Abstract:
:Various oncogenic agents were employed in tumor susceptibility studies of an inbred subline of BALB/cGn mice, BALB/cGnDu, which carries a mutant gene that results in spontaneous thymic involution in homozygous recessive individuals. Of 18 transplantable tumors, 3 in vitro transformed cell lines, 2 oncogenic papovaviruses and 3 chemical carcinogens evaluated, only the Harding-Passey amelanotic melanoma produced tumors in 100% of the normal adult mice injected. The S180 pleomorphic sarcoma produced tumors in 56% of normal adult mice. Although not tumorigenic in adults, the mKSA, Morris (rat) hepatoma No. 7777, and a human papovavirus - transformed human cell induced mouse tumor line [GI110(BK) B6D2 Tu] formed tumors in 100, 62 and 70%, respectively, of recipients inoculated as neonates. SV40 and human papovavirus BK virions, as well as sV40, BK, and spontaneous in vitro transformed BALB/cGnDu cells were not tumorigenic. Although the histocompatibility antigens of these animals have not been studied, no correlations could be made between the tumor susceptibility of these animals with regard to the commonly employed inbred line BALB/c nor with regard to the range of host susceptibility of the transplantable tumors. This inbred subline represents a new strain of mice whose genetic defect makes it useful for transplantation immunology and physiological genetics.
journal_name
Oncologyjournal_title
Oncologyauthors
Morrison DG,Moyer MP,Lynd FT,Rogers W,Moyer RCdoi
10.1159/000225643subject
Has Abstractpub_date
1982-01-01 00:00:00pages
228-33issue
4eissn
0030-2414issn
1423-0232journal_volume
39pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Adenocarcinoma of the stomach remains a significant cause of mortality worldwide. The majority of patients present with stage III or IV disease, negating surgery as a curative option. Numerous drugs have been tested over the past 2 decades in single-agent and combination chemotherapy trials. Given by intravenous bolus...
journal_title:Oncology
pub_type: 临床试验,杂志文章,评审
doi:10.1159/000227249
更新日期:1993-04-01 00:00:00
abstract::Tumor infiltrating lymphocytes induced by radiotherapy were analyzed by the biotin-avidin-horseradish peroxidase method. At the early dose of 4 Gy (400 rad) of irradiation (2 Gy X 2), remarkable infiltration of lymphocytes was observed surrounding cancer cells. This infiltration was mainly composed of Leu-3a+3b-positi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226523
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown. METHODS:We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at...
journal_title:Oncology
pub_type: 新闻
doi:10.1159/000509434
更新日期:2020-01-01 00:00:00
abstract::Between June 1980 and December 1984, 88 patients with stage III-IV ovarian carcinoma were entered in a study evaluating the role of debulking surgery and chemotherapy consisting of cyclophosphamide, doxorubicin, and cisplatin intravenously on day 1, every 4 weeks (CAP-1). The results after a median follow-up of 62 mon...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226801
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:It was the aim of this study to investigate the clinical differences between the tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib as second-line treatment for cytokine-refractory kidney cancer patients. METHODS:Twenty consecutive patients received continuous treatment of oral sorafenib at a dose of...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000151369
更新日期:2008-01-01 00:00:00
abstract::The newly isolated phenylpropanoids syringin, syringenin-apiosylglucoside, eleutheroside E and the high molecular lectins and viscotoxins were selected for a standardization of mistletoe extracts and drug preparation. The phenylpropanoids found in all alcoholic and aqueous extracts were suitable for an HPLC fingerprin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226416
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers. METHODS:We conducted a retrospective study of consecutively treated 22 inoperable biliary tract cancer patients with gemcitabine (500-1,000 mg/m(2) on days 1, 8, 15 every 4 weeks) as f...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000098109
更新日期:2006-01-01 00:00:00
abstract::An antiserum to human melanoma antigens was obtained from a melanoma patient after immunization with autologous irradiated cultured melanoma cells and bacillus Calmette-Guerin. Using the microcomplement fixation assay, the antiserum, at a titer of 1/1,800, was noted to bind strongly with 7 of 10 allogeneic cultured hu...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225702
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000209963
更新日期:2009-01-01 00:00:00
abstract::In pancreatic cancer (PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy. This review focuses on the role of carbohydrate antigen 19-9 (CA 19-...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000094888
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:Cancer-related fatigue is a common complaint during cancer treatment and is often associated with cognitive impairment. This study examined cognitive deficits that were associated with fatigue symptoms during external-beam radiation therapy (EBRT) in men with localized prostate cancer. METHODS:A total of 36 pa...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000487081
更新日期:2018-01-01 00:00:00
abstract::Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-ph...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000088069
更新日期:2005-01-01 00:00:00
abstract::Systemic chemotherapy for advanced gastric cancer is frequently associated with significant treatment-related toxicity, which is particularly serve in patients presenting with a poor general condition. A search for effective and low-toxic regimens for this group of patients is mandatory. A weekly 24-hour infusion of h...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227702
