Abstract:
BACKGROUND:Both irinotecan (CPT) and paclitaxel (Pac) are effective against non-small cell lung cancer (NSCLC), and besides, preclinical studies have demonstrated an additive or synergistic interaction between camptothecin and taxane. METHODS:We conducted a phase I/II study of combination chemotherapy consisting of Pac and CPT to determine qualitative and quantitative toxicities and efficacy of the combination against advanced NSCLC. We fixed the dose of CPT at 60 mg/m(2) and escalated the Pac dose in 10 or 20 mg/m(2) increments from a starting dose of 80 mg/m(2), and repeated the cycle every 2 weeks. Prophylactic G-CSF was also administered. RESULTS:Between February 1999 and April 2001, 24 patients were registered in the study. None of the patients had a history of prior chemotherapy, but surgical resection had been performed in 3 of them. None of the patients experienced dose-limiting toxicity (DLT) up to and including level 6. At dose level 7 of Pac, 180 mg/m(2), 2 patients experienced DLT, that is grades 2 and 3 dyspnea due to pneumonitis. Another patient experienced grade 1 dyspnea due to pneumonitis. Neutropenia, diarrhea, and other toxicities were mild; however, we concluded that dose level 7 of Pac was the maximum-tolerated dose. An objective response was observed in 58.3%. The median survival time was 370 days, and the 1-year survival rate was 54.2%. CONCLUSION:Pneumonitis was the DLT in this study, and Pac 160 mg/m(2) and CPT 60 mg/m(2) every 2 weeks are recommended for the phase II study. This combination shows appreciable activity against NSCLC.
journal_name
Oncologyjournal_title
Oncologyauthors
Yamada K,Ikehara M,Tanaka G,Nomura I,Oshita F,Noda Kdoi
10.1159/000077434subject
Has Abstractpub_date
2004-01-01 00:00:00pages
94-100issue
2eissn
0030-2414issn
1423-0232pii
77434journal_volume
66pub_type
临床试验,杂志文章相关文献
ONCOLOGY文献大全abstract:OBJECTIVES:Recently, it has been reported that expression of the HRK gene was significantly reduced by hypermethylation in astrocytic tumors. Our aim is to verify the alterations in the HRK gene in primary central nervous system lymphomas (PCNSLs). METHODS:We analyzed the hypermethylation status and expression of the ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000094322
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:This study reports the percentage of breast cancer survivors receiving ongoing benzodiazepines and the circumstances surrounding their usage. METHODS:The medical records of 1,000 consecutive breast cancer survivors who were no longer receiving adjuvant chemotherapy were reviewed. RESULTS:Among those patient...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000330814
更新日期:2011-01-01 00:00:00
abstract::The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times. Rats received either TMX or estradiol benzoate (E2B) for 3 or 7 days. Tumors were as...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226488
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:To determine the dose-limiting toxicities (DLTs) and the maximum-tolerated doses of the paclitaxel, oxaliplatin (LOHP) and capecitabine combination in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received escalating doses of paclitaxel (starting dose 100 mg/m2) and LOHP (starting dose 40 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000111088
更新日期:2007-01-01 00:00:00
abstract::We evaluated changes in serum albumin concentrations in 15 patients with advanced malignancy who were also receiving cisplatin. All 15 patients had serial measurements of serum albumin. The decrease in serum albumin from the time of the first dose of cisplatin to death correlated with liver platinum levels at autopsy ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226100
更新日期:1986-01-01 00:00:00
abstract::A pilot study was performed administering PCNU with radiation therapy to treat patients with high-grade astrocytomas and to explore the toxic effects of this drug regimen. PCNU at an initial dose of 110 mg/m2 i.v. was administered to 14 patients within 4 weeks after completion of cranial irradiation. Courses were repe...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226854
更新日期:1990-01-01 00:00:00
abstract::High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227119
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000323175
更新日期:2010-01-01 00:00:00
abstract::After exposure to the mutagen, ethylmethanesulfonate (EMS), or the carcinogen, urethane (UR), anchorage independence was observed in cultures derived from normal skin biopsies from patients with the heritable cancer syndrome, adenomatosis of the colon and rectum (ACR). Such colonies from methylcellulose suspension cul...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225478
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Standard therapy for postoperative pain after laparoscopic colorectal surgeries at the Tan Tock Seng Hospital consists of intravenous morphine via patient-controlled analgesia (PCA) for the first 24-48 h, followed by oral analgesics. We compared the efficacy and safety of oral controlled-release (CR) oxycodo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000143221
更新日期:2008-01-01 00:00:00
abstract::The role of p53, retinoblastoma (RB) and c-erbB-2 gene proteins in the pathogenesis of anal carcinomas has been examined. A total of 97 patients were included in the study. c-erbB-2, RB and p53 proteins were abnormal in 0, 5 and 34% of the cases, respectively. No correlation was observed between p53 and age, sex, tumo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227590
