Abstract:
OBJECTIVE:The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC. METHODS:Applying TaqMan allelic discrimination, we investigated AKAP10 Ile646Val (2073A>G) polymorphism in 288 Chinese CRC patients and 281 healthy controls. RESULTS:Logistic regression analysis revealed a significant association of AKAP10 Ile646Val (2073A>G) polymorphism with increased CRC risk (adjusted OR = 1.44, 95% CI 1.01-2.07, p = 0.02). Stratification analysis showed that the increased risk associated with the variant genotypes (GG+AG) was more evident in male subjects (adjusted OR = 1.48, 95% CI 0.94-2.34, p = 0.03). Compared with the AA genotype, the adjusted OR for the variant genotypes was 1.81 (95% CI 1.08-3.05, p = 0.01) among young subjects (age <57 years). Among individuals who did not smoke or who smoked lightly, there was a significantly increased risk with the variant genotypes (adjusted OR = 1.66, 95% CI 1.08-2.56, p = 0.02). We did not observe a relationship between the AKAP10 polymorphism and other clinicopathological and environmental factors. CONCLUSIONS:Our data suggested that the AKAP10 2073A>G variation is associated with an increased risk of CRC in the Chinese population.
journal_name
Oncologyjournal_title
Oncologyauthors
Wang MJ,Zhou ZG,Wang L,Yu YY,Zhang P,Zhang Y,Cui CF,Yang L,Li Y,Zhou B,Sun XFdoi
10.1159/000201572subject
Has Abstractpub_date
2009-01-01 00:00:00pages
199-204issue
3eissn
0030-2414issn
1423-0232pii
000201572journal_volume
76pub_type
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