Abstract:
:In pancreatic cancer (PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy. This review focuses on the role of carbohydrate antigen 19-9 (CA 19-9) as a prognostic tumor marker in PC and summarizes its contribution to monitoring treatment efficacy. We undertook a Medline/PubMed literature search to identify relevant trials that had analyzed the prognostic impact of CA 19-9 in patients treated with surgery, chemoradiotherapy and chemotherapy for PC. Additionally, relevant abstract publications from scientific meetings were included. In advanced PC, pretreatment CA 19-9 levels have a prognostic impact regarding overall survival. Also a CA 19-9 decline under chemotherapy can provide prognostic information for median survival. A 20% reduction of CA 19-9 baseline levels within the first 8 weeks of chemotherapy appears to be sufficient to define a prognostic relevant subgroup of patients ('CA 19-9 responder'). It still remains to be defined whether the CA 19-9 response is a more reliable method for evaluating treatment efficacy compared to conventional imaging.
journal_name
Oncologyjournal_title
Oncologyauthors
Boeck S,Stieber P,Holdenrieder S,Wilkowski R,Heinemann Vdoi
10.1159/000094888subject
Has Abstractpub_date
2006-01-01 00:00:00pages
255-64issue
4eissn
0030-2414issn
1423-0232pii
94888journal_volume
70pub_type
杂志文章,评审相关文献
ONCOLOGY文献大全abstract::Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined. In this study, we examined enzyme activity of TP in 24 primary colorectal carcinoma ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000065064
更新日期:2002-01-01 00:00:00
abstract::This study sought to examine the relationship between MUC1 expression at the deepest invasive portion, invasive/metastatic potential, and prognosis of colorectal cancer in relation to cellular proliferation. MUC1 expression was detected immunohistochemically using KL-6 antibody (anti-MUC1 monoclonal antibody) in 100 s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011868
更新日期:1998-07-01 00:00:00
abstract::Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333279
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To investigate the role of adjuvant radiation therapy in locoregional control in patients with locoregionally advanced papillary thyroid carcinoma (pT4 or pN1b) based on a comparison of a group that received radiation therapy and a group that did not receive radiation therapy. METHODS:A retrospective analys...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000444393
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000323175
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:The phosphatidylinositol 3-kinase (PI3K) pathway plays a critical role in ovarian cancer cell survival and proliferation. The aim of this study was to determine whether the suppression of the PI3K catalytic subunit p110alphainhibits the growth of ovarian cancer cells in vitro and in vivo. METHODS:The short h...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000218201
更新日期:2009-01-01 00:00:00
abstract::14 patients developed acute nonlymphocytic leukemia and 1 patient developed Burkitt's leukemia following longterm chemotherapy and/or radiotherapy for other disorders. The main primary disorders included multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma and breast carcinoma. Acute leukemia developed earlier ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225798
更新日期:1984-01-01 00:00:00
abstract::Etoposide is a highly schedule-dependent agent. We previously reported that a 21-day schedule of oral etoposide had good activity in small cell lung cancer (SCLC). The current phase II study was designed to test the combination of 21-day oral etoposide with cisplatin in hopes of capitalizing on etoposide's schedule de...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227108
更新日期:1992-01-01 00:00:00
abstract::We have applied a triple combination of 5-fluorouracil (5FU), vitamin A and cobalt-60 radiation (FAR therapy) to clinical treatment of head and neck tumors since 1972. The treatment of 33 patients with cancer of larynx and 15 patients with hypopharyngeal or cervical esophageal cancer with FAR therapy during three year...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225299
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVES:It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients. METHODS:Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151369
更新日期:2008-01-01 00:00:00
abstract::112 cases, of varying ages, which were diagnosed as having carcinoma of the bladder by cystoscopy and biopsy from the tumor, were investigated for the presence of alphafetoprotein (AFP) in the sera. 59 (52.6%) out of the total, showed positive results, and no false positive results occured. Radioimmunoassay was capabl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225188
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVES:18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is useful for differentiating benign from malignant lesions, evaluating tumor stage, monitoring the response to therapy and detecting tumor recurrence in a variety of malignancies. Nevertheless, its use in patients with hepatocellular carcinoma (H...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111715
更新日期:2007-01-01 00:00:00
abstract::The antiemetic effect of oral medium-dosed metoclopramide (MCL, 3.5 mg/kg b.w./cycle) and placebo for chemotherapy-induced emesis of a noncisplatin regimen was assessed for inpatients and outpatients in two double-blind placebo-controlled sequential analyses according to Bross (1952). MCL was given in 5 single doses o...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227153
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:It is well recognized that distinguishing benign from malignant papillary lesions of the breast may pose challenging diagnostic problems. To prospectively evaluate the potential role of mammography, ultrasound and image-guided core biopsy in the diagnosis of papillary lesions of the breast. METHODS:1,442 wo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000074643
更新日期:2003-01-01 00:00:00
abstract::Immunoperoxidase methods permit the demonstration of a variety of antigens in routinely processed tissues. The morphological detail obtained by this procedure is comparable to orthodox haematoxylin and eosin stained sections, and so offers the diagnostic pathologist the opportunity of simultaneously identifying normal...
