Abstract:
INTRODUCTION:Breast cancer is one of the leading causes of death worldwide and is the result of dysregulation of various signaling pathways in mammary epithelial cells. The mortality rate in patients suffering from breast cancer is high because the tumor cells have a prominent invasive capacity towards the surrounding tissues. Previous studies carried out in tumor cell models show that voltage-gated ion channels may be important molecular actors that contribute to the migratory and invasive capacity of the tumor cells. METHODS:In this study, by using an experimental strategy that combines cell and molecular biology assays with electrophysiological recording, we sought to determine whether the voltage-dependent sodium channel NaV1.5 regulates the migratory capacity of the human breast cancer cell line MDA-MB 231, when cells are maintained in the presence of epidermal growth factor (EGF), as an inductor of the epithelial-mesenchymal transition. RESULTS:Our data show that EGF stimulates the migratory capacity of MDA-MB 231 cells, by regulating the functional expression of NaV1.5 channels. Consistent with this, the stimulatory actions of the growth factor were prevented by the use of tetrodotoxin, an Na+ channel selective blocker, as well as by resveratrol, an antioxidant that can also affect Na+ channel activity. DISCUSSION:The understanding of molecular mechanisms, such as the EGF pathway in the progression of breast cancer is fundamental for the design of more effective therapeutic strategies for the disease.
journal_name
Oncologyjournal_title
Oncologyauthors
González-González L,González-Ramírez R,Flores A,Avelino-Cruz JE,Felix R,Monjaraz Edoi
10.1159/000501802subject
Has Abstractpub_date
2019-01-01 00:00:00pages
373-382issue
6eissn
0030-2414issn
1423-0232pii
000501802journal_volume
97pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::The historical aspects of drug development and evaluation are anecdotically related. Clinical trials have proven the effectiveness of animal tests in the vast majority of cases, and the effort has been well spent. Similar of more noteworthy success may be obtainable with model systems in the study of prostatic cancer....
journal_title:Oncology
pub_type: 历史文章,杂志文章
doi:10.1159/000225197
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS). METHODS:Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyz...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000492597
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Brain metastases develop frequently in patients with non-small cell lung cancer (NSCLC), and the prognosis for these patients is very poor. We evaluated the role of chemotherapy for patients with brain metastases from NSCLC. METHODS:We analyzed 30 patients who were discovered to have brain metastases during...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012185
更新日期:2000-11-01 00:00:00
abstract::The prognosis of brain glioblastoma is still very poor and the median survival time is generally less than 6 months. At present, no chemotherapy has appeared to influence its prognosis. On the other hand, recent advances in brain tumor biology have suggested that brain tumor growth is at least in part under a neuroend...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227533
更新日期:1996-01-01 00:00:00
abstract::Primary pancreatic lymphoma (PL) is an extremely rare disease, and large-scale studies are rarely performed even in Western countries, in which all cases of PL reported to date were of the B-cell type. Little information regarding PL is available in Japan. Nineteen cases of PL were collected through a nationwide study...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000058528
更新日期:2001-01-01 00:00:00
abstract::The local immunologic phenomena in the thyroid gland of 16 patients with chronic lymphocytic thyroiditis (CLTH) were investigated; 5 of these cases were associated with thyroid non-Hodgkin's lymphomas (NHL). All patients were admitted because of struma, growing slowly in patients with CLTH alone and rapidly in those w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226897
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:Recently, it has been reported that expression of the HRK gene was significantly reduced by hypermethylation in astrocytic tumors. Our aim is to verify the alterations in the HRK gene in primary central nervous system lymphomas (PCNSLs). METHODS:We analyzed the hypermethylation status and expression of the ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000094322
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Serrated adenoma (SA) consists of glands both with intraluminal projection of tall columnar cells, which resemble the terminally differentiated cells in the surface epithelium, and with concave short cells, which resemble progenitor crypt cells of the colon. The aim of this study was to clarify the relationsh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151359
更新日期:2008-01-01 00:00:00
abstract::Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and di...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000215581
更新日期:2009-01-01 00:00:00
abstract::Our previous trial with a docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen showed high response rates in metastatic squamous cell carcinoma of the esophagus (SCCE). The observed increased toxicity of the DCF regimen, however, was clinically harmful. S-1, an oral anticancer drug, has been approved as a combinatio...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000488861
更新日期:2018-01-01 00:00:00
abstract::Persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC). One of the characteristics of HCV infection is the unusual augmentation of oxidative stress, which is exacerbated by iron accumulation in the liver, as observed frequently in hepatitis C patients. U...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000333253
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial. METHODS:The aim of this pilot study was to assess the feasibility of postoperative combination chemotherapy followed by radiotherapy in patients aged 18-70 years with a histological diagnosis of PA, and Karnofsky perf...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000086780
