Oral medium-dosed metoclopramide versus placebo as highly effective antiemetic prophylaxis in in- and outpatients on noncisplatin chemotherapy.

Abstract:

:The antiemetic effect of oral medium-dosed metoclopramide (MCL, 3.5 mg/kg b.w./cycle) and placebo for chemotherapy-induced emesis of a noncisplatin regimen was assessed for inpatients and outpatients in two double-blind placebo-controlled sequential analyses according to Bross (1952). MCL was given in 5 single doses of 0.7 mg/kg b.w. at 0 h (loading) and at 2 h (i.e. start of chemotherapy) and 6, 10 and 14 h (as maintenance doses). Both studies ended after 8 sequential pairs in favor of MCL (2 alpha = 2 beta = 0.05). Major antiemetic protection (< 2 emetic episodes per 26 h) was achieved for 8/8 of inpatients and 7/8 of outpatients (placebo 0/8 and 0/8). Side effects neither required discontinuation of the antiemetic regimen nor additional therapy. The median of MCL plasma levels ranged from 150 to 750 ng/ml and terminal half-lives from 3.9 to 8.9 h.

journal_name

Oncology

journal_title

Oncology

authors

Vogt C,Hellenbrecht D,Saller R,Achtert G,Brockmann P,Hausleiter H

doi

10.1159/000227153

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

81-5

issue

2

eissn

0030-2414

issn

1423-0232

journal_volume

50

pub_type

临床试验,杂志文章,随机对照试验

相关文献

ONCOLOGY文献大全
  • Targeting Developmental Pathways: The Achilles Heel of Cancer?

    abstract::Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000478703

    authors: Dempke WCM,Fenchel K,Uciechowski P,Chevassut T

    更新日期:2017-01-01 00:00:00

  • Latent coagulation disorders evaluated by the assay of plasma thrombin-antithrombin III complexes in a large series of 'solid tumours'.

    abstract::Coagulation disorders are frequently detected in patients affected by different tumours even though clinical symptoms occur in a very small percentage of such subjects. Coagulation processes are probably involved in the mechanism of metastatic spread. We assayed the plasma levels of thrombin-antithrombin III (TAT) com...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227086

    authors: Bartoloni C,Guidi L,Tricerri A,Patriarca F,Pili R,Cursi F,Canetta M,Cappelli A,Vangeli M,Salvati F

    更新日期:1992-01-01 00:00:00

  • Targeted therapy in the treatment of metastatic renal cell cancer.

    abstract::The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000258504

    authors: Di Lorenzo G,Scagliarini S,Di Napoli M,Scognamiglio F,Rizzo M,Carteni' G

    更新日期:2009-01-01 00:00:00

  • Prognostic factors and outcomes in 28 cases of uterine leiomyosarcoma.

    abstract:OBJECTIVES:It was the aim of this study to evaluate clinicopathological characteristics and prognostic factors of uterine leiomyosarcomas (LMS). METHODS:Twenty-eight patients with uterine LMS were evaluated in this retrospective study. Their features and survival were analyzed by Kaplan-Meier and log-rank tests. RESU...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000331679

    authors: Loizzi V,Cormio G,Nestola D,Falagario M,Surgo A,Camporeale A,Putignano G,Selvaggi L

    更新日期:2011-01-01 00:00:00

  • Interleukin-2-based biochemotherapy for patients with stage IV melanoma: long-term survivors outside a clinical trial setting.

    abstract:BACKGROUND:The role of Interleukin-2 (IL-2)-based biochemotherapy (BCT) for patients with metastatic melanoma remains controversial and few data of patients treated outside a specialized trial setting are available. METHODS:Sixty-six consecutive patients treated with BCT for stage IV melanoma were analyzed retrospecti...

    journal_title:Oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000120029

    authors: Hess V,Herrmann R,Veelken H,Schwabe M

    更新日期:2007-01-01 00:00:00

  • Papillary microcarcinomas of the thyroid with preoperatively detectable lymph node metastasis show significantly higher aggressive characteristics on immunohistochemical examination.

