Abstract:
OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined with UFT plus leucovorin (LV) for metastatic colorectal cancer. METHODS:Escalating doses of irinotecan (90-110 mg/m(2)) were administered by 24-hour infusion on day 1. UFT 300 mg/m(2)/day and LV 75 mg/day were administered orally, in 3 divided daily doses, on days 3-7 and 10-14. The treatment cycles were repeated every 2 weeks. RESULTS:In the phase I study, the maximum tolerated dose of irinotecan was 110 mg/m(2) and the recommended dose for the phase II study was determined to be 100 mg/m(2). Thirty-six patients, including 3 patients at the recommended dose in the phase I study, were evaluated in the phase II study. The common grade 3/4 toxicities were leucopenia, neutropenia, diarrhea and anorexia. The response rate was 63.9%, and the median progression-free and overall survival times were 8.3 and 24.6 months, respectively. CONCLUSION:A 24-hour infusion of irinotecan combined with UFT/LV is feasible and active for metastatic colorectal cancer.
journal_name
Oncologyjournal_title
Oncologyauthors
Sadahiro S,Suzuki T,Maeda Y,Tanaka A,Ishikawa K,Makuuchi H,Murayama Cdoi
10.1159/000209963subject
Has Abstractpub_date
2009-01-01 00:00:00pages
338-41issue
5eissn
0030-2414issn
1423-0232pii
000209963journal_volume
76pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Hepatocellular carcinoma (HCC) is characterized as a highly chemoresistant cancer with no effective systemic therapy. Despite surgical or locoregional therapies, prognosis remains poor because of high tumor recurrence or tumor progression, and currently there are no well-established effective adjuvant therapies. The m...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000111705
更新日期:2007-01-01 00:00:00
abstract::Culture-induced cytotoxic (CIC) activity developed in 7-day culture in the presence of fetal calf serum of pleural effusion lymphocytes from patients with lung cancer which initially showed markedly low or no natural killing (NK) activity against K562 cells. The development of CIC activity was proliferation-dependent....
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225637
更新日期:1982-01-01 00:00:00
abstract::To evaluate the influence of delay between first symptom and first treatment upon survival the medical records of 596 patients with breast cancer were reviewed. The following intervals were considered: less than 3 months; 3-6 months and greater than 6 months. Patients in the less than 3 months delay group had a better...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226689
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will be helpful to understand the biological features of HER2-positive gastric cancer. METHODS:A total of 813 gastric cancer patients who underwent HER2 testing between January 2005 and December 2010 were included ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000368555
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of this study to report on the role of laparoscopic staging in a large series of locally advanced cervical cancer (LACC) patients and its impact on prognosis. METHODS:Consecutive patients with LACC were considered for surgical staging: gynecological examination, cystoscopy and laparoscopy with...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000351995
更新日期:2013-01-01 00:00:00
abstract::To clarify the inhibitory effect of telomere-mimic oligonucleotides on human cancer cell lines, we synthesized 18-mers (18T; n = 3), 24-mers (24T; n = 4) and 30-mers (30T; n = 5) of telomere-mimic phosphorothioate oligodeoxy nucleotides [5'-d(TTA GGG)n-3'] and examined their effects on the proliferation of human tumor...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055272
更新日期:1999-10-01 00:00:00
abstract::Empiric clinical trials have revealed new mechanisms by which hormonal therapies may exert their antitumor effects. Initial studies using escalated doses of agents like toremifene and megestrol acetate have yielded interesting results, showing responses in hormone-receptor-negative patients and in patients progressing...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227121
更新日期:1992-01-01 00:00:00
abstract::Gastrointestinal stem cells have the capacity for long-term self-replication and the ability to give rise to all other epithelial cell lineages. These properties make them essential since they maintain tissue homeostasis by regulating cell turnover depending on the current demand. However, they are also important play...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000086625
更新日期:2005-01-01 00:00:00
abstract::Chromosomal aberrations and sister chromatid exchanges were examined in 45 patients with nonseminomatous testicular cancer at different times after the termination of vinblastine, cisplatin and bleomycin (VPB) therapy and in 22 age-matched healthy men and untreated testicular cancer patients. After 36 months, the freq...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226859
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Expression of vascular endothelial growth factor (VEGF)-D by tumors is associated with metastasis to lymph nodes in mice. However, there are few reports concerning the clinical significance of VEGF-D protein in human carcinoma. METHODS:After confirming production of VEGF-D by eight colorectal carcinoma cell ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000070301
更新日期:2003-01-01 00:00:00
abstract::Increased cytosolic phospholipid-sensitive, Ca2+-dependent protein kinase C (PK-C) activity is correlated with the highly tumorigenic potential of rat embryo fibroblasts transformed by herpes simplex virus type 2 (HSV-2). Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a decrease in the c...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226561
更新日期:1988-01-01 00:00:00
abstract::In order to determine the operative indications of three-field lymph node dissection of esophageal cancer, attempts were made to collect data concerning procedures performed between 1983 and 1989 in major institutions in Japan, and the results from institutions performing three-field or two-field lymph node dissection...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226971
更新日期:1991-01-01 00:00:00
abstract::Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were determined in 8 patients with disseminated testicular carcinoma before, during and 1 year after termination of a combination chemotherapy with cis-diamminedichloroplatinum (CDDP). The decrease in median GFR in comparison with the pretreatment...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000225718
