Abstract:
:The authors have reviewed the medical records of 421 sessions of hyperthermia treatments in 73 patients treated between 1987 and 1992 at the University Heights Cancer Center and the Indiana University Medical Center in Indianapolis, Ind. Temperatures attained during the course of therapy on each patient have been averaged and the results were evaluated for complete, partial, or no response. All patients had previously failed conventional radiation therapy, chemotherapy and surgery. Responses were defined as: (1) Complete response-lesions that completely disappeared during treatment and the response was sustained for a minimum of 6 months. (2) Partial response-lesions that underwent a reduction in size of greater than 50%. (3) No response-less than 50% reduction in tumor size during the course of treatment. Response varied somewhat according to histology and anatomical site of treatment; however, complete response was achieved in 45%, partial response in 48% (for an overall response of 93%), and no response in 7% of the patients. The response achieved varied with temperature attained and a minimum temperature of 40 degrees C for 40 min produced the greatest number of responses. Response to hyperthermia was directly related to the temperature achieved and the length of time the temperature was applied.
journal_name
Oncologyjournal_title
Oncologyauthors
Shidnia H,Hornback N,Ford G,Shen RNdoi
10.1159/000227209subject
Has Abstractpub_date
1993-09-01 00:00:00pages
353-61issue
5eissn
0030-2414issn
1423-0232journal_volume
50pub_type
杂志文章,评审相关文献
ONCOLOGY文献大全abstract::Recent studies have demonstrated that nitroso chemical carcinogens activate guanylate cyclase (EC 4.6.1.2) which catalyzes the production of guanosine 3',5'-monophosphate. This nucleotide is thought to be involved in normal and abnormal cell growth. We examined the effect of 3 major classes of anticancer chemotherapeu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225362
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:Uveal melanoma primarily metastasizes hematogenously with metastases often confined to the liver. The aim of this study was to investigate the presence of circulating tumor cells (CTC) in patients with metastatic disease as a marker for systemic disease and to determine their prognostic relevance. METHODS:Bl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000328283
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000085701
更新日期:2005-01-01 00:00:00
abstract::CA 19-9 and tissue polypeptide antigen (TPA) were determined in the sera of 28 control subjects, 29 patients with pancreatic cancer, 26 with chronic pancreatitis and 62 with benign and malignant extra pancreatic diseases in order to compare their usefulness in diagnosing pancreatic cancer, to verify whether the combin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226525
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000458531
更新日期:2017-01-01 00:00:00
abstract::Lymphomas, which are frequently subdivided into Hodgkin's disease and non-Hodgkin's lymphoma, represent one of the more curable cancers that present as a solid tumor. Unfortunately, most patients cannot be cured with conventional chemotherapy, therefore new techniques have been developed including high-dose chemothera...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000012100
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT). METHODS:We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000479032
更新日期:2017-01-01 00:00:00
abstract::In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as p...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011880
更新日期:1998-07-01 00:00:00
abstract:PURPOSE:To confirm the safety and effectiveness of techniques to assist radiofrequency ablation (RFA) for difficult cases, we retrospectively evaluated successful treatment rates, early complications and local tumor progressions. PATIENTS AND METHODS:Between June 1999 and April 2009, a total of 341 patients with 535 n...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000315236
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Since its introduction by Morton in 1992, sentinel lymph node (SLN) biopsy has become a standard procedure in the staging and treatment of primary melanoma and clinically negative regional lymph nodes. The primary aims of this procedure are to ascertain the individual lymphatic drainage patterns of primary t...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000136795
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111131
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000346690
更新日期:2013-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is characterized as a highly chemoresistant cancer with no effective systemic therapy. Despite surgical or locoregional therapies, prognosis remains poor because of high tumor recurrence or tumor progression, and currently there are no well-established effective adjuvant therapies. The m...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000111705
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. METHODS:A total of 36 pa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000487081
更新日期:2018-01-01 00:00:00
