High-dose megestrol acetate as third-line endocrine therapy for metastatic breast cancer.

abstract：OBJECTIVES:The impact of ethnicity and the socioeconomic status (SES) among Caucasians is not well studied. Here, we examine the impact of income on melanoma presentation and prognosis within a Caucasian cohort, accounting for ethnicity, as some reports suggest increased melanoma incidence in Ashkenazi Jewish (AJ) BRCA...

journal_title：Oncology

authors： Salvaggio C,Han SW,Martires K,Robinson E,Madankumar R,Gumaste P,Polsky D,Stein J,Berman R,Shapiro R,Zhong J,Osman I

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...

journal_title：Oncology

authors： Markiewicz W,Ben-Arieh Y,Best L,Mordochovich D,Rinkevitch D

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Farnesyl diphosphate synthase (FPPs) produces FPP which is considered a branch-point intermediate in the synthesis of sterols and isoprenylated cellular metabolites. In this study we investigated whether detectable FPPs activity was present in human colorectal cancer (CRC), also evaluating in vitro the role o...

journal_title：Oncology

authors： Notarnicola M,Messa C,Cavallini A,Bifulco M,Tecce MF,Eletto D,Di Leo A,Montemurro S,Laezza C,Caruso MG

更新日期：2004-01-01 00:00:00

abstract：:Objective tumor responses and survival rates with standard chemotherapy options for small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) have been disappointing. However, several promising new classes of agents have emerged in recent years, including the taxanes, mitotic spindle inhibitors, antimetabol...

journal_title：Oncology

authors： Huang CH,Treat J

更新日期：2001-01-01 00:00:00

abstract：:Endoscopic ultrasound-guided pancreatic drainage (EUS-PD) was performed in a patient with unresectable pancreatic cancer who developed pancreatitis. In this case, EUS-PD was useful as salvage therapy for pancreatitis as the transpapillary approach was difficult. ...

journal_title：Oncology

authors： Kamata K,Takenaka M,Minaga K,Sakurai T,Watanabe T,Nishida N,Kudo M

更新日期：2017-01-01 00:00:00

abstract：:We have studied the effect of butyrate on mammary tumorigenesis by 7,12-dimethylbenz(a)anthracene. As reported previously, a high incidence of mammary tumors was observed in rats fed a basal diet containing 20% margarine. However, the enhancing effect of margarine was inhibited when sodium butyrate was supplemented in...

journal_title：Oncology

authors： Yanagi S,Yamashita M,Imai S

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:To investigate the relationship between the histopathologic effects of preoperative chemoradiotherapy in rectal cancer and the proteins, proliferating cell nuclear antigen (PCNA) and p53. METHODS:Samples from 73 tumors were examined. The histopathologic effects observed in the resected specimens induced by ...

journal_title：Oncology

authors： Díez M,Ramos P,Medrano MJ,Mugüerza JM,Villeta R,Lozano O,Escribano J,Noguerales F,Ruíz A,Granell J

更新日期：2003-01-01 00:00:00

abstract：:Gastric epithelial cells, identified in biopsy specimens from individuals with varying degrees of gastritis and cellular atypia, were classified according to morphology and reactivity with an adult tissue-absorbed rabbit antibody to 2nd trimester human fetal tissue. Sections of stomach from normal individuals and pati...

journal_title：Oncology

authors： Higgins PJ,Correa P,Cuello C,Lipkin M

更新日期：1984-01-01 00:00:00

abstract：:Lonidamine alone or in combination with hyperthermic perfusion, with or without melphalan, was investigated in 12 patients with stage II, III, and IV malignant melanoma. The authors evaluated the most effective methods and sequence of Lonidamine administration. Preliminary results suggest that the highest effectivenes...

journal_title：Oncology

authors： Cavaliere R,Di Filippo F,Varanese A,Carlini S,Calabro A,Aloe L,Piarulli L

更新日期：1984-01-01 00:00:00

abstract：:Nucleophosmin/B23 is a nucleolar phosphoprotein which redistributes from nucleoli to nucleoplasm (B23-translocation) when cells are exposed to certain anticancer drugs, particularly intercalators. The B23-translocation assay has been demonstrated in cell culture to correlate with drug effects and to detect drug-resist...

