The effect of minocin on the pericardium.

abstract：BACKGROUND:The survival rate of patients with lung cancer has increased significantly over the years, but there has been no further progress in third- or fourth-line therapy. We investigated the efficacy and tolerability of monotherapy with weekly vinorelbine, a semi-synthetic vinca alkaloid, in advanced non-small-cell...

journal_title：Oncology

authors： Kang DH,Kim JO,Jung SS,Park HS,Chung C,Park D,Lee JE

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Both irinotecan (CPT) and paclitaxel (Pac) are effective against non-small cell lung cancer (NSCLC), and besides, preclinical studies have demonstrated an additive or synergistic interaction between camptothecin and taxane. METHODS:We conducted a phase I/II study of combination chemotherapy consisting of Pa...

journal_title：Oncology

authors： Yamada K,Ikehara M,Tanaka G,Nomura I,Oshita F,Noda K

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...

journal_title：Oncology

authors： Ito Y,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:To evaluate the efficacy and toxicity of irinotecan and oxaliplatin plus 5-fluorouracil (FU) and leucovorin (FOLFIRINOX) as second-line therapy in metastatic pancreatic adenocarcinoma (MPA). PATIENTS AND METHODS:We retrospectively analyzed the medical records of 27 patients with MPA treated with FOLFIRINOX ...

journal_title：Oncology

authors： Assaf E,Verlinde-Carvalho M,Delbaldo C,Grenier J,Sellam Z,Pouessel D,Bouaita L,Baumgaertner I,Sobhani I,Tayar C,Paul M,Culine S

更新日期：2011-01-01 00:00:00

abstract：:This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...

journal_title：Oncology

authors： Chi KH,Chang YC,Chan WK,Liu JM,Law CK,Lo SS,Shu CH,Yen SH,Whang-Peng J,Chen KY

更新日期：1997-05-01 00:00:00

abstract：:Cisplatin is among the most active agents available for the therapy of non-small cell lung cancer (NSCLC). Its congener, carboplatin, has been the focus of intense clinical trials over the last several years because of its improved therapeutic index. Results from randomized trials have shown that carboplatin is active...

journal_title：Oncology

authors： Comis RL

更新日期：1993-11-01 00:00:00

abstract：:The local immunologic phenomena in the thyroid gland of 16 patients with chronic lymphocytic thyroiditis (CLTH) were investigated; 5 of these cases were associated with thyroid non-Hodgkin's lymphomas (NHL). All patients were admitted because of struma, growing slowly in patients with CLTH alone and rapidly in those w...

journal_title：Oncology

authors： Aozasa K,Tajima K,Tominaga N,Katagiri S,Yonezawa T,Matsuzuka F,Kuma K,Sawada M

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Mutations in the human telomerase reverse transcriptase (hTERT) gene promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of these mutations in liquid biopsies have been technically difficult because of the high GC content of the regions of interest within this promoter. We evalua...

journal_title：Oncology

authors： Ako S,Nouso K,Kinugasa H,Matsushita H,Terasawa H,Adachi T,Wada N,Takeuchi Y,Mandai M,Onishi H,Ikeda F,Shiraha H,Takaki A,Fujioka S,Mimura T,Okada H

更新日期：2020-01-01 00:00:00

abstract：:Thirty-five patients with metastatic breast cancer who had received one or two prior chemotherapeutic regimens were treated with elliptinium acetate at a dose of 80 mg/m2 for 3 days every 3 weeks. Of the 33 patients evaluable for response, 1 patient achieved complete remission, 4 achieved partial responses (15% overal...

journal_title：Oncology

authors： Buzdar AU,Hortobagyi GN,Esparza LT,Holmes FA,Ro JS,Fraschini G,Lichtiger B

更新日期：1990-01-01 00:00:00

abstract：:Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) w...

journal_title：Oncology

authors： Inuzuka T,Nishikawa H,Sekikawa A,Takeda H,Henmi S,Sakamoto A,Saito S,Kita R,Kimura T,Osaki Y,Kudo M

