Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia.

abstract：:Thirty-five patients with metastatic breast cancer who had received one or two prior chemotherapeutic regimens were treated with elliptinium acetate at a dose of 80 mg/m2 for 3 days every 3 weeks. Of the 33 patients evaluable for response, 1 patient achieved complete remission, 4 achieved partial responses (15% overal...

journal_title：Oncology

authors： Buzdar AU,Hortobagyi GN,Esparza LT,Holmes FA,Ro JS,Fraschini G,Lichtiger B

更新日期：1990-01-01 00:00:00

abstract：:Fourteen patients with advanced ovarian carcinoma (FIGO stages III-IV) resistant to cisplatin were submitted to an alternating regimen with doxorubicin (A), cyclophosphamide (C), bleomycin (B) and mitomycin C (M). All patients had measurable disease on entry into the study. No responses were observed while 3 patients,...

journal_title：Oncology

authors： Benedetti Panici P,Scambia G,Greggi S,Salerno G,Cento R,Mancuso S

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT). METHODS:We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and ...

journal_title：Oncology

authors： Nakamura A,Kojima Y,Miyazawa K,Matsumoto S,Iida H,Nagai H

更新日期：2017-01-01 00:00:00

abstract：:Surgical resection, transarterial chemoembolization, percutaneous ethanol injection therapy, radiofrequency ablation, and orthotopic liver transplantation are generally accepted treatment modalities in hepatocellular carcinoma, but there has been no standard therapy for patients at the advanced stage. Several combinat...

journal_title：Oncology

authors： Lee HC

更新日期：2008-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target in AML. Eradication of LSCs should be a critical and efficient therapeutic approach for the cure of AML. T-cell immunoglobulin mucin-3 (TIM-3) is expressed in most types of AML LSCs, but not in normal ...

journal_title：Oncology

authors： Kikushige Y,Miyamoto T

更新日期：2015-01-01 00:00:00

abstract：:Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality with recent increasing use to ablate brain tumors. When originally introduced in the late 1980s, the inability to precisely monitor and control the thermal ablation limited the adoption of LITT in neu...

journal_title：Oncology

authors： Rahmathulla G,Recinos PF,Kamian K,Mohammadi AM,Ahluwalia MS,Barnett GH

更新日期：2014-01-01 00:00:00

abstract：:Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...

journal_title：Oncology

authors： Scheithauer W,Depisch D,Schiessel R,Ludwig H

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:N-Acetylglucosaminyltransferase V (GnT-V) is a key enzyme in the formation of branching asparagine-linked oligosaccharides and is linked to tumor invasion and metastasis in colon and breast cancers. In normal esophageal epithelium, beta1,6-branched asparagine-linked oligosaccharides synthesized by GnT-V are s...

journal_title：Oncology

authors： Ishibashi Y,Dosaka-Akita H,Miyoshi E,Shindoh M,Miyamoto M,Kinoshita I,Miyazaki H,Itoh T,Kondo S,Nishimura M,Taniguchi N

更新日期：2005-01-01 00:00:00

abstract：:Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal...

journal_title：Oncology

authors： Yete S,D'Souza W,Saranath D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The Oncotype DX Breast Cancer Assay is a 21-gene assay used to predict the likelihood of distant recurrence and the benefit of chemotherapy in patients with node-negative, tamoxifen-treated breast cancer. Prior studies demonstrated 7-19% discordance, or a difference between the recurrence score (RS) and tumo...

journal_title：Oncology

authors： Blanter J,Zimmerman B,Tharakan S,Ru M,Cascetta K,Tiersten A

更新日期：2020-01-01 00:00:00

abstract：:In 29 patients (48 courses of chemotherapy), a randomized double-blind crossover study was undertaken to establish the antiemetic effectiveness of a combination of metoclopramide at a moderately high dose (5 mg/kg body weight) with 1 g methylprednisolone (treatment A) as compared with metoclopramide monotherapy (5 mg/...

journal_title：Oncology

authors： Ell C,König HJ,Brockmann P,Domschke S,Domschke W

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To compare chemotherapy-related and total medical costs among patients with colorectal cancer (CRC) receiving capecitabine or 5-fluorouracil (5-FU) monotherapy after surgical resection. METHODS:This retrospective, claim-based study utilized the Thomson Reuters Market Scan(R) databases to identify 1,396 CRC p...