journal_title：Oncology

authors： Finch RA,Chan PK

更新日期：1992-01-01 00:00:00

abstract：:Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined. In this study, we examined enzyme activity of TP in 24 primary colorectal carcinoma ...

journal_title：Oncology

authors： Mimori K,Matsuyama A,Yoshinaga K,Yamashita K,Masuda T,Inoue H,Ueo H,Mori M

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:It was the aim of this study to evaluate clinicopathological characteristics and prognostic factors of uterine leiomyosarcomas (LMS). METHODS:Twenty-eight patients with uterine LMS were evaluated in this retrospective study. Their features and survival were analyzed by Kaplan-Meier and log-rank tests. RESU...

journal_title：Oncology

authors： Loizzi V,Cormio G,Nestola D,Falagario M,Surgo A,Camporeale A,Putignano G,Selvaggi L

更新日期：2011-01-01 00:00:00

abstract：:Until a few decades ago neck dissection (ND) was the standard surgical approach for node-positive tumours. Nowadays patients with locally advanced head and neck cancer can be treated with definitive chemoradiation (CRT), which includes the treatment of the neck; however, results on residual viable tumour after conserv...

journal_title：Oncology

authors： Denaro N,Russi EG,Numico G,Pazzaia T,Vitiello R,Merlano MC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Bevacizumab (Avastin) significantly improves overall survival (OS) and progression-free survival (PFS) when combined with first-line irinotecan (IFL) plus bolus 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic colorectal cancer (CRC). This open-label, phase IV trial evaluated the efficac...

journal_title：Oncology

authors： Sobrero A,Ackland S,Clarke S,Perez-Carrión R,Chiara S,Gapski J,Mainwaring P,Langer B,Young S,AVIRI Trial investigators.

更新日期：2009-01-01 00:00:00

abstract：:This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...

journal_title：Oncology

authors： Chi KH,Chang YC,Chan WK,Liu JM,Law CK,Lo SS,Shu CH,Yen SH,Whang-Peng J,Chen KY

更新日期：1997-05-01 00:00:00

abstract：:The efficacy of recombinant interferon-alpha 2 in the treatment of advanced hairy cell leukaemia is investigated in 31 patients. Preliminary results show a complete and partial response rate of 69%. An optimal dose study utilizing maximal stimulation of an interferon-dependent pathway was carried out in 5 patients. Th...

journal_title：Oncology

authors： Huber C,Flener R,Gastl G

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Adenocarcinoma is the most frequent pathological type of stomach cancer. Hodgkin's lymphoma is a lymphoproliferative disease arising from lymphoid tissue which is characterized by Reed-Sternberg cells. Synchronous occurrence of these two malignancies has not been reported in the English literature so far. C...

journal_title：Oncology

authors： Comez G,Pehlivan Y,Kalender ME,Sevinc A,Sari I,Camci C

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Because the frequency of bile duct invasion in hepatocellular carcinoma (HCC) patients is very rare, there is limited clinical evidence to demonstrate the outcomes of systemic therapy in HCC with bile duct invasion. OBJECTIVE:Our aim was to clarify the efficacy and safety of sorafenib treatment in patient...

journal_title：Oncology

authors： Tanaka T,Kuzuya T,Ishigami M,Ito T,Ishizu Y,Honda T,Ishikawa T,Fujishiro M

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To define the cyclophosphamide (CTX) maximal tolerated dose when combined with fixed doses of gemcitabine, fluorouracil (5-FU) and folinic acid (leucovorin, LFA) in metastatic breast cancer patients pretreated with anthracyclines and taxanes. METHODS:Metastatic breast cancer patients aged < or = 75 years, with...

journal_title：Oncology

authors： Frasci G,D'Aiuto G,Comella P,Thomas R,Capasso I,Botti G,Cortino GR,Di Bonito M,Rubulotta R,Vallone P,Comella G

更新日期：2002-01-01 00:00:00

abstract：:Between 1986 and 1991, 35 patients with esophageal cancer (TNM stages II-IV) underwent transthoracic esophagectomy with lymph adenectomy and were subsequently treated with 5,000 cGy of radiation (days 1-40) and concurrently with two courses of chemotherapy (cisplatin, vindesine and pepleomycin, days 21-26 and 49-54). ...