更新日期：2011-01-01 00:00:00

abstract：:Primary fetal rat fibroblasts (FRF cells) were transfected with DNA extracted from BKV-transformed hamster kidney cells at low passage after transformation (HKBKlp cells) and at high passage after transformation (HKBKhp cells). Two transformed rat cell lines were obtained, FRF-DNA-HKBKlp cells and FRF-DNA-HKBKhp cells...

journal_title：Oncology

authors： Possati L,Collesi A,Rosciani C,Rubini C

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply in...

journal_title：Oncology

authors： Petrelli F,Ardito R,Ghidini A,Zaniboni A,Ghidini M,Barni S,Tomasello G

更新日期：2018-01-01 00:00:00

abstract：:The prognosis of brain glioblastoma is still very poor and the median survival time is generally less than 6 months. At present, no chemotherapy has appeared to influence its prognosis. On the other hand, recent advances in brain tumor biology have suggested that brain tumor growth is at least in part under a neuroend...

journal_title：Oncology

authors： Lissoni P,Meregalli S,Nosetto L,Barni S,Tancini G,Fossati V,Maestroni G

更新日期：1996-01-01 00:00:00

abstract：:Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...

journal_title：Oncology

authors： Baselga J,Hammond LA

更新日期：2002-01-01 00:00:00

abstract：:To evaluate the influence of delay between first symptom and first treatment upon survival the medical records of 596 patients with breast cancer were reviewed. The following intervals were considered: less than 3 months; 3-6 months and greater than 6 months. Patients in the less than 3 months delay group had a better...

journal_title：Oncology

authors： Machiavelli M,Leone B,Romero A,Perez J,Vallejo C,Bianco A,Rodriguez R,Estevez R,Chacon R,Dansky C

更新日期：1989-01-01 00:00:00

abstract：:In order to determine the operative indications of three-field lymph node dissection of esophageal cancer, attempts were made to collect data concerning procedures performed between 1983 and 1989 in major institutions in Japan, and the results from institutions performing three-field or two-field lymph node dissection...

journal_title：Oncology

authors： Isono K,Sato H,Nakayama K

更新日期：1991-01-01 00:00:00

abstract：:We have provided an in-depth, longitudinal, clinical/genetic/pathologic investigation of a family consonant with the sarcoma, breast cancer and brain tumors, lung and laryngeal cancer, leukemia, lymphoma, and adrenalcortical carcinoma syndrome. The pattern of cancer expression involves all three germinal layers with t...

journal_title：Oncology

authors： Lynch HT,Radford B,Lynch JF

更新日期：1990-01-01 00:00:00

abstract：:The value of a screening test for sytoxic chemotherapeutic agents in the treatment of advanced malignant disease is assessed by comparing the performances of 32 patients whose treatment followed closely the test recommendations with that of 31 patients whose treatment did not follow the predictions. The significant im...

journal_title：Oncology

authors： Wheeler TK,Dendy PP,Dawson A

更新日期：1974-01-01 00:00:00

abstract：:We analyzed the differential gene expression in the pancreatic cancer cell line NP-18 upon induction of apoptosis caused by cyclin-dependent kinase inhibition triggered by either overexpression of the tumor suppressor gene p16(INK4A)using an adenoviral construction or incubation with the chemical inhibitors, roscoviti...

journal_title：Oncology

authors： Blasco F,Peñuelas S,Cascalló M,Hernández JL,Alemany C,Masa M,Calbó J,Soler M,Nicolás M,Pérez-Torras S,Gómez A,Tarrasón G,Noé V,Mazo A,Ciudad CJ,Piulats J

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:Suboptimal debulking (>1 cm residual tumor) results in poor survival rates for patients with an advanced stage of ovarian cancer. The purpose of this study was to develop a prediction model, based on simple preoperative parameters, for patients with an advanced stage of ovarian cancer who are at risk of subo...

journal_title：Oncology

authors： de Jong D,Eijkemans MJ,Lie Fong S,Gerestein CG,Kooi GS,Baalbergen A,van der Burg ME,Burger CW,Ansink AC