journal_title：Oncology

authors： Chu E,Shi N,Wei W,Bendell JC,Cartwright T

更新日期：2009-01-01 00:00:00

abstract：:Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix. In the majority of cases, HPV proteins E6 and E7 are continuously expressed and bind a variety of cellular proteins. The precise mechanism of HPV-induced carcinogenesis has not been fully elucidated; there...

journal_title：Oncology

authors： Yaginuma Y,Yoda K,Ogawa K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...

journal_title：Oncology

authors： Horie K,Kawakami K,Fujita Y,Matsuda Y,Arai T,Suzui N,Miyazaki T,Koie T,Mizutani K,Ito M

更新日期：2020-01-01 00:00:00

abstract：:The serum detection of S100B, a new melanoma marker, has shown clinical significance in early studies. The aim of our study of 1, 339 serum samples from 412 different melanoma patients and 107 control patients was to prove the prognostic value of serum S100B levels in melanoma patients at different stages of disease a...

journal_title：Oncology

authors： Hauschild A,Engel G,Brenner W,Gläser R,Mönig H,Henze E,Christophers E

更新日期：1999-01-01 00:00:00

abstract：:The historical aspects of drug development and evaluation are anecdotically related. Clinical trials have proven the effectiveness of animal tests in the vast majority of cases, and the effort has been well spent. Similar of more noteworthy success may be obtainable with model systems in the study of prostatic cancer....

journal_title：Oncology

authors： Gaunt R

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:We conducted this study to compare tumor measurement by computed tomography (CT) and tumor response assessment between Response Evaluation Criteria In Solid Tumors (RECIST) 1.0 and RECIST 1.1 in patients with metastatic colorectal cancer (CRC). METHODS:We reviewed the medical records of patients with metasta...

journal_title：Oncology

authors： Jang HJ,Kim BC,Kim HS,Kim JH,Song HH,Kim JB,Park JJ,Yoon SN,Woo JY,Zang DY

更新日期：2014-01-01 00:00:00

abstract：:Culture-induced cytotoxic (CIC) activity developed in 7-day culture in the presence of fetal calf serum of pleural effusion lymphocytes from patients with lung cancer which initially showed markedly low or no natural killing (NK) activity against K562 cells. The development of CIC activity was proliferation-dependent....

journal_title：Oncology

authors： Uchida A,Micksche M

更新日期：1982-01-01 00:00:00

abstract：:Hemostatic abnormalities are rather frequent in cancer patients either in hematological or in solid tumors. Acute disseminated intravascular coagulation (DIC) is a rare coagulopathy in cancer patients, but when it develops it becomes rapidly fatal. Between June 1988 and December 1992 we observed 8 cases of acute DIC o...

journal_title：Oncology

authors： Pasquini E,Gianni L,Aitini E,Nicolini M,Fattori PP,Cavazzini G,Desiderio F,Monti F,Forghieri ME,Ravaioli A

更新日期：1995-11-01 00:00:00

abstract：:Fifteen patients, median age 64 years, presenting with advanced gastrointestinal adenocarcinomas, were included in this study. The treatment combination consisted of folinic acid (200 mg/m2, IV bolus injection) followed by 5-fluorouracil (5-FU; 400 mg/m2, 30-min infusion) for 5 consecutive days and mitomycin C (10 mg/...

journal_title：Oncology

authors： Becouarn Y,Brunet R,Bussières E,Marée D

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Radioimmunotherapy (RIT) is effective in treating relapsed/refractory follicular lymphoma (FL), with durable remissions in first-line consolidation. We hypothesized that RIT with ibritumomab tiuxetan (Zevalin®) would result in durable remissions by eliminating minimal residual disease after cytoreduction. M...

journal_title：Oncology

authors： Puvvada SD,Guillén-Rodríguez JM,Yan J,Inclán L,Heard K,Rivera XI,Anwer F,Mahadevan D,Schatz JH,Persky DO

更新日期：2018-01-01 00:00:00

abstract：:The expression of the drug resistance markers P glycoprotein (P-170), glutathione S transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) was analyzed in 16 human kidney carcinoma cell lines, 18 hematological malignancies, and 14 human breast carcinomas. We found a tendency for coexpression of increased P-170 and...

