Prognostic value of nm23 protein expression in renal cell carcinomas.

Abstract:

:In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as patient survival. Immunohistochemical staining of nm23-H1 and nm23-H2 was found in 68.4 and 50.5% of the cases, respectively. Significant differences in nm23-H1, but not nm23-H2 expression were noted with regard to nuclear grade and tumor size. The patients with nm23-H1-expression-negative tumors sized < or = 50 mm had a significantly poorer prognosis than their positive counterparts. Multivariate analysis using the Cox proportional hazards regression model indicated that the staging in the Robson system and expression of nm23-H1 were significant and independent prognostic factors for survival. However, no significant correlation between the incidence of metastasis and expression of nm23-H1 or nm23-H2 was found. The results imply that reduced expression of nm23-H1 influences the prognosis of patients with renal cell carcinomas, but not the likelihood of metastasis. In small tumors sized < or = 50 mm, reduced expression of nm23-H1 protein was suggested to be an especially strong predictor of a poor prognosis.

journal_name

Oncology

journal_title

Oncology

authors

Nakagawa Y,Tsumatani K,Kurumatani N,Cho M,Kitahori Y,Konishi N,Ozono S,Okajima E,Hirao Y,Hiasa Y

doi

10.1159/000011880

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

370-6

issue

4

eissn

0030-2414

issn

1423-0232

pii

ocl55370

journal_volume

55

pub_type

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