Combined evaluation of expressions of p53 and p21 proteins as prognostic factors for patients with gastric carcinoma.

abstract：:In order to determine the operative indications of three-field lymph node dissection of esophageal cancer, attempts were made to collect data concerning procedures performed between 1983 and 1989 in major institutions in Japan, and the results from institutions performing three-field or two-field lymph node dissection...

journal_title：Oncology

authors： Isono K,Sato H,Nakayama K

更新日期：1991-01-01 00:00:00

abstract：:A loss of heterozygosity (LOH) at the DCC gene locus was detected in colorectal tumors, and this LOH might be related to metastasis. The aim of this study was to determine DCC protein expression in colorectal cancer and to evaluate its prognostic value. Allelic loss of the DCC locus was observed in 16 of the 23 patien...

journal_title：Oncology

authors： Saito M,Yamaguchi A,Goi T,Tsuchiyama T,Nakagawara G,Urano T,Shiku H,Furukawa K

更新日期：1999-01-01 00:00:00

abstract：:Repeated ultraviolet light (UV) irradiation on the skin of rats caused ulceration, scarring and epithelial tumors; 38% of the animals had ear tumors and 5% skin tumors. Guinea pigs presented minimal evidence of neoplastic transformation; only two tumors were seen while hamsters displayed localized epidermal hyperplasi...

journal_title：Oncology

authors： Stenbäck F

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:This study reports the percentage of breast cancer survivors receiving ongoing benzodiazepines and the circumstances surrounding their usage. METHODS:The medical records of 1,000 consecutive breast cancer survivors who were no longer receiving adjuvant chemotherapy were reviewed. RESULTS:Among those patient...

journal_title：Oncology

authors： Vaidya R,Sood R,Karlin N,Jatoi A

更新日期：2011-01-01 00:00:00

abstract：:The encouraging results that have been reported for cisplatin combination chemotherapy in a minority of patients with cancer of unknown primary (CUP) together with the previously shown equal activity of carboplatin in this setting, prompted us to investigate the effectiveness of a carboplatin-containing regimen in a p...

journal_title：Oncology

authors： Briasoulis E,Tsavaris N,Fountzilas G,Athanasiadis A,Kosmidis P,Bafaloukos D,Skarlos D,Samantas E,Pavlidis N

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. M...

journal_title：Oncology

authors： Sekiya Y,Yamamoto E,Niimi K,Nishino K,Nakamura K,Kotani T,Kajiyama H,Shibata K,Kikkawa F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Patients with localized gastric adenocarcinoma (LGAC), who get pre-operative therapy, have heterogeneous/unpredictable outcomes. Predictive clinical variables/biomarkers are not established. METHODS:We analyzed 107 LGAC patients who had chemoradiation and surgery. LGACs were grouped for (1) presence/absence...

journal_title：Oncology

authors： Charalampakis N,Nogueras González GM,Elimova E,Wadhwa R,Shiozaki H,Shimodaira Y,Blum MA,Rogers JE,Harada K,Matamoros A Jr,Sagebiel T,Das P,Minsky BD,Lee JH,Weston B,Bhutani MS,Estrella JS,Badgwell BD,Ajani JA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cisplatin-pemetrexed combination chemotherapy is the current standard primary treatment for malignant pleural mesothelioma (MPM). It was first approved for untreated and unresectable MPM in the 2003 National Comprehensive Cancer Network (NCCN) guidelines. However, to date, standard treatments for patients wi...

journal_title：Oncology

authors： Koda Y,Kuribayashi K,Doi H,Kitajima K,Nakajima Y,Ishigaki H,Nakamura A,Minami T,Takahashi R,Yokoi T,Kijima T

更新日期：2020-10-14 00:00:00

abstract：BACKGROUND:Clinical significance of immunohistochemically detectable level of p53 protein has been reported, but with some limitation as a prognosticator of bladder cancer patients. Whether or not simultaneous evaluation of mdm2 and p53 expression in bladder cancer exceed the prognostic significance of conventional his...

journal_title：Oncology

authors： Shiina H,Igawa M,Shigeno K,Yamasaki Y,Urakami S,Yoneda T,Wada Y,Honda S,Nagasaki M

更新日期：1999-04-01 00:00:00

abstract：:Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...

journal_title：Oncology

authors： Watson DS,Brotherick I,Shenton BK,Wilson RG,Angus B,Varma JS,Campbell FC

