Abstract:
:The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high alpha-fetoprotein level, large size, high Ki-67 labeling index and poor prognosis. Cyclin A and B1 overexpression showed similar tendency to that of cdc2, but they were not recognized as independent prognostic factors by multivariate analysis. These findings suggest that cdc2 plays the most crucial role of the G2/M modulators in cell cycle progression and cell proliferation of HCC and significantly predicts the recurrence of this carcinoma.
journal_name
Oncologyjournal_title
Oncologyauthors
Ito Y,Takeda T,Sakon M,Monden M,Tsujimoto M,Matsuura Ndoi
10.1159/000012140subject
Has Abstractpub_date
2000-06-01 00:00:00pages
68-74issue
1eissn
0030-2414issn
1423-0232pii
12140journal_volume
59pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::The role of estrogen and estrogen-related growth factors in the mechanism of hormone dependency of endometrial adenocarcinoma cells was investigated. The proliferation of hormone-responsive human endometrial adenocarcinoma cells (Ishikawa cells), which possess both estrogen and progesterone receptors, was optimally st...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055257
更新日期:1998-12-01 00:00:00
abstract::362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227550
更新日期:1996-03-01 00:00:00
abstract::Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality with recent increasing use to ablate brain tumors. When originally introduced in the late 1980s, the inability to precisely monitor and control the thermal ablation limited the adoption of LITT in neu...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000362817
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT). METHODS:We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000479032
更新日期:2017-01-01 00:00:00
abstract::Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the correspon...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012165
更新日期:2000-09-01 00:00:00
abstract::The levels of bone-specific alkaline phosphatase (BALP) in plasma and tumour tissue samples of 20 Chinese patients with osteosarcoma in Hong Kong were measured by the wheat germ lectin precipitation technique. The plasma BALP levels in these patients were significantly higher than those of the normal subjects (p < 0.0...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227573
更新日期:1996-07-01 00:00:00
abstract::Nucleophosmin/B23 is a nucleolar phosphoprotein which redistributes from nucleoli to nucleoplasm (B23-translocation) when cells are exposed to certain anticancer drugs, particularly intercalators. The B23-translocation assay has been demonstrated in cell culture to correlate with drug effects and to detect drug-resist...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227043
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508922
更新日期:2020-01-01 00:00:00
abstract::The antiemetic effect of graded, single high-dose intravenous dexamethasone was studied in 27 patients receiving combination chemotherapy with either doxorubicin (50 mg/m2) or cis-platinum (100 mg/m2). A total of 57 cycles were individually evaluated, utilizing a detailed rating system. Nausea and vomiting did not occ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000226099
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:We investigated the efficacy of risk-adapted adjuvant paclitaxel/carboplatin chemotherapy in early-stage ovarian carcinoma. METHODS:Fifty-three patients were treated according to the risk of relapse: patients with stages IA or IB or with grade 1 (low risk) received 4 cycles of paclitaxel and carboplatin; pat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000334230
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To define the cyclophosphamide (CTX) maximal tolerated dose when combined with fixed doses of gemcitabine, fluorouracil (5-FU) and folinic acid (leucovorin, LFA) in metastatic breast cancer patients pretreated with anthracyclines and taxanes. METHODS:Metastatic breast cancer patients aged < or = 75 years, with...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000048243
更新日期:2002-01-01 00:00:00
abstract::To evaluate the influence of delay between first symptom and first treatment upon survival the medical records of 596 patients with breast cancer were reviewed. The following intervals were considered: less than 3 months; 3-6 months and greater than 6 months. Patients in the less than 3 months delay group had a better...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226689
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Clinical significance of immunohistochemically detectable level of p53 protein has been reported, but with some limitation as a prognosticator of bladder cancer patients. Whether or not simultaneous evaluation of mdm2 and p53 expression in bladder cancer exceed the prognostic significance of conventional his...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011971
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤ 1.5 × the upper limit of normal. METHODS:Documen...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000341152
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000089993
