Gemcitabine and cisplatin in refractory malignant lymphoma.

abstract：UNLABELLED:The outlook for patients with testicular germ cell cancer was dramatically improved by the introduction of cisplatin. Well-known side effects of cisplatin (nausea, vomiting, nephrotoxicity, myelosuppression) can be managed with preventive methods. The long life expectancy after this therapy draws attention t...

journal_title：Oncology

authors： Biró K,Baki M,Büki B,Noszek L,Jókúti L

更新日期：1997-09-01 00:00:00

abstract：:We have provided an in-depth, longitudinal, clinical/genetic/pathologic investigation of a family consonant with the sarcoma, breast cancer and brain tumors, lung and laryngeal cancer, leukemia, lymphoma, and adrenalcortical carcinoma syndrome. The pattern of cancer expression involves all three germinal layers with t...

journal_title：Oncology

authors： Lynch HT,Radford B,Lynch JF

更新日期：1990-01-01 00:00:00

abstract：:Results of a survey of concentrations of substances immunologically cross-reactive with insulin (SICRI), glucose and growth hormone in preprandially drawn blood of 84 patients suffering from bronchial epidermoid, microcellular and adenocarcinomas and 22 patients from sarcoidosis, tuberculosis and obstructive bronchiti...

journal_title：Oncology

authors： Baltić V,Levanat S,Petek M,Bratić-Mikes V,Pavelić K,Vuk-Pavlović S

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:Suboptimal debulking (>1 cm residual tumor) results in poor survival rates for patients with an advanced stage of ovarian cancer. The purpose of this study was to develop a prediction model, based on simple preoperative parameters, for patients with an advanced stage of ovarian cancer who are at risk of subo...

journal_title：Oncology

authors： de Jong D,Eijkemans MJ,Lie Fong S,Gerestein CG,Kooi GS,Baalbergen A,van der Burg ME,Burger CW,Ansink AC

更新日期：2007-01-01 00:00:00

abstract：:Increased cytosolic phospholipid-sensitive, Ca2+-dependent protein kinase C (PK-C) activity is correlated with the highly tumorigenic potential of rat embryo fibroblasts transformed by herpes simplex virus type 2 (HSV-2). Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a decrease in the c...

journal_title：Oncology

authors： Roddick VL,Krebs CR,Kucera LS,Daniel LW,Waite M

更新日期：1988-01-01 00:00:00

abstract：:Twenty-five patients with cutaneous melanoma were imaged with F(ab')2 fragments of antimelanoma monoclonal antibody (MoAb) 225.28S labeled with 99mTc and 131I or 111In. Out of 16 patients without evidence of metastatic lesions, 6 false-positive cases were observed. Only 4 out of 9 patients with known lesions showed po...

journal_title：Oncology

authors： Repetto L,Scopinaro G,Michelotti A,Claudiani F,Fusco V,Grimaldi A,Sertoli MR,Rosso R

更新日期：1988-01-01 00:00:00

abstract：:CA 19-9 and tissue polypeptide antigen (TPA) were determined in the sera of 28 control subjects, 29 patients with pancreatic cancer, 26 with chronic pancreatitis and 62 with benign and malignant extra pancreatic diseases in order to compare their usefulness in diagnosing pancreatic cancer, to verify whether the combin...

journal_title：Oncology

authors： Basso D,Fabris C,Del Favero G,Panucci A,Plebani M,Angonese C,Leandro G,Dodi G,Burlina A,Naccarato R

更新日期：1988-01-01 00:00:00

abstract：:The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...

journal_title：Oncology

authors： Jelić S,Kovcin V,Jovanović V,Oprić M,Milanović N

更新日期：1994-05-01 00:00:00

abstract：:Further biochemical characterization of the Albert hepatoma has been performed. The following results were obtained: In spite of often repeated transplantations and a medium growth rate, the Albert hepatoma does still contain organ-characteristic enzymes. We have found significant activities of glucokinase, glucose-6-...

journal_title：Oncology

authors： Sydow G

更新日期：1979-01-01 00:00:00

abstract：PURPOSE:In order to determine whether infection with Helicobacter pylori might be associated with pancreatic adenocarcinoma, we performed a study to compare the H. pylori seroprevalence rate between patients with pancreatic carcinoma and matched control subjects. PATIENTS AND METHODS:Blood samples from 92 patients wit...

