Immunoreactive MUC1 expression at the deepest invasive portion correlates with prognosis of colorectal cancer.


:This study sought to examine the relationship between MUC1 expression at the deepest invasive portion, invasive/metastatic potential, and prognosis of colorectal cancer in relation to cellular proliferation. MUC1 expression was detected immunohistochemically using KL-6 antibody (anti-MUC1 monoclonal antibody) in 100 surgically resected specimens of advanced colorectal cancer. Distinct staining of the luminal surfaces, defined as positive immunoreactive (IR)-MUC1 expression, was seen in more than 30% of the tumor cells at the deepest invasive portion. The proliferating cell nuclear antigen labeling index (PCNA-LI) was also examined in the same areas. IR-MUC1 expression was detected in 71 (71%) of 100 lesions. Lesions with lymphatic or venous invasion showed a significantly higher incidence of IR-MUC1 expression than those without lymphatic or venous invasion (80 vs. 42% and 82 vs. 61%, respectively). Lesions with lymph node metastasis showed a significantly higher incidence of IR-MUC1 expression than those without lymph node metastasis (88 vs. 53%). Lesions with liver metastasis showed a significantly higher incidence of IR-MUC1 expression than those without liver metastasis (92 vs. 59%). Dukes' stage was also significantly correlated with IR-MUC1 expression. The incidence of IR-MUC1 expression did not significantly differ with regard to histologic subclassification and depth of invasion. There was no significant correlation between IR-MUC1 expression and the PCNA-LI. IR-MUC1 expression at the deepest invasive portion revealed a significant correlation with prognosis; furthermore, in patients with better differentiated lesions, in those with lesions confined to muscularis propria or subserosa (subadventitial) invasion, in those with Dukes' B and C, or in those undergoing curative resection, IR-MUC1 expression significantly correlated with prognosis. Patients with high PCNA-LI lesions showed a significantly poorer prognosis than those with low PCNA-LI lesions. Only in patients undergoing curative resection, patients with IR-MUC1-positive and high PCNA-LI lesions showed a significantly poorer prognosis than those with IR-MUC1-negative and low PCNA-LI lesions. The significant risk factors in the order of poorer prognosis in patients undergoing curative resection by the multivariate analysis were the histologic grade (moderately-poorly, poorly or mucinous adenocarcinomas), IR-MUC1 expression, and lymph node metastasis. These results indicate that IR-MUC1 expression is an important predictor of the metastatic potential and the prognosis of colorectal cancer, independent of histologic grade, depth of invasion or cellular proliferative activity. Combined analysis of IR-MUC1 and histologic grade, and combined expression of IR-MUC1 and PCNA at the deepest invasive portion are especially useful in predicting colorectal cancer prognosis.






Hiraga Y,Tanaka S,Haruma K,Yoshihara M,Sumii K,Kajiyama G,Shimamoto F,Kohno N




Has Abstract


1998-07-01 00:00:00
















  • Endometrial cancer and the IGF system: a case-control study in Greece.

    abstract:OBJECTIVES:Insulin-like growth factor I (IGF-I) and other components of the IGF system have been implicated in the etiology of several human malignancies. We have undertaken a case-control study among Greek women to explore the relation of major components of the IGF system (IGF-I, IGF-II and IGF-binding protein 3, IGF...


    pub_type: 杂志文章


    authors: Petridou E,Koukoulomatis P,Alexe DM,Voulgaris Z,Spanos E,Trichopoulos D

    更新日期:2003-01-01 00:00:00

  • Phase II study of gemcitabine and cisplatin in patients with advanced or metastatic bladder cancer: long-term follow-up of a 3-week regimen.

    abstract:BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...


    pub_type: 杂志文章


    authors: Adamo V,Magno C,Spitaleri G,Garipoli C,Maisano C,Alafaci E,Adamo B,Rossello R,Scandurra G,Scimone A

    更新日期:2005-01-01 00:00:00

  • VEGF as a key mediator of angiogenesis in cancer.

    abstract::Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein with a molecular weight of approximately 45 kDa. It is the key mediator of angiogenesis (the formation of new blood vessels), and binds two VEGF receptors (VEGF receptor-1 and VEGF receptor-2), which are expressed on vascular endothelial cells. In...


    pub_type: 杂志文章,评审


    authors: Carmeliet P

    更新日期:2005-01-01 00:00:00

  • Phase I Dose-Escalation and Pharmacokinetic Study of Intravenous Aflibercept in Combination with Docetaxel, Cisplatin, and 5-Fluorouracil in Patients with Advanced Solid Malignancies.

