Abstract:
:In 323 of 1,620 patients with gastric cancer, the lesion was > or = 10 cm in maximum diameter. Studies were done with respect to clinicopathologic features and the prognosis. Patients with tumors > or = 10 cm were younger and women patients were more numerous compared to those with tumors < 10 cm. Tumors were more advanced and noncurative resection was usually done for these patients. A multivariate analysis showed that serosal invasion, liver metastasis, lymph node metastasis, operative curability, tissue differentiation, and extended lymph node dissection to be independent prognostic factors. This retrospective study showed that patients with a larger tumor are at an increased risk for tumor advancement and that they will benefit from curative resection and extended lymph node dissection.
journal_name
Oncologyjournal_title
Oncologyauthors
Maehara Y,Oiwa H,Oda S,Sakaguchi Y,Endo K,Ohno S,Sugimachi Kdoi
10.1159/000227424subject
Has Abstractpub_date
1995-01-01 00:00:00pages
35-40issue
1eissn
0030-2414issn
1423-0232journal_volume
52pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract:BACKGROUND:Gemcitabine monotherapy is the cornerstone of the treatment of patients suffering from advanced pancreatic cancer (PC). For a few years, new chemotherapeutic agents and combinations have been under validation. The use of such treatment makes it necessary to determine factors that could predict survival time....
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000120627
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The current study aimed to compare the therapeutic outcomes of surgery with those of chemoradiation for patients with advanced oropharyngeal cancer (OPC). METHODS:The data for 523 patients with previously untreated OPC were obtained from 12 institutions belonging to the Head and Neck Cancer Study Group in th...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000346908
更新日期:2013-01-01 00:00:00
abstract::Pancreatic intraepithelial neoplasia (PanIN) is a microscopic papillary noninvasive lesion arising from the pancreatic ductal epithelium. However, the natural history and time to progression of high-grade PanIN remain unclear. Herein, we report 2 cases of high-grade PanIN without morphological changes of the main panc...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000481237
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Clear cell renal cell carcinoma (CCRCC) is a malignant neoplasm frequently associated with an increase in circulating immune complexes (CIC). Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a disease involving the chorioretinal structures of the eye, and it is commonly observe...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000079505
更新日期:2004-01-01 00:00:00
abstract::A loss of heterozygosity (LOH) at the DCC gene locus was detected in colorectal tumors, and this LOH might be related to metastasis. The aim of this study was to determine DCC protein expression in colorectal cancer and to evaluate its prognostic value. Allelic loss of the DCC locus was observed in 16 of the 23 patien...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011954
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Surgery has traditionally been the treatment of choice for patients with potentially resectable esophageal carcinoma. Recently, however, definitive chemoradiotherapy (CRT) has been suggested as a preferred treatment modality. In this study, CRT results with or without surgery are compared. METHODS:A total o...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333448
更新日期:2011-01-01 00:00:00
abstract::HER2 amplification/overexpression is a marker of poor prognosis in breast cancer. The prognostic impact of HER2 positivity is lower in node-negative compared with node-positive women. The only significant, independent prognostic factors in breast cancer are node status, HER2 status and menopausal status. HER2-positive...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000055404
更新日期:2001-01-01 00:00:00
abstract::Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality with recent increasing use to ablate brain tumors. When originally introduced in the late 1980s, the inability to precisely monitor and control the thermal ablation limited the adoption of LITT in neu...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000362817
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. METHODS:We retro...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000327222
更新日期:2011-01-01 00:00:00
abstract::Immunochemical analysis of various tumors, representing 12 different tissue sites of origin, revealed a gamma-fetal antigen(gamma-FA)-like component in 17 of 23 malignant neoplasms of the mouse. This antigen was identified in extracts of spontaneous and carcinogen-induced murine tumors as well as in extracts of hepati...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225584
更新日期:1981-01-01 00:00:00
abstract::Small quantities of carcinogens, dl-ethionine, thiotepa, actinomycin D, and 1-(2-chloroethyl-3-cyclohexyl)-1-nitrosourea (CCNU) stimulated in vitro deoxyribonucleic acid (DNA) synthesis of the slime mutant of Neurospora crassa, while there was practically no effect on the DNA from the normal wild type 74A strain. All ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226503
更新日期:1987-01-01 00:00:00
abstract::This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227689
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China and, due to the limited efficacy of currently available therapies, is responsible for a large number of deaths. IFN-alpha therapy has shown promise in the treatment of various forms of human cancer and is considered in the trea...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000082928
