Effects of theophylline treatment on mouse B-16 melanoma cells in vitro.

abstract：OBJECTIVE:There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective of this study was to evaluate prognostic factors for long-term survival. METHODS:Two hundred fourteen stage I ovarian carcinomas (registered by the Tokai Ovarian Tumor Study Group from 1988 to 1999) were ana...

journal_title：Oncology

authors： Mizuno M,Kikkawa F,Shibata K,Kajiyama H,Suzuki T,Ino K,Kawai M,Mizutani S

更新日期：2003-01-01 00:00:00

abstract：:The activity of deoxycytidylate aminohydrolase, a pivotal enzyme for pyrimidine biosynthesis in mammalian tissue, is 100x greater in the Novikoff hepatoma harvested from the intraperitoneal cavity than in the same tumor excised from either subcutaneous or intramuscular sites. The increased enzyme activity in the intra...

journal_title：Oncology

authors： Sheid B

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays an important role in ovarian cancer. The interaction of platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth factor (VEGF) in the process of angiogenesis may represent an essential feature in the progression of the disease. METHODS:Patients with epitheli...

journal_title：Oncology

authors： Mathey S,Graeser MK,Zu Eulenburg C,Woelber L,Trillsch F,Jaenicke F,Müller V,Milde-Langosch K,Mahner S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Immuno-oncological (IO) therapies such as PD-1 and PD-L1 antibodies have been introduced in the treatment of advanced non-small cell lung cancer (NSCLC) since 2015 based on randomized trials showing unprecedented advantages in overall survival (OS) with hazard ratios (HRs) between 0.5 and 0.7. The impact of ...

journal_title：Oncology

authors： Faehling M,Kopp M,Schwenk B,Fallscheer S,Kramberg S,Eckert R

更新日期：2019-01-01 00:00:00

abstract：:Expression of ras p21 in human gastric cancers, benign lesions and normal tissues was immunohistochemically evaluated by the avidin-biotin peroxidase complex (ABC) method with anti-ras p21 monoclonal antibody rp-28. Positive p21 immunoreactivity was shown in 23 (77%) of 30 gastric cancers, in 13 (48%) of 27 benign les...

journal_title：Oncology

authors： Nakajima K,Kuzumaki N,Oda A,Kobayashi H,Katoh H,Tanabe T

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Ethnic disparities in cancers are associated with variability in clinical outcomes. We present a Surveillance Epidemiology and End RESULTS (SEER)-based outcome analysis of multiethnic Waldenström's macroglobulinemia (WM) patients. METHODS:Adult WM patients diagnosed in 1992 or later (n = 3,175) were analyze...

journal_title：Oncology

authors： Ailawadhi S,Kardosh A,Yang D,Cozen W,Patel G,Alamgir MA,Chanan-Khan AA

更新日期：2014-01-01 00:00:00

abstract：:The newly isolated phenylpropanoids syringin, syringenin-apiosylglucoside, eleutheroside E and the high molecular lectins and viscotoxins were selected for a standardization of mistletoe extracts and drug preparation. The phenylpropanoids found in all alcoholic and aqueous extracts were suitable for an HPLC fingerprin...

journal_title：Oncology

authors： Wagner H,Jordan E,Feil B

更新日期：1986-01-01 00:00:00

abstract：:Nucleophosmin/B23 is a nucleolar phosphoprotein which redistributes from nucleoli to nucleoplasm (B23-translocation) when cells are exposed to certain anticancer drugs, particularly intercalators. The B23-translocation assay has been demonstrated in cell culture to correlate with drug effects and to detect drug-resist...

journal_title：Oncology

authors： Finch RA,Chan PK

更新日期：1992-01-01 00:00:00

abstract：:A patient seen at presentation for Hodgkin's disease (HD) at stage IV B was successfully treated with MOPP. In remission he developed coeliac disease, controlled by dietary measures, but 26 months after the end of chemotherapy a severe dyspeptic syndrome appeared; endoscopy and barium meal suggested the presence of a ...

