Abstract:
:The historical aspects of drug development and evaluation are anecdotically related. Clinical trials have proven the effectiveness of animal tests in the vast majority of cases, and the effort has been well spent. Similar of more noteworthy success may be obtainable with model systems in the study of prostatic cancer.
journal_name
Oncologyjournal_title
Oncologyauthors
Gaunt Rdoi
10.1159/000225197subject
Has Abstractpub_date
1977-01-01 00:00:00pages
94-5issue
3eissn
0030-2414issn
1423-0232journal_volume
34pub_type
历史文章,杂志文章相关文献
ONCOLOGY文献大全abstract::The methodology of future antiemetic studies will reflect the need to address the problems identified in current studies. New preclinical information on the mechanisms of emesis and antiemetic action will allow more rational clinical study design. Prior to large randomized studies, phase I and II trials should define ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227648
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To investigate the potential benefit of intermittent chemotherapy, and to identify the eligibility criteria offering intermittent chemotherapy to patients with advanced urothelial cancer. MATERIALS AND METHODS:Twenty patients who responded or had stable disease after receiving 3 cycles of induction chemother...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000338770
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To report the outcomes of surgical resection of borderline resectable (BL) and locally advanced (LA) 'unresectable' pancreatic cancer after neoadjuvant chemotherapy. METHODS:A review of a prospectively maintained database for pancreatic resections was undertaken to identify patients undergoing resection for ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000371745
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS:The analysis enrolled 117 patients and the variables...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000477405
更新日期:2017-01-01 00:00:00
abstract::Twenty-two patients with metastatic breast carcinoma were treated with a combination of cisplatin (100 mg/m2 i.v. day 1) and etoposide (100 mg/m2 i.v. days 1-3). Eligible patients had measurable disease with normal organ functions, performance status < 3, age < 70 years and no previous chemotherapy for metastatic dise...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227364
更新日期:1994-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is characterized as a highly chemoresistant cancer with no effective systemic therapy. Despite surgical or locoregional therapies, prognosis remains poor because of high tumor recurrence or tumor progression, and currently there are no well-established effective adjuvant therapies. The m...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000111705
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Recently, it has been reported that expression of the HRK gene was significantly reduced by hypermethylation in astrocytic tumors. Our aim is to verify the alterations in the HRK gene in primary central nervous system lymphomas (PCNSLs). METHODS:We analyzed the hypermethylation status and expression of the ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000094322
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Cisplatin-pemetrexed combination chemotherapy is the current standard primary treatment for malignant pleural mesothelioma (MPM). It was first approved for untreated and unresectable MPM in the 2003 National Comprehensive Cancer Network (NCCN) guidelines. However, to date, standard treatments for patients wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000510691
更新日期:2020-10-14 00:00:00
abstract::Objective tumor responses and survival rates with standard chemotherapy options for small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) have been disappointing. However, several promising new classes of agents have emerged in recent years, including the taxanes, mitotic spindle inhibitors, antimetabol...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000055387
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Our aim is to assess the clinicopathological significance of E-cadherin and beta-catenin expression, as well as their association with apoptosis in gallbladder cancers. METHODS:The expression of E-cadherin and beta-catenin proteins was examined in 4 biliary tract cancer cell lines and 49 gallbladder cancer s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000100478
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Uveal melanoma primarily metastasizes hematogenously with metastases often confined to the liver. The aim of this study was to investigate the presence of circulating tumor cells (CTC) in patients with metastatic disease as a marker for systemic disease and to determine their prognostic relevance. METHODS:Bl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000328283
更新日期:2011-01-01 00:00:00
abstract::To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011995
更新日期:1999-07-01 00:00:00
abstract::The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258504
更新日期:2009-01-01 00:00:00
abstract::Aromatase inhibitor (AI) is widely used as an endocrine treatment in postmenopausal patients with hormone receptor-positive breast cancer. To identify useful prognostic factors for patients with metastatic breast cancer treated with AI therapy, we investigated the association between several hormone receptor-related f...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000319540
