been examined. A total of 97 patients were included in the study. c-erbB-2, RB and p53 proteins were abnormal in 0, 5 and 34% of the cases, respectively. No correlation was observed between p53 and age, sex, tumo...

journal_title：Oncology

authors： Tanum G,Holm R

更新日期：1996-09-01 00:00:00

abstract：:The aim of this study was to both develop and validate a nomogram based on the Ki-67 index to predict recurrence. We constructed a nomogram using the Cox proportional hazards model with 953 N0 and N1 postoperative hormone receptor (HR)-positive breast cancer patients and validated it in an external cohort of 895 patie...

journal_title：Oncology

authors： Park YH,Im SA,Cho EY,Ahn JH,Woo SY,Kim S,Keam B,Lee JE,Han W,Nam SJ,Park IA,Noh DY,Yang JH,Ahn JS,Im YH

更新日期：2014-01-01 00:00:00

abstract：:Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...

journal_title：Oncology

authors： Baselga J,Hammond LA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:A germline BIM deletion polymorphism has been proposed to predict a poor treatment efficacy of certain kinase inhibitors. The current study aimed to explore whether the BIM deletion polymorphism predicts the treatment efficacy of sorafenib for advanced hepatocellular carcinoma (HCC). METHODS:All patients wh...

journal_title：Oncology

authors： Shao YY,Chang YL,Huang CY,Hsu CH,Cheng AL

更新日期：2013-01-01 00:00:00

abstract：AIMS:We investigated the relationship between serum leptin concentrations and polymorphism of the leptin receptor gene and breast cancer. METHODS:Serum leptin concentrations were measured by enzyme-linked immunosorbent assay in 47 women with invasive breast cancer compared with 41 age-matched controls without cancer. ...

journal_title：Oncology

authors： Liu CL,Chang YC,Cheng SP,Chern SR,Yang TL,Lee JJ,Guo IC,Chen CP

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...

journal_title：Oncology

authors： Adamo V,Magno C,Spitaleri G,Garipoli C,Maisano C,Alafaci E,Adamo B,Rossello R,Scandurra G,Scimone A

更新日期：2005-01-01 00:00:00

abstract：:Male and female mice of strains C3H/eB and C57BL/6 were injected subcutaneously with methylcholanthrene (MCA) dissolved in olive oil; mice injected with olive oil served as controls. After intervals of from 2 to 13 weeks, experimental and control mice were injected intraperitoneally with 51Cr-labeled rat red cells (RR...

journal_title：Oncology

authors： Schrieber R,Stern K

更新日期：1984-01-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used worldwide in cancer patients for over 1 year, and (only 5 years from the first publication on the clinical use of this growth factor) experience is rapidly accumulating in many oncological situations. Several randomized studies have confirme...

journal_title：Oncology

authors： Bronchud MH

更新日期：1994-03-01 00:00:00

abstract：:We started a treatment trial for malignant pericardial tamponade with intracavitary oxytetracycline, 500-1,000 mg/day, administered via an indwelling pericardial cannula after extraction of as much pericardial fluid as possible. This procedure was repeated every 24 h for 6 consecutive days or until no more fluid could...

journal_title：Oncology

authors： Grau JJ,Estapé J,Palombo H,Roca M,Daniels M,Tarragó E,Viñolas N

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:In order to determine whether infection with Helicobacter pylori might be associated with pancreatic adenocarcinoma, we performed a study to compare the H. pylori seroprevalence rate between patients with pancreatic carcinoma and matched control subjects. PATIENTS AND METHODS:Blood samples from 92 patients wit...

journal_title：Oncology

authors： Raderer M,Wrba F,Kornek G,Maca T,Koller DY,Weinlaender G,Hejna M,Scheithauer W

更新日期：1998-01-01 00:00:00

abstract：:Primary and secondary prevention of hepatocellular carcinoma (HCC) which has become endemic worldwide in recent years are the most important issues in reducing mortality of HCC patients. Among several compounds previously reported for secondary prevention, treatment with interferon (IFN) is widely applied and shows en...