journal_title：Oncology

authors： Eridani S,Singh AK

更新日期：1986-01-01 00:00:00

abstract：:Hemostatic abnormalities are rather frequent in cancer patients either in hematological or in solid tumors. Acute disseminated intravascular coagulation (DIC) is a rare coagulopathy in cancer patients, but when it develops it becomes rapidly fatal. Between June 1988 and December 1992 we observed 8 cases of acute DIC o...

journal_title：Oncology

authors： Pasquini E,Gianni L,Aitini E,Nicolini M,Fattori PP,Cavazzini G,Desiderio F,Monti F,Forghieri ME,Ravaioli A

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:We investigated stanniocalcin 1 (STC 1) expression to assess its clinical utility as a blood marker in patients with gastric cancer and evaluated its biological impact in terms of tumor aggressiveness. METHODS:Blood specimens from 93 patients with gastric cancer and 21 normal healthy volunteers were assessed...

journal_title：Oncology

authors： Arigami T,Uenosono Y,Ishigami S,Hagihara T,Haraguchi N,Matsushita D,Yanagita S,Nakajo A,Okumura H,Hokita S,Natsugoe S

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:ETS-1 has been identified as a proto-oncogene and a transcription factor for tumor angiogenesis, which is essential for the growth, invasion and metastasis of solid tumors. The aim is to investigate the clinical implications of ETS-1 expression in peritoneal metastatic lesions of ovarian cancers. METHODS:In ...

journal_title：Oncology

authors： Fujimoto J,Aoki I,Toyoki H,Khatun S,Sato E,Sakaguchi H,Tamaya T

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:Insulin-like growth factor I (IGF-I) and other components of the IGF system have been implicated in the etiology of several human malignancies. We have undertaken a case-control study among Greek women to explore the relation of major components of the IGF system (IGF-I, IGF-II and IGF-binding protein 3, IGF...

journal_title：Oncology

authors： Petridou E,Koukoulomatis P,Alexe DM,Voulgaris Z,Spanos E,Trichopoulos D

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions. Epithelial syndecan-1 expression is reduced in several malignant tumours, but in breast and pancreatic cancer, increased expression has also been described. Loss of...

journal_title：Oncology

authors： Leivonen M,Lundin J,Nordling S,von Boguslawski K,Haglund C

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:N-Acetylglucosaminyltransferase V (GnT-V) is a key enzyme in the formation of branching asparagine-linked oligosaccharides and is linked to tumor invasion and metastasis in colon and breast cancers. In normal esophageal epithelium, beta1,6-branched asparagine-linked oligosaccharides synthesized by GnT-V are s...

journal_title：Oncology

authors： Ishibashi Y,Dosaka-Akita H,Miyoshi E,Shindoh M,Miyamoto M,Kinoshita I,Miyazaki H,Itoh T,Kondo S,Nishimura M,Taniguchi N

更新日期：2005-01-01 00:00:00

abstract：:We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this serie...

journal_title：Oncology

authors： Vider M,Kashmiri R,Hunter L,Moses B,Meeker WR,Utley JF,Maruyama Y

更新日期：1974-01-01 00:00:00

abstract：BACKGROUND:Brain metastases develop frequently in patients with non-small cell lung cancer (NSCLC), and the prognosis for these patients is very poor. We evaluated the role of chemotherapy for patients with brain metastases from NSCLC. METHODS:We analyzed 30 patients who were discovered to have brain metastases during...

journal_title：Oncology

authors： Fujita A,Fukuoka S,Takabatake H,Tagaki S,Sekine K

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Whether recurrence after surgery and primary metastatic pancreatic cancer should be included in the same category when conducting gemcitabine-based clinical trials remains controversial. OBJECTIVE:To clarify the outcomes of recurrent and metastatic pancreatic cancers. METHODS:326 patients who received gemc...

journal_title：Oncology

authors： Hashimoto K,Ueno H,Ikeda M,Kojima Y,Hagihara A,Kondo S,Morizane C,Okusaka T

更新日期：2009-01-01 00:00:00

abstract：:Two randomized controlled trials identified that transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) shows a significant survival benefit compared with controls, after a long-term controversy. Thus, TACE is the current standard of care for patients presenting with multinodular HCC. Monit...

