Prognostic value of nm23 protein expression in renal cell carcinomas.


:In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as patient survival. Immunohistochemical staining of nm23-H1 and nm23-H2 was found in 68.4 and 50.5% of the cases, respectively. Significant differences in nm23-H1, but not nm23-H2 expression were noted with regard to nuclear grade and tumor size. The patients with nm23-H1-expression-negative tumors sized < or = 50 mm had a significantly poorer prognosis than their positive counterparts. Multivariate analysis using the Cox proportional hazards regression model indicated that the staging in the Robson system and expression of nm23-H1 were significant and independent prognostic factors for survival. However, no significant correlation between the incidence of metastasis and expression of nm23-H1 or nm23-H2 was found. The results imply that reduced expression of nm23-H1 influences the prognosis of patients with renal cell carcinomas, but not the likelihood of metastasis. In small tumors sized < or = 50 mm, reduced expression of nm23-H1 protein was suggested to be an especially strong predictor of a poor prognosis.






Nakagawa Y,Tsumatani K,Kurumatani N,Cho M,Kitahori Y,Konishi N,Ozono S,Okajima E,Hirao Y,Hiasa Y




Has Abstract


1998-07-01 00:00:00
















  • Bigenotypic and biphenotypic appearance of immunoglobulin light chains in 1 of 3 non-Hodgkin's lymphoma xenografts.

    abstract::Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearr...


    pub_type: 杂志文章


    authors: Kopper L,Bánkfalvi A,Földi J,Mihalik R,Magyar M,Aczél A

    更新日期:1990-01-01 00:00:00

  • Treatment of advanced primary lung cancer associated with malignant pleural effusion by the combination of immunotherapy and chemotherapy.

    abstract::Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were ...


    pub_type: 杂志文章


    authors: Miyao H,Chou T,Ito K,Moriyama H,Mitsuma S,Wakabayashi M,Yoshizawa H,Arakawa M

    更新日期:1994-01-01 00:00:00

  • High-dose chemotherapy and autologous hematopoietic stem cell transplantation: the lymphoma experience and its potential relevance to solid tumors.

    abstract::Lymphomas, which are frequently subdivided into Hodgkin's disease and non-Hodgkin's lymphoma, represent one of the more curable cancers that present as a solid tumor. Unfortunately, most patients cannot be cured with conventional chemotherapy, therefore new techniques have been developed including high-dose chemothera...


    pub_type: 杂志文章,评审


    authors: Armitage JO

    更新日期:2000-04-01 00:00:00

  • Phase II study of combined administration of 5-fluorouracil, epirubicin and mitomycin-C by hepatic artery infusion in patients with liver metastases of gastric cancer.

    abstract::This multicenter phase II study evaluated the efficacy of the FEM regimen (5-fluorouracil 333 mg/m(2) each week, epirubicin 30 mg/m(2) once every 4 weeks and mitomycin-C 2.7 mg/m(2) once every 2 weeks) administered by hepatic artery infusion (HAI) for unresectable hepatic metastases of gastric cancer. The response rat...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kumada T,Arai Y,Itoh K,Takayasu Y,Nakamura K,Ariyoshi Y,Tajima K

    更新日期:1999-10-01 00:00:00

  • Immuno-Oncological Treatment and Tumor Mass in Non-Small Cell Lung Cancer: Case-Control Analysis of Overall Survival in Routine Clinical Practice.

    abstract:BACKGROUND:Immuno-oncological (IO) therapies such as PD-1 and PD-L1 antibodies have been introduced in the treatment of advanced non-small cell lung cancer (NSCLC) since 2015 based on randomized trials showing unprecedented advantages in overall survival (OS) with hazard ratios (HRs) between 0.5 and 0.7. The impact of ...


    pub_type: 杂志文章


    authors: Faehling M,Kopp M,Schwenk B,Fallscheer S,Kramberg S,Eckert R

    更新日期:2019-01-01 00:00:00

  • Immunologic and immunohistochemical studies on chronic lymphocytic thyroiditis with or without thyroid lymphoma.

    abstract::The local immunologic phenomena in the thyroid gland of 16 patients with chronic lymphocytic thyroiditis (CLTH) were investigated; 5 of these cases were associated with thyroid non-Hodgkin's lymphomas (NHL). All patients were admitted because of struma, growing slowly in patients with CLTH alone and rapidly in those w...


    pub_type: 杂志文章


    authors: Aozasa K,Tajima K,Tominaga N,Katagiri S,Yonezawa T,Matsuzuka F,Kuma K,Sawada M