更新日期：1999-01-01 00:00:00

abstract：:Thirty-five patients with metastatic breast cancer who had received one or two prior chemotherapeutic regimens were treated with elliptinium acetate at a dose of 80 mg/m2 for 3 days every 3 weeks. Of the 33 patients evaluable for response, 1 patient achieved complete remission, 4 achieved partial responses (15% overal...

journal_title：Oncology

authors： Buzdar AU,Hortobagyi GN,Esparza LT,Holmes FA,Ro JS,Fraschini G,Lichtiger B

更新日期：1990-01-01 00:00:00

abstract：:Lonidamine was studied in advanced cancer patients. The drug was given orally by single or repeated administrations. Single doses ranged from 150 to 450 mg. Repeated administrations were performed with progressively increasing doses: 450-900 mg daily. Lonidamine lacked severe toxic effects after both single and prolon...

journal_title：Oncology

authors： Barduagni A,Barduagni M,Di Lauro L,Nardi M,Gallo Curcio C,Tonachella R,Ciottoli GB,Delle Chiaie S

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:Superficially spreading early gastric cancer is characterized by wide horizontal extension without deep vertical invasion. This study aimed to clarify the clinicopathological characteristics and prognosis of this rare disease. METHODS:We defined superficially spreading early gastric cancer as any tumor inva...

journal_title：Oncology

authors： Kunisaki C,Akiyama H,Nomura M,Matsuda G,Otsuka Y,Ono H,Shimada H

更新日期：2005-01-01 00:00:00

abstract：:The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...

journal_title：Oncology

authors： Di Lorenzo G,Scagliarini S,Di Napoli M,Scognamiglio F,Rizzo M,Carteni' G

更新日期：2009-01-01 00:00:00

abstract：:High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...

journal_title：Oncology

authors： Cruz JM,Muss HB,Russell G

更新日期：1992-01-01 00:00:00

abstract：:This multicenter phase II study evaluated the efficacy of the FEM regimen (5-fluorouracil 333 mg/m(2) each week, epirubicin 30 mg/m(2) once every 4 weeks and mitomycin-C 2.7 mg/m(2) once every 2 weeks) administered by hepatic artery infusion (HAI) for unresectable hepatic metastases of gastric cancer. The response rat...

journal_title：Oncology

authors： Kumada T,Arai Y,Itoh K,Takayasu Y,Nakamura K,Ariyoshi Y,Tajima K

更新日期：1999-10-01 00:00:00

abstract：:The levels of bone-specific alkaline phosphatase (BALP) in plasma and tumour tissue samples of 20 Chinese patients with osteosarcoma in Hong Kong were measured by the wheat germ lectin precipitation technique. The plasma BALP levels in these patients were significantly higher than those of the normal subjects (p < 0.0...

journal_title：Oncology

authors： Liu PP,Leung KS,Kumta SM,Lee KM,Fung KP

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Wernicke's encephalopathy (WE) is a neurological emergency which presents with symptoms of confusion, ophthalmoplegia, and ataxia. Cancer patients are at high risk of this acute encephalopathy due to chronic malnutrition, chemotherapy-induced nausea and vomiting, and consumption of thiamine by rapidly growin...

journal_title：Oncology

authors： Kuo SH,Debnam JM,Fuller GN,de Groot J

更新日期：2009-01-01 00:00:00

abstract：:The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...

journal_title：Oncology

authors： Jelić S,Kovcin V,Jovanović V,Oprić M,Milanović N

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:The pretreatment neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been reported to be useful as markers for prognostic factors and metastasis in several cancers. The aim of this study was to identify the predictor of lymph node (LN) metastasis by pretreatment NLR and PLR in...

journal_title：Oncology

authors： Aoyama T,Takano M,Miyamoto M,Yoshikawa T,Kato K,Sakamoto T,Takasaki K,Matsuura H,Soyama H,Hirata J,Suzuki A,Sasa H,Tsuda H,Furuya K

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) have been identified and shown to have prognostic and predictive roles in several types of carcinoma. More recently, aneuploid CTCs have become subject of a growing interest, as aneuploidy is considered a hallmark of cancer often associated with poor prognosis. Here, we aimed t...