journal_title：Oncology

authors： Minami Y,Kudo M

更新日期：2013-01-01 00:00:00

abstract：:Macroscopic morphology, histology and ultrastructure of BK virus (BKV)-induced hamster and mouse tumors were investigated. Groups of animals were immunosuppressed to study the relationship between immune system and BKV oncogenesis. Ependymomas had the highest incidence, followed by tumors of pancreatic islets, osteosa...

journal_title：Oncology

authors： Altavilla G,Carrà L,Alberti S,Corallini A,Cavazzini L,Fabris G,Aleotti A,Barbanti-Brodano G

更新日期：1983-01-01 00:00:00

abstract：:Autoantibodies (AAb) directed against the nuclear phosphoprotein p53 can be detected in patients with various forms of cancer. The objective was to determine the prevalence of p53 AAb at the time of diagnosis in ovarian cancer patients and to correlate the presence of p53 AAb with clinicopathological parameters. Sera ...

journal_title：Oncology

authors： Vogl FD,Stickeler E,Weyermann M,Köhler T,Grill HJ,Negri G,Kreienberg R,Runnebaum IB

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. METHODS:A total of 36 pa...

journal_title：Oncology

authors： Feng LR,Espina A,Saligan LN

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The RUNX proteins are a family of transcriptional factors that have essential functions during embryogenesis and development, whereas deregulation in expression of RUNXs is often linked to tumor formation. To date, there has been no study describing the precise expression, prognostic impact and methylation s...

journal_title：Oncology

authors： Tonomoto Y,Tachibana M,Dhar DK,Onoda T,Hata K,Ohnuma H,Tanaka T,Nagasue N

更新日期：2007-01-01 00:00:00

abstract：:In pancreatic cancer (PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy. This review focuses on the role of carbohydrate antigen 19-9 (CA 19-...

journal_title：Oncology

authors： Boeck S,Stieber P,Holdenrieder S,Wilkowski R,Heinemann V

更新日期：2006-01-01 00:00:00

abstract：:Zinostatin stimalamer (SMANCS) is a lipophilic intra-arterial chemotherapeutic agent for hepatocellular carcinoma (HCC). In our previous study, transcatheter arterial infusion chemotherapy using SMANCS for HCC showed a response rate of 20%. In an effort to obtain a superior anti-tumor effect against HCC, we conducted ...

journal_title：Oncology

authors： Okusaka T,Okada S,Ueno H,Ikeda M,Iwata R,Furukawa H,Takayasu K,Moriyama N,Sato T,Sato K

更新日期：2002-01-01 00:00:00

abstract：:Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal...

journal_title：Oncology

authors： Yete S,D'Souza W,Saranath D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Identification of high-risk stage II colorectal cancer (CRC) patients, potential candidates for adjuvant chemotherapy, is challenging. Current clinical guidelines rely mainly on histopathological markers with relatively weak prognostic value. This motivates further search for prognostic markers. METHODS:Thi...

journal_title：Oncology

authors： Dimberg J,Andersson RE,Haglund S

更新日期：2020-01-01 00:00:00

abstract：:The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times. Rats received either TMX or estradiol benzoate (E2B) for 3 or 7 days. Tumors were as...

journal_title：Oncology

authors： Boccardo F,Cerruti G,De Menech R,Valenti G,Zanardi S

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the antitumor activity and safety of an epirubicin, cisplatin, and capecitabine (ECX) combination in patients with metastatic or advanced gastric cancer. PATIENTS AND METHODS:Patients with metastatic or advanced measurable gastric adenocarcinoma received ECX combina...

journal_title：Oncology

authors： Cho EK,Lee WK,Im SA,Lee SN,Park SH,Bang SM,Park DK,Park YH,Shin DB,Lee JH

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of lo...

journal_title：Oncology

authors： Miglietta L,Vanella P,Canobbio L,Naso C,Cerisola N,Meszaros P,Parodi MA,Morabito F

更新日期：2010-01-01 00:00:00