Abstract:
:5-Azacytidine (NSC-102 816) was prepared synthetically and independently isolated from the culture filtrate of Streptoverticillium ladakanus. It is an s-triazine analogue of cytidine possessing a broad spectrum of biological effects. In mammalian tissueit is phosphorylated to 5-azacytidine 5-phosphates and incorporated into different species of RNAs and into DNA. 5-Azacytidine 5-monophosphate inhibits orotidine 5-phosphate decarboxylase blocking thus the de novo pyrimidine synthesis. Following the administration of 5-azacytidine a rapid breakdown of liver polyribosomes has been observed; furthermore, in different systems a profound inhibitory effect of the drug on the maturation of ribosomal RNA has been found. 5-Azacytidine interferes with different induced liver enzymes; in some cases their activity is elevated since the rate of enzyme degradation is decreased. The cytostatic effect of the drug is directed primarily against lymphatic leukemia although some recent reports indicate its action also against human solid tumours. Chemotherapy of leukemic mice by 5-azacytidine results simultaneously in the depressed synthesis of liver and spleen polyamines. 5-Azacytidine exhibits furthermutagenic, abortive, immunosuppressive, antimitotic, radioprotective and virostatic effects. The drug also affects DNA and protein synthesis in embryonic tissues, cells intissue culture, regenerating livers, in bacteria and phages. The changes associated with the emergence of resistance towards 5-azacytidine are associated with the decreased activity of uridine kinase in mouse leukemia cells. On the contrary, in adult rate livers5-azacytidine administration leads to the increased activity of this enzyme. Differentauthors have used 5-azacytidine as a tool for the study of biochemical mechanisms connected with a cell proliferation and division.
journal_name
Oncologyjournal_title
Oncologyauthors
Cihák Adoi
10.1159/000224981subject
Has Abstractpub_date
1974-01-01 00:00:00pages
405-22issue
5eissn
0030-2414issn
1423-0232journal_volume
30pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333279
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To assess whether the use of an organ-specific treatment could improve event-free survival (EFS) and overall survival as endpoints in testicular lymphoma in the early stage: IE and IIE. METHODS:Thirty-four patients were selected to be treated with orchiectomy following six cycles of anthracycline-based comb...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000081319
更新日期:2004-01-01 00:00:00
abstract::The relationship of vitamins to cancer is very complex. Three types of interactions are possible: the effect of vitamins on tumor growth, the effect of tumors on vitamin metabolism, and the effect of vitamins on chemical carcinogens and anti-tumor chemotherapeutic agents. The significance of vitamins with particular r...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000225139
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:New effective therapy is desirable for patients with non-small cell lung cancer (NSCLC) who have failed previous treatments. Fractionated administration of paclitaxel may be less toxic and more active against NSCLC. The aim of this study was to evaluate the activity and toxicity of weekly paclitaxel therapy f...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000079481
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of neoadjuvant treatment comprising weekly high-dose 5-fluorouracil (5-FU) as a 24-hour infusion, folinic acid (FA) and biweekly oxaliplatin (L-OHP), followed by metastatic resection in patients with primarily resectable liver metastases of colorectal cancer (CRC). PATIENTS ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000067772
更新日期:2003-01-01 00:00:00
abstract::ACNU was highly effective for Sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of ACNU for SLC showed clear dependence upon tumor size. Nonspecific activation of host-defence mechanism by Propionibacterium acnes contributed to the suppression for ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225309
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC). METHODS:Nine previously reported predictive markers for liver metastasis and/or prognosis (COX-2, dysadherin, E-cadherin, beta-catenin, Ki-67, p53, laminin5gamma2, matrilysin and MUC...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151667
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The pretreatment neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been reported to be useful as markers for prognostic factors and metastasis in several cancers. The aim of this study was to identify the predictor of lymph node (LN) metastasis by pretreatment NLR and PLR in...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000497184
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. OBJECTIVE:We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. METHODS:We retrospectively examined 649 consecutive patients with HCC who underwent curative...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000477173
更新日期:2017-01-01 00:00:00
abstract::This paper presents clinical observations on 130 patients with carcinoma of the pancreas, including 19 with periampullary cancer, the first large study of this disease in Iraq. All of the patients were admitted to the First (one of three) Surgical Unit of the University of Baghdad Teaching Hospital (the Medical City) ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225670
更新日期:1982-01-01 00:00:00
abstract::The expression of the drug resistance markers P glycoprotein (P-170), glutathione S transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) was analyzed in 16 human kidney carcinoma cell lines, 18 hematological malignancies, and 14 human breast carcinomas. We found a tendency for coexpression of increased P-170 and...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227075
更新日期:1992-01-01 00:00:00
abstract::In 12 patients with gastric cancer and in 14 with large bowel neoplasia, classified according to the TNM system, some major blood indices of hemostasis, platelet activation and fibrinolysis were assessed before and for 1 month after surgery, to show whether possible variations of such indices may provide useful clues ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226828
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:Angiogenesis plays an important role in ovarian cancer. The interaction of platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth factor (VEGF) in the process of angiogenesis may represent an essential feature in the progression of the disease. METHODS:Patients with epitheli...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000351032
