Analysis of prognostic factors of pediatric-type sarcomas in adult patients.

abstract：:Cisplatin is among the most active agents available for the therapy of non-small cell lung cancer (NSCLC). Its congener, carboplatin, has been the focus of intense clinical trials over the last several years because of its improved therapeutic index. Results from randomized trials have shown that carboplatin is active...

journal_title：Oncology

authors： Comis RL

更新日期：1993-11-01 00:00:00

abstract：:Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...

journal_title：Oncology

authors： Dempke WCM,Fenchel K,Uciechowski P,Chevassut T

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES AND METHODS:Tumor dormancy and resistance to cytotoxic agents are key limiting events in the treatment of malignant diseases. To determine whether both are influenced by the extracellular milieu in which tumors reside, HT1080 human fibrosarcoma, MCF-7 breast carcinoma and OSCORT osteosarcoma cell proliferati...

journal_title：Oncology

authors： Pogány G,Timár F,Oláh J,Harisi R,Polony G,Paku S,Bocsi J,Jeney A,Laurie GW

更新日期：2001-01-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used worldwide in cancer patients for over 1 year, and (only 5 years from the first publication on the clinical use of this growth factor) experience is rapidly accumulating in many oncological situations. Several randomized studies have confirme...

journal_title：Oncology

authors： Bronchud MH

更新日期：1994-03-01 00:00:00

abstract：:112 cases, of varying ages, which were diagnosed as having carcinoma of the bladder by cystoscopy and biopsy from the tumor, were investigated for the presence of alphafetoprotein (AFP) in the sera. 59 (52.6%) out of the total, showed positive results, and no false positive results occured. Radioimmunoassay was capabl...

journal_title：Oncology

authors： Alsabti EA

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Transcatheter arterial chemoembolization (TACE) is a standard therapy used in the treatment of intermediate hepatocellular carcinoma (HCC). Recently, balloon-occluded TACE (B-TACE) has been developed. PURPOSE:This study aimed to clarify the effects of B-TACE in patients with HCC, with a focus on which drug ...

journal_title：Oncology

authors： Shirono T,Iwamoto H,Niizeki T,Shimose S,Nakano M,Satani M,Okamura S,Noda Y,Kamachi N,Kuromatsu R,Sakai M,Nomiyama M,Kuwano T,Tanaka M,Koga H,Torimura T

更新日期：2019-01-01 00:00:00

abstract：:Hemostatic abnormalities are rather frequent in cancer patients either in hematological or in solid tumors. Acute disseminated intravascular coagulation (DIC) is a rare coagulopathy in cancer patients, but when it develops it becomes rapidly fatal. Between June 1988 and December 1992 we observed 8 cases of acute DIC o...

journal_title：Oncology

authors： Pasquini E,Gianni L,Aitini E,Nicolini M,Fattori PP,Cavazzini G,Desiderio F,Monti F,Forghieri ME,Ravaioli A

更新日期：1995-11-01 00:00:00

abstract：:Lonidamine alone or in combination with hyperthermic perfusion, with or without melphalan, was investigated in 12 patients with stage II, III, and IV malignant melanoma. The authors evaluated the most effective methods and sequence of Lonidamine administration. Preliminary results suggest that the highest effectivenes...

journal_title：Oncology

authors： Cavaliere R,Di Filippo F,Varanese A,Carlini S,Calabro A,Aloe L,Piarulli L

更新日期：1984-01-01 00:00:00

abstract：:Flow cytometric (FCM) DNA studies were performed on cell suspensions obtained by endoscopic biopsy in 73 patients with gastric cancer and in 61 patients with gastric remnant. In cancer, DNA aneuploidies were detected in 49 tumors (67.1%), including 51.7% (15/29) of early gastric cancers and 77.3% (34/44) of advanced g...

journal_title：Oncology

authors： Kimura H,Kanno M,Takamura H,Arakawa H,Maeda K,Uogishi M,Sodani H,Kawashima T

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Transarterial chemoembolization (TACE) is recommended as a first-line therapy for hepatocellular carcinoma (HCC) patients ineligible for curative therapy and without portal invasion. The Assessment for Retreatment with TACE (ART) scoring system was recently proposed for identifying patients who would not show...

