Abstract:
:An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection. The overexpression of the c-ErbB-2 protein was observed in 27.4% of the patients. The c-ErbB-2 positivity showed a statistically significant correlation with nodal status and stage. The patients with an overexpression of the c-ErbB-2 protein had a tendency to a shorter survival than those without, but it was not statistically significant (p = 0.08). The 5-year survival rate after surgery was 54% in the negative staining group to the c-ErbB-2 protein and 49% in the positive staining group. This suggests that the c-ErbB-2 protein has a possible role in lymph node metastasis. Therefore overexpression of the c-ErbB-2 protein is a useful indicator of disease progression in gastric carcinoma patients who received curative surgery.
journal_name
Oncologyjournal_title
Oncologyauthors
Lee HR,Kim JH,Uhm HD,Ahn JB,Rha SY,Cho JY,Lee JI,Lee KH,Chung HC,Roh JK,Min JS,Lee KS,Shin DH,Kim BS,Hong SW,Choi JHdoi
10.1159/000227559subject
Has Abstractpub_date
1996-05-01 00:00:00pages
192-7issue
3eissn
0030-2414issn
1423-0232journal_volume
53pub_type
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