Abstract:
:A number of therapeutic agents including L-asparaginase, Actinomycin-D, CCNU, Hydroxyurea, 5-FU, Cis-platinum, Cyclophosphamide, orchiectomy, Adriamycin and DES alone and in various combinations has been applied against the Dunning R-3327 rat prostatic adenocarcinoma subline G. We have found a parallel between the results of this study and those of similar therapeutic application to the human tumor. We conclude that this animal model may prove to be a useful screening system for agents against human prostatic cancer.
journal_name
Oncologyjournal_title
Oncologyauthors
Block NL,Camuzzi F,Denefrio J,Troner M,Claflin A,Stover B,Politano VAdoi
10.1159/000225202subject
Has Abstractpub_date
1977-01-01 00:00:00pages
110-3issue
3eissn
0030-2414issn
1423-0232journal_volume
34pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::In 12 patients with gastric cancer and in 14 with large bowel neoplasia, classified according to the TNM system, some major blood indices of hemostasis, platelet activation and fibrinolysis were assessed before and for 1 month after surgery, to show whether possible variations of such indices may provide useful clues ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226828
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify biomarkers for predicting the efficacy of docetaxel, cisplatin, and S-1 (DCS) therapy for advanced gastric cancer using microarrays of biopsy specimens before chemotherapy. METHODS:Nineteen samples were taken from 19 patients with unresectable metastatic gastric cancer ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000464329
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES AND METHODS:The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the co...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000069308
更新日期:2003-01-01 00:00:00
abstract::This paper presents clinical observations on 130 patients with carcinoma of the pancreas, including 19 with periampullary cancer, the first large study of this disease in Iraq. All of the patients were admitted to the First (one of three) Surgical Unit of the University of Baghdad Teaching Hospital (the Medical City) ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225670
更新日期:1982-01-01 00:00:00
abstract::Empiric clinical trials have revealed new mechanisms by which hormonal therapies may exert their antitumor effects. Initial studies using escalated doses of agents like toremifene and megestrol acetate have yielded interesting results, showing responses in hormone-receptor-negative patients and in patients progressing...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227121
更新日期:1992-01-01 00:00:00
abstract::High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227119
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China and, due to the limited efficacy of currently available therapies, is responsible for a large number of deaths. IFN-alpha therapy has shown promise in the treatment of various forms of human cancer and is considered in the trea...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000082928
更新日期:2004-01-01 00:00:00
abstract::Ifosfamide is one of the best-known alkylating agents. In advanced epithelial ovarian cancer, it has been tested in association with cisplatin, achieving results equal, if not better than cyclophosphamide, with acceptable toxicity. In second-line therapy, it shows remarkable activity, even in patients refractory to ci...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000073361
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Cancer patients have a higher risk for thrombosis that is usually related to advanced stage and poor prognosis. This study aimed to identify the clinical picture and outcome of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients with pulmonary embolism (PE). PATIENTS AND METHODS:Fr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000229503
更新日期:2009-01-01 00:00:00
abstract::The present communication reports data on the lipid biosynthesis of Ehrlich ascites tumor cells grown in culture media supplemented with modified sera. Whereas the metabolisms of [14C]pyruvate and [14C]mevalonate are identical in all media tested, the incorporation of [14C] acetate is higher in medium with dialyzed se...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225321
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. METHODS:A total of 36 pa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000487081
更新日期:2018-01-01 00:00:00
abstract::Aromatase inhibitor (AI) is widely used as an endocrine treatment in postmenopausal patients with hormone receptor-positive breast cancer. To identify useful prognostic factors for patients with metastatic breast cancer treated with AI therapy, we investigated the association between several hormone receptor-related f...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000319540
更新日期:2010-01-01 00:00:00
abstract::Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000066198
更新日期:2002-01-01 00:00:00
abstract::23 patients received cis-platinum, doxorubicin and cyclophosphamide for gynecologic malignancy between December 1, 1980 and December 1, 1982. Each patient was randomized with each course of chemotherapy to receive intravenous droperidol or the combination of promethazine and chlorpromazine rectal suppositories as an a...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000225997
更新日期:1985-01-01 00:00:00