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVES:Calcitriol, 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3)) has potent antiproliferative effects and potentiates the antitumor activity of many other cytotoxic drugs. 1,25-D(3) plasma pharmacokinetic (PK) parameters associated with antitumor activity in experimental animal models are unknown. The objective of th...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000076336
更新日期:2004-01-01 00:00:00
abstract::Results of a survey of concentrations of substances immunologically cross-reactive with insulin (SICRI), glucose and growth hormone in preprandially drawn blood of 84 patients suffering from bronchial epidermoid, microcellular and adenocarcinomas and 22 patients from sarcoidosis, tuberculosis and obstructive bronchiti...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226026
更新日期:1985-01-01 00:00:00
abstract::An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227559
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Sorafenib, a multitargeted tyrosine kinase inhibitor, is now the treatment of choice for systemic therapy of patients with advanced hepatocellular carcinoma (HCC). Herein, we present the clinical characteristics and outcomes of patients with advanced HCC who were treated with sorafenib. METHODS:Data of 201 ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000327591
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤ 1.5 × the upper limit of normal. METHODS:Documen...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000341152
更新日期:2012-01-01 00:00:00
abstract::The serum detection of S100B, a new melanoma marker, has shown clinical significance in early studies. The aim of our study of 1, 339 serum samples from 412 different melanoma patients and 107 control patients was to prove the prognostic value of serum S100B levels in melanoma patients at different stages of disease a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011989
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:This pharmacokinetic study of S-1 was conducted in patients in whom glomerular filtration rate (GFR) was directly measured to explore the possibility of adjusting the S-1 dose on the basis of GFR in patients with normal or nearly normal renal function. METHODS:S-1 was given to 12 patients twice daily for 28 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000337232
更新日期:2012-01-01 00:00:00
abstract::High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227119
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Wernicke's encephalopathy (WE) is a neurological emergency which presents with symptoms of confusion, ophthalmoplegia, and ataxia. Cancer patients are at high risk of this acute encephalopathy due to chronic malnutrition, chemotherapy-induced nausea and vomiting, and consumption of thiamine by rapidly growin...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000174951
更新日期:2009-01-01 00:00:00
abstract::Cancer pain management had received relatively little attention until the late 1990s, when approximately 100,000 new cancer cases and 60,000 cancer deaths occurred each year in Korea. In 2001, a Cancer Pain Management Guideline was prepared for the first time by the Korean Society of Hospice and Palliative Care. This ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000143211
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Keratin (K) 19 positivity has been reported to be a useful predictive marker for recurrence in patients with hepatocellular carcinoma (HCC) who have undergone hepatic resection. We investigated the clinical usefulness of K19 positivity in patients who had received curative radiofrequency ablation (RFA). METH...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000328448
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Both irinotecan (CPT) and paclitaxel (Pac) are effective against non-small cell lung cancer (NSCLC), and besides, preclinical studies have demonstrated an additive or synergistic interaction between camptothecin and taxane. METHODS:We conducted a phase I/II study of combination chemotherapy consisting of Pa...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000077434
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:To assess whether the use of an organ-specific treatment could improve event-free survival (EFS) and overall survival as endpoints in testicular lymphoma in the early stage: IE and IIE. METHODS:Thirty-four patients were selected to be treated with orchiectomy following six cycles of anthracycline-based comb...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000081319
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions. Epithelial syndecan-1 expression is reduced in several malignant tumours, but in breast and pancreatic cancer, increased expression has also been described. Loss of...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000080280
更新日期:2004-01-01 00:00:00
abstract::The aim of this study was to both develop and validate a nomogram based on the Ki-67 index to predict recurrence. We constructed a nomogram using the Cox proportional hazards model with 953 N0 and N1 postoperative hormone receptor (HR)-positive breast cancer patients and validated it in an external cohort of 895 patie...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000362281
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To determine the dose-limiting toxicities (DLTs) and the maximum-tolerated doses of the paclitaxel, oxaliplatin (LOHP) and capecitabine combination in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received escalating doses of paclitaxel (starting dose 100 mg/m2) and LOHP (starting dose 40 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000111088
更新日期:2007-01-01 00:00:00
abstract::The antiemetic effect of graded, single high-dose intravenous dexamethasone was studied in 27 patients receiving combination chemotherapy with either doxorubicin (50 mg/m2) or cis-platinum (100 mg/m2). A total of 57 cycles were individually evaluated, utilizing a detailed rating system. Nausea and vomiting did not occ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000226099
更新日期:1986-01-01 00:00:00