Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostate cancer.

abstract：BACKGROUND:Whether recurrence after surgery and primary metastatic pancreatic cancer should be included in the same category when conducting gemcitabine-based clinical trials remains controversial. OBJECTIVE:To clarify the outcomes of recurrent and metastatic pancreatic cancers. METHODS:326 patients who received gemc...

journal_title：Oncology

authors： Hashimoto K,Ueno H,Ikeda M,Kojima Y,Hagihara A,Kondo S,Morizane C,Okusaka T

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:To examine the efficacy and prognostic benefits of radiotherapy (RT) in patients who have unresectable advanced hepatocellular carcinoma (HCC) with invasion to intrahepatic large vessels (IHLVs). METHODS:Sixty-eight patients who had advanced HCC with invasion to IHLVs were studied. Thirty-two consecutive pa...

journal_title：Oncology

authors： Nakazawa T,Adachi S,Kitano M,Isobe Y,Kokubu S,Hidaka H,Ono K,Okuwaki Y,Watanabe M,Shibuya A,Saigenji K

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Irinotecan has, in general, been administered as a 90-min infusion. However, several studies have demonstrated that continuous infusion seems to be a promising method of delivering irinotecan. This phase I/II trial was performed to evaluate the efficacy and safety of continuous infusion of irinotecan combined...

journal_title：Oncology

authors： Sadahiro S,Suzuki T,Maeda Y,Tanaka A,Ishikawa K,Makuuchi H,Murayama C

更新日期：2009-01-01 00:00:00

abstract：:Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal...

journal_title：Oncology

authors： Yete S,D'Souza W,Saranath D

更新日期：2018-01-01 00:00:00

abstract：:To evaluate the influence of delay between first symptom and first treatment upon survival the medical records of 596 patients with breast cancer were reviewed. The following intervals were considered: less than 3 months; 3-6 months and greater than 6 months. Patients in the less than 3 months delay group had a better...

journal_title：Oncology

authors： Machiavelli M,Leone B,Romero A,Perez J,Vallejo C,Bianco A,Rodriguez R,Estevez R,Chacon R,Dansky C

更新日期：1989-01-01 00:00:00

abstract：:The use of the blood-brain barrier and of tumor-specific antibodies to concentrate boron selectivity in gliomas for neutron capture therapy is considered experimentally and theoretically. The time-dependent concentration of two anionic boranes, B12 H11 SH2- and B12 H11 SOSB12 H114-, in the blood, brain, and tumor of ...

journal_title：Oncology

authors： Tolpin EI,Wellum GR,Dohan FC Jr,Kornblith PL,Zamenhof RG

更新日期：1975-01-01 00:00:00

abstract：:Aberrant glycosylation of membrane components due to specific alterations of glycosyltransferase activity is a common feature of carcinoma cells and is usually associated with invasion and metastasis. In a prospective study, the enzyme activity of the sialyltransferases ST6GAL-I and ST3GAL-III was studied in gastric c...

journal_title：Oncology

authors： Gretschel S,Haensch W,Schlag PM,Kemmner W

更新日期：2003-01-01 00:00:00

abstract：:The MXT mouse transplantable mammary cancer is characterized by significant amounts of steroid hormone receptors. Moreover this model, as other solid tumors, contains diverse subpopulations of neoplastic cells. In the present study we have examined this pattern as well as the influence of exogenous physiologic doses o...

journal_title：Oncology

authors： Kiss R,Leclercq G,Danguy A

更新日期：1985-01-01 00:00:00

abstract：:This study sought to examine the relationship between MUC1 expression at the deepest invasive portion, invasive/metastatic potential, and prognosis of colorectal cancer in relation to cellular proliferation. MUC1 expression was detected immunohistochemically using KL-6 antibody (anti-MUC1 monoclonal antibody) in 100 s...

journal_title：Oncology

authors： Hiraga Y,Tanaka S,Haruma K,Yoshihara M,Sumii K,Kajiyama G,Shimamoto F,Kohno N

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays an important role in ovarian cancer. The interaction of platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth factor (VEGF) in the process of angiogenesis may represent an essential feature in the progression of the disease. METHODS:Patients with epitheli...

journal_title：Oncology

authors： Mathey S,Graeser MK,Zu Eulenburg C,Woelber L,Trillsch F,Jaenicke F,Müller V,Milde-Langosch K,Mahner S

更新日期：2013-01-01 00:00:00

abstract：:High-dose megestrol acetate (800 mg/day) was administered to 34 patients as third-line endocrine therapy for metastatic breast cancer after progression on standard-dose megestrol acetate (160 mg/day). Among the 32 evaluable patients, no complete or partial response occurred. Ten patients remained stable and 22 progres...

journal_title：Oncology

authors： Cruz JM,Muss HB,Russell G

更新日期：1992-01-01 00:00:00

abstract：:Coagulation disorders are frequently detected in patients affected by different tumours even though clinical symptoms occur in a very small percentage of such subjects. Coagulation processes are probably involved in the mechanism of metastatic spread. We assayed the plasma levels of thrombin-antithrombin III (TAT) com...

journal_title：Oncology

authors： Bartoloni C,Guidi L,Tricerri A,Patriarca F,Pili R,Cursi F,Canetta M,Cappelli A,Vangeli M,Salvati F

