Immunohistochemical detection of P glycoprotein, glutathione S transferase and DNA topoisomerase II in human tumors.

abstract：BACKGROUND/AIM:Erlotinib and chemotherapy have shown similar efficacy for pretreated non-small cell lung cancer (NSCLC) patients, but none of the large studies have selected patients based on histology. We present a retrospective single-center series of advanced non-squamous NSCLC patients treated with erlotinib or pem...

journal_title：Oncology

authors： Zugazagoitia J,Puente J,González-Larriba JL,Manzano A,Sotelo M,Hernández S,Sanz J,Pérez P,Díaz-Rubio E

更新日期：2013-01-01 00:00:00

abstract：:Ifosfamide is one of the best-known alkylating agents. In advanced epithelial ovarian cancer, it has been tested in association with cisplatin, achieving results equal, if not better than cyclophosphamide, with acceptable toxicity. In second-line therapy, it shows remarkable activity, even in patients refractory to ci...

journal_title：Oncology

authors： Lissoni AA,Fei F,Rossi R,Fruscio R,Villa A,Zani G

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prostate carcinoma models and the molecular/cellular basis of its activity. ...

journal_title：Oncology

authors： Supino R,Polizzi D,Pavesi R,Pratesi G,Guano F,Capranico G,Palumbo M,Sissi C,Richter S,Beggiolin G,Menta E,Pezzoni G,Spinelli S,Torriani D,Carenini N,Dal Bo L,Facchinetti F,Tortoreto M,Zunino F

更新日期：2001-01-01 00:00:00

abstract：:We examined the expression of p16, the CDKN2A gene product, in EBV-associated gastric carcinomas (EBV-GCs). EBV-GCs were identified by detecting EBV-encoded small RNA (EBER) using an in situ hybridization assay of paraffin-embedded tissue. Two non-EBV-GC cases for each EBV-GC case were selected, matched for age, sex, ...

journal_title：Oncology

authors： Koriyama C,Kitajima S,Nomoto M,Sueyoshi K,Itoh T,Eizuru Y,Yonezawa S,Akiba S

更新日期：2004-01-01 00:00:00

abstract：:Thermochemosensitivity was examined in vitro by a human tumor clonogenic assay (HTCA) using specimens obtained surgically from 43 patients with colorectal cancer. We found that the percentages of patients whose cells showed higher sensitivity (greater than 70% inhibition of colony formation) to hyperthermia alone were...

journal_title：Oncology

authors： Murakami A,Koga S,Maeta M

更新日期：1988-01-01 00:00:00

abstract：:Various oncogenic agents were employed in tumor susceptibility studies of an inbred subline of BALB/cGn mice, BALB/cGnDu, which carries a mutant gene that results in spontaneous thymic involution in homozygous recessive individuals. Of 18 transplantable tumors, 3 in vitro transformed cell lines, 2 oncogenic papovaviru...

journal_title：Oncology

authors： Morrison DG,Moyer MP,Lynd FT,Rogers W,Moyer RC

更新日期：1982-01-01 00:00:00

abstract：:We have studied the effect of butyrate on mammary tumorigenesis by 7,12-dimethylbenz(a)anthracene. As reported previously, a high incidence of mammary tumors was observed in rats fed a basal diet containing 20% margarine. However, the enhancing effect of margarine was inhibited when sodium butyrate was supplemented in...

journal_title：Oncology

authors： Yanagi S,Yamashita M,Imai S

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Whether recurrence after surgery and primary metastatic pancreatic cancer should be included in the same category when conducting gemcitabine-based clinical trials remains controversial. OBJECTIVE:To clarify the outcomes of recurrent and metastatic pancreatic cancers. METHODS:326 patients who received gemc...

journal_title：Oncology

authors： Hashimoto K,Ueno H,Ikeda M,Kojima Y,Hagihara A,Kondo S,Morizane C,Okusaka T

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:ETS-1 has been identified as a proto-oncogene and a transcription factor for tumor angiogenesis, which is essential for the growth, invasion and metastasis of solid tumors. The aim is to investigate the clinical implications of ETS-1 expression in peritoneal metastatic lesions of ovarian cancers. METHODS:In ...

