Abstract:
OBJECTIVES:To investigate the role of adjuvant radiation therapy in locoregional control in patients with locoregionally advanced papillary thyroid carcinoma (pT4 or pN1b) based on a comparison of a group that received radiation therapy and a group that did not receive radiation therapy. METHODS:A retrospective analysis was performed on 165 patients with locoregionally advanced papillary thyroid carcinoma who underwent treatment between 2002 and 2011. Of these, 32 patients received adjuvant radiation therapy, and 133 patients did not receive radiation therapy. RESULTS:The median follow-up period was 7.2 years (range, 3.4-13.6) for the overall study population. The 10-year locoregional recurrence-free survival rates for patients in the radiation therapy and no radiation therapy groups were 83.9 and 60.8%, respectively (p = 0.037). The overall survival rate and distant recurrence-free survival rate were not different between the two groups (p = 0.076 and p = 0.813, respectively). Multivariate analysis showed that adjuvant radiation therapy was an independent prognostic factor for locoregional recurrence-free survival (p = 0.040). CONCLUSIONS:Adjuvant radiation therapy for patients with either pT4 or pN1b disease improved locoregional recurrence-free survival and might be of benefit for patients with these high-risk features by reducing the need for additional salvage treatment after locoregional recurrence.
journal_name
Oncologyjournal_title
Oncologyauthors
Lee NK,Kim CY,Baek SK,Jung KYdoi
10.1159/000444393subject
Has Abstractpub_date
2016-01-01 00:00:00pages
209-14issue
4eissn
0030-2414issn
1423-0232pii
000444393journal_volume
90pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract:OBJECTIVE:To evaluate the feasibility of conducting a patient satisfaction survey in the oncology hospital setting, using a multidimensional patient satisfaction questionnaire to be completed at home. METHODS:Socio-demographic and clinical data were collected for 133 consecutive patients. Patients were asked to comple...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055362
更新日期:2001-01-01 00:00:00
abstract::Until a few decades ago neck dissection (ND) was the standard surgical approach for node-positive tumours. Nowadays patients with locally advanced head and neck cancer can be treated with definitive chemoradiation (CRT), which includes the treatment of the neck; however, results on residual viable tumour after conserv...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000346132
更新日期:2013-01-01 00:00:00
abstract::Between 1986 and 1991, 35 patients with esophageal cancer (TNM stages II-IV) underwent transthoracic esophagectomy with lymph adenectomy and were subsequently treated with 5,000 cGy of radiation (days 1-40) and concurrently with two courses of chemotherapy (cisplatin, vindesine and pepleomycin, days 21-26 and 49-54). ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227198
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:The RUNX proteins are a family of transcriptional factors that have essential functions during embryogenesis and development, whereas deregulation in expression of RUNXs is often linked to tumor formation. To date, there has been no study describing the precise expression, prognostic impact and methylation s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000135350
更新日期:2007-01-01 00:00:00
abstract::Antineoplastic properties of different Schiff bases obtained by the interaction of 5-nitrofuran with substituted pyrimidines have been examined both in vitro and in vivo. In vitro studies on L 5178Y/asparaginase sensitive, HL 60 and P 388 cell lines and in vivo studies on the P 388 cell line indicate that all the comp...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226864
更新日期:1990-01-01 00:00:00
abstract::High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227119
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:This phase I study (EudraCT No. 2006-001177-25) investigated aflibercept, a vascular endothelial growth factor decoy receptor protein (VEGF Trap), in combination with docetaxel, cisplatin, and 5-fluorouracil in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received 2, 4, or 6 mg/kg of intr...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000440958
更新日期:2016-01-01 00:00:00
abstract::A transplantable transitional cell murine bladder tumor induced by N-[4-(5-nitro-2-furyl)-thiazolyl] formamide (FANFT) was characterized by tumor growth, survival time and response to chemotherapy drugs, cis-dichloro-trans-dihydroxy-bis-iso-propylamine platinum IV (CHIP), cis- diaminedichloro platinum II (DDP), cyclop...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225822
更新日期:1984-01-01 00:00:00
abstract::The present communication reports data on the lipid biosynthesis of Ehrlich ascites tumor cells grown in culture media supplemented with modified sera. Whereas the metabolisms of [14C]pyruvate and [14C]mevalonate are identical in all media tested, the incorporation of [14C] acetate is higher in medium with dialyzed se...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225321
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:The phosphatidylinositol 3-kinase (PI3K) pathway plays a critical role in ovarian cancer cell survival and proliferation. The aim of this study was to determine whether the suppression of the PI3K catalytic subunit p110alphainhibits the growth of ovarian cancer cells in vitro and in vivo. METHODS:The short h...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000218201
更新日期:2009-01-01 00:00:00
abstract::Calcitriol (1,25-dihydroxycholecalciferol) has antiproliferative and/or proapoptotic effects on many cell types and the glucocorticoid dexamethasone enhances these effects. We have shown that calcitriol modulates several key signaling proteins involved in differentiation, proliferation and apoptosis in tumor-derived m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000098872
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of neoadjuvant treatment comprising weekly high-dose 5-fluorouracil (5-FU) as a 24-hour infusion, folinic acid (FA) and biweekly oxaliplatin (L-OHP), followed by metastatic resection in patients with primarily resectable liver metastases of colorectal cancer (CRC). PATIENTS ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000067772