    更新日期:1991-01-01 00:00:00

  • p53 autoantibodies in patients with primary ovarian cancer are associated with higher age, advanced stage and a higher proportion of p53-positive tumor cells.

    abstract::Autoantibodies (AAb) directed against the nuclear phosphoprotein p53 can be detected in patients with various forms of cancer. The objective was to determine the prevalence of p53 AAb at the time of diagnosis in ovarian cancer patients and to correlate the presence of p53 AAb with clinicopathological parameters. Sera ...


    pub_type: 杂志文章


    authors: Vogl FD,Stickeler E,Weyermann M,Köhler T,Grill HJ,Negri G,Kreienberg R,Runnebaum IB

    更新日期:1999-11-01 00:00:00

  • Plasma thrombin-antithrombin complexes, latent coagulation disorders and metastatic spread in lung cancer: a longitudinal study.

    abstract::In patients affected with different tumours, disorders concerning clotting are frequently observed. The biological processes leading to coagulation are probably involved in the mechanisms of metastasis. We studied plasma levels of thrombin-antithrombin III complexes (TAT) in 90 patients affected with lung tumours subg...


    pub_type: 杂志文章


    authors: Tricerri A,Vangeli M,Errani AR,Guidi L,Canetta M,Vaccarino M,De Santis C,Ipsevich F,Salvati F,Bartoloni C

    更新日期:1996-11-01 00:00:00

  • A case-control study of breast cancer and psychotropic drug use.

    abstract::The relative risk of breast cancer incidence and tumor promotion associated with psychotropic drug consumption was evaluated in 151 patients with newly diagnosed neoplasms and 151 hospital controls. No significantly altered risk of breast cancer was found in association with the use of diazepam, chlordiazepoxide, anti...


    pub_type: 杂志文章


    authors: Wallace RB,Sherman BM,Bean JA

    更新日期:1982-01-01 00:00:00

  • Prognostic impact of multiple allelic losses on metastatic recurrence in hepatocellular carcinoma after curative resection.

    abstract::Loss of heterozygosity (LOH) on chromosomes 13q, 16q and 17p has been associated with the progression of hepatocellular carcinoma (HCC). To investigate the prognostic impact of such LOH, we examined the metastasis-free survival of curatively resected HCC cases, in whom these LOHs were analyzed. Among the 49 HCC patien...


    pub_type: 杂志文章


    authors: Nishida N,Fukuda Y,Komeda T,Ito T,Nishimura T,Minata M,Kuno M,Katsuma H,Ikai I,Yamaoka Y,Nakao K

    更新日期:2002-01-01 00:00:00

  • Cimetidine and coumarin therapy of renal cell carcinoma. A pilot study.

    abstract::Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months)...


    pub_type: 临床试验,杂志文章


    authors: Kokron O,Maca S,Gasser G,Schmidt PR

    更新日期:1991-01-01 00:00:00

  • Immunoreactive MUC1 expression at the deepest invasive portion correlates with prognosis of colorectal cancer.

    abstract::This study sought to examine the relationship between MUC1 expression at the deepest invasive portion, invasive/metastatic potential, and prognosis of colorectal cancer in relation to cellular proliferation. MUC1 expression was detected immunohistochemically using KL-6 antibody (anti-MUC1 monoclonal antibody) in 100 s...


    pub_type: 杂志文章


    authors: Hiraga Y,Tanaka S,Haruma K,Yoshihara M,Sumii K,Kajiyama G,Shimamoto F,Kohno N

    更新日期:1998-07-01 00:00:00

  • Chemotherapy of the transplantable adenocarcinoma (R-3327) of the Copenhagen rat.

    abstract::A number of therapeutic agents including L-asparaginase, Actinomycin-D, CCNU, Hydroxyurea, 5-FU, Cis-platinum, Cyclophosphamide, orchiectomy, Adriamycin and DES alone and in various combinations has been applied against the Dunning R-3327 rat prostatic adenocarcinoma subline G. We have found a parallel between the res...


    pub_type: 杂志文章


    authors: Block NL,Camuzzi F,Denefrio J,Troner M,Claflin A,Stover B,Politano VA

    更新日期:1977-01-01 00:00:00

  • Targeted therapy in the treatment of metastatic renal cell cancer.

    abstract::The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...


    pub_type: 杂志文章,评审


    authors: Di Lorenzo G,Scagliarini S,Di Napoli M,Scognamiglio F,Rizzo M,Carteni' G

    更新日期:2009-01-01 00:00:00

  • Amplification of ERBB-2 (HER-2/NEU) oncogene in different neoplasms of patients from USSR.

