Abstract:
BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 centers. We identified 72 out of 240 patients with recurrent disease (28% stage I-II and 72% stage III-IV at diagnosis). RESULTS:In 56% of patients, the clear cell histology was pure. Twenty-five patients were platinum-resistant, 18 were platinum-sensitive with a platinum-free interval (PFI) of 6-12 months, and 29 had a PFI >12 months. Upon recurrence, 47% of patients were treated with platinum chemotherapy according to the PFI. The overall response rate (RR) to platinum was 80%, with 55, 100, and 80% RR in patients with PFI of 6-12, >12, and >24 months. The RR to nonplatinum agents in resistant patients was 33%. Among the nonplatinum agents used in primary and secondary resistant cases, gemcitabine, administered in 12 cases, had a higher activity (RR = 66%) compared to topotecan or liposomal doxorubicin (n = 31; RR = 33 and 10%, respectively). CONCLUSIONS:This study showed that the treatment of recurrent ovarian CCC should be based on the PFI as in the other subtypes. Data in platinum-resistant patients suggest gemcitabine as the drug with the highest activity. We recommend that gemcitabine be studied prospectively in a phase 2 trial.
journal_name
Oncologyjournal_title
Oncologyauthors
Esposito F,Cecere SC,Magazzino F,Katsaros D,Ottaiano A,Gadducci A,Pisano C,Scalone S,Rabaiotti E,Salutari V,Cormio G,Canuto EM,Greggi S,Savarese A,Marinaccio M,Scollo P,Santeufemia DA,Sacco C,Facchini G,Pignata Sdoi
10.1159/000358730subject
Has Abstractpub_date
2014-01-01 00:00:00pages
351-8issue
5-6eissn
0030-2414issn
1423-0232pii
000358730journal_volume
86pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract:BACKGROUND:In most guidelines, no other interventional therapy but liver transplantation is recommended for the treatment of hepatocellular carcinoma (HCC) with Child-Pugh C cirrhosis (CP-C). However, in Japan, patients were sometimes treated with expectation of benefit. SUMMARY:A workshop was conducted to explore the...
journal_title:Oncology
pub_type:
doi:10.1159/000368152
更新日期:2014-01-01 00:00:00
abstract::Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226719
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers. METHODS:We conducted a retrospective study of consecutively treated 22 inoperable biliary tract cancer patients with gemcitabine (500-1,000 mg/m(2) on days 1, 8, 15 every 4 weeks) as f...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000098109
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000089993
更新日期:2005-01-01 00:00:00
abstract::Studies were made of the therapeutic response of six human colorectal tumor lines serially transplanted in immunosuppressed mice. The tumors with adenomatous structure showed greater sensitivity against different cytotoxic agents than the gelatinous ones. Among the drugs, 5-FU, BCNU and MeCCNU proved to be the most ef...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225496
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). PATIENTS AND METHODS:We analyzed TrkB expression in 161 GC patients by immunohistochemist...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151615
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Insulin-like growth factor I (IGF-I) and other components of the IGF system have been implicated in the etiology of several human malignancies. We have undertaken a case-control study among Greek women to explore the relation of major components of the IGF system (IGF-I, IGF-II and IGF-binding protein 3, IGF...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000070291
更新日期:2003-01-01 00:00:00
abstract::Mice of four different inbred strains (CBA, Balb/c, C57Bl/6 and DBA/2), bearing different transplanted tumours (methylcholanthrene-induced sarcomas, B16 melanoma and P-815 mastocytoma), were tested for cellular immune reactivity to the synthetic encephalitogenic peptide of human myelin basic protein by the leucocyte a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225732
更新日期:1983-01-01 00:00:00
abstract::To determine the relationship between neoplastic transformation and increased genetic instability, spontaneous and induced mutation rates were compared in a nontumorigenic, immortalized human bronchial epithelial cell line (NL20) and a tumorigenic cell line (NL20T) spontaneously derived from the NL20 line. Using the h...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227713
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVES:The neutrophil-to-lymphocyte ratio (NLR) has been proposed as an indicator of cancer-related inflammation. The aim of our study was to examine the prognostic value of the NLR for patients with advanced gastric cancer receiving second-line chemotherapy. METHODS:The association of overall survival (OS) in sec...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000493427
更新日期:2019-01-01 00:00:00
abstract::Recent studies have demonstrated that nitroso chemical carcinogens activate guanylate cyclase (EC 4.6.1.2) which catalyzes the production of guanosine 3',5'-monophosphate. This nucleotide is thought to be involved in normal and abnormal cell growth. We examined the effect of 3 major classes of anticancer chemotherapeu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225362
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown. METHODS:We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at...
journal_title:Oncology
pub_type: 新闻
doi:10.1159/000509434
更新日期:2020-01-01 00:00:00
abstract::In the 2010 version of the Japan Society of Hepatology (JSH) consensus-based treatment algorithm for the management of hepatocellular carcinoma (HCC), transarterial chemoembolization (TACE) failure/refractoriness was defined assuming the use of superselective lipiodol TACE, which has been widely used worldwide and par...