journal_title：Oncology

authors： Saito T,Shigemitsu Y,Kinoshita T,Shimoda K,Abe T,Nakamura A,Chikuba K,Kobayashi M

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Transforming growth factor beta (TGF-β) plays an important role in tumorigenesis and metastasis. It works as a tumor suppressor in the normal colon, but acts as a cancer promoter during the late stages of colorectal carcinogenesis. High expression of TGF-β is known to be associated with advanced stages, tumor...

journal_title：Oncology

authors： Chun HK,Jung KU,Choi YL,Hong HK,Kim SH,Yun SH,Kim HC,Lee WY,Cho YB

更新日期：2014-01-01 00:00:00

abstract：:Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-ph...

journal_title：Oncology

authors： Tímár J,Tóvári J,Rásó E,Mészáros L,Bereczky B,Lapis K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...

journal_title：Oncology

authors： Miyakita H,Sadahiro S,Suzuki T,Chan LF,Ogimi T,Okada K,Yamamoto S,Kajiwara H

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Our aim was to assess FDG-PET/CT as a surrogate biomarker of the pathological complete response in locally advanced rectal cancer treated with neoadjuvant chemoradiation. METHODS:T3-4 and/or N+ rectal cancer patients were treated prospectively with capecitabine-based chemoradiation and total mesorectal exci...

journal_title：Oncology

authors： Bampo C,Alessi A,Fantini S,Bertarelli G,de Braud F,Bombardieri E,Valvo F,Crippa F,Di Bartolomeo M,Mariani L,Milione M,Biondani P,Avuzzi B,Chiruzzi C,Pietrantonio F

更新日期：2013-01-01 00:00:00

abstract：:The mode of growth of tumour cells from primary breast carcinoma in the axillary nodes is shown to be related to the oestrogen receptor (ER) status of the primary tumour. ER-positive primaries are described as tending to show sinophilic growth, the tumour cells spreading along the nodal sinuses; while the ER-negative ...

journal_title：Oncology

authors： Hartveit F,Thorsen T,Tangen M,Maehle BO,Thoresen S,Halvorsen JF

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxi...

journal_title：Oncology

authors： Haag GM,Byl A,Jäger D,Berger AK

更新日期：2017-01-01 00:00:00

abstract：:Macroscopic morphology, histology and ultrastructure of BK virus (BKV)-induced hamster and mouse tumors were investigated. Groups of animals were immunosuppressed to study the relationship between immune system and BKV oncogenesis. Ependymomas had the highest incidence, followed by tumors of pancreatic islets, osteosa...

journal_title：Oncology

authors： Altavilla G,Carrà L,Alberti S,Corallini A,Cavazzini L,Fabris G,Aleotti A,Barbanti-Brodano G

更新日期：1983-01-01 00:00:00

abstract：:The best treatment for primary gastric lymphomas (PGL) has not yet been defined. Eighty-three patients with stage I/II PGL are documented, focusing on prognostic factors, treatment-related morbidity and mortality, and therapeutic outcome. Chemotherapy improved survival in comparison to local treatments, i.e. gastrecto...

journal_title：Oncology

authors： Ferreri AJ,Cordio S,Paro S,Ponzoni M,Freschi M,Veglia F,Villa E

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. METHODS:We retro...

journal_title：Oncology

authors： Ahn HK,Uhm JE,Lee J,Lim DH,Seo SW,Sung KS,Lee SJ,Lee DJ,Baek KK,Kim WS,Park JO

更新日期：2011-01-01 00:00:00

abstract：:Thrombopoietin (TPO) is a recently discovered hematopoietic growth factor which stimulates the production and maturation of megakaryocytes. In this study, we used a modified MTT assay to examine the in vitro growth-stimulatory effects of recombinant human (rh) TPO and recombinant human stem cell factor (rhSCF) on eigh...

journal_title：Oncology

authors： Shinohara A,Shimizu E,Takada M,Sone S

更新日期：1996-09-01 00:00:00