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Patients with localized esophageal and esophagogastric junction cancer (EAC) receive chemoradiation and then surgery (trimodality, TMT) or definitive chemoradiation (bimodality, BMT). Distant metastases (DMs) are common but the details of their distribution and timing in a large cohort have not been describe...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000360703
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of our study to evaluate the efficacy and safety of weekly topotecan in patients with advanced or recurrent cervical disease. METHODS:Topotecan was administered intravenously as a weekly infusion at a dose of 3.5 mg/m(2) on days 1, 8 and 15 of a 28-day cycle. After the second cycle, the dose w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000330537
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES AND METHODS:The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the co...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000069308
更新日期:2003-01-01 00:00:00
abstract::This paper reviews the effectiveness of local interleukin-2 (IL-2) therapy and its effector induction mechanisms in vivo. Local therapy with IL-2 and/or lymphokine-activated killer (LAK) cells is associated with far fewer side effects than systemic treatment. Local infusions of IL-2 into malignant pleural effusions an...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227331
更新日期:1994-03-01 00:00:00
abstract::203 tumor specimens from 175 patients were studied. Amplification of ERBB-2 was detected in 14 out of 63 (22%) cases of breast carcinoma, in 1 out of 23 patients with ovarian cancers, in 1 out of 19 cases of colon carcinoma and in 1 out of 27 patients with thyroid cancer. We failed to find more than one copy of ERBB-2...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227032
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Previous data showed that distant metastatic breast cancer (MBC) might be curable in up to 3% of the cases in selected patients, mostly young, with good performance status and with low-volume metastatic disease, mainly by an aggressive multidisciplinary approach including aggressive combination chemotherapy ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000500298
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Clinical significance of immunohistochemically detectable level of p53 protein has been reported, but with some limitation as a prognosticator of bladder cancer patients. Whether or not simultaneous evaluation of mdm2 and p53 expression in bladder cancer exceed the prognostic significance of conventional his...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011971
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Standard therapy for postoperative pain after laparoscopic colorectal surgeries at the Tan Tock Seng Hospital consists of intravenous morphine via patient-controlled analgesia (PCA) for the first 24-48 h, followed by oral analgesics. We compared the efficacy and safety of oral controlled-release (CR) oxycodo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000143221
更新日期:2008-01-01 00:00:00
abstract::Previous studies have demonstrated a rise in serum alpha-1-antitrypsin at advanced stages of malignancy. These, together with results of animal experiments with another anti-proteinase, aprotinin, have prompted studies of the plasma alpha-1-antitrypsin in the early stages of malignancy, using cervical carcinoma as a m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225093
更新日期:1976-01-01 00:00:00
abstract::Tumor infiltrating lymphocytes induced by radiotherapy were analyzed by the biotin-avidin-horseradish peroxidase method. At the early dose of 4 Gy (400 rad) of irradiation (2 Gy X 2), remarkable infiltration of lymphocytes was observed surrounding cancer cells. This infiltration was mainly composed of Leu-3a+3b-positi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226523
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:It is unclear for whom new anti-human epidermal growth factor receptor 2 (anti-HER2) agents, such as pertuzumab and T-DM1, should be considered. We investigated prognostic factors before neoadjuvant chemotherapy (NAC) among HER2-positive invasive breast cancer patients and those after NAC among patients who ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502910
更新日期:2020-01-01 00:00:00
abstract::38 of 306 patients survived beyond 5 years after resection of an exocrine pancreatic carcinoma during a period from 1971 to 1993. Amongst the long-term survivors there were 12 patients with ductal, 22 with ampullary, 3 with distal bile duct and 1 with duodenal cancer. An active operative strategy was employed in order...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227488
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVES:A phase II study was performed to investigate the safety and efficacy of concurrent chemoradiotherapy (CCRT) combined with an orally active fluoropyrimidine, S-1, plus cisplatin for locally advanced esophageal cancer (LAEC). METHODS:CCRT comprised 2 courses, a 30-Gy radiotherapy over 3 weeks plus daily oral...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000348383
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Surgery has traditionally been the treatment of choice for patients with potentially resectable esophageal carcinoma. Recently, however, definitive chemoradiotherapy (CRT) has been suggested as a preferred treatment modality. In this study, CRT results with or without surgery are compared. METHODS:A total o...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333448
更新日期:2011-01-01 00:00:00
abstract::Vascular endothelial growth factor C (VEGF-C) is considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we clarified the clinicopathological features of early gastric carcinoma (EGC) that has metastasized to the lymph nodes, as well as the corre...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055312
更新日期:2001-01-01 00:00:00
abstract::This multicenter phase II study evaluated the efficacy of the FEM regimen (5-fluorouracil 333 mg/m(2) each week, epirubicin 30 mg/m(2) once every 4 weeks and mitomycin-C 2.7 mg/m(2) once every 2 weeks) administered by hepatic artery infusion (HAI) for unresectable hepatic metastases of gastric cancer. The response rat...
journal_title:Oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000012034
更新日期:1999-10-01 00:00:00
abstract::In a registry of 24,105 cancers, 15 patients were found to have three primary cancers in different organs. Decreasing time intervals between sequential diagnoses and then death were noted. Occurrence and sequence of cancer sites appeared to be random. Stage of second and third cancers tended, on the average, to be mor...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225051
更新日期:1975-01-01 00:00:00