    abstract::203 tumor specimens from 175 patients were studied. Amplification of ERBB-2 was detected in 14 out of 63 (22%) cases of breast carcinoma, in 1 out of 23 patients with ovarian cancers, in 1 out of 19 cases of colon carcinoma and in 1 out of 27 patients with thyroid cancer. We failed to find more than one copy of ERBB-2...


    pub_type: 杂志文章


    authors: Knyazev PG,Imyanitov EN,Chernitca OI,Nikiforova IF,Hanson KP

    更新日期:1992-01-01 00:00:00

  • Phase II evaluation of Ly156758 in metastatic breast cancer.

    abstract::Fourteen patients with disseminated breast cancer with primary or secondary resistance to tamoxifen were treated with LY156758. There were no complete or partial responses and 1 patient showed a minor response. These data illustrate that LY156758 did not have significant antitumor activity in patients previously treat...


    pub_type: 杂志文章


    authors: Buzdar AU,Marcus C,Holmes F,Hug V,Hortobagyi G

    更新日期:1988-01-01 00:00:00

  • Cyclophosphamide, mitoxantrone, fluorouracil versus conventional CMF as adjuvant treatment in node-positive breast cancer patients. A Hellenic Cooperative Oncology Group Study.

    abstract::362 evaluable node-positive patients with stage II breast cancer were randomized, receiving either 6 cycles of conventional CMF or 6 cycles of the combination of cyclophosphamide (500 mg/m2), mitoxantrone (Novantrone 10 mg/m2), and fluorouracil (500 mg/m2; CNF). After a median follow-up of 51 months, 64 (36%) patients...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fountzilas G,Polichronis A,Katsohis K,Gennatas K,Toussis D,Skarlos D,Kosmidis P,Vassilaros S,Semoglou C,Giannakakis T,Fahantidis E,Klouvas G,Tsavaris N,Konstantaras C,Makrantonakis P,Kolotas C,Zamboglou N,Tsiliakos S,

    更新日期:1996-03-01 00:00:00

  • The role of neck dissection after radical chemoradiation for locally advanced head and neck cancer: should we move back?.

    abstract::Until a few decades ago neck dissection (ND) was the standard surgical approach for node-positive tumours. Nowadays patients with locally advanced head and neck cancer can be treated with definitive chemoradiation (CRT), which includes the treatment of the neck; however, results on residual viable tumour after conserv...


    pub_type: 杂志文章,评审


    authors: Denaro N,Russi EG,Numico G,Pazzaia T,Vitiello R,Merlano MC

    更新日期:2013-01-01 00:00:00

  • Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostate cancer.

    abstract::Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer. Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated w...


    pub_type: 杂志文章


    authors: Dunzendorfer U,Relyea NM,Kleinert E,Balis ME,Whitmore WF Jr

    更新日期:1983-01-01 00:00:00

  • c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling.

    abstract:OBJECTIVE:Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. M...


    pub_type: 杂志文章


    authors: Sekiya Y,Yamamoto E,Niimi K,Nishino K,Nakamura K,Kotani T,Kajiyama H,Shibata K,Kikkawa F

    更新日期:2017-01-01 00:00:00

  • Circulating and disseminated tumor cells in the clinical management of breast cancer patients: unanswered questions.

    abstract::Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and di...


    pub_type: 杂志文章,评审


    authors: Amadori A,Rossi E,Zamarchi R,Carli P,Pastorelli D,Jirillo A

    更新日期:2009-01-01 00:00:00

  • Effects of cycloheximide on chromatin-bound and -unbound PCNA in HeLa cells.

    abstract::We examined the effects of cycloheximide on the amount of chromatin-bound and -unbound PCNA subpopulations in HeLa cells. The chromatin-bound PCNA content decreased rapidly in the presence of cycloheximide, whereas the reduction of the total amount of PCNA was minimal even 24 h after the treatment with cycloheximide. ...


    pub_type: 杂志文章


    authors: Sasaki K,Kurose A,Uesugi N,Kato A

    更新日期:1995-09-01 00:00:00

  • Histone deacetylase in chronic lymphocytic leukemia.

    abstract:BACKGROUND:Elevated histone deacetylase (HDAC) isoenzyme levels have been described in patients with carcinomas and leukemias. HDAC inhibitors (HDACi) have shown promise in the treatment of carcinomas and are currently under intense research. To make better use of HDACi in treating chronic lymphocytic leukemia (CLL), H...