journal_title：Oncology

authors： Napolitano A,Minelli A,Santini D,Tonini G,Vincenzi B

更新日期：2020-01-01 00:00:00

abstract：:Anticipatory nausea and vomiting (ANV) are learned responses to chemotherapy that develop in up to 25% of patients by the fourth treatment cycle. Post-treatment nausea and emesis must occur before development of ANV can take place. Certain patient characteristics and other responses to chemotherapy can also be used to...

journal_title：Oncology

authors： Morrow GR,Rosenthal SN

更新日期：1996-06-01 00:00:00

abstract：INTRODUCTION:Carcinoma of the biliary system is a rare tumor entity, and patients with advanced disease face a dismal prognosis. Because of the absence of standard chemotherapy for advanced biliary carcinoma, we have performed two consecutive studies to evaluate the clinical potential of 5-fluorouracil, leucovorin and ...

journal_title：Oncology

authors： Raderer M,Hejna MH,Valencak JB,Kornek GV,Weinländer GS,Bareck E,Lenauer J,Brodowicz T,Lang F,Scheithauer W

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify biomarkers for predicting the efficacy of docetaxel, cisplatin, and S-1 (DCS) therapy for advanced gastric cancer using microarrays of biopsy specimens before chemotherapy. METHODS:Nineteen samples were taken from 19 patients with unresectable metastatic gastric cancer ...

journal_title：Oncology

authors： Kitamura S,Tanahashi T,Aoyagi E,Nakagawa T,Okamoto K,Kimura T,Miyamoto H,Mitsui Y,Rokutan K,Muguruma N,Takayama T

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Early detection of esophageal cancer is hampered by paucity of molecular markers for diagnosis of this aggressive gastrointestinal malignancy in early stages. We recently identified TC21/R-Ras2, a small GTP-binding protein (SMG) in esophageal squamous cell carcinomas (ESCCs) by differential display. This stu...

journal_title：Oncology

authors： Sharma R,Sud N,Chattopadhyay TK,Ralhan R

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Insulin-like growth factor I (IGF-I) and other components of the IGF system have been implicated in the etiology of several human malignancies. We have undertaken a case-control study among Greek women to explore the relation of major components of the IGF system (IGF-I, IGF-II and IGF-binding protein 3, IGF...

journal_title：Oncology

authors： Petridou E,Koukoulomatis P,Alexe DM,Voulgaris Z,Spanos E,Trichopoulos D

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To evaluate two docetaxel-based regimens as first-line treatment in advanced breast cancer patients. METHODS:Patients were randomly assigned to docetaxel/gemcitabine (arm A: docetaxel 75 mg/m(2) on day 1, gemcitabine 1,000 mg/m(2) on days 1 and 8) or docetaxel/capecitabine (arm B: docetaxel 75 mg/m(2) on day...

journal_title：Oncology

authors： Vici P,Giotta F,Di Lauro L,Sergi D,Vizza E,Mariani L,Latorre A,Pizzuti L,D'Amico C,Giannarelli D,Colucci G

更新日期：2011-01-01 00:00:00

abstract：:The authors have reviewed the medical records of 421 sessions of hyperthermia treatments in 73 patients treated between 1987 and 1992 at the University Heights Cancer Center and the Indiana University Medical Center in Indianapolis, Ind. Temperatures attained during the course of therapy on each patient have been aver...

journal_title：Oncology

authors： Shidnia H,Hornback N,Ford G,Shen RN

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of percutaneous cementoplasty for painful bone metastasis from hepatocellular carcinoma (HCC). METHODS:Cementoplasty was performed for 22 metastatic bone tumors in 13 patients. All patients had intractable pain and were diagnosed as metastatic bone tumor from HCC. The ostyneedle was in...

journal_title：Oncology

authors： Kodama H,Aikata H,Uka K,Takaki S,Mori N,Waki K,Jeong SC,Kawakami Y,Shirakawa H,Takahashi S,Toyota N,Ito K,Chayama K

更新日期：2007-01-01 00:00:00

abstract：:Twenty-five patients with cutaneous melanoma were imaged with F(ab')2 fragments of antimelanoma monoclonal antibody (MoAb) 225.28S labeled with 99mTc and 131I or 111In. Out of 16 patients without evidence of metastatic lesions, 6 false-positive cases were observed. Only 4 out of 9 patients with known lesions showed po...

journal_title：Oncology

authors： Repetto L,Scopinaro G,Michelotti A,Claudiani F,Fusco V,Grimaldi A,Sertoli MR,Rosso R

更新日期：1988-01-01 00:00:00