journal_title：Oncology

authors： Efferth T,Mattern J,Volm M

更新日期：1992-01-01 00:00:00

abstract：:Several reports have demonstrated an adverse effect of perioperative blood transfusions on the survival of patients with various solid tumors treated surgically. We retrospectively investigated the relationship between perioperative blood transfusions and the survival of 501 patients who underwent radical subtotal gas...

journal_title：Oncology

authors： Choi JH,Chung HC,Yoo NC,Lee HR,Lee KH,Kim JH,Roh JK,Min JS,Lee KS,Kim BS

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:Keratin (K) 19 positivity has been reported to be a useful predictive marker for recurrence in patients with hepatocellular carcinoma (HCC) who have undergone hepatic resection. We investigated the clinical usefulness of K19 positivity in patients who had received curative radiofrequency ablation (RFA). METH...

journal_title：Oncology

authors： Tsuchiya K,Komuta M,Yasui Y,Tamaki N,Hosokawa T,Ueda K,Kuzuya T,Itakura J,Nakanishi H,Takahashi Y,Kurosaki M,Asahina Y,Enomoto N,Sakamoto M,Izumi N

更新日期：2011-01-01 00:00:00

abstract：:Malignant gastrointestinal neuroectodermal tumor (GNET) is an aggressive rare tumor, primarily occurring in young adults with frequent local-regional metastases and recurrence after local control. The tumor is characterized by the presence of EWSR1-ATF1 or EWSR1-CREB1 and immunohistochemical positivity for S-100 prote...

journal_title：Oncology

authors： Subbiah V,Holmes O,Gowen K,Spritz D,Amini B,Wang WL,Schrock AB,Meric-Bernstam F,Zinner R,Piha-Paul S,Zarzour M,Elvin JA,Erlich RL,Stockman DL,Vergilio JA,Suh JH,Stephens PJ,Miller V,Ross JS,Ali SM

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Serrated adenoma (SA) consists of glands both with intraluminal projection of tall columnar cells, which resemble the terminally differentiated cells in the surface epithelium, and with concave short cells, which resemble progenitor crypt cells of the colon. The aim of this study was to clarify the relationsh...

journal_title：Oncology

authors： Jiao YF,Nakamura S,Sugai T,Yamada N,Habano W

更新日期：2008-01-01 00:00:00

abstract：:Recent studies have demonstrated that nitroso chemical carcinogens activate guanylate cyclase (EC 4.6.1.2) which catalyzes the production of guanosine 3',5'-monophosphate. This nucleotide is thought to be involved in normal and abnormal cell growth. We examined the effect of 3 major classes of anticancer chemotherapeu...

journal_title：Oncology

authors： Vesely DL,Levey GS

更新日期：1979-01-01 00:00:00

abstract：:Nontumor-bearing C3H/He mice were splenectomized and intravenously inoculated 7 days later with Streptococcus pneumoniae, Pseudomonas aeruginosa, or Escherichia coli. The survival rate was reduced by splenectomy in the animals inoculated with S. pneumoniae, but did not change in those inoculated with P. aeruginosa or ...

journal_title：Oncology

authors： Ando T,Motokawa I,Sakurai K,Ohmura Y,Matsunaga K,Fujii T,Yoshikumi C,Taguchi T

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Identification of high-risk stage II colorectal cancer (CRC) patients, potential candidates for adjuvant chemotherapy, is challenging. Current clinical guidelines rely mainly on histopathological markers with relatively weak prognostic value. This motivates further search for prognostic markers. METHODS:Thi...

journal_title：Oncology

authors： Dimberg J,Andersson RE,Haglund S

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:We investigated the efficacy of risk-adapted adjuvant paclitaxel/carboplatin chemotherapy in early-stage ovarian carcinoma. METHODS:Fifty-three patients were treated according to the risk of relapse: patients with stages IA or IB or with grade 1 (low risk) received 4 cycles of paclitaxel and carboplatin; pat...

journal_title：Oncology

authors： Bamias A,Bamia C,Karadimou A,Soupos N,Zagouri F,Rodolakis A,Haidopoulos D,Vlahos G,Thomakos N,Antsaklis A,Dimopoulos MA

更新日期：2011-01-01 00:00:00