Prognostic relevance of circulating tumor cells in metastatic uveal melanoma.

abstract：:To clarify the inhibitory effect of telomere-mimic oligonucleotides on human cancer cell lines, we synthesized 18-mers (18T; n = 3), 24-mers (24T; n = 4) and 30-mers (30T; n = 5) of telomere-mimic phosphorothioate oligodeoxy nucleotides [5'-d(TTA GGG)n-3'] and examined their effects on the proliferation of human tumor...

journal_title：Oncology

authors： Saeki T,Takashima S,Tachibana M,Koga M,Hiyama E,Salomon DS,Holland JF,Ohnuma T

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial. METHODS:The aim of this pilot study was to assess the feasibility of postoperative combination chemotherapy followed by radiotherapy in patients aged 18-70 years with a histological diagnosis of PA, and Karnofsky perf...

journal_title：Oncology

authors： Reni M,Passoni P,Bonetto E,Balzano G,Panucci MG,Zerbi A,Ronzoni M,Staudacher C,Villa E,Di Carlo V

更新日期：2005-01-01 00:00:00

abstract：:Nicotinamide, the amide derivative of vitamin B(3), cooperates with retinoic acid (RA), a form of vitamin A, and 1,25-dihydroxyvitamin D(3) (D3), to regulate cell differentiation and proliferation of human myeloblastic leukemia cells. In human myeloblastic leukemia cells, RA or D3 are known to cause MAPK signaling lea...

journal_title：Oncology

authors： Shen M,Yen A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 cen...

journal_title：Oncology

authors： Esposito F,Cecere SC,Magazzino F,Katsaros D,Ottaiano A,Gadducci A,Pisano C,Scalone S,Rabaiotti E,Salutari V,Cormio G,Canuto EM,Greggi S,Savarese A,Marinaccio M,Scollo P,Santeufemia DA,Sacco C,Facchini G,Pignata S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...

journal_title：Oncology

authors： Horie K,Kawakami K,Fujita Y,Matsuda Y,Arai T,Suzui N,Miyazaki T,Koie T,Mizutani K,Ito M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages remain unclear. The latest prognostic outcomes in clinical Stage (cStage) II/III ESCC with NAC were herein elucidated. PATIENTS AND METHODS:NAC prior to curative treatmen...

journal_title：Oncology

authors： Yamashita K,Hosoda K,Moriya H,Katada C,Sugawara M,Mieno H,Komori S,Katada N,Watanabe M

更新日期：2017-01-01 00:00:00

abstract：:The diagnostic imaging of hepatocellular carcinoma (HCC) has recently undergone marked progress. The advent of the ultrasound (US) contrast agent Sonazoid, approved in January 2007, and magnetic resonance imaging (MRI) with the liver-specific MRI contrast agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic ac...

journal_title：Oncology

authors： Kudo M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Radioimmunotherapy (RIT) is effective in treating relapsed/refractory follicular lymphoma (FL), with durable remissions in first-line consolidation. We hypothesized that RIT with ibritumomab tiuxetan (Zevalin®) would result in durable remissions by eliminating minimal residual disease after cytoreduction. M...

journal_title：Oncology

authors： Puvvada SD,Guillén-Rodríguez JM,Yan J,Inclán L,Heard K,Rivera XI,Anwer F,Mahadevan D,Schatz JH,Persky DO

更新日期：2018-01-01 00:00:00

abstract：:This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...

journal_title：Oncology

authors： Chi KH,Chang YC,Chan WK,Liu JM,Law CK,Lo SS,Shu CH,Yen SH,Whang-Peng J,Chen KY

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:Breast cancer (BC) is the most frequent female carcinoma and the major cause of death in women aged 35--50 years. The total number of patients surviving BC and especially the morbidity rate of patients below the age of 55 years has increased significantly in the last several years. As a consequence, the number ...

journal_title：Oncology

authors： Beckmann MW,Jap D,Djahansouzi S,Nestle-Krämling C,Kuschel B,Dall P,Brumm C,Bender HG

