Infiltration of Leu-3a+3b-positive lymphocytes and expression of human leukocyte antigen DR on tumor tissue induced by radiation therapy.


:Tumor infiltrating lymphocytes induced by radiotherapy were analyzed by the biotin-avidin-horseradish peroxidase method. At the early dose of 4 Gy (400 rad) of irradiation (2 Gy X 2), remarkable infiltration of lymphocytes was observed surrounding cancer cells. This infiltration was mainly composed of Leu-3a+3b-positive lymphocytes, and human leukocyte antigen DR-positive tumor and interstitial cells were remarkably observed.






Ogawa Y,Maeda T,Seguchi H,Hamada F,Inomata T,Yoshida S,Kishimoto S,Saito H




Has Abstract


1988-01-01 00:00:00














  • A case-control study of breast cancer and psychotropic drug use.

    abstract::The relative risk of breast cancer incidence and tumor promotion associated with psychotropic drug consumption was evaluated in 151 patients with newly diagnosed neoplasms and 151 hospital controls. No significantly altered risk of breast cancer was found in association with the use of diazepam, chlordiazepoxide, anti...


    pub_type: 杂志文章


    authors: Wallace RB,Sherman BM,Bean JA

    更新日期:1982-01-01 00:00:00

  • The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer.

    abstract:AIMS:We investigated the relationship between serum leptin concentrations and polymorphism of the leptin receptor gene and breast cancer. METHODS:Serum leptin concentrations were measured by enzyme-linked immunosorbent assay in 47 women with invasive breast cancer compared with 41 age-matched controls without cancer. ...


    pub_type: 杂志文章


    authors: Liu CL,Chang YC,Cheng SP,Chern SR,Yang TL,Lee JJ,Guo IC,Chen CP

    更新日期:2007-01-01 00:00:00

  • Frequent occurrence of abnormal E-cadherin/beta-catenin protein expression in advanced gallbladder cancers and its association with decreased apoptosis.

    abstract:OBJECTIVE:Our aim is to assess the clinicopathological significance of E-cadherin and beta-catenin expression, as well as their association with apoptosis in gallbladder cancers. METHODS:The expression of E-cadherin and beta-catenin proteins was examined in 4 biliary tract cancer cell lines and 49 gallbladder cancer s...


    pub_type: 杂志文章


    authors: Hirata K,Ajiki T,Okazaki T,Horiuchi H,Fujita T,Kuroda Y

    更新日期:2006-01-01 00:00:00

  • Energy status in HeLa cells after treatment with an arresting anticancer drug.

    abstract::The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...


    pub_type: 杂志文章


    authors: Al-Awadi FM,Al-Bader AA

    更新日期:1987-01-01 00:00:00

  • In vitro and in vivo growth inhibition of SC-M1 gastric cancer cells by retinoic acid.

    abstract::Retinoids are differentiating agents that have been used successfully for the treatment of acute promyelocytic leukemia. When combined with interferons, they are active in preventing second malignancies in patients with head and neck cancer. Our previous studies have demonstrated cytostatic effects of alltrans-retinoi...


    pub_type: 杂志文章


    authors: Jiang SY,Shyu RY,Chen HY,Lee MM,Wu KL,Yeh MY

    更新日期:1996-07-01 00:00:00

  • Results with CCNU in resistant Hodgkin's and non-Hodgkin's lymphoma.

    abstract::72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma...


    pub_type: 杂志文章


    authors: Stolinsky DC,Solomon J,Weiner JM,Bateman JR

    更新日期:1976-01-01 00:00:00

  • Histone deacetylase in chronic lymphocytic leukemia.

    abstract:BACKGROUND:Elevated histone deacetylase (HDAC) isoenzyme levels have been described in patients with carcinomas and leukemias. HDAC inhibitors (HDACi) have shown promise in the treatment of carcinomas and are currently under intense research. To make better use of HDACi in treating chronic lymphocytic leukemia (CLL), H...


    pub_type: 杂志文章


    authors: Wang JC,Kafeel MI,Avezbakiyev B,Chen C,Sun Y,Rathnasabapathy C,Kalavar M,He Z,Burton J,Lichter S

    更新日期:2011-01-01 00:00:00

  • Effect of Neoadjuvant Nab-Paclitaxel plus Gemcitabine Therapy on Overall Survival in Patients with Borderline Resectable Pancreatic Cancer: A Prospective Multicenter Phase II Trial (NAC-GA Trial).

    abstract::We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a prima...


    pub_type: 杂志文章,多中心研究


    authors: Okada KI,Shimokawa T,Hirono S,Kawai M,Sho M,Satoi S,Matsumoto I,Eguchi H,Murakami Y,Yamada S,Doi M,Yamaue H,NAC-GA investigators.

