Abstract:
OBJECTIVE:It was the aim of this study to report on the role of laparoscopic staging in a large series of locally advanced cervical cancer (LACC) patients and its impact on prognosis. METHODS:Consecutive patients with LACC were considered for surgical staging: gynecological examination, cystoscopy and laparoscopy with peritoneal biopsies and peritoneal fluid cytology. RESULTS:Between February 2000 and September 2010, a total of 167 women were evaluated. In 5 patients, laparoscopy could not be performed. One hundred and sixty-two patients had correct laparoscopic staging: 49 International Federation of Gynecology and Obstetrics (FIGO) stage IB-IIA (>4 cm), 67 IIB, 39 III, and 7 IVA. Abdominal spread was found in 33 cases (20%). There was a minor laparoscopy complication rate of 1%. We found a significant difference in the distribution of peritoneal spread for tumor grade and FIGO stage (p = 0.01 and p < 0.0001, respectively), whereas no statistically significant difference for the histological type was found [p = not significant (NS)]. The median follow-up was 80 months (range 4-144). The median overall survival was 65 months. The patients without abdominal spread did not benefit from a significantly longer survival (median overall survival of 59 vs. 70 months; p = NS). CONCLUSIONS:Laparoscopic staging in cervical cancer is a safe and feasible technique but it does not modify the prognosis of LACC patients.
journal_name
Oncologyjournal_title
Oncologyauthors
Benedetti Panici P,Perniola G,Tomao F,Fischetti M,Savone D,Di Donato V,Angioli R,Muzii Ldoi
10.1159/000351995subject
Has Abstractpub_date
2013-01-01 00:00:00pages
160-5issue
3eissn
0030-2414issn
1423-0232pii
000351995journal_volume
85pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226444
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:BRAF D594G mutations in colorectal cancer patients are not clearly understood. We retrospectively investigated the clinicopathological features of colorectal cancers with BRAF D594G mutations. METHODS:We selected 908 colorectal cancer patients who underwent surgical resection from January 2008 to January 201...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000447402
更新日期:2016-01-01 00:00:00
abstract::An experimental model is introduced for the study of liver metastases using intrasplenically injected EL-4 and Lewis lung tumor cells. Fluorinated pyrimidine derivatives, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil, showed inhibitory effects on the frequencies of liver metastases. Immunosuppressive effects...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226989
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:Calcitriol, 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3)) has potent antiproliferative effects and potentiates the antitumor activity of many other cytotoxic drugs. 1,25-D(3) plasma pharmacokinetic (PK) parameters associated with antitumor activity in experimental animal models are unknown. The objective of th...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000076336
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:To investigate the role of adjuvant radiation therapy in locoregional control in patients with locoregionally advanced papillary thyroid carcinoma (pT4 or pN1b) based on a comparison of a group that received radiation therapy and a group that did not receive radiation therapy. METHODS:A retrospective analys...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000444393
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Adenocarcinoma is the most frequent pathological type of stomach cancer. Hodgkin's lymphoma is a lymphoproliferative disease arising from lymphoid tissue which is characterized by Reed-Sternberg cells. Synchronous occurrence of these two malignancies has not been reported in the English literature so far. C...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000136799
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Pegylated liposomal doxorubicin (PLD) and capecitabine (CAP) have separately shown significant antitumor activity in a wide range of solid tumors. A phase I study was conducted in order to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of their combination in patients with refr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000090494
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Nucleoside and nucleobase derivatives are currently used in the treatment of a variety of solid tumors; however, the role of plasma membrane transporters as biomarkers of drug metabolism has not been fully addressed. Thus, the purpose of this study was to determine whether the concentrative nucleoside transport...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000094541
更新日期:2006-01-01 00:00:00
abstract::The relationship of vitamins to cancer is very complex. Three types of interactions are possible: the effect of vitamins on tumor growth, the effect of tumors on vitamin metabolism, and the effect of vitamins on chemical carcinogens and anti-tumor chemotherapeutic agents. The significance of vitamins with particular r...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000225139
更新日期:1976-01-01 00:00:00
abstract::Previous studies have demonstrated a rise in serum alpha-1-antitrypsin at advanced stages of malignancy. These, together with results of animal experiments with another anti-proteinase, aprotinin, have prompted studies of the plasma alpha-1-antitrypsin in the early stages of malignancy, using cervical carcinoma as a m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225093
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:To better determine docetaxel activity in patients with well-defined anthracycline-resistant breast cancer. METHODS:From October 1996, we carried out a phase II trial in 69 heavily pretreated patients with advanced breast cancer with docetaxel 100 mg/m(2) by a 1-hour infusion on day 1, with cycles repeated e...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000055298
更新日期:2001-01-01 00:00:00
abstract::As the antitumor activity of radiation is mediated via its interaction with oxygen to form labile free radicals, the intratumoral oxygen level has an important influence on the ability of radiation therapy to kill malignant cells. By decreasing the oxygen-carrying capacity of the blood, anemia may result in tumor hypo...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000067147