更新日期：2001-01-01 00:00:00

abstract：:We have studied the effect of butyrate on mammary tumorigenesis by 7,12-dimethylbenz(a)anthracene. As reported previously, a high incidence of mammary tumors was observed in rats fed a basal diet containing 20% margarine. However, the enhancing effect of margarine was inhibited when sodium butyrate was supplemented in...

journal_title：Oncology

authors： Yanagi S,Yamashita M,Imai S

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:To investigate the potential benefit of intermittent chemotherapy, and to identify the eligibility criteria offering intermittent chemotherapy to patients with advanced urothelial cancer. MATERIALS AND METHODS:Twenty patients who responded or had stable disease after receiving 3 cycles of induction chemother...

journal_title：Oncology

authors： Onishi T,Sasaki T,Hoshina A

更新日期：2012-01-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used worldwide in cancer patients for over 1 year, and (only 5 years from the first publication on the clinical use of this growth factor) experience is rapidly accumulating in many oncological situations. Several randomized studies have confirme...

journal_title：Oncology

authors： Bronchud MH

更新日期：1994-03-01 00:00:00

abstract：:The effects on gastric and duodenal mucosa induced by cisplatin plus etoposide (PE) chemotherapy were investigated in 32 patients with lung cancer. They were submitted to gastroduodenoscopy before receiving cisplatin 100 mg/m2 (day 1) plus etoposide at a mean dose of 107 mg/m2 (days 1, 3 and 5). Endoscopic examination...

journal_title：Oncology

authors： Sartori S,Nielsen I,Maestri A,Beltrami D,Trevisani L,Pazzi P

更新日期：1991-01-01 00:00:00

abstract：:The activities of established and experimental antitumor drugs were tested against the BRO and MeWo human melanomas transplanted in the subrenal capsule of phenotypically immunocompetent (CBA x C57BL/6)F1 mice. Immunosuppression was achieved with preliminary whole-body radiation, and cytological examination showed tha...

journal_title：Oncology

authors： Ryabkova VI,Lockshin A,Strukov IG,Sokolova VK

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:The well-being of oncologists is important to the well-being of their patients. While much is known about oncologist distress, little is known about oncologist well-being. We set out to evaluate oncologist well-being and the personal wellness promotion strategies used by oncologists. PATIENTS AND METHODS:We pe...

journal_title：Oncology

authors： Shanafelt TD,Novotny P,Johnson ME,Zhao X,Steensma DP,Lacy MQ,Rubin J,Sloan J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:We assessed the prognostic value of the nuclear DNA content measured in the primary tumours of 123 patients with stage II or stage III colorectal cancer (CRC). METHODS:Isolated nuclei from paraffin sections were stained with the Feulgen reaction, and DNA was measured using a computer-assisted image analysis...

journal_title：Oncology

authors： Buhmeida A,Algars A,Ristamäki R,Collan Y,Syrjänen K,Pyrhönen S

更新日期：2006-01-01 00:00:00

abstract：:Rapid advances in our understanding of the biology and pathology of lymphoproliferative disorders, permitted mainly by new diagnostic tools, constantly change our approach to this heterogenous group of disorders. In this review of the more indolent subgroup of lymphoproliferative disorders, some of the recent advances...

journal_title：Oncology

authors： Eek R,Falkson G

更新日期：1997-11-01 00:00:00

abstract：:Novel human estrogen receptor (ER)-beta was identified in cDNA libraries from human testis. ER-beta specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-beta might not conserve the same physiological functions as does ER-alpha. Therefore, the clinical significance of the expression of ER-...

journal_title：Oncology

authors： Fujimoto J,Hirose R,Sakaguchi H,Tamaya T

更新日期：2000-05-01 00:00:00

abstract：:The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...

journal_title：Oncology

authors： Markiewicz W,Ben-Arieh Y,Best L,Mordochovich D,Rinkevitch D

更新日期：1993-11-01 00:00:00

abstract：:Methyl-CCNU (NSC-95441) was administered to patients with malignant melanoma in a split dose schedule. Nausea and vomiting were eliminated as clinical problems during therapy. Response rate to the drug seemed somewhat lower than the average of three previously reported disease-oriented phase II trials, though the diff...