更新日期:2005-01-01 00:00:00
abstract::The best treatment for primary gastric lymphomas (PGL) has not yet been defined. Eighty-three patients with stage I/II PGL are documented, focusing on prognostic factors, treatment-related morbidity and mortality, and therapeutic outcome. Chemotherapy improved survival in comparison to local treatments, i.e. gastrecto...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011978
更新日期:1999-01-01 00:00:00
abstract::Aberrant glycosylation of membrane components due to specific alterations of glycosyltransferase activity is a common feature of carcinoma cells and is usually associated with invasion and metastasis. In a prospective study, the enzyme activity of the sialyltransferases ST6GAL-I and ST3GAL-III was studied in gastric c...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000072339
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The prognosis of patients with locally advanced squamous cell carcinoma (SCC) of the tongue is poor. Postoperative chemoradiotherapy (CRT) improves locoregional control and survival in high-risk patients. We investigated the prognostic factors for clinical T4a tongue SCC, and elucidated whether postoperative ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000446439
更新日期:2016-01-01 00:00:00
abstract::Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227317
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:In order to determine whether infection with Helicobacter pylori might be associated with pancreatic adenocarcinoma, we performed a study to compare the H. pylori seroprevalence rate between patients with pancreatic carcinoma and matched control subjects. PATIENTS AND METHODS:Blood samples from 92 patients wit...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011830
更新日期:1998-01-01 00:00:00
abstract::We examined the expression of p16, the CDKN2A gene product, in EBV-associated gastric carcinomas (EBV-GCs). EBV-GCs were identified by detecting EBV-encoded small RNA (EBER) using an in situ hybridization assay of paraffin-embedded tissue. Two non-EBV-GC cases for each EBV-GC case were selected, matched for age, sex, ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000080290
更新日期:2004-01-01 00:00:00
abstract::The efficacy of recombinant interferon-alpha 2 in the treatment of advanced hairy cell leukaemia is investigated in 31 patients. Preliminary results show a complete and partial response rate of 69%. An optimal dose study utilizing maximal stimulation of an interferon-dependent pathway was carried out in 5 patients. Th...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226076
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Mutations in the human telomerase reverse transcriptase (hTERT) gene promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of these mutations in liquid biopsies have been technically difficult because of the high GC content of the regions of interest within this promoter. We evalua...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000506135
更新日期:2020-01-01 00:00:00
abstract::72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225162
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000346690
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of our study to evaluate the efficacy and safety of weekly topotecan in patients with advanced or recurrent cervical disease. METHODS:Topotecan was administered intravenously as a weekly infusion at a dose of 3.5 mg/m(2) on days 1, 8 and 15 of a 28-day cycle. After the second cycle, the dose w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000330537
更新日期:2011-01-01 00:00:00
abstract::An increase in serum iron levels and a decrease in serum unsaturated iron binding capacity (uIBC) were noted following the administration of cisplatinum to 9 children with malignancies. The mean serum iron concentration increased from a pretreatment level of 75.7 +/- 30.5 micrograms/ml to a posttreatment level of 162....
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226657
更新日期:1988-01-01 00:00:00
abstract::The newly isolated phenylpropanoids syringin, syringenin-apiosylglucoside, eleutheroside E and the high molecular lectins and viscotoxins were selected for a standardization of mistletoe extracts and drug preparation. The phenylpropanoids found in all alcoholic and aqueous extracts were suitable for an HPLC fingerprin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226416
更新日期:1986-01-01 00:00:00
abstract::Using a Gompertzian pharmacodynamic model, we have studied the changes induced by graded doses of adriamycin (AM) on the growth of intramuscular Lewis lung carcinoma (3LL) and its lung metastases in C57Bl/6 mice. An interpretation of the drug's effects on free growth of the tumor cells is given in the Appendix. Unlike...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225709
更新日期:1983-01-01 00:00:00
abstract::C57BL/6 mice with progressive B-16 melanoma develop a generalized immunosuppression, as measured by their lack of response to SRBC in vivo and in vitro. The severity of immunosuppression increases with the progress of the tumor, and is due to the generation of an antigen-nonspecific suppressor cell. Suppressor cells w...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225480
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS:Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000489217
更新日期:2018-01-01 00:00:00
abstract::A large number of targeted anticancer drugs are currently under development and most of them will have a companion diagnostic linked to their use. If a diagnostic assay is developed in conjunction with a targeted anticancer drug, such an assay will later end up determining the conditions for the use of the drug after ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000353454
更新日期:2013-01-01 00:00:00
abstract::A cost-effectiveness analysis is one form of full economic evaluation where drug acquisition costs and the costs that are incurred as a result of using a particular treatment are assessed together with clinical efficacy. This paper reviews two such studies. One of the studies was a prospective randomised cost-effectiv...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227175
更新日期:1993-05-01 00:00:00