Abstract:
:Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 expression were assessed by flow cytometry in disaggregated tumors. Cyclin D3 expression and S-phase fraction were independently related to Duke's stage. In Duke's stage C tumors, a higher proportion of cells expressed cyclin D3 (14.4 vs. 8.8%, mean; p < 0.05 by Mann-Whitney U test) and were in DNA synthesis (S) phase (21.1 vs. 9.7%, mean; p < 0.05 by Mann-Whitney U test). Neoplastic deregulation of cyclin D3 expression may provide a selective growth advantage which is related to stage in human colorectal cancer.
journal_name
Oncologyjournal_title
Oncologyauthors
Watson DS,Brotherick I,Shenton BK,Wilson RG,Angus B,Varma JS,Campbell FCdoi
10.1159/000011932subject
Has Abstractpub_date
1999-01-01 00:00:00pages
66-72issue
1eissn
0030-2414issn
1423-0232pii
ocl56066journal_volume
56pub_type
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