    abstract:OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000085701

    authors: Ito Y,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

    更新日期:2005-01-01 00:00:00

  • Demonstration and diagnostic significance of pro-gastrin-releasing peptide in medullary thyroid carcinoma.

    abstract::The expression of pro-gastrin-releasing peptide (proGRP) in medullary thyroid carcinoma (MTC) and other histological types of thyroid carcinoma was studied by an immunohistochemical technique, using polyclonal anti-proGRP antiserum. Immunoreactivity for proGRP was detected exclusively in MTC (n = 7); other histologica...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000012148

    authors: Inaji H,Komoike Y,Motomura K,Higashiyama M,Ohtsuru M,Funai H,Kasugai T,Koyama H

    更新日期:2000-08-01 00:00:00

  • Hand-Foot Syndrome and Post-Progression Treatment Are the Good Predictors of Better Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Study.

    abstract:OBJECTIVE:To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. METHODS:The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general ho...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000481241

    authors: Ogawa C,Morita M,Omura A,Noda T,Kubo A,Matsunaka T,Tamaki H,Shibatoge M,Tsutsui A,Senoh T,Nagano T,Takaguchi K,Tani J,Morishita A,Yoneyama H,Masaki T,Moriya A,Ando M,Deguchi A,Kokudo Y,Minami Y,Ueshima K,Sakur

    更新日期:2017-01-01 00:00:00

  • Unexpectedly low incorporation of isotopic acetate into lipids of Ehrlich ascites tumor cells cultured in lipid-poor medium.

    abstract::The present communication reports data on the lipid biosynthesis of Ehrlich ascites tumor cells grown in culture media supplemented with modified sera. Whereas the metabolisms of [14C]pyruvate and [14C]mevalonate are identical in all media tested, the incorporation of [14C] acetate is higher in medium with dialyzed se...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225321

    authors: Löffler M,Schneider F

    更新日期:1979-01-01 00:00:00

  • Trial of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) in advanced bronchogenic carcinoma 1,2,3.

    abstract::A total of 103 patients with lung cancer was treated with CCNU 130 mg/m2 orally every 6 weeks; 65 patients survived at least 6 weeks. Partial responses occurred in 7 patients. Leukopenia, thrombocytopenia, and nausea were frequent toxic effects. CCNU has slight efficacy in advanced lung cancer. No increase in survival...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225035

    authors: Stolinsky DC,Bull FE,Pajak TF,Bateman JR

    更新日期:1975-01-01 00:00:00

  • Therapeutic response assessment of transcatheter arterial chemoembolization for hepatocellular carcinoma: ultrasonography, CT and MR imaging.

    abstract::Two randomized controlled trials identified that transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) shows a significant survival benefit compared with controls, after a long-term controversy. Thus, TACE is the current standard of care for patients presenting with multinodular HCC. Monit...

    journal_title:Oncology

    pub_type: 杂志文章,评审

    doi:10.1159/000345891

    authors: Minami Y,Kudo M

    更新日期:2013-01-01 00:00:00

  • Differences in cellular proteins between high and low metastatic potential sublines from the methylcholanthrene-induced rat fibrosarcoma cell line.

    abstract::The purpose of the present study was to determine with two-dimensional electrophoresis whether two sublines (high and low metastatic potential to lymph nodes) of rat fibrosarcoma induced by methylcholanthrene have differences in cellular proteins. The high metastatic potential subline had a specific protein in the pro...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227028

    authors: Minato K,Manabe T,Okuyama N,Sasaki Y,Nakagawa K,Saijo N

    更新日期:1992-01-01 00:00:00

  • Surgery for exocrine pancreatic cancer--who are the 5- and 10-year survivors?

    abstract::38 of 306 patients survived beyond 5 years after resection of an exocrine pancreatic carcinoma during a period from 1971 to 1993. Amongst the long-term survivors there were 12 patients with ductal, 22 with ampullary, 3 with distal bile duct and 1 with duodenal cancer. An active operative strategy was employed in order...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227488

    authors: Klempnauer J,Ridder GJ,Bektas H,Pichlmayr R

    更新日期:1995-09-01 00:00:00

  • Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma.

