Abstract:
:In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as patient survival. Immunohistochemical staining of nm23-H1 and nm23-H2 was found in 68.4 and 50.5% of the cases, respectively. Significant differences in nm23-H1, but not nm23-H2 expression were noted with regard to nuclear grade and tumor size. The patients with nm23-H1-expression-negative tumors sized < or = 50 mm had a significantly poorer prognosis than their positive counterparts. Multivariate analysis using the Cox proportional hazards regression model indicated that the staging in the Robson system and expression of nm23-H1 were significant and independent prognostic factors for survival. However, no significant correlation between the incidence of metastasis and expression of nm23-H1 or nm23-H2 was found. The results imply that reduced expression of nm23-H1 influences the prognosis of patients with renal cell carcinomas, but not the likelihood of metastasis. In small tumors sized < or = 50 mm, reduced expression of nm23-H1 protein was suggested to be an especially strong predictor of a poor prognosis.
journal_name
Oncologyjournal_title
Oncologyauthors
Nakagawa Y,Tsumatani K,Kurumatani N,Cho M,Kitahori Y,Konishi N,Ozono S,Okajima E,Hirao Y,Hiasa Ydoi
10.1159/000011880subject
Has Abstractpub_date
1998-07-01 00:00:00pages
370-6issue
4eissn
0030-2414issn
1423-0232pii
ocl55370journal_volume
55pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract:BACKGROUND:Identification of high-risk stage II colorectal cancer (CRC) patients, potential candidates for adjuvant chemotherapy, is challenging. Current clinical guidelines rely mainly on histopathological markers with relatively weak prognostic value. This motivates further search for prognostic markers. METHODS:Thi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000507118
更新日期:2020-01-01 00:00:00
abstract::In 86 children with acute lymphocytic leukemia (ALL) and in 6 children with medulloblastoma 253 24-hour methotrexate (MTX) infusions with 150, 500, and 700 mg/m2 were performed. MTX concentrations in plasma and cerebrospinal fluid (CSF) were measured with a specific radioimmunoassay. In 131 infusions with 500 mg/m2 gi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225828
更新日期:1984-01-01 00:00:00
abstract::The effects of theophylline treatment on mouse B-16 melanoma cell growth, metabolism, and membrane antigen expression in vitro were studied. Theophylline treatment inhibited DNA synthesis and the cell growth rate, and caused an elevation of intracellular cAMP levels. Cells treated with theophylline became elongated an...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225467
更新日期:1980-01-01 00:00:00
abstract::A number of therapeutic agents including L-asparaginase, Actinomycin-D, CCNU, Hydroxyurea, 5-FU, Cis-platinum, Cyclophosphamide, orchiectomy, Adriamycin and DES alone and in various combinations has been applied against the Dunning R-3327 rat prostatic adenocarcinoma subline G. We have found a parallel between the res...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225202
更新日期:1977-01-01 00:00:00
abstract::The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011850
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000346690
更新日期:2013-01-01 00:00:00
abstract::Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40-50 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats resulted in a marked decrease in the growth rate of both tumors. Exhaustive extraction of the corn oil with water indicated that the act...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225184
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Transcatheter arterial chemoembolization (TACE) is a standard therapy used in the treatment of intermediate hepatocellular carcinoma (HCC). Recently, balloon-occluded TACE (B-TACE) has been developed. PURPOSE:This study aimed to clarify the effects of B-TACE in patients with HCC, with a focus on which drug ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492822
更新日期:2019-01-01 00:00:00
abstract::Recent studies have demonstrated that nitroso chemical carcinogens activate guanylate cyclase (EC 4.6.1.2) which catalyzes the production of guanosine 3',5'-monophosphate. This nucleotide is thought to be involved in normal and abnormal cell growth. We examined the effect of 3 major classes of anticancer chemotherapeu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225362
更新日期:1979-01-01 00:00:00
abstract::Eleven postmenopausal patients with advanced breast cancer were assessed for their response and endocrine changes to low-dose aminoglutethimide (250 mg twice a day) therapy without steroid administration. In 7 cases an objective response was registered; 1 patient had a stabilization of the disease lasting for 9 months...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227006
更新日期:1992-01-01 00:00:00
abstract::Lymphomas, which are frequently subdivided into Hodgkin's disease and non-Hodgkin's lymphoma, represent one of the more curable cancers that present as a solid tumor. Unfortunately, most patients cannot be cured with conventional chemotherapy, therefore new techniques have been developed including high-dose chemothera...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000012100
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVES:To assess whether the use of an organ-specific treatment could improve event-free survival (EFS) and overall survival as endpoints in testicular lymphoma in the early stage: IE and IIE. METHODS:Thirty-four patients were selected to be treated with orchiectomy following six cycles of anthracycline-based comb...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000081319
更新日期:2004-01-01 00:00:00
abstract::Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225395
更新日期:1980-01-01 00:00:00
abstract::112 cases, of varying ages, which were diagnosed as having carcinoma of the bladder by cystoscopy and biopsy from the tumor, were investigated for the presence of alphafetoprotein (AFP) in the sera. 59 (52.6%) out of the total, showed positive results, and no false positive results occured. Radioimmunoassay was capabl...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225188
更新日期:1977-01-01 00:00:00