journal_title：Oncology

authors： Fujimoto J,Aoki I,Toyoki H,Khatun S,Sato E,Sakaguchi H,Tamaya T

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Cisplatin-pemetrexed combination chemotherapy is the current standard primary treatment for malignant pleural mesothelioma (MPM). It was first approved for untreated and unresectable MPM in the 2003 National Comprehensive Cancer Network (NCCN) guidelines. However, to date, standard treatments for patients wi...

journal_title：Oncology

authors： Koda Y,Kuribayashi K,Doi H,Kitajima K,Nakajima Y,Ishigaki H,Nakamura A,Minami T,Takahashi R,Yokoi T,Kijima T

更新日期：2020-10-14 00:00:00

abstract：:We report a rare case of a patient with an intrasplenic malignant fibrous histiocytoma (MFH) and chronic myelogenous leukemia. The neoplasms were synchronous in their onset and evolution. The peculiarity of the primary site of the MFH, the genetic implications of multiple primary tumors in a single patient, and the co...

journal_title：Oncology

authors： Bonilla F,Provencio M,Fernandez E,España P

更新日期：1994-09-01 00:00:00

abstract：:The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...

journal_title：Oncology

authors： Allgayer H,Babic R,Beyer BC,Grützner KU,Tarabichi A,Schildberg FW,Heiss MM

更新日期：1998-03-01 00:00:00

abstract：:Rapid advances in our understanding of the biology and pathology of lymphoproliferative disorders, permitted mainly by new diagnostic tools, constantly change our approach to this heterogenous group of disorders. In this review of the more indolent subgroup of lymphoproliferative disorders, some of the recent advances...

journal_title：Oncology

authors： Eek R,Falkson G

更新日期：1997-11-01 00:00:00

abstract：:We have measures serial carcinoembryonic antigen (CEA) titers in 92 patients, randomly selected from the patient population of a Radiotherapeutic Clinic, to correlate with clinical and follow-up evaluation. 57 out of 92 patients had positive CEA levels (2.5 ng/ml) or 62 percent of proven cancer patients. In this serie...

journal_title：Oncology

authors： Vider M,Kashmiri R,Hunter L,Moses B,Meeker WR,Utley JF,Maruyama Y

更新日期：1974-01-01 00:00:00

abstract：OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...

journal_title：Oncology

authors： Ito Y,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Gemcitabine monotherapy is the cornerstone of the treatment of patients suffering from advanced pancreatic cancer (PC). For a few years, new chemotherapeutic agents and combinations have been under validation. The use of such treatment makes it necessary to determine factors that could predict survival time....

journal_title：Oncology

authors： Maréchal R,Demols A,Gay F,De Maertelaere V,Arvanitaki M,Hendlisz A,Van Laethem JL

更新日期：2007-01-01 00:00:00

abstract：:Three polycyclic hydrocarbons: benzo(a)pyrene; dibenz(a,h)-anthracene and dibenz(a,c)anthracene, differing in their carcinogenicity, were administered to female rats. The comparative intracellular localization of these compounds was studied by fluorescence microscopy. The two carcinogenic molecules were localized both...

journal_title：Oncology

authors： Stora C

更新日期：1980-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer is one of the leading causes of death worldwide and is the result of dysregulation of various signaling pathways in mammary epithelial cells. The mortality rate in patients suffering from breast cancer is high because the tumor cells have a prominent invasive capacity towards the surrounding ...

journal_title：Oncology

authors： González-González L,González-Ramírez R,Flores A,Avelino-Cruz JE,Felix R,Monjaraz E

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Breast cancer (BC) is the most frequent female carcinoma and the major cause of death in women aged 35--50 years. The total number of patients surviving BC and especially the morbidity rate of patients below the age of 55 years has increased significantly in the last several years. As a consequence, the number ...

journal_title：Oncology

authors： Beckmann MW,Jap D,Djahansouzi S,Nestle-Krämling C,Kuschel B,Dall P,Brumm C,Bender HG

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES AND METHODS:Tumor dormancy and resistance to cytotoxic agents are key limiting events in the treatment of malignant diseases. To determine whether both are influenced by the extracellular milieu in which tumors reside, HT1080 human fibrosarcoma, MCF-7 breast carcinoma and OSCORT osteosarcoma cell proliferati...

journal_title：Oncology

authors： Pogány G,Timár F,Oláh J,Harisi R,Polony G,Paku S,Bocsi J,Jeney A,Laurie GW

更新日期：2001-01-01 00:00:00

abstract：:C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM stagin...