journal_title：Oncology

authors： Arizumi T,Ueshima K,Iwanishi M,Minami T,Chishina H,Kono M,Takita M,Kitai S,Inoue T,Yada N,Hagiwara S,Ida H,Minami Y,Sakurai T,Nishida N,Kitano M,Kudo M

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC. METHODS:Ap...

journal_title：Oncology

authors： Wang MJ,Zhou ZG,Wang L,Yu YY,Zhang P,Zhang Y,Cui CF,Yang L,Li Y,Zhou B,Sun XF

更新日期：2009-01-01 00:00:00

abstract：:The effects of the gamma-amino-n-butyric acid (GABA)A receptor agonist muscimol, and the GABAB receptor agonist baclofen, on colon carcinogenesis induced by azoxymethane in Wistar rats were tested. Administration of either muscimol or baclofen had no influence on the incidence of colon tumors at week 30. However, almo...

journal_title：Oncology

authors： Tatsuta M,Iishi H,Baba M,Taniguchi H

更新日期：1992-01-01 00:00:00

abstract：:Endoscopic ultrasound-guided pancreatic drainage (EUS-PD) was performed in a patient with unresectable pancreatic cancer who developed pancreatitis. In this case, EUS-PD was useful as salvage therapy for pancreatitis as the transpapillary approach was difficult. ...

journal_title：Oncology

authors： Kamata K,Takenaka M,Minaga K,Sakurai T,Watanabe T,Nishida N,Kudo M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:This open-label, randomized phase III trial evaluated larotaxel/cisplatin versus gemcitabine/cisplatin as first-line treatment for locally advanced (T4b) or metastatic urothelial tract or bladder cancer. METHODS:Patients were randomized to larotaxel 50 mg/m(2) with cisplatin 75 mg/m(2) every 3 weeks (larota...

journal_title：Oncology

authors： Sternberg CN,Skoneczna IA,Castellano D,Theodore C,Blais N,Voog E,Bellmunt J,Peters F,Le-Guennec S,Cerbone L,Risse ML,Machiels JP

更新日期：2013-01-01 00:00:00

abstract：:Novel human estrogen receptor (ER)-beta was identified in cDNA libraries from human testis. ER-beta specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-beta might not conserve the same physiological functions as does ER-alpha. Therefore, the clinical significance of the expression of ER-...

journal_title：Oncology

authors： Fujimoto J,Hirose R,Sakaguchi H,Tamaya T

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:There is no standard second-line therapy for patients with oesophagogastric cancer who progress following first-line chemotherapy for advanced disease or relapse following radical multi-modality therapy. The aim of this retrospective study was to evaluate survival following rechallenge with platinum plus fluoro...

journal_title：Oncology

authors： Okines AF,Asghar U,Cunningham D,Ashley S,Ashton J,Jackson K,Hawkes E,Chau I

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility of conducting a patient satisfaction survey in the oncology hospital setting, using a multidimensional patient satisfaction questionnaire to be completed at home. METHODS:Socio-demographic and clinical data were collected for 133 consecutive patients. Patients were asked to comple...

journal_title：Oncology

authors： Brédart A,Razavi D,Robertson C,Didier F,Scaffidi E,Fonzo D,Autier P,de Haes JC

更新日期：2001-01-01 00:00:00

abstract：:Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) w...

journal_title：Oncology

authors： Inuzuka T,Nishikawa H,Sekikawa A,Takeda H,Henmi S,Sakamoto A,Saito S,Kita R,Kimura T,Osaki Y,Kudo M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions. Epithelial syndecan-1 expression is reduced in several malignant tumours, but in breast and pancreatic cancer, increased expression has also been described. Loss of...

journal_title：Oncology

authors： Leivonen M,Lundin J,Nordling S,von Boguslawski K,Haglund C

更新日期：2004-01-01 00:00:00

abstract：:Of 352 patients with colorectal carcinoma followed for a minimum of 5 years after surgery, 39 cases (11.1%; median age 60 years) had mucinous adenocarcinoma, and 4 (1.1%; median age 62 years) had signet-ring cell carcinoma. Mucinous carcinomas were most frequently located in the rectum (61.5%) and in the sigmoid colon...

