Pretreatment Neutrophil-to-Lymphocyte Ratio Was a Predictor of Lymph Node Metastasis in Endometrial Cancer Patients.

abstract：PURPOSE:We investigated whether a 5-fluorouracil (5-FU)-resistant tumor could regain chemosensitivity after the administration of 5-aza-2'-deoxycytidine (DAC) as a demethylating agent. METHODS:Human colorectal cancer cells (SW48) are characterized by the hypermethylation of proapoptotic genes. They were transplanted i...

journal_title：Oncology

authors： Morita S,Iida S,Kato K,Takagi Y,Uetake H,Sugihara K

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Sorafenib, a multitargeted tyrosine kinase inhibitor, is now the treatment of choice for systemic therapy of patients with advanced hepatocellular carcinoma (HCC). Herein, we present the clinical characteristics and outcomes of patients with advanced HCC who were treated with sorafenib. METHODS:Data of 201 ...

journal_title：Oncology

authors： Baek KK,Kim JH,Uhm JE,Park SH,Lee J,Park JO,Park YS,Kang WK,Lim HY

更新日期：2011-01-01 00:00:00

abstract：:Chromosomal aberrations and sister chromatid exchanges were examined in 45 patients with nonseminomatous testicular cancer at different times after the termination of vinblastine, cisplatin and bleomycin (VPB) therapy and in 22 age-matched healthy men and untreated testicular cancer patients. After 36 months, the freq...

journal_title：Oncology

authors： Gundy S,Baki M,Bodrogi I,Czeizel A

更新日期：1990-01-01 00:00:00

abstract：:Since aspirin was found to cause a persistent decrease in pyruvate kinase activity, which is a prominent characteristic of the hepatic promoters, the effect of aspirin on hepatic tumorigenesis in the rat has been studied. Male Wistar rats were initiated with a diet containing 0.06% 3'-methyl-4-dimethylamino-azobenzene...

journal_title：Oncology

authors： Yanagi S,Yamashita M,Hiasa Y

更新日期：1993-07-01 00:00:00

abstract：:Empiric clinical trials have revealed new mechanisms by which hormonal therapies may exert their antitumor effects. Initial studies using escalated doses of agents like toremifene and megestrol acetate have yielded interesting results, showing responses in hormone-receptor-negative patients and in patients progressing...

journal_title：Oncology

authors： Abrams JS,Gutheil J,Aisner J

更新日期：1992-01-01 00:00:00

abstract：:Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months)...

journal_title：Oncology

authors： Kokron O,Maca S,Gasser G,Schmidt PR

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP...

journal_title：Oncology

authors： Ulusoy G,Adali O,Tumer TB,Sahin G,Gozdasoglu S,Arinç E

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Surgery has traditionally been the treatment of choice for patients with potentially resectable esophageal carcinoma. Recently, however, definitive chemoradiotherapy (CRT) has been suggested as a preferred treatment modality. In this study, CRT results with or without surgery are compared. METHODS:A total o...

journal_title：Oncology

authors： Salek R,Tabrizi FV,Bezenjani SE,Saedi HS,Ashkiki MH,Hosainzadeh SM,Mohtashami S

更新日期：2011-01-01 00:00:00

abstract：:Cases are presented in which 111In-bleomycin accumulated in Virchow's gland metastasis from squamous cell carcinoma of the uterine cervix, and in paratracheal lymphatic gland metastasis from embryonal carcinoma of the right ovary. Thus, this radiopharmaceutical was found to be of great use for assessment of metastatic...

journal_title：Oncology

authors： Kida T,Ikeda M

更新日期：1986-01-01 00:00:00

abstract：:Sixteen patients with histologically confirmed inoperable hepatocellular carcinoma were treated with vindesine 3 mg/m2 i.v. weekly. Anemia, leukopenia and neuritis were documented but no severe or life-threatening toxicity was seen. There were no objective responses among the 14 evaluable patients. Eight had a no chan...

journal_title：Oncology

authors： Falkson G,Burger W

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Whether recurrence after surgery and primary metastatic pancreatic cancer should be included in the same category when conducting gemcitabine-based clinical trials remains controversial. OBJECTIVE:To clarify the outcomes of recurrent and metastatic pancreatic cancers. METHODS:326 patients who received gemc...

journal_title：Oncology

authors： Hashimoto K,Ueno H,Ikeda M,Kojima Y,Hagihara A,Kondo S,Morizane C,Okusaka T

更新日期：2009-01-01 00:00:00

abstract：:The methodology of future antiemetic studies will reflect the need to address the problems identified in current studies. New preclinical information on the mechanisms of emesis and antiemetic action will allow more rational clinical study design. Prior to large randomized studies, phase I and II trials should define ...

journal_title：Oncology

authors： Olver IN

更新日期：1996-06-01 00:00:00

abstract：:Fifteen patients, median age 64 years, presenting with advanced gastrointestinal adenocarcinomas, were included in this study. The treatment combination consisted of folinic acid (200 mg/m2, IV bolus injection) followed by 5-fluorouracil (5-FU; 400 mg/m2, 30-min infusion) for 5 consecutive days and mitomycin C (10 mg/...

journal_title：Oncology

authors： Becouarn Y,Brunet R,Bussières E,Marée D

更新日期：1988-01-01 00:00:00

abstract：:The historical aspects of drug development and evaluation are anecdotically related. Clinical trials have proven the effectiveness of animal tests in the vast majority of cases, and the effort has been well spent. Similar of more noteworthy success may be obtainable with model systems in the study of prostatic cancer....