    abstract::The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high alpha-fetoprotein level, large size, high...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000012140

    authors: Ito Y,Takeda T,Sakon M,Monden M,Tsujimoto M,Matsuura N

    更新日期:2000-06-01 00:00:00

  • Serum alphafetoprotein in bladder carcinoma.

    abstract::112 cases, of varying ages, which were diagnosed as having carcinoma of the bladder by cystoscopy and biopsy from the tumor, were investigated for the presence of alphafetoprotein (AFP) in the sera. 59 (52.6%) out of the total, showed positive results, and no false positive results occured. Radioimmunoassay was capabl...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225188

    authors: Alsabti EA

    更新日期:1977-01-01 00:00:00

  • Is capecitabine efficacious in triple negative metastatic breast cancer?

    abstract:BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000323175

    authors: Kotsori AA,Dolly S,Sheri A,Parton M,Shaunak N,Ashley S,Walsh G,Johnston S,Smith IE

    更新日期:2010-01-01 00:00:00

  • Proliferative activity of Hürthle cell thyroid tumours.

    abstract::To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000011995

    authors: Cör A

    更新日期:1999-07-01 00:00:00

  • Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer.

    abstract::The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000011850

    authors: Allgayer H,Babic R,Beyer BC,Grützner KU,Tarabichi A,Schildberg FW,Heiss MM

    更新日期:1998-03-01 00:00:00

  • Expression of platelet-activating factor receptor: a novel prognosticator in patients with hepatocellular carcinoma following hepatectomy.

    abstract:BACKGROUNDS AND AIMS:Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a phospholipid mediator and acts by binding to a specific G-protein-coupled receptor. Though various functions of PAF have been associated with tumor activities, the mechanism of PAF-PAF receptor signaling in the de...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000113149

    authors: Kitagawa D,Taketomi A,Kayashima H,Kuroda Y,Itoh S,Yamashita Y,Maehara Y

    更新日期:2007-01-01 00:00:00

  • Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection.

    abstract:BACKGROUND:The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. OBJECTIVE:We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. METHODS:We retrospectively examined 649 consecutive patients with HCC who underwent curative...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000477173

    authors: Lee HW,Choi GH,Kim DY,Park YN,Kim KS,Choi JS,Ahn SH,Han KH

    更新日期:2017-01-01 00:00:00

  • Phase II study of combined administration of 5-fluorouracil, epirubicin and mitomycin-C by hepatic artery infusion in patients with liver metastases of gastric cancer.

    abstract::This multicenter phase II study evaluated the efficacy of the FEM regimen (5-fluorouracil 333 mg/m(2) each week, epirubicin 30 mg/m(2) once every 4 weeks and mitomycin-C 2.7 mg/m(2) once every 2 weeks) administered by hepatic artery infusion (HAI) for unresectable hepatic metastases of gastric cancer. The response rat...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000012034

    authors: Kumada T,Arai Y,Itoh K,Takayasu Y,Nakamura K,Ariyoshi Y,Tajima K

    更新日期:1999-10-01 00:00:00

  • Studies of actinomycin D induced B23-translocation in P388D1 cells implanted in DBA/2 mice.

    abstract::Nucleophosmin/B23 is a nucleolar phosphoprotein which redistributes from nucleoli to nucleoplasm (B23-translocation) when cells are exposed to certain anticancer drugs, particularly intercalators. The B23-translocation assay has been demonstrated in cell culture to correlate with drug effects and to detect drug-resist...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227043

    authors: Finch RA,Chan PK

    更新日期:1992-01-01 00:00:00

  • PET scans for decision-making in metastatic renal cell carcinoma: a single-institution evaluation.

    abstract:OBJECTIVE:Therapeutic decision-making in metastatic renal cell carcinoma (MRCC) is based on conventional radiological evaluation. Fluorodeoxyglucose positron emission tomography (FDG-PET) scans may modify this strategy. METHODS:Patients with MRCC for whom a therapeutic decision had been made underwent an FDG-PET scan ...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000097946

    authors: Dilhuydy MS,Durieux A,Pariente A,de Clermont H,Pasticier G,Monteil J,Ravaud A