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:It is unclear for whom new anti-human epidermal growth factor receptor 2 (anti-HER2) agents, such as pertuzumab and T-DM1, should be considered. We investigated prognostic factors before neoadjuvant chemotherapy (NAC) among HER2-positive invasive breast cancer patients and those after NAC among patients who ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502910
更新日期:2020-01-01 00:00:00
abstract::Between June 1980 and December 1984, 88 patients with stage III-IV ovarian carcinoma were entered in a study evaluating the role of debulking surgery and chemotherapy consisting of cyclophosphamide, doxorubicin, and cisplatin intravenously on day 1, every 4 weeks (CAP-1). The results after a median follow-up of 62 mon...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226801
更新日期:1990-01-01 00:00:00
abstract::From January 1991 to August 1993, 237 women with metastatic breast cancer were recruited into a multicentric phase II clinical trial designed to assess the cardioprotective activity of Cardioxane (ICRF-187). All patients were treated with 5-fluorouracil 500 mg/m2, doxorubicin 50 mg/m2, cyclophosphamide 500 mg/m2 (FDC)...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227467
更新日期:1995-05-01 00:00:00
abstract::Macroscopic morphology, histology and ultrastructure of BK virus (BKV)-induced hamster and mouse tumors were investigated. Groups of animals were immunosuppressed to study the relationship between immune system and BKV oncogenesis. Ependymomas had the highest incidence, followed by tumors of pancreatic islets, osteosa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225777
更新日期:1983-01-01 00:00:00
abstract::The antiemetic effect of graded, single high-dose intravenous dexamethasone was studied in 27 patients receiving combination chemotherapy with either doxorubicin (50 mg/m2) or cis-platinum (100 mg/m2). A total of 57 cycles were individually evaluated, utilizing a detailed rating system. Nausea and vomiting did not occ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000226099
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC). METHODS:Nine previously reported predictive markers for liver metastasis and/or prognosis (COX-2, dysadherin, E-cadherin, beta-catenin, Ki-67, p53, laminin5gamma2, matrilysin and MUC...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151667
更新日期:2008-01-01 00:00:00
abstract::2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant food-derived mutagenic/carcinogenic heterocyclic amine (HCA), has attracted particular attention as a probable human colon carcinogen. Some studies have shown that PhIP administered in the post-initiation phase is able to enhance rat colon carci...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000127423
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for patients with advanced stage (stage III or IV) head and neck squamous cell carcinoma (HNSCC) following primary radiotherapy (RT) or concomitant chemoradiotherapy. METHODS:From January 2001 to January 2003, 149 ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000086982
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To determine the dose-limiting toxicities (DLTs) and the maximum-tolerated doses of the paclitaxel, oxaliplatin (LOHP) and capecitabine combination in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received escalating doses of paclitaxel (starting dose 100 mg/m2) and LOHP (starting dose 40 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000111088
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression by regulating DNA repair, cell division and apoptosis. One major function of wild-type p53 is to control the onset of DNA replication at the G1-S boundary by inducing p21 protein, which promotes cell cycle arrest b...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000066223
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:Primary chemoradiotherapy for locally advanced pancreatic cancer (LAPC) may improve local control, curative resection rate and long-term survival. We performed a phase II study to evaluate toxicity and activity of primary radiation therapy and concurrent chemotherapy with gemcitabine (GEM) twice weekly in pa...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000086993
更新日期:2005-01-01 00:00:00
abstract::To improve the ability of an in vitro drug sensitivity test to predict in vivo effects, we applied a drug concentration that was pharmacokinetically equivalent to plasma levels and collagen gel droplet-embedded culture with a high cloning efficiency. We reported that the cell-killing effect of cell cycle phase-nonspec...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227569
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Identification of high-risk stage II colorectal cancer (CRC) patients, potential candidates for adjuvant chemotherapy, is challenging. Current clinical guidelines rely mainly on histopathological markers with relatively weak prognostic value. This motivates further search for prognostic markers. METHODS:Thi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000507118
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:We investigated stanniocalcin 1 (STC 1) expression to assess its clinical utility as a blood marker in patients with gastric cancer and evaluated its biological impact in terms of tumor aggressiveness. METHODS:Blood specimens from 93 patients with gastric cancer and 21 normal healthy volunteers were assessed...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000341390
更新日期:2012-01-01 00:00:00
abstract::The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258504
更新日期:2009-01-01 00:00:00
abstract::We evaluated changes in serum albumin concentrations in 15 patients with advanced malignancy who were also receiving cisplatin. All 15 patients had serial measurements of serum albumin. The decrease in serum albumin from the time of the first dose of cisplatin to death correlated with liver platinum levels at autopsy ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226100
更新日期:1986-01-01 00:00:00
abstract::In 12 patients with gastric cancer and in 14 with large bowel neoplasia, classified according to the TNM system, some major blood indices of hemostasis, platelet activation and fibrinolysis were assessed before and for 1 month after surgery, to show whether possible variations of such indices may provide useful clues ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226828
更新日期:1990-01-01 00:00:00
abstract::Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and di...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000215581
更新日期:2009-01-01 00:00:00