journal_title：Oncology

authors： Wittes RE,Hong WK,Gatchell L,Krakoff IH,Golbey RB

更新日期：1977-01-01 00:00:00

abstract：:In squamous cell carcinoma of the head and neck (SCCHN), hypoxia is considered a crucial physiological modulator for malignant progression, wherebythe plasminogen activation system is involved in overlapping functions such as moulding of the extracellular matrix, cell proliferation and signal transduction. Little is k...

journal_title：Oncology

authors： Sprague LD,Mengele K,Schilling D,Geurts-Moespot A,Sweep FC,Stadler P,Schmitt M,Molls M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Mutations in the human telomerase reverse transcriptase (hTERT) gene promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of these mutations in liquid biopsies have been technically difficult because of the high GC content of the regions of interest within this promoter. We evalua...

journal_title：Oncology

authors： Ako S,Nouso K,Kinugasa H,Matsushita H,Terasawa H,Adachi T,Wada N,Takeuchi Y,Mandai M,Onishi H,Ikeda F,Shiraha H,Takaki A,Fujioka S,Mimura T,Okada H

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The prognosis of patients with locally advanced squamous cell carcinoma (SCC) of the tongue is poor. Postoperative chemoradiotherapy (CRT) improves locoregional control and survival in high-risk patients. We investigated the prognostic factors for clinical T4a tongue SCC, and elucidated whether postoperative ...

journal_title：Oncology

authors： Yokota T,Iida Y,Ogawa H,Kamijo T,Onozawa Y,Todaka A,Hamauchi S,Onoe T,Nakagawa M,Yurikusa T,Tanuma A,Yamashita A,Nishimura T,Yasui H,Onitsuka T

更新日期：2016-01-01 00:00:00

abstract：:The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...

journal_title：Oncology

authors： Al-Awadi FM,Al-Bader AA

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is useful for differentiating benign from malignant lesions, evaluating tumor stage, monitoring the response to therapy and detecting tumor recurrence in a variety of malignancies. Nevertheless, its use in patients with hepatocellular carcinoma (H...

journal_title：Oncology

authors： Yoon KT,Kim JK,Kim DY,Ahn SH,Lee JD,Yun M,Rha SY,Chon CY,Han KH

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The present study sought to evaluate an inflammation-based prognostic score (Glasgow prognostic score, GPS) and the neutrophil to lymphocyte ratio (NLR) as prognostic factors in patients receiving chemotherapy for advanced gastric cancer. METHODS:The study enrolled 224 patients who received chemotherapy for...

journal_title：Oncology

authors： Namikawa T,Munekage E,Munekage M,Maeda H,Yatabe T,Kitagawa H,Kobayashi M,Hanazaki K

更新日期：2016-01-01 00:00:00

abstract：:Fourteen patients with disseminated breast cancer with primary or secondary resistance to tamoxifen were treated with LY156758. There were no complete or partial responses and 1 patient showed a minor response. These data illustrate that LY156758 did not have significant antitumor activity in patients previously treat...

journal_title：Oncology

authors： Buzdar AU,Marcus C,Holmes F,Hug V,Hortobagyi G

更新日期：1988-01-01 00:00:00

abstract：:Pancreatic intraepithelial neoplasia (PanIN) is a microscopic papillary noninvasive lesion arising from the pancreatic ductal epithelium. However, the natural history and time to progression of high-grade PanIN remain unclear. Herein, we report 2 cases of high-grade PanIN without morphological changes of the main panc...

journal_title：Oncology

authors： Yamao K,Takenaka M,Nakai A,Omoto S,Kamata K,Minaga K,Miyata T,Imai H,Sakurai T,Watanabe T,Nishida N,Matsumoto I,Takeyama Y,Chikugo T,Kudo M

更新日期：2017-01-01 00:00:00

abstract：:Between June 1980 and December 1984, 88 patients with stage III-IV ovarian carcinoma were entered in a study evaluating the role of debulking surgery and chemotherapy consisting of cyclophosphamide, doxorubicin, and cisplatin intravenously on day 1, every 4 weeks (CAP-1). The results after a median follow-up of 62 mon...

journal_title：Oncology

authors： Wils JA

更新日期：1990-01-01 00:00:00