journal_title：Oncology

authors： Raderer M,Wrba F,Kornek G,Maca T,Koller DY,Weinlaender G,Hejna M,Scheithauer W

更新日期：1998-01-01 00:00:00

abstract：:Novel human estrogen receptor (ER)-beta was identified in cDNA libraries from human testis. ER-beta specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-beta might not conserve the same physiological functions as does ER-alpha. Therefore, the clinical significance of the expression of ER-...

journal_title：Oncology

authors： Fujimoto J,Hirose R,Sakaguchi H,Tamaya T

更新日期：2000-05-01 00:00:00

abstract：:Fourteen patients with disseminated breast cancer with primary or secondary resistance to tamoxifen were treated with LY156758. There were no complete or partial responses and 1 patient showed a minor response. These data illustrate that LY156758 did not have significant antitumor activity in patients previously treat...

journal_title：Oncology

authors： Buzdar AU,Marcus C,Holmes F,Hug V,Hortobagyi G

更新日期：1988-01-01 00:00:00

abstract：:Capecitabine is converted to 5-fluorouracil by thymidine phosphorylase, and mitomycin C is capable of upregulating the expression of thymidine phosphorylase suggesting a synergistic effect. Fifty-three patients (median age 62 years) with anthracycline- and taxane-resistant, metastatic breast cancer received mitomycin ...

journal_title：Oncology

authors： Massacesi C,La Cesa A,Marcucci F,Pilone A,Rocchi MB,Zepponi L,Santini D,Tonini G,Burattini L

更新日期：2006-01-01 00:00:00

abstract：:Gastrointestinal stem cells have the capacity for long-term self-replication and the ability to give rise to all other epithelial cell lineages. These properties make them essential since they maintain tissue homeostasis by regulating cell turnover depending on the current demand. However, they are also important play...

journal_title：Oncology

authors： Schier S,Wright NA

更新日期：2005-01-01 00:00:00

abstract：:The activity and toxicity of UFT (Tegafur and Uracil) in a 4:1 molar concentration, plus leucovorin (LV), were evaluated in the treatment of 45 patients with advanced, bidimensionally measurable metastatic colorectal carcinoma. Initially 350 and later 300 mg/m2/day, plus 150 mg LV, as administered in divided doses eve...

journal_title：Oncology

authors： Pazdur R

更新日期：1997-01-01 00:00:00

abstract：:The serum detection of S100B, a new melanoma marker, has shown clinical significance in early studies. The aim of our study of 1, 339 serum samples from 412 different melanoma patients and 107 control patients was to prove the prognostic value of serum S100B levels in melanoma patients at different stages of disease a...

journal_title：Oncology

authors： Hauschild A,Engel G,Brenner W,Gläser R,Mönig H,Henze E,Christophers E

更新日期：1999-01-01 00:00:00

abstract：:Intratumoral metabolism and synthesis of estrogens are considered to play very important roles in the pathogenesis and development of various sex steroid-dependent neoplasms including breast and endometrial carcinoma. 17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) isozymes catalyze the interconversion of estradiol...

journal_title：Oncology

authors： Sasano H,Suzuki T,Takeyama J,Utsunomiya H,Ito K,Ariga N,Moriya T

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine the prognostic value of the preoperative serum alpha-L-fucosidase (AFU) activity in colorectal cancer and to assess whether it could add prognostic information that Dukes' stages do not give. METHODS:A postoperative follow-up of 137 colorectal cancer patients was perform...

journal_title：Oncology

authors： Ayude D,Páez De La Cadena M,Martínez-Zorzano VS,Fernández-Briera A,Rodríguez-Berrocal FJ

更新日期：2003-01-01 00:00:00

abstract：:In 323 of 1,620 patients with gastric cancer, the lesion was > or = 10 cm in maximum diameter. Studies were done with respect to clinicopathologic features and the prognosis. Patients with tumors > or = 10 cm were younger and women patients were more numerous compared to those with tumors < 10 cm. Tumors were more adv...