journal_title：Oncology

authors： Drahovsky D,Dunzendorfer U,Ziegenhagen G,Drahovsky M,Kellen JA

更新日期：1981-01-01 00:00:00

abstract：:Twenty-seven patients with advanced measurable colorectal carcinoma were treated with a combination protocol consisting of folinic acid (FA) 200 mg/m2 i.v. bolus followed by 5-fluorouracil (5-FU) 550 mg/m2, and cisplatin (CIS) 20 mg/m2 each administered as a 2-hour i.v. infusion. Treatment was given on 4 consecutive d...

journal_title：Oncology

authors： Scheithauer W,Depisch D,Schiessel R,Ludwig H

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays an important role in ovarian cancer. The interaction of platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth factor (VEGF) in the process of angiogenesis may represent an essential feature in the progression of the disease. METHODS:Patients with epitheli...

journal_title：Oncology

authors： Mathey S,Graeser MK,Zu Eulenburg C,Woelber L,Trillsch F,Jaenicke F,Müller V,Milde-Langosch K,Mahner S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:We evaluated the efficacy and safety of bolus 5-fluorouracil (5-FU) and leucovorin combined with weekly paclitaxel (FLTAX) in advanced gastric cancer (GC) patients. METHODS:Patients with untreated stage IV GC received paclitaxel 80 mg/m(2) as a 1-hour infusion, followed by 5-FU 600 mg/m(2) as a bolus infusio...

journal_title：Oncology

authors： Matsubara J,Shimada Y,Kato K,Nagai Y,Iwasa S,Nakajima TE,Hamaguchi T,Yamada Y,Takagi S,Kobayashi K,Yoshioka A,Nakayama N,Tsuji A

更新日期：2011-01-01 00:00:00

abstract：:Chemotherapy-induced peripheral neurotoxicity is a major problem because it represents the dose-limiting side effect of a significant number of antineoplastic drugs, such as vinca alkaloids. Hereditary neuropathies usually predispose to severe vincristine neurotoxicity. Here, we report the case of a 56-year-old man wi...

journal_title：Oncology

authors： Colpo A,Wilson FH,Nardi V,Hochberg E

更新日期：2012-01-01 00:00:00

abstract：:An antiserum to human melanoma antigens was obtained from a melanoma patient after immunization with autologous irradiated cultured melanoma cells and bacillus Calmette-Guerin. Using the microcomplement fixation assay, the antiserum, at a titer of 1/1,800, was noted to bind strongly with 7 of 10 allogeneic cultured hu...

journal_title：Oncology

authors： Leong SP,Cooperband SR,Deckers PJ,Sutherland CM,Fried RM,Krementz ET

更新日期：1983-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) has been shown to be highly responsive to chemotherapy. The major limiting toxicity was myelotoxicity. Recently, the role of granulocyte colony-stimulating factor (G-CSF) in reducing chemotherapy-induced neutropenic sepsis has been well established. In this study, we tested whether recom...

journal_title：Oncology

authors： Wang CH,Wang HM,Chen JS,Chang WJ,Lai GM

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:New effective therapy is desirable for patients with non-small cell lung cancer (NSCLC) who have failed previous treatments. Fractionated administration of paclitaxel may be less toxic and more active against NSCLC. The aim of this study was to evaluate the activity and toxicity of weekly paclitaxel therapy f...

journal_title：Oncology

authors： Yasuda K,Igishi T,Kawasaki Y,Kato K,Matsumoto S,Katayama S,Sako T,Shigeoka Y,Suyama H,Sugitani A,Yamamoto M,Hitsuda Y,Shimizu E

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression by regulating DNA repair, cell division and apoptosis. One major function of wild-type p53 is to control the onset of DNA replication at the G1-S boundary by inducing p21 protein, which promotes cell cycle arrest b...

journal_title：Oncology

authors： Okuyama T,Maehara Y,Kabashima A,Takahashi I,Kakeji Y,Sugimachi K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Immuno-oncological (IO) therapies such as PD-1 and PD-L1 antibodies have been introduced in the treatment of advanced non-small cell lung cancer (NSCLC) since 2015 based on randomized trials showing unprecedented advantages in overall survival (OS) with hazard ratios (HRs) between 0.5 and 0.7. The impact of ...

journal_title：Oncology

authors： Faehling M,Kopp M,Schwenk B,Fallscheer S,Kramberg S,Eckert R

更新日期：2019-01-01 00:00:00