    更新日期:2006-01-01 00:00:00

  • Phase II trial of cisplatin and etoposide as first-line therapy in metastatic breast carcinoma.

    abstract::Twenty-two patients with metastatic breast carcinoma were treated with a combination of cisplatin (100 mg/m2 i.v. day 1) and etoposide (100 mg/m2 i.v. days 1-3). Eligible patients had measurable disease with normal organ functions, performance status < 3, age < 70 years and no previous chemotherapy for metastatic dise...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000227364

    authors: Lluch A,Azagra P,Cervantes A,Muñoz M,Alberola V,Santabarbara P,García-Conde J

    更新日期:1994-07-01 00:00:00

  • Synergistic combination therapy of 5-fluorouracil, vitamin A and cobalt-60 radiation upon head and neck tumors.

    abstract::We have applied a triple combination of 5-fluorouracil (5FU), vitamin A and cobalt-60 radiation (FAR therapy) to clinical treatment of head and neck tumors since 1972. The treatment of 33 patients with cancer of larynx and 15 patients with hypopharyngeal or cervical esophageal cancer with FAR therapy during three year...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000225299

    authors: Komiyama S,Hiroto I,Ryu S,Nakashima T,Kuwano M,Endo H

    更新日期:1978-01-01 00:00:00

  • Amplification of ERBB-2 (HER-2/NEU) oncogene in different neoplasms of patients from USSR.

    abstract::203 tumor specimens from 175 patients were studied. Amplification of ERBB-2 was detected in 14 out of 63 (22%) cases of breast carcinoma, in 1 out of 23 patients with ovarian cancers, in 1 out of 19 cases of colon carcinoma and in 1 out of 27 patients with thyroid cancer. We failed to find more than one copy of ERBB-2...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000227032

    authors: Knyazev PG,Imyanitov EN,Chernitca OI,Nikiforova IF,Hanson KP

    更新日期:1992-01-01 00:00:00

  • Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion.

    abstract:INTRODUCTION:Because the frequency of bile duct invasion in hepatocellular carcinoma (HCC) patients is very rare, there is limited clinical evidence to demonstrate the outcomes of systemic therapy in HCC with bile duct invasion. OBJECTIVE:Our aim was to clarify the efficacy and safety of sorafenib treatment in patient...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000507051

    authors: Tanaka T,Kuzuya T,Ishigami M,Ito T,Ishizu Y,Honda T,Ishikawa T,Fujishiro M

    更新日期:2020-01-01 00:00:00

  • Cyclophosphamide, mitoxantrone, fluorouracil versus conventional CMF as adjuvant treatment in node-positive breast cancer patients. A Hellenic Cooperative Oncology Group Study.

    abstract::362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...

    journal_title:Oncology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000227550

    authors: Fountzilas G,Polichronis A,Katsohis K,Gennatas K,Toussis D,Skarlos D,Kosmidis P,Vassilaros S,Semoglou C,Giannakakis T,Fahantidis E,Klouvas G,Tsavaris N,Konstantaras C,Makrantonakis P,Kolotas C,Zamboglou N,Tsiliakos S,

    更新日期:1996-03-01 00:00:00

  • Phase II evaluation of 5-fluorouracil, folinic acid and cisplatin in advanced-stage colorectal adenocarcinoma.

    abstract::Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000226719

    authors: Scheithauer W,Depisch D,Schiessel R,Ludwig H

    更新日期:1989-01-01 00:00:00

  • Patient-controlled analgesia versus oral controlled-release oxycodone - are they interchangeable for acute postoperative pain after laparoscopic colorectal surgeries?

    abstract:BACKGROUND:Standard therapy for postoperative pain after laparoscopic colorectal surgeries at the Tan Tock Seng Hospital consists of intravenous morphine via patient-controlled analgesia (PCA) for the first 24-48 h, followed by oral analgesics. We compared the efficacy and safety of oral controlled-release (CR) oxycodo...

    journal_title:Oncology

    pub_type: 杂志文章

    doi:10.1159/000143221

    authors: Ho HS

    更新日期:2008-01-01 00:00:00