Hypoalbuminemia in patients receiving cisplatin: correlation between liver platinum and decrease in serum albumin.

abstract：:To extend the information on the mutagenic effect of methylazoxymethanol (MAM) acetate, which has been established as a potent carcinogen, the frequency of sister-chromatid exchange (SCE) was determined in bone marrow cells of Sprague Dawley rats and in cultured rat lymphocytes. To get differentially stained chromatid...

journal_title：Oncology

authors： Gloser H

更新日期：1982-01-01 00:00:00

abstract：:C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM stagin...

journal_title：Oncology

authors： Drahovsky D,Dunzendorfer U,Ziegenhagen G,Drahovsky M,Kellen JA

更新日期：1981-01-01 00:00:00

abstract：:Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-ph...

journal_title：Oncology

authors： Tímár J,Tóvári J,Rásó E,Mészáros L,Bereczky B,Lapis K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...

journal_title：Oncology

authors： Adamo V,Magno C,Spitaleri G,Garipoli C,Maisano C,Alafaci E,Adamo B,Rossello R,Scandurra G,Scimone A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...

journal_title：Oncology

authors： Kotsori AA,Dolly S,Sheri A,Parton M,Shaunak N,Ashley S,Walsh G,Johnston S,Smith IE

更新日期：2010-01-01 00:00:00

abstract：:To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...

journal_title：Oncology

authors： Cör A

更新日期：1999-07-01 00:00:00

abstract：:To evaluate the influence of delay between first symptom and first treatment upon survival the medical records of 596 patients with breast cancer were reviewed. The following intervals were considered: less than 3 months; 3-6 months and greater than 6 months. Patients in the less than 3 months delay group had a better...

journal_title：Oncology

authors： Machiavelli M,Leone B,Romero A,Perez J,Vallejo C,Bianco A,Rodriguez R,Estevez R,Chacon R,Dansky C

更新日期：1989-01-01 00:00:00

abstract：:A demonstration multiphasic cancer screening program was conducted in a rural village in Thailand under the coordination of Bangkok's National Cancer Institute. The village's physician, mayor, and other members of the community assumed a variety of volunteer roles in order to provide logistical support. In short, this...

journal_title：Oncology

authors： Lynch HT,Pitakspraiwan P,Sombooncharoen S,Phanthumchinda P,Vechmon U,Srivanwat G,Schutz RJ,Lynch JF

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:This open-label, randomized phase III trial evaluated larotaxel/cisplatin versus gemcitabine/cisplatin as first-line treatment for locally advanced (T4b) or metastatic urothelial tract or bladder cancer. METHODS:Patients were randomized to larotaxel 50 mg/m(2) with cisplatin 75 mg/m(2) every 3 weeks (larota...

journal_title：Oncology

authors： Sternberg CN,Skoneczna IA,Castellano D,Theodore C,Blais N,Voog E,Bellmunt J,Peters F,Le-Guennec S,Cerbone L,Risse ML,Machiels JP

更新日期：2013-01-01 00:00:00

abstract：:Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...

journal_title：Oncology

authors： Scheithauer W,Depisch D,Schiessel R,Ludwig H

更新日期：1989-01-01 00:00:00

abstract：:Lonidamine was studied in advanced cancer patients. The drug was given orally by single or repeated administrations. Single doses ranged from 150 to 450 mg. Repeated administrations were performed with progressively increasing doses: 450-900 mg daily. Lonidamine lacked severe toxic effects after both single and prolon...

journal_title：Oncology

authors： Barduagni A,Barduagni M,Di Lauro L,Nardi M,Gallo Curcio C,Tonachella R,Ciottoli GB,Delle Chiaie S

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:We investigated the efficacy of risk-adapted adjuvant paclitaxel/carboplatin chemotherapy in early-stage ovarian carcinoma. METHODS:Fifty-three patients were treated according to the risk of relapse: patients with stages IA or IB or with grade 1 (low risk) received 4 cycles of paclitaxel and carboplatin; pat...

journal_title：Oncology

authors： Bamias A,Bamia C,Karadimou A,Soupos N,Zagouri F,Rodolakis A,Haidopoulos D,Vlahos G,Thomakos N,Antsaklis A,Dimopoulos MA

更新日期：2011-01-01 00:00:00

abstract：:Culture-induced cytotoxic (CIC) activity developed in 7-day culture in the presence of fetal calf serum of pleural effusion lymphocytes from patients with lung cancer which initially showed markedly low or no natural killing (NK) activity against K562 cells. The development of CIC activity was proliferation-dependent....

journal_title：Oncology

authors： Uchida A,Micksche M

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply in...

journal_title：Oncology

authors： Petrelli F,Ardito R,Ghidini A,Zaniboni A,Ghidini M,Barni S,Tomasello G

更新日期：2018-01-01 00:00:00

abstract：:Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...

journal_title：Oncology

authors： Largillier R,Valenza B,Ferrero JM,Novo C,Creisson A,Lesbats G,Mari V,Hebert C,Chamorey E

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:New effective therapy is desirable for patients with non-small cell lung cancer (NSCLC) who have failed previous treatments. Fractionated administration of paclitaxel may be less toxic and more active against NSCLC. The aim of this study was to evaluate the activity and toxicity of weekly paclitaxel therapy f...

journal_title：Oncology

authors： Yasuda K,Igishi T,Kawasaki Y,Kato K,Matsumoto S,Katayama S,Sako T,Shigeoka Y,Suyama H,Sugitani A,Yamamoto M,Hitsuda Y,Shimizu E

更新日期：2004-01-01 00:00:00

abstract：:Empiric clinical trials have revealed new mechanisms by which hormonal therapies may exert their antitumor effects. Initial studies using escalated doses of agents like toremifene and megestrol acetate have yielded interesting results, showing responses in hormone-receptor-negative patients and in patients progressing...

