Abstract:
:Quercetin, a mutagenic but noncarcinogenic flavonoid, inhibited the increased incorporation of inorganic phosphate into phospholipids of human embryo fibroblasts induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter. Quercetin also inhibited TPA-induced increases of sugar transport and RNA synthesis in chick embryo fibroblasts, and TPA-induced aggregation of human platelets. These results suggest that quercetin may have antitumor promoter activity, which provides a possible reason why quercetin does not develop malignant tumors despite its mutagenicity.
journal_name
Oncologyjournal_title
Oncologyauthors
Nishino H,Nishino A,Iwashima A,Tanaka K,Matsuura Tdoi
10.1159/000225805subject
Has Abstractpub_date
1984-01-01 00:00:00pages
120-3issue
2eissn
0030-2414issn
1423-0232journal_volume
41pub_type
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