journal_title：Oncology

authors： Kudo M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Patients with localized gastric adenocarcinoma (LGAC), who get pre-operative therapy, have heterogeneous/unpredictable outcomes. Predictive clinical variables/biomarkers are not established. METHODS:We analyzed 107 LGAC patients who had chemoradiation and surgery. LGACs were grouped for (1) presence/absence...

journal_title：Oncology

authors： Charalampakis N,Nogueras González GM,Elimova E,Wadhwa R,Shiozaki H,Shimodaira Y,Blum MA,Rogers JE,Harada K,Matamoros A Jr,Sagebiel T,Das P,Minsky BD,Lee JH,Weston B,Bhutani MS,Estrella JS,Badgwell BD,Ajani JA

更新日期：2016-01-01 00:00:00

abstract：:Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearr...

journal_title：Oncology

authors： Kopper L,Bánkfalvi A,Földi J,Mihalik R,Magyar M,Aczél A

更新日期：1990-01-01 00:00:00

abstract：:The methodology of future antiemetic studies will reflect the need to address the problems identified in current studies. New preclinical information on the mechanisms of emesis and antiemetic action will allow more rational clinical study design. Prior to large randomized studies, phase I and II trials should define ...

journal_title：Oncology

authors： Olver IN

更新日期：1996-06-01 00:00:00

abstract：:The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times. Rats received either TMX or estradiol benzoate (E2B) for 3 or 7 days. Tumors were as...

journal_title：Oncology

authors： Boccardo F,Cerruti G,De Menech R,Valenti G,Zanardi S

更新日期：1987-01-01 00:00:00

abstract：:After exposure to the mutagen, ethylmethanesulfonate (EMS), or the carcinogen, urethane (UR), anchorage independence was observed in cultures derived from normal skin biopsies from patients with the heritable cancer syndrome, adenomatosis of the colon and rectum (ACR). Such colonies from methylcellulose suspension cul...

journal_title：Oncology

authors： Danes BS

更新日期：1980-01-01 00:00:00

abstract：:The local immunologic phenomena in the thyroid gland of 16 patients with chronic lymphocytic thyroiditis (CLTH) were investigated; 5 of these cases were associated with thyroid non-Hodgkin's lymphomas (NHL). All patients were admitted because of struma, growing slowly in patients with CLTH alone and rapidly in those w...

journal_title：Oncology

authors： Aozasa K,Tajima K,Tominaga N,Katagiri S,Yonezawa T,Matsuzuka F,Kuma K,Sawada M

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...

journal_title：Oncology

authors： Horie K,Kawakami K,Fujita Y,Matsuda Y,Arai T,Suzui N,Miyazaki T,Koie T,Mizutani K,Ito M

更新日期：2020-01-01 00:00:00

abstract：:Primary pancreatic lymphoma (PL) is an extremely rare disease, and large-scale studies are rarely performed even in Western countries, in which all cases of PL reported to date were of the B-cell type. Little information regarding PL is available in Japan. Nineteen cases of PL were collected through a nationwide study...

journal_title：Oncology

authors： Nishimura R,Takakuwa T,Hoshida Y,Tsujimoto M,Aozasa K

更新日期：2001-01-01 00:00:00

abstract：:To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...

journal_title：Oncology

authors： Cör A

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Oncogene-driven stress-related DNA damage has been observed in lesions of colon cancer. Furthermore, DNA sensors and nucleases are stimulated during active DNA damage and replication. However, their changes and influences with respect to cancer remain largely unknown. METHODS:The gene expression levels of cG...

journal_title：Oncology

authors： Yang CA,Huang HY,Chang YS,Lin CL,Lai IL,Chang JG

更新日期：2017-01-01 00:00:00

abstract：:The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...

journal_title：Oncology

authors： Di Lorenzo G,Scagliarini S,Di Napoli M,Scognamiglio F,Rizzo M,Carteni' G

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The therapeutic potential of chemotherapy in the treatment of recurrent or metastatic non-small cell lung carcinoma (NSCLC) seems modest. Thus, the search for novel agents and combination regimens with a superior therapeutic index has a high priority. The present combination regimen consisting of mitomycin C...

journal_title：Oncology

authors： Hejna M,Kornek GV,Raderer M,Marosi L,Schneeweiss B,Greul R,Weinländer G,Valencak J,Huber H,Scheithauer W

更新日期：1998-11-01 00:00:00