journal_title：Oncology

authors： Gaunt R

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:The current study aimed to compare the therapeutic outcomes of surgery with those of chemoradiation for patients with advanced oropharyngeal cancer (OPC). METHODS:The data for 523 patients with previously untreated OPC were obtained from 12 institutions belonging to the Head and Neck Cancer Study Group in th...

journal_title：Oncology

authors： Kano S,Homma A,Hayashi R,Kawabata K,Yoshino K,Iwae S,Hasegawa Y,Nibu K,Kato T,Shiga K,Matsuura K,Monden N,Fujii M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. OBJECTIVE:We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. METHODS:We retrospectively examined 649 consecutive patients with HCC who underwent curative...

journal_title：Oncology

authors： Lee HW,Choi GH,Kim DY,Park YN,Kim KS,Choi JS,Ahn SH,Han KH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...

journal_title：Oncology

authors： Miyakita H,Sadahiro S,Suzuki T,Chan LF,Ogimi T,Okada K,Yamamoto S,Kajiwara H

更新日期：2020-01-01 00:00:00

abstract：:Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...

journal_title：Oncology

authors： Stora C

更新日期：1980-01-01 00:00:00

abstract：:6 cases of endodermal sinus tumor of the ovary are presented. In 4 patients pure endodermal sinus tumor was found microscopically. 1 patient had endodermal sinus tumor in one ovary and gonadoblastoma in the contralateral one. In another case endodermal sinus tumor was accompanied by an embryonal teratoma. Histological...

journal_title：Oncology

authors： Sikorowa L,Morawski A,Piatkowski Z

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...

journal_title：Oncology

authors： Chu E,Shi N,Wei W,Bendell JC,Cartwright T

更新日期：2009-01-01 00:00:00

abstract：:Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...

journal_title：Oncology

authors： Watson DS,Brotherick I,Shenton BK,Wilson RG,Angus B,Varma JS,Campbell FC

更新日期：1999-01-01 00:00:00

abstract：:In order to determine the operative indications of three-field lymph node dissection of esophageal cancer, attempts were made to collect data concerning procedures performed between 1983 and 1989 in major institutions in Japan, and the results from institutions performing three-field or two-field lymph node dissection...

journal_title：Oncology

authors： Isono K,Sato H,Nakayama K

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:Suboptimal debulking (>1 cm residual tumor) results in poor survival rates for patients with an advanced stage of ovarian cancer. The purpose of this study was to develop a prediction model, based on simple preoperative parameters, for patients with an advanced stage of ovarian cancer who are at risk of subo...

journal_title：Oncology

authors： de Jong D,Eijkemans MJ,Lie Fong S,Gerestein CG,Kooi GS,Baalbergen A,van der Burg ME,Burger CW,Ansink AC

更新日期：2007-01-01 00:00:00

abstract：:Several reports have demonstrated an adverse effect of perioperative blood transfusions on the survival of patients with various solid tumors treated surgically. We retrospectively investigated the relationship between perioperative blood transfusions and the survival of 501 patients who underwent radical subtotal gas...

journal_title：Oncology

authors： Choi JH,Chung HC,Yoo NC,Lee HR,Lee KH,Kim JH,Roh JK,Min JS,Lee KS,Kim BS

更新日期：1995-03-01 00:00:00

abstract：:Oxaliplatin-based chemotherapy is an effective first-line treatment option for patients with metastatic colorectal cancer (mCRC), which, in combination with targeted therapies and a sequential treatment approach using all active agents, has extended median overall survival to 2 years and beyond. Prolonged survival bri...

journal_title：Oncology

authors： Grothey A

更新日期：2010-01-01 00:00:00

abstract：:To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...

journal_title：Oncology

authors： Cör A

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the antitumor activity and safety of an epirubicin, cisplatin, and capecitabine (ECX) combination in patients with metastatic or advanced gastric cancer. PATIENTS AND METHODS:Patients with metastatic or advanced measurable gastric adenocarcinoma received ECX combina...

journal_title：Oncology

authors： Cho EK,Lee WK,Im SA,Lee SN,Park SH,Bang SM,Park DK,Park YH,Shin DB,Lee JH

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:BRAF D594G mutations in colorectal cancer patients are not clearly understood. We retrospectively investigated the clinicopathological features of colorectal cancers with BRAF D594G mutations. METHODS:We selected 908 colorectal cancer patients who underwent surgical resection from January 2008 to January 201...

journal_title：Oncology

authors： Amaki-Takao M,Yamaguchi T,Natsume S,Iijima T,Wakaume R,Takahashi K,Matsumoto H,Miyaki M

更新日期：2016-01-01 00:00:00

abstract：:In 29 patients (48 courses of chemotherapy), a randomized double-blind crossover study was undertaken to establish the antiemetic effectiveness of a combination of metoclopramide at a moderately high dose (5 mg/kg body weight) with 1 g methylprednisolone (treatment A) as compared with metoclopramide monotherapy (5 mg/...

journal_title：Oncology

authors： Ell C,König HJ,Brockmann P,Domschke S,Domschke W

更新日期：1985-01-01 00:00:00

abstract：:Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40-50 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats resulted in a marked decrease in the growth rate of both tumors. Exhaustive extraction of the corn oil with water indicated that the act...

journal_title：Oncology

authors： Gilbertson JR,Gelman RA,Ove P,Coetzee ML

更新日期：1977-01-01 00:00:00