    abstract:PURPOSE:This phase I study (EudraCT No. 2006-001177-25) investigated aflibercept, a vascular endothelial growth factor decoy receptor protein (VEGF Trap), in combination with docetaxel, cisplatin, and 5-fluorouracil in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received 2, 4, or 6 mg/kg of intr...


    pub_type: 杂志文章,多中心研究


    authors: Bahleda R,Baker J,Massard C,Gadgeel SM,Rogers JE,Izzedine H,Deutsch E,Garris JL,Khan A,Boelle E,Assadourian S,Soria JC,Ajani JA

    更新日期:2016-01-01 00:00:00

  • Models, mechanisms and management of anticipatory nausea and emesis.

    abstract::Anticipatory nausea and vomiting (ANV) are learned responses to chemotherapy that develop in up to 25% of patients by the fourth treatment cycle. Post-treatment nausea and emesis must occur before development of ANV can take place. Certain patient characteristics and other responses to chemotherapy can also be used to...


    pub_type: 杂志文章,评审


    authors: Morrow GR,Rosenthal SN

    更新日期:1996-06-01 00:00:00

  • Expression of N-acetylglucosaminyltransferase V in the development of human esophageal cancers: immunohistochemical data from carcinomas and nearby noncancerous lesions.

    abstract:OBJECTIVE:N-Acetylglucosaminyltransferase V (GnT-V) is a key enzyme in the formation of branching asparagine-linked oligosaccharides and is linked to tumor invasion and metastasis in colon and breast cancers. In normal esophageal epithelium, beta1,6-branched asparagine-linked oligosaccharides synthesized by GnT-V are s...


    pub_type: 杂志文章


    authors: Ishibashi Y,Dosaka-Akita H,Miyoshi E,Shindoh M,Miyamoto M,Kinoshita I,Miyazaki H,Itoh T,Kondo S,Nishimura M,Taniguchi N

    更新日期:2005-01-01 00:00:00

  • Sinophobic growth in oestrogen receptor-negative metastatic breast cancer.

    abstract::The mode of growth of tumour cells from primary breast carcinoma in the axillary nodes is shown to be related to the oestrogen receptor (ER) status of the primary tumour. ER-positive primaries are described as tending to show sinophilic growth, the tumour cells spreading along the nodal sinuses; while the ER-negative ...


    pub_type: 杂志文章


    authors: Hartveit F,Thorsen T,Tangen M,Maehle BO,Thoresen S,Halvorsen JF

    更新日期:1983-01-01 00:00:00

  • Methyl-CCNU in malignant melanoma--a divided dose schedule of administration.

    abstract::Methyl-CCNU (NSC-95441) was administered to patients with malignant melanoma in a split dose schedule. Nausea and vomiting were eliminated as clinical problems during therapy. Response rate to the drug seemed somewhat lower than the average of three previously reported disease-oriented phase II trials, though the diff...


    pub_type: 杂志文章


    authors: Wittes RE,Hong WK,Gatchell L,Krakoff IH,Golbey RB

    更新日期:1977-01-01 00:00:00

  • Secretion of extracellular matrix (fibronectin), growth factor (transforming growth factor beta) and protease (cathepsin D) by hepatoma cells.

    abstract::We investigated facilitation of invasion by growth factors and chemotactic factors in tumor cell lines, particularly hepatocellular carcinoma. Hepatoma cells (PLC/PRF/5 and Hep G2) showed strong chemotaxis toward their respective conditioned media while metastatic pancreatic cancer cells (SU.86.86) and colon cancer ce...


    pub_type: 杂志文章


    authors: Ito H,Miyazaki M,Nishimura F,Nakajima N

    更新日期:2000-04-01 00:00:00

  • Haematological evaluation of weekly therapy with topotecan for the treatment of recurrent ovarian cancer resistant to platinum-based therapy.

    abstract::Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...


    pub_type: 杂志文章


    authors: Largillier R,Valenza B,Ferrero JM,Novo C,Creisson A,Lesbats G,Mari V,Hebert C,Chamorey E

    更新日期:2007-01-01 00:00:00

  • Weekly 24-hour infusion of high-dose 5-fluorouracil and leucovorin in the treatment of advanced gastric cancers. An effective and low-toxic regimen for patients with poor general condition.

    abstract::Systemic chemotherapy for advanced gastric cancer is frequently associated with significant treatment-related toxicity, which is particularly serve in patients presenting with a poor general condition. A search for effective and low-toxic regimens for this group of patients is mandatory. A weekly 24-hour infusion of h...


    pub_type: 临床试验,杂志文章


    authors: Hsu CH,Yeh KH,Chen LT,Liu JM,Jan CM,Lin JT,Chen YC,Cheng AL

    更新日期:1997-07-01 00:00:00

  • Comparative study of the cellular localization of three polycyclic hydrocarbons differing in their carcinogenicity.