更新日期:2004-01-01 00:00:00
abstract::Mice of four different inbred strains (CBA, Balb/c, C57Bl/6 and DBA/2), bearing different transplanted tumours (methylcholanthrene-induced sarcomas, B16 melanoma and P-815 mastocytoma), were tested for cellular immune reactivity to the synthetic encephalitogenic peptide of human myelin basic protein by the leucocyte a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225732
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). METHODS:The analysis enrolled 117 patients and the variables...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000477405
更新日期:2017-01-01 00:00:00
abstract::A sulfur-containing amino acid compound, S-allyl cysteine (SAC), derived from garlic extract inhibited proliferation of nine human and murine melanoma cell line in a dose-dependent manner (1.2-10 mM) assessed by a [3H]thymidine incorporation assay. Three control human lymphoblastoid cell lines were not inhibited by SA...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227149
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for patients with advanced stage (stage III or IV) head and neck squamous cell carcinoma (HNSCC) following primary radiotherapy (RT) or concomitant chemoradiotherapy. METHODS:From January 2001 to January 2003, 149 ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000086982
更新日期:2005-01-01 00:00:00
abstract::From January 1991 to August 1993, 237 women with metastatic breast cancer were recruited into a multicentric phase II clinical trial designed to assess the cardioprotective activity of Cardioxane (ICRF-187). All patients were treated with 5-fluorouracil 500 mg/m2, doxorubicin 50 mg/m2, cyclophosphamide 500 mg/m2 (FDC)...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227467
更新日期:1995-05-01 00:00:00
abstract::Between June 1980 and December 1984, 88 patients with stage III-IV ovarian carcinoma were entered in a study evaluating the role of debulking surgery and chemotherapy consisting of cyclophosphamide, doxorubicin, and cisplatin intravenously on day 1, every 4 weeks (CAP-1). The results after a median follow-up of 62 mon...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226801
更新日期:1990-01-01 00:00:00
abstract::Chemotherapy-induced peripheral neurotoxicity is a major problem because it represents the dose-limiting side effect of a significant number of antineoplastic drugs, such as vinca alkaloids. Hereditary neuropathies usually predispose to severe vincristine neurotoxicity. Here, we report the case of a 56-year-old man wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000336602
更新日期:2012-01-01 00:00:00
abstract::In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as p...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011880
更新日期:1998-07-01 00:00:00
abstract::We investigated the effects of piroxicam, a cyclooxygenase inhibitor, and esculetin, a lipoxygenase inhibitor, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female rats. Seven days after receiving a 5-mg dose of DMBA, rats were fed either a high-fat (20% soybean oil) or low-fat (0.5% soybe...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227374
更新日期:1994-09-01 00:00:00
abstract::Cancer pain management had received relatively little attention until the late 1990s, when approximately 100,000 new cancer cases and 60,000 cancer deaths occurred each year in Korea. In 2001, a Cancer Pain Management Guideline was prepared for the first time by the Korean Society of Hospice and Palliative Care. This ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000143211
更新日期:2008-01-01 00:00:00
abstract::The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227232
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000346690
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Uveal melanoma primarily metastasizes hematogenously with metastases often confined to the liver. The aim of this study was to investigate the presence of circulating tumor cells (CTC) in patients with metastatic disease as a marker for systemic disease and to determine their prognostic relevance. METHODS:Bl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000328283
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Preclinical studies indicated that imatinib may have single-agent activity in glioblastoma through inhibition of tyrosine kinase activity and also that it might enhance the efficacy of radiotherapy. We therefore sought to investigate clinical efficacy in patients with newly diagnosed and recurrent glioblastoma ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502483
更新日期:2020-01-01 00:00:00
abstract::Lymph node and distant metastasis were comparatively studied in 225 oral carcinomas, and factors predisposing toward metastasis were investigated using clinical and immunohistopathological approaches. Neither the sites of tumors nor T-stage was correlated with either type of metastasis. Tumor cell differentiation was ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012090
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508688
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:This study was performed to investigate the activity and safety of high dose 5-fluorouracil (5-FU) given as a weekly 24-hour infusion in combination with folinic acid plus mitomycin C in patients with advanced gastric cancer. PATIENTS AND METHODS:Chemonaive patients with locally advanced inoperable, recurrent ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000012130
更新日期:2000-06-01 00:00:00