journal_title：Oncology

authors： Secco GB,Fardelli R,Campora E,Lapertosa G,Gentile R,Zoli S,Prior C

更新日期：1994-01-01 00:00:00

abstract：:Male and female mice of strains C3H/eB and C57BL/6 were injected subcutaneously with methylcholanthrene (MCA) dissolved in olive oil; mice injected with olive oil served as controls. After intervals of from 2 to 13 weeks, experimental and control mice were injected intraperitoneally with 51Cr-labeled rat red cells (RR...

journal_title：Oncology

authors： Schrieber R,Stern K

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Gemcitabine monotherapy is the cornerstone of the treatment of patients suffering from advanced pancreatic cancer (PC). For a few years, new chemotherapeutic agents and combinations have been under validation. The use of such treatment makes it necessary to determine factors that could predict survival time....

journal_title：Oncology

authors： Maréchal R,Demols A,Gay F,De Maertelaere V,Arvanitaki M,Hendlisz A,Van Laethem JL

更新日期：2007-01-01 00:00:00

abstract：:The activity and toxicity of UFT (Tegafur and Uracil) in a 4:1 molar concentration, plus leucovorin (LV), were evaluated in the treatment of 45 patients with advanced, bidimensionally measurable metastatic colorectal carcinoma. Initially 350 and later 300 mg/m2/day, plus 150 mg LV, as administered in divided doses eve...

journal_title：Oncology

authors： Pazdur R

更新日期：1997-01-01 00:00:00

abstract：:In order to assess the feasibility of a sequential hormonal treatment after tamoxifen failure, 24 postmenopausal advanced breast cancer patients (median age 60 years; ECOG PS < or = 1) were treated with formestane (4-hydroxyandrostenedione) 250 mg i.m. fortnightly; 19 patients were estrogen receptor-positive. The site...

journal_title：Oncology

authors： Noberasco C,Bajetta E,Zilembo N,Di Leo A,Cappuzzo F,Bartoli C,Bono A,Bichisao E

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of lo...

journal_title：Oncology

authors： Miglietta L,Vanella P,Canobbio L,Naso C,Cerisola N,Meszaros P,Parodi MA,Morabito F

更新日期：2010-01-01 00:00:00

abstract：:Calcitriol (1,25-dihydroxycholecalciferol) has antiproliferative and/or proapoptotic effects on many cell types and the glucocorticoid dexamethasone enhances these effects. We have shown that calcitriol modulates several key signaling proteins involved in differentiation, proliferation and apoptosis in tumor-derived m...

journal_title：Oncology

authors： Flynn G,Chung I,Yu WD,Romano M,Modzelewski RA,Johnson CS,Trump DL

更新日期：2006-01-01 00:00:00

abstract：:Tumor cell apoptosis, proliferation and p27 expression using an in situ apoptosis detection kit, anti-Ki67 antibody and anti-p27 antibody were investigated in 171 colorectal adenocarcinoma specimens, together with the assessment of mutated p53 expression. No apparent association was observed among p27 expression, muta...

journal_title：Oncology

authors： Tenjo T,Toyoda M,Okuda J,Watanabe I,Yamamoto T,Tanaka K,Ohtani M,Nohara T,Kawasaki H,Tanigawa N

更新日期：2000-01-01 00:00:00

abstract：:In pancreatic cancer (PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy. This review focuses on the role of carbohydrate antigen 19-9 (CA 19-...

journal_title：Oncology

authors： Boeck S,Stieber P,Holdenrieder S,Wilkowski R,Heinemann V

更新日期：2006-01-01 00:00:00

abstract：:This paper reviews the effectiveness of local interleukin-2 (IL-2) therapy and its effector induction mechanisms in vivo. Local therapy with IL-2 and/or lymphokine-activated killer (LAK) cells is associated with far fewer side effects than systemic treatment. Local infusions of IL-2 into malignant pleural effusions an...

journal_title：Oncology

authors： Sone S,Ogura T

更新日期：1994-03-01 00:00:00

abstract：:Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were ...

journal_title：Oncology

authors： Miyao H,Chou T,Ito K,Moriyama H,Mitsuma S,Wakabayashi M,Yoshizawa H,Arakawa M

更新日期：1994-01-01 00:00:00