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:We performed a pilot study to evaluate the effect of the high-dose gemcitabine-cisplatin combination in a brief weekly regimen in the treatment of primary refractory diffuse large cell lymphoma with high or high-intermediate clinical risk. METHODS:Thirty patients refractory to first-line anthracycline-based ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000077995
更新日期:2004-01-01 00:00:00
abstract::Studies were made of the therapeutic response of six human colorectal tumor lines serially transplanted in immunosuppressed mice. The tumors with adenomatous structure showed greater sensitivity against different cytotoxic agents than the gelatinous ones. Among the drugs, 5-FU, BCNU and MeCCNU proved to be the most ef...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225496
更新日期:1980-01-01 00:00:00
abstract::A number of therapeutic agents including L-asparaginase, Actinomycin-D, CCNU, Hydroxyurea, 5-FU, Cis-platinum, Cyclophosphamide, orchiectomy, Adriamycin and DES alone and in various combinations has been applied against the Dunning R-3327 rat prostatic adenocarcinoma subline G. We have found a parallel between the res...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225202
更新日期:1977-01-01 00:00:00
abstract::In order to assess the feasibility of a sequential hormonal treatment after tamoxifen failure, 24 postmenopausal advanced breast cancer patients (median age 60 years; ECOG PS < or = 1) were treated with formestane (4-hydroxyandrostenedione) 250 mg i.m. fortnightly; 19 patients were estrogen receptor-positive. The site...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227510
更新日期:1995-11-01 00:00:00
abstract::In a registry of 24,105 cancers, 15 patients were found to have three primary cancers in different organs. Decreasing time intervals between sequential diagnoses and then death were noted. Occurrence and sequence of cancer sites appeared to be random. Stage of second and third cancers tended, on the average, to be mor...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225051
更新日期:1975-01-01 00:00:00
abstract::After nearly four decades of clinical experience with the fluoropyrimidines, 5-fluorouracil (5-FU) remains an integral part of chemotherapy for colorectal cancer. A range of 5-FU treatment regimens with or without biochemical modulation are currently used and toxicity appears to be schedule dependent. The use of oral ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000055262
更新日期:1999-07-01 00:00:00
abstract::The diagnostic imaging of hepatocellular carcinoma (HCC) has recently undergone marked progress. The advent of the ultrasound (US) contrast agent Sonazoid, approved in January 2007, and magnetic resonance imaging (MRI) with the liver-specific MRI contrast agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic ac...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000333265
更新日期:2011-01-01 00:00:00
abstract::CA 19-9 and tissue polypeptide antigen (TPA) were determined in the sera of 28 control subjects, 29 patients with pancreatic cancer, 26 with chronic pancreatitis and 62 with benign and malignant extra pancreatic diseases in order to compare their usefulness in diagnosing pancreatic cancer, to verify whether the combin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226525
更新日期:1988-01-01 00:00:00
abstract::To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011995
更新日期:1999-07-01 00:00:00
abstract:PURPOSE:Patient nonadherence to oral antineoplastic therapy is a well-recognized barrier to effective treatment. In order to identify patients who may need additional support to become adherent, it is important to have a useful tool that takes into account all the parameters of adherence to prescription. The aim of thi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000342087
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Anaplastic oligodendrogliomas (AO) are uncommon primary brain tumors whose natural history, prognosis, and optimal management are not yet fully understood. However, they are associated with a better prognosis and response to multimodality therapy based on specific molecular changes. In this multicenter retro...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000074479
更新日期:2003-01-01 00:00:00
abstract::Mice of four different inbred strains (CBA, Balb/c, C57Bl/6 and DBA/2), bearing different transplanted tumours (methylcholanthrene-induced sarcomas, B16 melanoma and P-815 mastocytoma), were tested for cellular immune reactivity to the synthetic encephalitogenic peptide of human myelin basic protein by the leucocyte a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225732
更新日期:1983-01-01 00:00:00
abstract::Etoposide is a highly schedule-dependent agent. We previously reported that a 21-day schedule of oral etoposide had good activity in small cell lung cancer (SCLC). The current phase II study was designed to test the combination of 21-day oral etoposide with cisplatin in hopes of capitalizing on etoposide's schedule de...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227108
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial. METHODS:The aim of this pilot study was to assess the feasibility of postoperative combination chemotherapy followed by radiotherapy in patients aged 18-70 years with a histological diagnosis of PA, and Karnofsky perf...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000086780
更新日期:2005-01-01 00:00:00
abstract::38 of 306 patients survived beyond 5 years after resection of an exocrine pancreatic carcinoma during a period from 1971 to 1993. Amongst the long-term survivors there were 12 patients with ductal, 22 with ampullary, 3 with distal bile duct and 1 with duodenal cancer. An active operative strategy was employed in order...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227488
更新日期:1995-09-01 00:00:00
abstract::Malignant gastrointestinal neuroectodermal tumor (GNET) is an aggressive rare tumor, primarily occurring in young adults with frequent local-regional metastases and recurrence after local control. The tumor is characterized by the presence of EWSR1-ATF1 or EWSR1-CREB1 and immunohistochemical positivity for S-100 prote...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000449204
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. M...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000458529
更新日期:2017-01-01 00:00:00