更新日期:2003-01-01 00:00:00
abstract::Although the incidence of gastric cancer has been declining in Western countries, it is still a major health problem and a leading cause of cancer mortality. Surgery is the mainstay of treatment for gastric adenocarcinoma. However, even among patients undergoing gastrectomy with curative intent, 5-year survival rates ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258494
更新日期:2009-01-01 00:00:00
abstract::As TS-1 and docetaxel (TXT) have different mechanisms of antitumor activity, the combination therapy is expected to have a higher response. Human gastric cancer xenografts SC-2, St-40, and SC-4 inoculated into nude rats were treated with TS-1 alone (TS-1 12 mg/kg/day, day 1-14), TXT alone (TXT 2 mg/kg/day, day 1 or da...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000086767
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:It is unclear for whom new anti-human epidermal growth factor receptor 2 (anti-HER2) agents, such as pertuzumab and T-DM1, should be considered. We investigated prognostic factors before neoadjuvant chemotherapy (NAC) among HER2-positive invasive breast cancer patients and those after NAC among patients who ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502910
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Immuno-oncological (IO) therapies such as PD-1 and PD-L1 antibodies have been introduced in the treatment of advanced non-small cell lung cancer (NSCLC) since 2015 based on randomized trials showing unprecedented advantages in overall survival (OS) with hazard ratios (HRs) between 0.5 and 0.7. The impact of ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000500885
更新日期:2019-01-01 00:00:00
abstract::Systemic chemotherapy for advanced gastric cancer is frequently associated with significant treatment-related toxicity, which is particularly serve in patients presenting with a poor general condition. A search for effective and low-toxic regimens for this group of patients is mandatory. A weekly 24-hour infusion of h...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227702
更新日期:1997-07-01 00:00:00
abstract::72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225162
更新日期:1976-01-01 00:00:00
abstract::The methodology of future antiemetic studies will reflect the need to address the problems identified in current studies. New preclinical information on the mechanisms of emesis and antiemetic action will allow more rational clinical study design. Prior to large randomized studies, phase I and II trials should define ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227648
更新日期:1996-06-01 00:00:00
abstract::Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target in AML. Eradication of LSCs should be a critical and efficient therapeutic approach for the cure of AML. T-cell immunoglobulin mucin-3 (TIM-3) is expressed in most types of AML LSCs, but not in normal ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000431062
更新日期:2015-01-01 00:00:00
abstract::Cases are presented in which 111In-bleomycin accumulated in Virchow's gland metastasis from squamous cell carcinoma of the uterine cervix, and in paratracheal lymphatic gland metastasis from embryonal carcinoma of the right ovary. Thus, this radiopharmaceutical was found to be of great use for assessment of metastatic...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226373
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508922
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000458531
更新日期:2017-01-01 00:00:00
abstract::In pancreatic cancer (PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy. This review focuses on the role of carbohydrate antigen 19-9 (CA 19-...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000094888
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prostate carcinoma models and the molecular/cellular basis of its activity. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055380
更新日期:2001-01-01 00:00:00
abstract::Studies were made of the therapeutic response of six human colorectal tumor lines serially transplanted in immunosuppressed mice. The tumors with adenomatous structure showed greater sensitivity against different cytotoxic agents than the gelatinous ones. Among the drugs, 5-FU, BCNU and MeCCNU proved to be the most ef...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225496
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:It is well recognized that distinguishing benign from malignant papillary lesions of the breast may pose challenging diagnostic problems. To prospectively evaluate the potential role of mammography, ultrasound and image-guided core biopsy in the diagnosis of papillary lesions of the breast. METHODS:1,442 wo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000074643
更新日期:2003-01-01 00:00:00
abstract::The serum detection of S100B, a new melanoma marker, has shown clinical significance in early studies. The aim of our study of 1, 339 serum samples from 412 different melanoma patients and 107 control patients was to prove the prognostic value of serum S100B levels in melanoma patients at different stages of disease a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011989
更新日期:1999-01-01 00:00:00
abstract::The authors have reviewed the medical records of 421 sessions of hyperthermia treatments in 73 patients treated between 1987 and 1992 at the University Heights Cancer Center and the Indiana University Medical Center in Indianapolis, Ind. Temperatures attained during the course of therapy on each patient have been aver...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227209
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Variations in the incidence of cancer can be influenced by diet and specific lifestyles. In the last years, diet has been evaluated as an important factor in the development of ovarian cancer, even though the results have not been consistent. Dietary factors related to the risk of ovarian cancer in Mexican w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000063814
更新日期:2002-01-01 00:00:00