更新日期:2010-01-01 00:00:00
abstract::A multidrug-resistant (MDR) cell line isolated from HOB1 lymphoma cells was characterized. The MDR phenotype in this cell line was typified by resistance to vincristine with varying degrees of cross-resistance to Adriamycin, colcemid and actinomycin D. Decreased intracellular [3H]vincristine with concurrent increase i...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227300
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Oncogene-driven stress-related DNA damage has been observed in lesions of colon cancer. Furthermore, DNA sensors and nucleases are stimulated during active DNA damage and replication. However, their changes and influences with respect to cancer remain largely unknown. METHODS:The gene expression levels of cG...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000452281
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to both develop and validate a nomogram based on the Ki-67 index to predict recurrence. We constructed a nomogram using the Cox proportional hazards model with 953 N0 and N1 postoperative hormone receptor (HR)-positive breast cancer patients and validated it in an external cohort of 895 patie...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000362281
更新日期:2014-01-01 00:00:00
abstract::72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225162
更新日期:1976-01-01 00:00:00
abstract::A sulfur-containing amino acid compound, S-allyl cysteine (SAC), derived from garlic extract inhibited proliferation of nine human and murine melanoma cell line in a dose-dependent manner (1.2-10 mM) assessed by a [3H]thymidine incorporation assay. Three control human lymphoblastoid cell lines were not inhibited by SA...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227149
更新日期:1993-01-01 00:00:00
abstract::Using a Gompertzian pharmacodynamic model, we have studied the changes induced by graded doses of adriamycin (AM) on the growth of intramuscular Lewis lung carcinoma (3LL) and its lung metastases in C57Bl/6 mice. An interpretation of the drug's effects on free growth of the tumor cells is given in the Appendix. Unlike...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225709
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:The current study aimed to compare the therapeutic outcomes of surgery with those of chemoradiation for patients with advanced oropharyngeal cancer (OPC). METHODS:The data for 523 patients with previously untreated OPC were obtained from 12 institutions belonging to the Head and Neck Cancer Study Group in th...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000346908
更新日期:2013-01-01 00:00:00
abstract::Thermochemosensitivity was examined in vitro by a human tumor clonogenic assay (HTCA) using specimens obtained surgically from 43 patients with colorectal cancer. We found that the percentages of patients whose cells showed higher sensitivity (greater than 70% inhibition of colony formation) to hyperthermia alone were...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226568
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000236048
更新日期:2009-01-01 00:00:00
abstract::The role of estrogen and estrogen-related growth factors in the mechanism of hormone dependency of endometrial adenocarcinoma cells was investigated. The proliferation of hormone-responsive human endometrial adenocarcinoma cells (Ishikawa cells), which possess both estrogen and progesterone receptors, was optimally st...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055257
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:The neutrophil-to-lymphocyte ratio (NLR) has been proposed as an indicator of cancer-related inflammation. The aim of our study was to examine the prognostic value of the NLR for patients with advanced gastric cancer receiving second-line chemotherapy. METHODS:The association of overall survival (OS) in sec...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000493427
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Immuno-oncological (IO) therapies such as PD-1 and PD-L1 antibodies have been introduced in the treatment of advanced non-small cell lung cancer (NSCLC) since 2015 based on randomized trials showing unprecedented advantages in overall survival (OS) with hazard ratios (HRs) between 0.5 and 0.7. The impact of ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000500885
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:This open-label, randomized phase III trial evaluated larotaxel/cisplatin versus gemcitabine/cisplatin as first-line treatment for locally advanced (T4b) or metastatic urothelial tract or bladder cancer. METHODS:Patients were randomized to larotaxel 50 mg/m(2) with cisplatin 75 mg/m(2) every 3 weeks (larota...
journal_title:Oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000354085
更新日期:2013-01-01 00:00:00
abstract::Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011932
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000209963
更新日期:2009-01-01 00:00:00
abstract::Quercetin, a mutagenic but noncarcinogenic flavonoid, inhibited the increased incorporation of inorganic phosphate into phospholipids of human embryo fibroblasts induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter. Quercetin also inhibited TPA-induced increases of sugar transport and RNA syn...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225805
更新日期:1984-01-01 00:00:00