    更新日期:2017-01-01 00:00:00

  • Progress of cancer pain management in Korea.

    abstract::Cancer pain management had received relatively little attention until the late 1990s, when approximately 100,000 new cancer cases and 60,000 cancer deaths occurred each year in Korea. In 2001, a Cancer Pain Management Guideline was prepared for the first time by the Korean Society of Hospice and Palliative Care. This ...


    pub_type: 杂志文章


    authors: Lee JY,Ahn JS

    更新日期:2008-01-01 00:00:00

  • A multicenter phase II randomized trial of docetaxel/gemcitabine versus docetaxel/capecitabine as first-line treatment for advanced breast cancer: a Gruppo Oncologico Italia Meridionale study.

    abstract:OBJECTIVE:To evaluate two docetaxel-based regimens as first-line treatment in advanced breast cancer patients. METHODS:Patients were randomly assigned to docetaxel/gemcitabine (arm A: docetaxel 75 mg/m(2) on day 1, gemcitabine 1,000 mg/m(2) on days 1 and 8) or docetaxel/capecitabine (arm B: docetaxel 75 mg/m(2) on day...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vici P,Giotta F,Di Lauro L,Sergi D,Vizza E,Mariani L,Latorre A,Pizzuti L,D'Amico C,Giannarelli D,Colucci G

    更新日期:2011-01-01 00:00:00

  • Loss of p16/CDKN2A protein in Epstein-Barr virus-associated gastric carcinoma.

    abstract::We examined the expression of p16, the CDKN2A gene product, in EBV-associated gastric carcinomas (EBV-GCs). EBV-GCs were identified by detecting EBV-encoded small RNA (EBER) using an in situ hybridization assay of paraffin-embedded tissue. Two non-EBV-GC cases for each EBV-GC case were selected, matched for age, sex, ...


    pub_type: 杂志文章


    authors: Koriyama C,Kitajima S,Nomoto M,Sueyoshi K,Itoh T,Eizuru Y,Yonezawa S,Akiba S

    更新日期:2004-01-01 00:00:00

  • Multiple persistent keratoacanthomas.

    abstract::A unique case of multiple keratoacanthomas is described, with involvement of the face and lower extremities with persistent lesions clinically and histologically diagnostic of keratoacanthomas. The lower extremity lesions appear as giant keratoacanthomas, with evolution into a distinctive confluent plaque. This import...


    pub_type: 杂志文章


    authors: Schwartz RA

    更新日期:1979-01-01 00:00:00

  • Oral medium-dosed metoclopramide versus placebo as highly effective antiemetic prophylaxis in in- and outpatients on noncisplatin chemotherapy.

    abstract::The antiemetic effect of oral medium-dosed metoclopramide (MCL, 3.5 mg/kg b.w./cycle) and placebo for chemotherapy-induced emesis of a noncisplatin regimen was assessed for inpatients and outpatients in two double-blind placebo-controlled sequential analyses according to Bross (1952). MCL was given in 5 single doses o...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vogt C,Hellenbrecht D,Saller R,Achtert G,Brockmann P,Hausleiter H

    更新日期:1993-03-01 00:00:00

  • Companion diagnostics in oncology - current status and future aspects.

    abstract::A large number of targeted anticancer drugs are currently under development and most of them will have a companion diagnostic linked to their use. If a diagnostic assay is developed in conjunction with a targeted anticancer drug, such an assay will later end up determining the conditions for the use of the drug after ...


    pub_type: 杂志文章,评审


    authors: Jørgensen JT

    更新日期:2013-01-01 00:00:00

  • Second-line chemotherapy in recurrent clear cell ovarian cancer: results from the multicenter italian trials in ovarian cancer (MITO-9).

    abstract:BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 cen...