    pub_type: 杂志文章


    authors: Wang JC,Kafeel MI,Avezbakiyev B,Chen C,Sun Y,Rathnasabapathy C,Kalavar M,He Z,Burton J,Lichter S

    更新日期:2011-01-01 00:00:00

  • Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer.

    abstract:BACKGROUND:Bevacizumab (Avastin) significantly improves overall survival (OS) and progression-free survival (PFS) when combined with first-line irinotecan (IFL) plus bolus 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic colorectal cancer (CRC). This open-label, phase IV trial evaluated the efficac...


    pub_type: 杂志文章,多中心研究


    authors: Sobrero A,Ackland S,Clarke S,Perez-Carrión R,Chiara S,Gapski J,Mainwaring P,Langer B,Young S,AVIRI Trial investigators.

    更新日期:2009-01-01 00:00:00

  • Impact of Socioeconomic Status and Ethnicity on Melanoma Presentation and Recurrence in Caucasian Patients.

    abstract:OBJECTIVES:The impact of ethnicity and the socioeconomic status (SES) among Caucasians is not well studied. Here, we examine the impact of income on melanoma presentation and prognosis within a Caucasian cohort, accounting for ethnicity, as some reports suggest increased melanoma incidence in Ashkenazi Jewish (AJ) BRCA...


    pub_type: 杂志文章


    authors: Salvaggio C,Han SW,Martires K,Robinson E,Madankumar R,Gumaste P,Polsky D,Stein J,Berman R,Shapiro R,Zhong J,Osman I

    更新日期:2016-01-01 00:00:00

  • Gastric non-Hodgkin's lymphoma after successful treatment of Hodgkin's disease.

    abstract::A patient seen at presentation for Hodgkin's disease (HD) at stage IV B was successfully treated with MOPP. In remission he developed coeliac disease, controlled by dietary measures, but 26 months after the end of chemotherapy a severe dyspeptic syndrome appeared; endoscopy and barium meal suggested the presence of a ...


    pub_type: 杂志文章


    authors: Eridani S,Singh AK

    更新日期:1986-01-01 00:00:00

  • Hand-Foot Syndrome and Post-Progression Treatment Are the Good Predictors of Better Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Study.

    abstract:OBJECTIVE:To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. METHODS:The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general ho...


    pub_type: 临床试验,杂志文章


    authors: Ogawa C,Morita M,Omura A,Noda T,Kubo A,Matsunaka T,Tamaki H,Shibatoge M,Tsutsui A,Senoh T,Nagano T,Takaguchi K,Tani J,Morishita A,Yoneyama H,Masaki T,Moriya A,Ando M,Deguchi A,Kokudo Y,Minami Y,Ueshima K,Sakur

    更新日期:2017-01-01 00:00:00

  • Long-term prognosis of stage I ovarian carcinoma. Prognostic importance of intraoperative rupture.

    abstract:OBJECTIVE:There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective of this study was to evaluate prognostic factors for long-term survival. METHODS:Two hundred fourteen stage I ovarian carcinomas (registered by the Tokai Ovarian Tumor Study Group from 1988 to 1999) were ana...


    pub_type: 杂志文章,多中心研究


    authors: Mizuno M,Kikkawa F,Shibata K,Kajiyama H,Suzuki T,Ino K,Kawai M,Mizutani S

    更新日期:2003-01-01 00:00:00

  • Single-agent gemcitabine for biliary tract cancers. Study outcomes and systematic review of the literature.

    abstract:OBJECTIVE:The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers. METHODS:We conducted a retrospective study of consecutively treated 22 inoperable biliary tract cancer patients with gemcitabine (500-1,000 mg/m(2) on days 1, 8, 15 every 4 weeks) as f...


    pub_type: 杂志文章,评审


    authors: Kiba T,Nishimura T,Matsumoto S,Hatano E,Mori A,Yasumi S,Doi R,Ikai I,Kitano T,Nishimura T,Yoshikawa K,Ishiguro H,Yanagihara K,Doi E,Teramukai S,Fukushima M

    更新日期:2006-01-01 00:00:00

  • Overexpression of tyrosine kinase B protein as a predictor for distant metastases and prognosis in gastric carcinoma.

    abstract:OBJECTIVE:Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC). PATIENTS AND METHODS:We analyzed TrkB expression in 161 GC patients by immunohistochemist...


    pub_type: 杂志文章


    authors: Zhang Y,Fujiwara Y,Doki Y,Takiguchi S,Yasuda T,Miyata H,Yamazaki M,Ngan CY,Yamamoto H,Ma Q,Monden M

    更新日期:2008-01-01 00:00:00