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:We evaluated the efficacy and safety of bolus 5-fluorouracil (5-FU) and leucovorin combined with weekly paclitaxel (FLTAX) in advanced gastric cancer (GC) patients. METHODS:Patients with untreated stage IV GC received paclitaxel 80 mg/m(2) as a 1-hour infusion, followed by 5-FU 600 mg/m(2) as a bolus infusio...

journal_title：Oncology

authors： Matsubara J,Shimada Y,Kato K,Nagai Y,Iwasa S,Nakajima TE,Hamaguchi T,Yamada Y,Takagi S,Kobayashi K,Yoshioka A,Nakayama N,Tsuji A

更新日期：2011-01-01 00:00:00

abstract：:Expression of ras p21 in human gastric cancers, benign lesions and normal tissues was immunohistochemically evaluated by the avidin-biotin peroxidase complex (ABC) method with anti-ras p21 monoclonal antibody rp-28. Positive p21 immunoreactivity was shown in 23 (77%) of 30 gastric cancers, in 13 (48%) of 27 benign les...

journal_title：Oncology

authors： Nakajima K,Kuzumaki N,Oda A,Kobayashi H,Katoh H,Tanabe T

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Transforming growth factor beta (TGF-β) plays an important role in tumorigenesis and metastasis. It works as a tumor suppressor in the normal colon, but acts as a cancer promoter during the late stages of colorectal carcinogenesis. High expression of TGF-β is known to be associated with advanced stages, tumor...

journal_title：Oncology

authors： Chun HK,Jung KU,Choi YL,Hong HK,Kim SH,Yun SH,Kim HC,Lee WY,Cho YB

更新日期：2014-01-01 00:00:00

abstract：:Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...

journal_title：Oncology

authors： Scheithauer W,Depisch D,Schiessel R,Ludwig H

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of lo...

journal_title：Oncology

authors： Miglietta L,Vanella P,Canobbio L,Naso C,Cerisola N,Meszaros P,Parodi MA,Morabito F

更新日期：2010-01-01 00:00:00

abstract：:Small quantities of carcinogens, dl-ethionine, thiotepa, actinomycin D, and 1-(2-chloroethyl-3-cyclohexyl)-1-nitrosourea (CCNU) stimulated in vitro deoxyribonucleic acid (DNA) synthesis of the slime mutant of Neurospora crassa, while there was practically no effect on the DNA from the normal wild type 74A strain. All ...

journal_title：Oncology

authors： Beljanski M,Dutta SK

更新日期：1987-01-01 00:00:00

abstract：:Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and di...

journal_title：Oncology

authors： Amadori A,Rossi E,Zamarchi R,Carli P,Pastorelli D,Jirillo A

更新日期：2009-01-01 00:00:00

abstract：:The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of developing lung cancer, with individuals with high activity being at incre...

journal_title：Oncology

authors： Agúndez JA,Gallardo L,Ledesma MC,Lozano L,Rodriguez-Lescure A,Pontes JC,Iglesias-Moreno MC,Poch J,Ladero JM,Benítez J

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Expression of vascular endothelial growth factor (VEGF)-D by tumors is associated with metastasis to lymph nodes in mice. However, there are few reports concerning the clinical significance of VEGF-D protein in human carcinoma. METHODS:After confirming production of VEGF-D by eight colorectal carcinoma cell ...

journal_title：Oncology

authors： Funaki H,Nishimura G,Harada S,Ninomiya I,Terada I,Fushida S,Tani T,Fujimura T,Kayahara M,Shimizu K,Ohta T,Miwa K

更新日期：2003-01-01 00:00:00

abstract：:The report describes the lethal exitus of a 44-year-old woman after repeated criminal poisoning with N-nitrosodimethylamine. She died 32 months following the initial symptoms and developed a liver cirrhosis with multiple bleeding, a hemolytic syndrome and diabetes mellitus. ...

journal_title：Oncology

authors： Fussgaenger RD,Ditschuneit H

更新日期：1980-01-01 00:00:00