    abstract::Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...


    pub_type: 杂志文章


    authors: Stora C

    更新日期:1980-01-01 00:00:00

  • Inhibition of nitroso chemical carcinogen activation of rat hepatic guanylate cyclase by anticancer agents.

    abstract::Recent studies have demonstrated that nitroso chemical carcinogens activate guanylate cyclase (EC which catalyzes the production of guanosine 3',5'-monophosphate. This nucleotide is thought to be involved in normal and abnormal cell growth. We examined the effect of 3 major classes of anticancer chemotherapeu...


    pub_type: 杂志文章


    authors: Vesely DL,Levey GS

    更新日期:1979-01-01 00:00:00

  • Systemic chemotherapy of hepatocellular carcinoma--Korean experience.

    abstract::Surgical resection, transarterial chemoembolization, percutaneous ethanol injection therapy, radiofrequency ablation, and orthotopic liver transplantation are generally accepted treatment modalities in hepatocellular carcinoma, but there has been no standard therapy for patients at the advanced stage. Several combinat...


    pub_type: 杂志文章


    authors: Lee HC

    更新日期:2008-01-01 00:00:00

  • Priming action on progesterone receptor synthesis by estradiol and tamoxifen in the 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinoma.

    abstract::The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times. Rats received either TMX or estradiol benzoate (E2B) for 3 or 7 days. Tumors were as...


    pub_type: 杂志文章


    authors: Boccardo F,Cerruti G,De Menech R,Valenti G,Zanardi S

    更新日期:1987-01-01 00:00:00

  • Stem cell relationships and the origin of gastrointestinal cancer.

    abstract::Gastrointestinal stem cells have the capacity for long-term self-replication and the ability to give rise to all other epithelial cell lineages. These properties make them essential since they maintain tissue homeostasis by regulating cell turnover depending on the current demand. However, they are also important play...


    pub_type: 杂志文章,评审


    authors: Schier S,Wright NA

    更新日期:2005-01-01 00:00:00

  • Capecitabine and mitomycin C is an effective combination for anthracycline- and taxane-resistant metastatic breast cancer.

    abstract::Capecitabine is converted to 5-fluorouracil by thymidine phosphorylase, and mitomycin C is capable of upregulating the expression of thymidine phosphorylase suggesting a synergistic effect. Fifty-three patients (median age 62 years) with anthracycline- and taxane-resistant, metastatic breast cancer received mitomycin ...


    pub_type: 杂志文章


    authors: Massacesi C,La Cesa A,Marcucci F,Pilone A,Rocchi MB,Zepponi L,Santini D,Tonini G,Burattini L

    更新日期:2006-01-01 00:00:00

  • Cyclin D3 expression, cell proliferation and pathological stage of human primary colorectal cancer.

    abstract::Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...


    pub_type: 杂志文章


    authors: Watson DS,Brotherick I,Shenton BK,Wilson RG,Angus B,Varma JS,Campbell FC

    更新日期:1999-01-01 00:00:00

  • c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling.

    abstract:OBJECTIVE:Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. M...


    pub_type: 杂志文章


    authors: Sekiya Y,Yamamoto E,Niimi K,Nishino K,Nakamura K,Kotani T,Kajiyama H,Shibata K,Kikkawa F

    更新日期:2017-01-01 00:00:00

  • Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma.

    abstract::The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high alpha-fetoprotein level, large size, high...


    pub_type: 杂志文章


    authors: Ito Y,Takeda T,Sakon M,Monden M,Tsujimoto M,Matsuura N

    更新日期:2000-06-01 00:00:00

  • Fetal antigens in the precursor stages of gastric cancer.

    abstract::Gastric epithelial cells, identified in biopsy specimens from individuals with varying degrees of gastritis and cellular atypia, were classified according to morphology and reactivity with an adult tissue-absorbed rabbit antibody to 2nd trimester human fetal tissue. Sections of stomach from normal individuals and pati...


    pub_type: 杂志文章


    authors: Higgins PJ,Correa P,Cuello C,Lipkin M

    更新日期:1984-01-01 00:00:00

  • Intensive chemotherapy plus recombinant human granulocyte-colony stimulating factor support for distant metastatic nasopharyngeal carcinoma. A preliminary report.

    abstract::Nasopharyngeal carcinoma (NPC) has been shown to be highly responsive to chemotherapy. The major limiting toxicity was myelotoxicity. Recently, the role of granulocyte colony-stimulating factor (G-CSF) in reducing chemotherapy-induced neutropenic sepsis has been well established. In this study, we tested whether recom...