journal_title：Oncology

authors： Abrams JS,Gutheil J,Aisner J

更新日期：1992-01-01 00:00:00

abstract：:The purpose of this study was to evaluate in a dog model whether intrapericardial instillation of tetracycline is superior to the effect of drainage alone in causing pericardial adhesions and cavity obliteration. Twelve mongrel dogs were randomly divided into two experimental groups. All dogs received a pericardial dr...

journal_title：Oncology

authors： Markiewicz W,Ben-Arieh Y,Best L,Mordochovich D,Rinkevitch D

更新日期：1993-11-01 00:00:00

abstract：:Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) w...

journal_title：Oncology

authors： Inuzuka T,Nishikawa H,Sekikawa A,Takeda H,Henmi S,Sakamoto A,Saito S,Kita R,Kimura T,Osaki Y,Kudo M

更新日期：2011-01-01 00:00:00

abstract：:The MXT mouse transplantable mammary cancer is characterized by significant amounts of steroid hormone receptors. Moreover this model, as other solid tumors, contains diverse subpopulations of neoplastic cells. In the present study we have examined this pattern as well as the influence of exogenous physiologic doses o...

journal_title：Oncology

authors： Kiss R,Leclercq G,Danguy A

更新日期：1985-01-01 00:00:00

abstract：:The paper presents the experience with watch-and-wait policy following radical surgery in 25 patients with primary gastric non-Hodgkin's (NH) lymphoma localized to the gastric wall. The median follow-up is at the moment 40 months (range 18-85). Only 3/25 patients have relapsed (during the first year of the follow-up) ...

journal_title：Oncology

authors： Jelić S,Kovcin V,Jovanović V,Oprić M,Milanović N

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVES:It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients. METHODS:Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of...

journal_title：Oncology

authors： Herrmann E,Bierer S,Gerss J,Köpke T,Hertle L,Wülfing C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Bevacizumab (Avastin) significantly improves overall survival (OS) and progression-free survival (PFS) when combined with first-line irinotecan (IFL) plus bolus 5-fluorouracil (5-FU) and leucovorin (LV) in patients with metastatic colorectal cancer (CRC). This open-label, phase IV trial evaluated the efficac...

journal_title：Oncology

authors： Sobrero A,Ackland S,Clarke S,Perez-Carrión R,Chiara S,Gapski J,Mainwaring P,Langer B,Young S,AVIRI Trial investigators.

更新日期：2009-01-01 00:00:00

abstract：:5-Azacytidine (NSC-102 816) was prepared synthetically and independently isolated from the culture filtrate of Streptoverticillium ladakanus. It is an s-triazine analogue of cytidine possessing a broad spectrum of biological effects. In mammalian tissueit is phosphorylated to 5-azacytidine 5-phosphates and incorporate...

journal_title：Oncology

authors： Cihák A

更新日期：1974-01-01 00:00:00

abstract：OBJECTIVE:Ovarian cancer is the most lethal gynecological malignancy, but information relevant to prognosis and outcomes remain unknown. Here, we used statistical methods to focus specifically on interactions between candidate prognostic variables. METHODS AND RESULTS:Univariate, multivariate, and elastic net modeling...

journal_title：Oncology

authors： Jatoi A,Vierkant RA,Hawthorne KM,Block MS,Ramus SJ,Larson NB,Fridley BL,Goode EL

更新日期：2016-01-01 00:00:00

abstract：:Chromosomal analysis of three human non-Hodgkin's lymphoma (NHL) xenografts revealed common extra 14q+ segment and other individual clonal markers without involvement of immunoglobulin light-chain regions. Two NHL xenografts (HT 58 and HT 130) showed restricted lambda light chain expression and deleted kappa and rearr...

journal_title：Oncology

authors： Kopper L,Bánkfalvi A,Földi J,Mihalik R,Magyar M,Aczél A

更新日期：1990-01-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used worldwide in cancer patients for over 1 year, and (only 5 years from the first publication on the clinical use of this growth factor) experience is rapidly accumulating in many oncological situations. Several randomized studies have confirme...

journal_title：Oncology

authors： Bronchud MH

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVES:The impact of ethnicity and the socioeconomic status (SES) among Caucasians is not well studied. Here, we examine the impact of income on melanoma presentation and prognosis within a Caucasian cohort, accounting for ethnicity, as some reports suggest increased melanoma incidence in Ashkenazi Jewish (AJ) BRCA...

journal_title：Oncology

authors： Salvaggio C,Han SW,Martires K,Robinson E,Madankumar R,Gumaste P,Polsky D,Stein J,Berman R,Shapiro R,Zhong J,Osman I

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will be helpful to understand the biological features of HER2-positive gastric cancer. METHODS:A total of 813 gastric cancer patients who underwent HER2 testing between January 2005 and December 2010 were included ...

journal_title：Oncology

authors： Park JS,Rha SY,Chung HC,Jung M,Kim KH,Jun HJ,Kim H,An JY,Kim HI,Cheong JH,Hyung WJ,Noh SH,Kim HS

更新日期：2015-01-01 00:00:00

abstract：:To clarify the inhibitory effect of telomere-mimic oligonucleotides on human cancer cell lines, we synthesized 18-mers (18T; n = 3), 24-mers (24T; n = 4) and 30-mers (30T; n = 5) of telomere-mimic phosphorothioate oligodeoxy nucleotides [5'-d(TTA GGG)n-3'] and examined their effects on the proliferation of human tumor...

journal_title：Oncology

authors： Saeki T,Takashima S,Tachibana M,Koga M,Hiyama E,Salomon DS,Holland JF,Ohnuma T

更新日期：1999-10-01 00:00:00