abstract::Originally referred to as 'lymphoepithelioma', undifferentiated and poorly differentiated nasopharyngeal carcinoma (NPC) tissues showed intense lymphoinfiltration. In a study of cryosections from 15 NPC tissues, we found that infiltrating lymphoid elements were comprised predominantly of lymphocytes, but plasma cells,...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226945
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Ovarian cancer is the most lethal gynecological malignancy, but information relevant to prognosis and outcomes remain unknown. Here, we used statistical methods to focus specifically on interactions between candidate prognostic variables. METHODS AND RESULTS:Univariate, multivariate, and elastic net modeling...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000442710
更新日期:2016-01-01 00:00:00
abstract::The expression of the drug resistance markers P glycoprotein (P-170), glutathione S transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) was analyzed in 16 human kidney carcinoma cell lines, 18 hematological malignancies, and 14 human breast carcinomas. We found a tendency for coexpression of increased P-170 and...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227075
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES AND METHODS:Tumor dormancy and resistance to cytotoxic agents are key limiting events in the treatment of malignant diseases. To determine whether both are influenced by the extracellular milieu in which tumors reside, HT1080 human fibrosarcoma, MCF-7 breast carcinoma and OSCORT osteosarcoma cell proliferati...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055329
更新日期:2001-01-01 00:00:00
abstract::The antiemetic effect of oral medium-dosed metoclopramide (MCL, 3.5 mg/kg b.w./cycle) and placebo for chemotherapy-induced emesis of a noncisplatin regimen was assessed for inpatients and outpatients in two double-blind placebo-controlled sequential analyses according to Bross (1952). MCL was given in 5 single doses o...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227153
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:The role of Interleukin-2 (IL-2)-based biochemotherapy (BCT) for patients with metastatic melanoma remains controversial and few data of patients treated outside a specialized trial setting are available. METHODS:Sixty-six consecutive patients treated with BCT for stage IV melanoma were analyzed retrospecti...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000120029
更新日期:2007-01-01 00:00:00
abstract::Vascular endothelial growth factor C (VEGF-C) is considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we clarified the clinicopathological features of early gastric carcinoma (EGC) that has metastasized to the lymph nodes, as well as the corre...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000055312
更新日期:2001-01-01 00:00:00
abstract::Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226719
更新日期:1989-01-01 00:00:00
abstract::Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011932
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The survival rate of patients with lung cancer has increased significantly over the years, but there has been no further progress in third- or fourth-line therapy. We investigated the efficacy and tolerability of monotherapy with weekly vinorelbine, a semi-synthetic vinca alkaloid, in advanced non-small-cell...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000502343
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Our aim is to assess the clinicopathological significance of E-cadherin and beta-catenin expression, as well as their association with apoptosis in gallbladder cancers. METHODS:The expression of E-cadherin and beta-catenin proteins was examined in 4 biliary tract cancer cell lines and 49 gallbladder cancer s...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000100478
更新日期:2006-01-01 00:00:00
abstract::Ifosfamide is relatively well tolerated but it can be associated occasionally with life-threatening complications such as arrhythmias and heart failure, severe encephalopathy and hemorrhagic cystitis. Mesna administration can control the urothelial toxicity of ifosfamide, but it is without effect on the other complica...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000073351
更新日期:2003-01-01 00:00:00
abstract::As TS-1 and docetaxel (TXT) have different mechanisms of antitumor activity, the combination therapy is expected to have a higher response. Human gastric cancer xenografts SC-2, St-40, and SC-4 inoculated into nude rats were treated with TS-1 alone (TS-1 12 mg/kg/day, day 1-14), TXT alone (TXT 2 mg/kg/day, day 1 or da...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000086767
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:We investigated whether a 5-fluorouracil (5-FU)-resistant tumor could regain chemosensitivity after the administration of 5-aza-2'-deoxycytidine (DAC) as a demethylating agent. METHODS:Human colorectal cancer cells (SW48) are characterized by the hypermethylation of proapoptotic genes. They were transplanted i...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000107110
更新日期:2006-01-01 00:00:00
abstract::Lonidamine was studied in advanced cancer patients. The drug was given orally by single or repeated administrations. Single doses ranged from 150 to 450 mg. Repeated administrations were performed with progressively increasing doses: 450-900 mg daily. Lonidamine lacked severe toxic effects after both single and prolon...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225891
更新日期:1984-01-01 00:00:00
abstract::The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high alpha-fetoprotein level, large size, high...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012140
更新日期:2000-06-01 00:00:00