    pub_type: 杂志文章


    authors: Wang CH,Wang HM,Chen JS,Chang WJ,Lai GM

    更新日期:1997-01-01 00:00:00

  • Thermochemosensitivity: augmentation by hyperthermia of cytotoxicity of anticancer drugs against human colorectal cancers, measured by the human tumor clonogenic assay.

    abstract::Thermochemosensitivity was examined in vitro by a human tumor clonogenic assay (HTCA) using specimens obtained surgically from 43 patients with colorectal cancer. We found that the percentages of patients whose cells showed higher sensitivity (greater than 70% inhibition of colony formation) to hyperthermia alone were...


    pub_type: 杂志文章


    authors: Murakami A,Koga S,Maeta M

    更新日期:1988-01-01 00:00:00

  • Second-line chemotherapy in recurrent clear cell ovarian cancer: results from the multicenter italian trials in ovarian cancer (MITO-9).

    abstract:BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 cen...


    pub_type: 杂志文章


    authors: Esposito F,Cecere SC,Magazzino F,Katsaros D,Ottaiano A,Gadducci A,Pisano C,Scalone S,Rabaiotti E,Salutari V,Cormio G,Canuto EM,Greggi S,Savarese A,Marinaccio M,Scollo P,Santeufemia DA,Sacco C,Facchini G,Pignata S

    更新日期:2014-01-01 00:00:00

  • Deoxycytidylate aminohydrolase activity in the Novikoff hepatoma is dependent on the localization of the tumor.

    abstract::The activity of deoxycytidylate aminohydrolase, a pivotal enzyme for pyrimidine biosynthesis in mammalian tissue, is 100x greater in the Novikoff hepatoma harvested from the intraperitoneal cavity than in the same tumor excised from either subcutaneous or intramuscular sites. The increased enzyme activity in the intra...


    pub_type: 杂志文章


    authors: Sheid B

    更新日期:1990-01-01 00:00:00

  • Bigenotypic and biphenotypic appearance of immunoglobulin light chains in 1 of 3 non-Hodgkin's lymphoma xenografts.

    abstract::Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearr...


    pub_type: 杂志文章


    authors: Kopper L,Bánkfalvi A,Földi J,Mihalik R,Magyar M,Aczél A

    更新日期:1990-01-01 00:00:00

  • Oral medium-dosed metoclopramide versus placebo as highly effective antiemetic prophylaxis in in- and outpatients on noncisplatin chemotherapy.

    abstract::The antiemetic effect of oral medium-dosed metoclopramide (MCL, 3.5 mg/kg b.w./cycle) and placebo for chemotherapy-induced emesis of a noncisplatin regimen was assessed for inpatients and outpatients in two double-blind placebo-controlled sequential analyses according to Bross (1952). MCL was given in 5 single doses o...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vogt C,Hellenbrecht D,Saller R,Achtert G,Brockmann P,Hausleiter H

    更新日期:1993-03-01 00:00:00

  • Amplification of ERBB-2 (HER-2/NEU) oncogene in different neoplasms of patients from USSR.

    abstract::203 tumor specimens from 175 patients were studied. Amplification of ERBB-2 was detected in 14 out of 63 (22%) cases of breast carcinoma, in 1 out of 23 patients with ovarian cancers, in 1 out of 19 cases of colon carcinoma and in 1 out of 27 patients with thyroid cancer. We failed to find more than one copy of ERBB-2...


    pub_type: 杂志文章


    authors: Knyazev PG,Imyanitov EN,Chernitca OI,Nikiforova IF,Hanson KP

    更新日期:1992-01-01 00:00:00

  • Prognostic significance of p27(kip1) protein expression and spontaneous apoptosis in patients with colorectal adenocarcinomas.

    abstract::Tumor cell apoptosis, proliferation and p27 expression using an in situ apoptosis detection kit, anti-Ki67 antibody and anti-p27 antibody were investigated in 171 colorectal adenocarcinoma specimens, together with the assessment of mutated p53 expression. No apparent association was observed among p27 expression, muta...


    pub_type: 杂志文章


    authors: Tenjo T,Toyoda M,Okuda J,Watanabe I,Yamamoto T,Tanaka K,Ohtani M,Nohara T,Kawasaki H,Tanigawa N

    更新日期:2000-01-01 00:00:00

  • Growth inhibition and modulation of cell markers of melanoma by S-allyl cysteine.

    abstract::A sulfur-containing amino acid compound, S-allyl cysteine (SAC), derived from garlic extract inhibited proliferation of nine human and murine melanoma cell line in a dose-dependent manner (1.2-10 mM) assessed by a [3H]thymidine incorporation assay. Three control human lymphoblastoid cell lines were not inhibited by SA...


    pub_type: 杂志文章


    authors: Takeyama H,Hoon DS,Saxton RE,Morton DL,Irie RF

    更新日期:1993-01-01 00:00:00