journal_title:Oncology
pub_type: 共识发展会议,杂志文章,实务指引,评审
doi:10.1159/000368142
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To confirm the safety and effectiveness of techniques to assist radiofrequency ablation (RFA) for difficult cases, we retrospectively evaluated successful treatment rates, early complications and local tumor progressions. PATIENTS AND METHODS:Between June 1999 and April 2009, a total of 341 patients with 535 n...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000315236
更新日期:2010-07-01 00:00:00
abstract::Ifosfamide is relatively well tolerated but it can be associated occasionally with life-threatening complications such as arrhythmias and heart failure, severe encephalopathy and hemorrhagic cystitis. Mesna administration can control the urothelial toxicity of ifosfamide, but it is without effect on the other complica...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000073351
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To evaluate two docetaxel-based regimens as first-line treatment in advanced breast cancer patients. METHODS:Patients were randomly assigned to docetaxel/gemcitabine (arm A: docetaxel 75 mg/m(2) on day 1, gemcitabine 1,000 mg/m(2) on days 1 and 8) or docetaxel/capecitabine (arm B: docetaxel 75 mg/m(2) on day...
journal_title:Oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000334432
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. METHODS:We retro...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000327222
更新日期:2011-01-01 00:00:00
abstract::Chromosomal aberrations and sister chromatid exchanges were examined in 45 patients with nonseminomatous testicular cancer at different times after the termination of vinblastine, cisplatin and bleomycin (VPB) therapy and in 22 age-matched healthy men and untreated testicular cancer patients. After 36 months, the freq...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226859
更新日期:1990-01-01 00:00:00
abstract::Macroscopic morphology, histology and ultrastructure of BK virus (BKV)-induced hamster and mouse tumors were investigated. Groups of animals were immunosuppressed to study the relationship between immune system and BKV oncogenesis. Ependymomas had the highest incidence, followed by tumors of pancreatic islets, osteosa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225777
更新日期:1983-01-01 00:00:00
abstract::In 86 children with acute lymphocytic leukemia (ALL) and in 6 children with medulloblastoma 253 24-hour methotrexate (MTX) infusions with 150, 500, and 700 mg/m2 were performed. MTX concentrations in plasma and cerebrospinal fluid (CSF) were measured with a specific radioimmunoassay. In 131 infusions with 500 mg/m2 gi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225828
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prostate carcinoma models and the molecular/cellular basis of its activity. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055380
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Clinical significance of immunohistochemically detectable level of p53 protein has been reported, but with some limitation as a prognosticator of bladder cancer patients. Whether or not simultaneous evaluation of mdm2 and p53 expression in bladder cancer exceed the prognostic significance of conventional his...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011971
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:New effective therapy is desirable for patients with non-small cell lung cancer (NSCLC) who have failed previous treatments. Fractionated administration of paclitaxel may be less toxic and more active against NSCLC. The aim of this study was to evaluate the activity and toxicity of weekly paclitaxel therapy f...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000079481
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify biomarkers for predicting the efficacy of docetaxel, cisplatin, and S-1 (DCS) therapy for advanced gastric cancer using microarrays of biopsy specimens before chemotherapy. METHODS:Nineteen samples were taken from 19 patients with unresectable metastatic gastric cancer ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000464329
更新日期:2017-01-01 00:00:00
abstract::Fourteen patients with advanced ovarian carcinoma (FIGO stages III-IV) resistant to cisplatin were submitted to an alternating regimen with doxorubicin (A), cyclophosphamide (C), bleomycin (B) and mitomycin C (M). All patients had measurable disease on entry into the study. No responses were observed while 3 patients,...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226836
更新日期:1990-01-01 00:00:00
abstract::The activity and toxicity of UFT (Tegafur and Uracil) in a 4:1 molar concentration, plus leucovorin (LV), were evaluated in the treatment of 45 patients with advanced, bidimensionally measurable metastatic colorectal carcinoma. Initially 350 and later 300 mg/m2/day, plus 150 mg LV, as administered in divided doses eve...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227741
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The survival rate of patients with lung cancer has increased significantly over the years, but there has been no further progress in third- or fourth-line therapy. We investigated the efficacy and tolerability of monotherapy with weekly vinorelbine, a semi-synthetic vinca alkaloid, in advanced non-small-cell...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502343
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China and, due to the limited efficacy of currently available therapies, is responsible for a large number of deaths. IFN-alpha therapy has shown promise in the treatment of various forms of human cancer and is considered in the trea...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000082928
更新日期:2004-01-01 00:00:00
abstract::Tumor infiltrating lymphocytes induced by radiotherapy were analyzed by the biotin-avidin-horseradish peroxidase method. At the early dose of 4 Gy (400 rad) of irradiation (2 Gy X 2), remarkable infiltration of lymphocytes was observed surrounding cancer cells. This infiltration was mainly composed of Leu-3a+3b-positi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226523
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Osteosarcoma is a rare malignancy, and patients with this disease benefit from adjuvant chemotherapy. While cisplatin, anthracyclines and ifosfamide are the most commonly used agents in the treatment of osteosarcoma, a search for the best combination with higher efficacy and minimal toxicity continues. We pl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000113017
更新日期:2007-01-01 00:00:00