abstract::Several reports have demonstrated an adverse effect of perioperative blood transfusions on the survival of patients with various solid tumors treated surgically. We retrospectively investigated the relationship between perioperative blood transfusions and the survival of 501 patients who underwent radical subtotal gas...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227452
更新日期:1995-03-01 00:00:00
abstract::The activity and toxicity of UFT (Tegafur and Uracil) in a 4:1 molar concentration, plus leucovorin (LV), were evaluated in the treatment of 45 patients with advanced, bidimensionally measurable metastatic colorectal carcinoma. Initially 350 and later 300 mg/m2/day, plus 150 mg LV, as administered in divided doses eve...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227741
更新日期:1997-01-01 00:00:00
abstract::The present communication reports the inhibitory action of aminoglutethimide on 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary carcinogenesis in virgin female Holtzman rats. When 20 mg of DMBA is given to the rats and maintained on normal diet for 32 weeks, approximately 70% of the animals develop mammary tum...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226013
更新日期:1985-01-01 00:00:00
abstract::The antiemetic effect of oral medium-dosed metoclopramide (MCL, 3.5 mg/kg b.w./cycle) and placebo for chemotherapy-induced emesis of a noncisplatin regimen was assessed for inpatients and outpatients in two double-blind placebo-controlled sequential analyses according to Bross (1952). MCL was given in 5 single doses o...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227153
更新日期:1993-03-01 00:00:00
abstract::Flow cytometric (FCM) DNA studies were performed on cell suspensions obtained by endoscopic biopsy in 73 patients with gastric cancer and in 61 patients with gastric remnant. In cancer, DNA aneuploidies were detected in 49 tumors (67.1%), including 51.7% (15/29) of early gastric cancers and 77.3% (34/44) of advanced g...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227389
更新日期:1994-11-01 00:00:00
abstract::Surgical resection, transarterial chemoembolization, percutaneous ethanol injection therapy, radiofrequency ablation, and orthotopic liver transplantation are generally accepted treatment modalities in hepatocellular carcinoma, but there has been no standard therapy for patients at the advanced stage. Several combinat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000173432
更新日期:2008-01-01 00:00:00
abstract::We report four cases of Hodgkin's disease (HD) relapsing after complete remission for over a 10-year period after the initial therapy. Three of the patients had mixed-cellularity subtypes as a primary histological diagnosis, and the rebiopsies demonstrated mixed cellularity in all very late relapse cases. Two patients...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227474
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Even though the pathological background contributes to lymph node metastasis, the biological characteristics of tumors have also gained wide attention. In this study, the expression of the cadherin-catenin complex and p53 was studied in early gastric cancer. Their correlation with lymph node m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012020
更新日期:1999-01-01 00:00:00
abstract::Capecitabine is converted to 5-fluorouracil by thymidine phosphorylase, and mitomycin C is capable of upregulating the expression of thymidine phosphorylase suggesting a synergistic effect. Fifty-three patients (median age 62 years) with anthracycline- and taxane-resistant, metastatic breast cancer received mitomycin ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000096250
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:This study was performed to investigate the activity and safety of high dose 5-fluorouracil (5-FU) given as a weekly 24-hour infusion in combination with folinic acid plus mitomycin C in patients with advanced gastric cancer. PATIENTS AND METHODS:Chemonaive patients with locally advanced inoperable, recurrent ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000012130
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial. METHODS:The aim of this pilot study was to assess the feasibility of postoperative combination chemotherapy followed by radiotherapy in patients aged 18-70 years with a histological diagnosis of PA, and Karnofsky perf...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000086780
更新日期:2005-01-01 00:00:00
abstract::Aromatase inhibitor (AI) is widely used as an endocrine treatment in postmenopausal patients with hormone receptor-positive breast cancer. To identify useful prognostic factors for patients with metastatic breast cancer treated with AI therapy, we investigated the association between several hormone receptor-related f...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000319540
更新日期:2010-01-01 00:00:00
abstract::The mode of growth of tumour cells from primary breast carcinoma in the axillary nodes is shown to be related to the oestrogen receptor (ER) status of the primary tumour. ER-positive primaries are described as tending to show sinophilic growth, the tumour cells spreading along the nodal sinuses; while the ER-negative ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225735
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:We investigated whether a 5-fluorouracil (5-FU)-resistant tumor could regain chemosensitivity after the administration of 5-aza-2'-deoxycytidine (DAC) as a demethylating agent. METHODS:Human colorectal cancer cells (SW48) are characterized by the hypermethylation of proapoptotic genes. They were transplanted i...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000107110
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:To examine the efficacy and prognostic benefits of radiotherapy (RT) in patients who have unresectable advanced hepatocellular carcinoma (HCC) with invasion to intrahepatic large vessels (IHLVs). METHODS:Sixty-eight patients who had advanced HCC with invasion to IHLVs were studied. Thirty-two consecutive pa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000120996
更新日期:2007-01-01 00:00:00
abstract::362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227550
更新日期:1996-03-01 00:00:00