    pub_type: 杂志文章


    authors: Esposito F,Cecere SC,Magazzino F,Katsaros D,Ottaiano A,Gadducci A,Pisano C,Scalone S,Rabaiotti E,Salutari V,Cormio G,Canuto EM,Greggi S,Savarese A,Marinaccio M,Scollo P,Santeufemia DA,Sacco C,Facchini G,Pignata S

    更新日期:2014-01-01 00:00:00

  • Targeting Developmental Pathways: The Achilles Heel of Cancer?

    abstract::Developmental pathways (e.g., Notch, Hippo, Hedgehog, Wnt, and TGF-β/BMP/FGF) are networks of genes that act co-ordinately to establish the body plan, and disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Interestingly, all developmental path...


    pub_type: 杂志文章,评审


    authors: Dempke WCM,Fenchel K,Uciechowski P,Chevassut T

    更新日期:2017-01-01 00:00:00

  • A phase II study of carboplatin in nasopharyngeal carcinoma.

    abstract::This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...


    pub_type: 临床试验,杂志文章


    authors: Chi KH,Chang YC,Chan WK,Liu JM,Law CK,Lo SS,Shu CH,Yen SH,Whang-Peng J,Chen KY

    更新日期:1997-05-01 00:00:00

  • Prognostic Factors and Multidisciplinary Postoperative Chemoradiotherapy for Clinical T4a Tongue Cancer.

    abstract:OBJECTIVE:The prognosis of patients with locally advanced squamous cell carcinoma (SCC) of the tongue is poor. Postoperative chemoradiotherapy (CRT) improves locoregional control and survival in high-risk patients. We investigated the prognostic factors for clinical T4a tongue SCC, and elucidated whether postoperative ...


    pub_type: 杂志文章


    authors: Yokota T,Iida Y,Ogawa H,Kamijo T,Onozawa Y,Todaka A,Hamauchi S,Onoe T,Nakagawa M,Yurikusa T,Tanuma A,Yamashita A,Nishimura T,Yasui H,Onitsuka T

    更新日期:2016-01-01 00:00:00

  • Epidermal Growth Factor Potentiates Migration of MDA-MB 231 Breast Cancer Cells by Increasing NaV1.5 Channel Expression.

    abstract:INTRODUCTION:Breast cancer is one of the leading causes of death worldwide and is the result of dysregulation of various signaling pathways in mammary epithelial cells. The mortality rate in patients suffering from breast cancer is high because the tumor cells have a prominent invasive capacity towards the surrounding ...


    pub_type: 杂志文章


    authors: González-González L,González-Ramírez R,Flores A,Avelino-Cruz JE,Felix R,Monjaraz E

    更新日期:2019-01-01 00:00:00

  • Overcoming Tamoxifen Resistance by Regulation of Del-1 in Breast Cancer.

    abstract:BACKGROUND:Hormone receptor-positive breast cancer accounts for nearly two-thirds of breast cancer cases; it ultimately acquires resistance during endocrine treatment and becomes more aggressive. This study evaluated the role of developmental endothelial locus (Del)-1 in tamoxifen-resistant (TAM-R) breast cancer. METH...


    pub_type: 杂志文章


    authors: Lee J,Jeong JH,Jung JH,Kim WW,Lee SJ,Park JY,Park JY,Kang SH,Kim EA,Park JH,Chae YS,Park HY

    更新日期:2019-01-01 00:00:00

  • Cytogenetic testing of mutagenic and radioprotective effects of mesna.

    abstract::The effects of mesna (sodium 2-mercaptoethane-sulfonate) on the frequency of sister chromatid exchange (SCE) and chromosomal aberrations were studied in PHA-stimulated lymphocytes in vitro. Our data give no evidence for either an increase of SCE or chromosomal aberrations and, thus, do not suggest a mutagenic or cance...


    pub_type: 杂志文章


    authors: Becher R,Kakati S,Gibas Z,Sandberg AA

    更新日期:1983-01-01 00:00:00

  • Ondansetron: a cost-effective advance in anti-emetic therapy.

    abstract::A cost-effectiveness analysis is one form of full economic evaluation where drug acquisition costs and the costs that are incurred as a result of using a particular treatment are assessed together with clinical efficacy. This paper reviews two such studies. One of the studies was a prospective randomised cost-effectiv...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cox F,Hirsch J

