Abstract:
:Cisplatin is among the most active agents available for the therapy of non-small cell lung cancer (NSCLC). Its congener, carboplatin, has been the focus of intense clinical trials over the last several years because of its improved therapeutic index. Results from randomized trials have shown that carboplatin is active in NSCLC, and that it can be effectively integrated into combination chemotherapy programs, with survival benefits comparable to cisplatin-containing regimens. Ongoing trials address critical issues, including: the optimization of platinum dose by either varying the carboplatin dose or combining cisplatin and carboplatin; evaluating the activity of carboplatin-containing programs with stem-cell support; and combining low-dose carboplatin with radiation therapy in an attempt to integrate these effective modalities. Finally, the availability of new active agents such as TAXOL (paclitaxel) and the camptothecin analogs has led to clinical trials to determine the optimal interaction between these agents and carboplatin.
journal_name
Oncologyjournal_title
Oncologyauthors
Comis RLdoi
10.1159/000227259subject
Has Abstractpub_date
1993-11-01 00:00:00pages
37-41eissn
0030-2414issn
1423-0232journal_volume
50 Suppl 2pub_type
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