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000209963
更新日期:2009-01-01 00:00:00
abstract::Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000127384
更新日期:2007-01-01 00:00:00
abstract::Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000485322
更新日期:2018-01-01 00:00:00
abstract::Novel human estrogen receptor (ER)-beta was identified in cDNA libraries from human testis. ER-beta specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-beta might not conserve the same physiological functions as does ER-alpha. Therefore, the clinical significance of the expression of ER-...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012121
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508922
更新日期:2020-01-01 00:00:00
abstract::In order to determine the operative indications of three-field lymph node dissection of esophageal cancer, attempts were made to collect data concerning procedures performed between 1983 and 1989 in major institutions in Japan, and the results from institutions performing three-field or two-field lymph node dissection...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226971
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:The microenvironment of cancer plays a critical role in its progression. However, the molecular features of cancer-associated fibroblasts (CAFs) are less well understood than those of cancer cells. We investigated the clinicopathological significance of podoplanin expression in stromal fibroblasts in patients...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226112
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508688
更新日期:2020-01-01 00:00:00
abstract::An antiserum to human melanoma antigens was obtained from a melanoma patient after immunization with autologous irradiated cultured melanoma cells and bacillus Calmette-Guerin. Using the microcomplement fixation assay, the antiserum, at a titer of 1/1,800, was noted to bind strongly with 7 of 10 allogeneic cultured hu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225702
更新日期:1983-01-01 00:00:00
abstract::Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226855
更新日期:1990-01-01 00:00:00
abstract::The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227232
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVES:18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is useful for differentiating benign from malignant lesions, evaluating tumor stage, monitoring the response to therapy and detecting tumor recurrence in a variety of malignancies. Nevertheless, its use in patients with hepatocellular carcinoma (H...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111715
更新日期:2007-01-01 00:00:00
abstract::38 of 306 patients survived beyond 5 years after resection of an exocrine pancreatic carcinoma during a period from 1971 to 1993. Amongst the long-term survivors there were 12 patients with ductal, 22 with ampullary, 3 with distal bile duct and 1 with duodenal cancer. An active operative strategy was employed in order...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227488
更新日期:1995-09-01 00:00:00
abstract::Retinoids are differentiating agents that have been used successfully for the treatment of acute promyelocytic leukemia. When combined with interferons, they are active in preventing second malignancies in patients with head and neck cancer. Our previous studies have demonstrated cytostatic effects of alltrans-retinoi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227583
更新日期:1996-07-01 00:00:00
abstract:PURPOSE:This phase I study (EudraCT No. 2006-001177-25) investigated aflibercept, a vascular endothelial growth factor decoy receptor protein (VEGF Trap), in combination with docetaxel, cisplatin, and 5-fluorouracil in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received 2, 4, or 6 mg/kg of intr...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000440958
更新日期:2016-01-01 00:00:00
abstract::The encouraging results that have been reported for cisplatin combination chemotherapy in a minority of patients with cancer of unknown primary (CUP) together with the previously shown equal activity of carboplatin in this setting, prompted us to investigate the effectiveness of a carboplatin-containing regimen in a p...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000011890
更新日期:1998-09-01 00:00:00
abstract::The authors have reviewed the medical records of 421 sessions of hyperthermia treatments in 73 patients treated between 1987 and 1992 at the University Heights Cancer Center and the Indiana University Medical Center in Indianapolis, Ind. Temperatures attained during the course of therapy on each patient have been aver...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227209
更新日期:1993-09-01 00:00:00
abstract::Capecitabine is converted to 5-fluorouracil by thymidine phosphorylase, and mitomycin C is capable of upregulating the expression of thymidine phosphorylase suggesting a synergistic effect. Fifty-three patients (median age 62 years) with anthracycline- and taxane-resistant, metastatic breast cancer received mitomycin ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000096250
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The phosphatidylinositol 3-kinase (PI3K) pathway plays a critical role in ovarian cancer cell survival and proliferation. The aim of this study was to determine whether the suppression of the PI3K catalytic subunit p110alphainhibits the growth of ovarian cancer cells in vitro and in vivo. METHODS:The short h...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000218201
更新日期:2009-01-01 00:00:00