journal_title:Oncology
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:The objective of this phase III trial was to compare chemotherapy combined with bevacizumab versus chemotherapy alone in the treatment of patients with advanced colorectal cancer. METHODS:From September 2004 till September 2008, 222 treatment-naive patients were enrolled and divided into 2 arms: 114 arm A pa...
journal_title:Oncology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000320520
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 cen...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000358730
更新日期:2014-01-01 00:00:00
abstract::We examined the expression of p16, the CDKN2A gene product, in EBV-associated gastric carcinomas (EBV-GCs). EBV-GCs were identified by detecting EBV-encoded small RNA (EBER) using an in situ hybridization assay of paraffin-embedded tissue. Two non-EBV-GC cases for each EBV-GC case were selected, matched for age, sex, ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000080290
更新日期:2004-01-01 00:00:00
abstract::Nucleophosmin/B23 is a nucleolar phosphoprotein which redistributes from nucleoli to nucleoplasm (B23-translocation) when cells are exposed to certain anticancer drugs, particularly intercalators. The B23-translocation assay has been demonstrated in cell culture to correlate with drug effects and to detect drug-resist...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227043
更新日期:1992-01-01 00:00:00
abstract::The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011850
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:The De Gramont regimen (or high-dose LV5FU2, HD-LV5FU2) is considered a standard treatment for metastatic colorectal cancer. The aim of the study was to evaluate the efficacy and the costs of three regimens as compared to HD-LV5FU2: raltitrexed (R), LV5FU2 with a lower dose of folinic acid (LD-LV5FU2), and w...
journal_title:Oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000100448
更新日期:2006-01-01 00:00:00
abstract::We analyzed the differential gene expression in the pancreatic cancer cell line NP-18 upon induction of apoptosis caused by cyclin-dependent kinase inhibition triggered by either overexpression of the tumor suppressor gene p16(INK4A)using an adenoviral construction or incubation with the chemical inhibitors, roscoviti...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000081329
更新日期:2004-01-01 00:00:00
abstract::Fourteen patients with advanced ovarian carcinoma (FIGO stages III-IV) resistant to cisplatin were submitted to an alternating regimen with doxorubicin (A), cyclophosphamide (C), bleomycin (B) and mitomycin C (M). All patients had measurable disease on entry into the study. No responses were observed while 3 patients,...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226836
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Keratin (K) 19 positivity has been reported to be a useful predictive marker for recurrence in patients with hepatocellular carcinoma (HCC) who have undergone hepatic resection. We investigated the clinical usefulness of K19 positivity in patients who had received curative radiofrequency ablation (RFA). METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000328448
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Anaplastic oligodendrogliomas (AO) are uncommon primary brain tumors whose natural history, prognosis, and optimal management are not yet fully understood. However, they are associated with a better prognosis and response to multimodality therapy based on specific molecular changes. In this multicenter retro...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000074479
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Wernicke's encephalopathy (WE) is a neurological emergency which presents with symptoms of confusion, ophthalmoplegia, and ataxia. Cancer patients are at high risk of this acute encephalopathy due to chronic malnutrition, chemotherapy-induced nausea and vomiting, and consumption of thiamine by rapidly growin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000174951
更新日期:2009-01-01 00:00:00
abstract::The role of p53, retinoblastoma (RB) and c-erbB-2 gene proteins in the pathogenesis of anal carcinomas has been examined. A total of 97 patients were included in the study. c-erbB-2, RB and p53 proteins were abnormal in 0, 5 and 34% of the cases, respectively. No correlation was observed between p53 and age, sex, tumo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227590
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:We conducted this study to compare tumor measurement by computed tomography (CT) and tumor response assessment between Response Evaluation Criteria In Solid Tumors (RECIST) 1.0 and RECIST 1.1 in patients with metastatic colorectal cancer (CRC). METHODS:We reviewed the medical records of patients with metasta...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000357714
更新日期:2014-01-01 00:00:00
abstract::Small quantities of carcinogens, dl-ethionine, thiotepa, actinomycin D, and 1-(2-chloroethyl-3-cyclohexyl)-1-nitrosourea (CCNU) stimulated in vitro deoxyribonucleic acid (DNA) synthesis of the slime mutant of Neurospora crassa, while there was practically no effect on the DNA from the normal wild type 74A strain. All ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226503
更新日期:1987-01-01 00:00:00
abstract::58 consecutively referred, previously untreated patients with nodular lymphomas (stages III and IV) were treated with two different combination chemotherapy regimens-(cyclophosphamide, vincristine and prednisone (COP), and BCNU , cyclophosphamide, vincristine, melphalan and prednisone (M-2) - to compare remission indu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225814
更新日期:1984-01-01 00:00:00