    更新日期:1993-05-01 00:00:00

  • Cyclin D3 expression, cell proliferation and pathological stage of human primary colorectal cancer.

    abstract::Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...


    pub_type: 杂志文章


    authors: Watson DS,Brotherick I,Shenton BK,Wilson RG,Angus B,Varma JS,Campbell FC

    更新日期:1999-01-01 00:00:00

  • Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion.

    abstract:INTRODUCTION:Because the frequency of bile duct invasion in hepatocellular carcinoma (HCC) patients is very rare, there is limited clinical evidence to demonstrate the outcomes of systemic therapy in HCC with bile duct invasion. OBJECTIVE:Our aim was to clarify the efficacy and safety of sorafenib treatment in patient...


    pub_type: 杂志文章


    authors: Tanaka T,Kuzuya T,Ishigami M,Ito T,Ishizu Y,Honda T,Ishikawa T,Fujishiro M

    更新日期:2020-01-01 00:00:00

  • Effect of reoxygenation on the hypoxia-induced up-regulation of serine protease inhibitor PAI-1 in head and neck cancer cells.

    abstract::In squamous cell carcinoma of the head and neck (SCCHN), hypoxia is considered a crucial physiological modulator for malignant progression, wherebythe plasminogen activation system is involved in overlapping functions such as moulding of the extracellular matrix, cell proliferation and signal transduction. Little is k...


    pub_type: 杂志文章


    authors: Sprague LD,Mengele K,Schilling D,Geurts-Moespot A,Sweep FC,Stadler P,Schmitt M,Molls M

    更新日期:2006-01-01 00:00:00

  • Establishment and characterization of a human ovarian serous cystadenocarcinoma cell line that produces the tumor markers CA-125 and tissue polypeptide antigen.

    abstract::A cultured cell line (SHIN-3) derived from a human ovarian serous cystadenocarcinoma which consistently produces two tumor markers, CA-125 and tissue polypeptide antigen (TPA) was established. After 1 week of culture of 1 x 10(5) cells, high levels of tumor marker were observed (the total CA-125 release was 1,500 U an...


    pub_type: 杂志文章


    authors: Imai S,Kiyozuka Y,Maeda H,Noda T,Hosick HL

    更新日期:1990-01-01 00:00:00

  • Antiemetic study methodology: recommendations for future studies.

    abstract::The methodology of future antiemetic studies will reflect the need to address the problems identified in current studies. New preclinical information on the mechanisms of emesis and antiemetic action will allow more rational clinical study design. Prior to large randomized studies, phase I and II trials should define ...


    pub_type: 杂志文章,评审


    authors: Olver IN

    更新日期:1996-06-01 00:00:00

  • Effects of cycloheximide on chromatin-bound and -unbound PCNA in HeLa cells.

    abstract::We examined the effects of cycloheximide on the amount of chromatin-bound and -unbound PCNA subpopulations in HeLa cells. The chromatin-bound PCNA content decreased rapidly in the presence of cycloheximide, whereas the reduction of the total amount of PCNA was minimal even 24 h after the treatment with cycloheximide. ...


    pub_type: 杂志文章


    authors: Sasaki K,Kurose A,Uesugi N,Kato A

    更新日期:1995-09-01 00:00:00

  • Mitomycin therapy in gastric cancer.

    abstract::Adenocarcinoma of the stomach remains a significant cause of mortality worldwide. The majority of patients present with stage III or IV disease, negating surgery as a curative option. Numerous drugs have been tested over the past 2 decades in single-agent and combination chemotherapy trials. Given by intravenous bolus...


    pub_type: 临床试验,杂志文章,评审


    authors: Schnall S,Macdonald JS

    更新日期:1993-04-01 00:00:00

  • Benzodiazepine use in breast cancer survivors: findings from a consecutive series of 1,000 patients.

    abstract:OBJECTIVE:This study reports the percentage of breast cancer survivors receiving ongoing benzodiazepines and the circumstances surrounding their usage. METHODS:The medical records of 1,000 consecutive breast cancer survivors who were no longer receiving adjuvant chemotherapy were reviewed. RESULTS:Among those patient...


    pub_type: 杂志文章


    authors: Vaidya R,Sood R,Karlin N,Jatoi A

    更新日期:2011-01-01 00:00:00