abstract::Two randomized controlled trials identified that transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) shows a significant survival benefit compared with controls, after a long-term controversy. Thus, TACE is the current standard of care for patients presenting with multinodular HCC. Monit...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000345891
更新日期:2013-01-01 00:00:00
abstract::Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months)...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000226905
更新日期:1991-01-01 00:00:00
abstract::The toxicity of 1-[2-(diethylamino)ethyl]reserpine (DL-152) has been measured for 4 transplantable mouse tumors. DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injectio...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226516
更新日期:1987-01-01 00:00:00
abstract::Thrombopoietin (TPO) is a recently discovered hematopoietic growth factor which stimulates the production and maturation of megakaryocytes. In this study, we used a modified MTT assay to examine the in vitro growth-stimulatory effects of recombinant human (rh) TPO and recombinant human stem cell factor (rhSCF) on eigh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227600
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility of conducting a patient satisfaction survey in the oncology hospital setting, using a multidimensional patient satisfaction questionnaire to be completed at home. METHODS:Socio-demographic and clinical data were collected for 133 consecutive patients. Patients were asked to comple...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055362
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Wernicke's encephalopathy (WE) is a neurological emergency which presents with symptoms of confusion, ophthalmoplegia, and ataxia. Cancer patients are at high risk of this acute encephalopathy due to chronic malnutrition, chemotherapy-induced nausea and vomiting, and consumption of thiamine by rapidly growin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000174951
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:We investigated the efficacy of risk-adapted adjuvant paclitaxel/carboplatin chemotherapy in early-stage ovarian carcinoma. METHODS:Fifty-three patients were treated according to the risk of relapse: patients with stages IA or IB or with grade 1 (low risk) received 4 cycles of paclitaxel and carboplatin; pat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000334230
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The pretreatment neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been reported to be useful as markers for prognostic factors and metastasis in several cancers. The aim of this study was to identify the predictor of lymph node (LN) metastasis by pretreatment NLR and PLR in...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000497184
更新日期:2019-01-01 00:00:00
abstract::A transplantable transitional cell murine bladder tumor induced by N-[4-(5-nitro-2-furyl)-thiazolyl] formamide (FANFT) was characterized by tumor growth, survival time and response to chemotherapy drugs, cis-dichloro-trans-dihydroxy-bis-iso-propylamine platinum IV (CHIP), cis- diaminedichloro platinum II (DDP), cyclop...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225822
更新日期:1984-01-01 00:00:00
abstract::Loss of heterozygosity (LOH) on chromosomes 13q, 16q and 17p has been associated with the progression of hepatocellular carcinoma (HCC). To investigate the prognostic impact of such LOH, we examined the metastasis-free survival of curatively resected HCC cases, in whom these LOHs were analyzed. Among the 49 HCC patien...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000048260
更新日期:2002-01-01 00:00:00
abstract::The activity and toxicity of UFT (Tegafur and Uracil) in a 4:1 molar concentration, plus leucovorin (LV), were evaluated in the treatment of 45 patients with advanced, bidimensionally measurable metastatic colorectal carcinoma. Initially 350 and later 300 mg/m2/day, plus 150 mg LV, as administered in divided doses eve...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227741
更新日期:1997-01-01 00:00:00
abstract::We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this serie...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000224965
更新日期:1974-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508922
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:The neutrophil-to-lymphocyte ratio (NLR) has been proposed as an indicator of cancer-related inflammation. The aim of our study was to examine the prognostic value of the NLR for patients with advanced gastric cancer receiving second-line chemotherapy. METHODS:The association of overall survival (OS) in sec...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000493427
更新日期:2019-01-01 00:00:00
abstract::Cases are presented in which 111In-bleomycin accumulated in Virchow's gland metastasis from squamous cell carcinoma of the uterine cervix, and in paratracheal lymphatic gland metastasis from embryonal carcinoma of the right ovary. Thus, this radiopharmaceutical was found to be of great use for assessment of metastatic...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226373
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 cen...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000358730
更新日期:2014-01-01 00:00:00