journal_title：Oncology

authors： Maehara Y,Oiwa H,Oda S,Sakaguchi Y,Endo K,Ohno S,Sugimachi K

更新日期：1995-01-01 00:00:00

abstract：:After exposure to the mutagen, ethylmethanesulfonate (EMS), or the carcinogen, urethane (UR), anchorage independence was observed in cultures derived from normal skin biopsies from patients with the heritable cancer syndrome, adenomatosis of the colon and rectum (ACR). Such colonies from methylcellulose suspension cul...

journal_title：Oncology

authors： Danes BS

更新日期：1980-01-01 00:00:00

abstract：:The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...

journal_title：Oncology

authors： Allgayer H,Babic R,Beyer BC,Grützner KU,Tarabichi A,Schildberg FW,Heiss MM

更新日期：1998-03-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant food-derived mutagenic/carcinogenic heterocyclic amine (HCA), has attracted particular attention as a probable human colon carcinogen. Some studies have shown that PhIP administered in the post-initiation phase is able to enhance rat colon carci...

journal_title：Oncology

authors： Doi K,Hagihara A,Wei M,Yunoki T,Fukushima S,Wanibuchi H

更新日期：2007-01-01 00:00:00

abstract：:During the period 1965-1980, 84 patients with Wilms' tumor, neuroblastoma and Ewing's sarcoma were treated at the University of Rochester Medical Center. All patients were evaluated for the presence of congenital abnormalities. Ten of 34 (29%) patients with Wilms' tumor, 3 of 32 (9%) patients with neuroblastoma, and 0...

journal_title：Oncology

authors： Nakissa N,Constine LS,Rubin P,Strohl R

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Anthracycline is used to treat various types of cancer; however, cardiotoxicity negatively affects patient prognosis. OBJECTIVES:The aim of the present study was to investigate serial changes in levels of cardiac troponin I (TnI) and B-type natriuretic peptide (BNP) in patients treated with anthracycline-co...

journal_title：Oncology

authors： Oikawa M,Yoshihisa A,Yokokawa T,Misaka T,Yaegashi D,Miyata M,Nakazato K,Ishida T,Takeishi Y

更新日期：2020-01-01 00:00:00

abstract：:In pancreatic cancer (PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy. This review focuses on the role of carbohydrate antigen 19-9 (CA 19-...

journal_title：Oncology

authors： Boeck S,Stieber P,Holdenrieder S,Wilkowski R,Heinemann V

更新日期：2006-01-01 00:00:00

abstract：:The levels of 3',5'-cyclic adenosine monophosphate (cAMP) were measured in a high malignant and a low malignant clone of murine fibrosarcoma cells isolated from a common parent in a normal mouse fibroblasts at various stages of growth. There was an inverse correlation between the degree of malignant potential and the ...

journal_title：Oncology

authors： Elgebaly S,Kunkel S,Lovett EJ,Varani J

更新日期：1982-01-01 00:00:00

abstract：:Persistent infection with hepatitis C virus (HCV) is a major risk toward development of hepatocellular carcinoma. A number of transgenic mouse lines carrying the cDNA of HCV genome have been established and evaluated in the study of HCV pathogenesis. Among those, the studies using transgenic mouse lines that carry the...

journal_title：Oncology

authors： Koike K,Tsutsumi T,Yotsuyanagi H,Moriya K

更新日期：2010-07-01 00:00:00

abstract：:Tumor infiltrating lymphocytes induced by radiotherapy were analyzed by the biotin-avidin-horseradish peroxidase method. At the early dose of 4 Gy (400 rad) of irradiation (2 Gy X 2), remarkable infiltration of lymphocytes was observed surrounding cancer cells. This infiltration was mainly composed of Leu-3a+3b-positi...

journal_title：Oncology

authors： Ogawa Y,Maeda T,Seguchi H,Hamada F,Inomata T,Yoshida S,Kishimoto S,Saito H

更新日期：1988-01-01 00:00:00

abstract：:Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...

journal_title：Oncology

authors： Stora C

更新日期：1980-01-01 00:00:00

abstract：:Cancer pain management had received relatively little attention until the late 1990s, when approximately 100,000 new cancer cases and 60,000 cancer deaths occurred each year in Korea. In 2001, a Cancer Pain Management Guideline was prepared for the first time by the Korean Society of Hospice and Palliative Care. This ...

journal_title：Oncology

authors： Lee JY,Ahn JS

更新日期：2008-01-01 00:00:00