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Mutations in the human telomerase reverse transcriptase (hTERT) gene promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of these mutations in liquid biopsies have been technically difficult because of the high GC content of the regions of interest within this promoter. We evalua...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000506135
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:We evaluated the psychometric properties of the Korean version of the European Organization for Research and Treatment of Cancer QLQ-PR25 when applied to Korean prostate cancer (PC) patients. METHODS:A total of 172 patients who underwent curative radical prostatectomy (RP) with or without adjuvant androgen d...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000355689
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Both irinotecan (CPT) and paclitaxel (Pac) are effective against non-small cell lung cancer (NSCLC), and besides, preclinical studies have demonstrated an additive or synergistic interaction between camptothecin and taxane. METHODS:We conducted a phase I/II study of combination chemotherapy consisting of Pa...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000077434
更新日期:2004-01-01 00:00:00
abstract::This is a case report of hyperpyrexia, shock and death following initial injection of low-dose bleomycin (7.5 units) for a poorly differentiated metastatic carcinoma. Premedication with high-dose dexamethasone and acetaminophen did not abort the reaction. A review of the literature uncovered one nearly fatal reaction ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225462
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:To investigate the potential benefit of intermittent chemotherapy, and to identify the eligibility criteria offering intermittent chemotherapy to patients with advanced urothelial cancer. MATERIALS AND METHODS:Twenty patients who responded or had stable disease after receiving 3 cycles of induction chemother...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000338770
更新日期:2012-01-01 00:00:00
abstract::The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226444
更新日期:1987-01-01 00:00:00
abstract::Malignant gastrointestinal neuroectodermal tumor (GNET) is an aggressive rare tumor, primarily occurring in young adults with frequent local-regional metastases and recurrence after local control. The tumor is characterized by the presence of EWSR1-ATF1 or EWSR1-CREB1 and immunohistochemical positivity for S-100 prote...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000449204
更新日期:2016-01-01 00:00:00
abstract::Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months)...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000226905
更新日期:1991-01-01 00:00:00
abstract::The expression of the drug resistance markers P glycoprotein (P-170), glutathione S transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) was analyzed in 16 human kidney carcinoma cell lines, 18 hematological malignancies, and 14 human breast carcinomas. We found a tendency for coexpression of increased P-170 and...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227075
更新日期:1992-01-01 00:00:00
abstract::Further biochemical characterization of the Albert hepatoma has been performed. The following results were obtained: In spite of often repeated transplantations and a medium growth rate, the Albert hepatoma does still contain organ-characteristic enzymes. We have found significant activities of glucokinase, glucose-6-...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225357
更新日期:1979-01-01 00:00:00
abstract::The aim of this study is to compare the levels of carcinoembryonic antigen (CEA) in the gastric juice, stomach mucosa and plasma of gastrectomy patients at risk of developing cancer with those in normal controls and gastric cancer subjects. Blood samples, gastric juices and biopsy material were taken from 52 patients ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226354
更新日期:1986-01-01 00:00:00
abstract::In 323 of 1,620 patients with gastric cancer, the lesion was > or = 10 cm in maximum diameter. Studies were done with respect to clinicopathologic features and the prognosis. Patients with tumors > or = 10 cm were younger and women patients were more numerous compared to those with tumors < 10 cm. Tumors were more adv...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227424
更新日期:1995-01-01 00:00:00
abstract::During the period 1965-1980, 84 patients with Wilms' tumor, neuroblastoma and Ewing's sarcoma were treated at the University of Rochester Medical Center. All patients were evaluated for the presence of congenital abnormalities. Ten of 34 (29%) patients with Wilms' tumor, 3 of 32 (9%) patients with neuroblastoma, and 0...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226064
更新日期:1985-01-01 00:00:00
abstract::112 cases, of varying ages, which were diagnosed as having carcinoma of the bladder by cystoscopy and biopsy from the tumor, were investigated for the presence of alphafetoprotein (AFP) in the sera. 59 (52.6%) out of the total, showed positive results, and no false positive results occured. Radioimmunoassay was capabl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225188
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. METHODS:The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general ho...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000481241
更新日期:2017-01-01 00:00:00