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Transcatheter arterial chemoembolization (TACE) is a standard therapy used in the treatment of intermediate hepatocellular carcinoma (HCC). Recently, balloon-occluded TACE (B-TACE) has been developed. PURPOSE:This study aimed to clarify the effects of B-TACE in patients with HCC, with a focus on which drug ...

journal_title：Oncology

authors： Shirono T,Iwamoto H,Niizeki T,Shimose S,Nakano M,Satani M,Okamura S,Noda Y,Kamachi N,Kuromatsu R,Sakai M,Nomiyama M,Kuwano T,Tanaka M,Koga H,Torimura T

更新日期：2019-01-01 00:00:00

abstract：:We have studied the effect of butyrate on mammary tumorigenesis by 7,12-dimethylbenz(a)anthracene. As reported previously, a high incidence of mammary tumors was observed in rats fed a basal diet containing 20% margarine. However, the enhancing effect of margarine was inhibited when sodium butyrate was supplemented in...

journal_title：Oncology

authors： Yanagi S,Yamashita M,Imai S

更新日期：1993-07-01 00:00:00

abstract：:1-beta-D-Arabinofuranosylcytosine-5'-stearylphosphate (fosteabine) was administered orally to patients with myelodysplastic syndromes (MDS); refractory anemia with excess of blasts (RAEB), RAEB in transformation, acute leukemia derived from RAEB and chronic myelomonocytic leukemia, in an early phase II study in a mult...

journal_title：Oncology

authors： Ohno R,Tatsumi N,Hirano M,Imai K,Mizoguchi H,Nakamura T,Kosaka M,Takatsuki K,Yamaya T,Toyama K

更新日期：1991-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is characterized as a highly chemoresistant cancer with no effective systemic therapy. Despite surgical or locoregional therapies, prognosis remains poor because of high tumor recurrence or tumor progression, and currently there are no well-established effective adjuvant therapies. The m...

journal_title：Oncology

authors： Pang RW,Poon RT

更新日期：2007-01-01 00:00:00

abstract：:The newly isolated phenylpropanoids syringin, syringenin-apiosylglucoside, eleutheroside E and the high molecular lectins and viscotoxins were selected for a standardization of mistletoe extracts and drug preparation. The phenylpropanoids found in all alcoholic and aqueous extracts were suitable for an HPLC fingerprin...

journal_title：Oncology

authors： Wagner H,Jordan E,Feil B

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:Anti-p53 levels detected by different methods were compared in a predefined group of patients with breast cancer and correlated with p53 antigen expression in the corresponding tumors. METHODS:P53 autoantibodies were investigated in 165 patients with primary breast cancer using ELISAs with recombinant or nat...

journal_title：Oncology

authors： Volkmann M,Sinn HP,Gaugel D,Frey M,Hajjar Y,Ludwig J,Hänsel S,Bastert G,Wallwiener D,Fiehn W,Zentgraf H,Huober J

更新日期：2002-01-01 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C) is considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we clarified the clinicopathological features of early gastric carcinoma (EGC) that has metastasized to the lymph nodes, as well as the corre...

journal_title：Oncology

authors： Kabashima A,Maehara Y,Kakeji Y,Sugimachi K

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China and, due to the limited efficacy of currently available therapies, is responsible for a large number of deaths. IFN-alpha therapy has shown promise in the treatment of various forms of human cancer and is considered in the trea...

journal_title：Oncology

authors： Wu WZ,Sun HC,Gao YQ,Li Y,Wang L,Zhou K,Liu KD,Iliakis G,Tang ZY

更新日期：2004-01-01 00:00:00

abstract：:We report a rare case of a patient with an intrasplenic malignant fibrous histiocytoma (MFH) and chronic myelogenous leukemia. The neoplasms were synchronous in their onset and evolution. The peculiarity of the primary site of the MFH, the genetic implications of multiple primary tumors in a single patient, and the co...

journal_title：Oncology

authors： Bonilla F,Provencio M,Fernandez E,España P

更新日期：1994-09-01 00:00:00

abstract：:The relationship between p53 overexpression and clinicopathologic variables in gastric cancer was evaluated using 304 paraffin-embedded gastric tumor tissues. DO7, a murine monoclonal antiserum to p53 protein, was used for the immunohistochemical analysis. Positive staining was found in 129 tumors (42.2% of all tumors...

journal_title：Oncology

authors： Kim JH,Uhm HD,Gong SJ,Shin DH,Choi JH,Lee HR,Noh SH,Kim BS,Cho JY,Rha SY,Yoo NC,Chung HC,Roh JK,Min JS,Lee KS,Kim BS

更新日期：1997-03-01 00:00:00

abstract：:Cases are presented in which 111In-bleomycin accumulated in Virchow's gland metastasis from squamous cell carcinoma of the uterine cervix, and in paratracheal lymphatic gland metastasis from embryonal carcinoma of the right ovary. Thus, this radiopharmaceutical was found to be of great use for assessment of metastatic...

journal_title：Oncology

authors： Kida T,Ikeda M

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. OBJECTIVE:We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. METHODS:We retrospectively examined 649 consecutive patients with HCC who underwent curative...

journal_title：Oncology

authors： Lee HW,Choi GH,Kim DY,Park YN,Kim KS,Choi JS,Ahn SH,Han KH

更新日期：2017-01-01 00:00:00

abstract：:Empiric clinical trials have revealed new mechanisms by which hormonal therapies may exert their antitumor effects. Initial studies using escalated doses of agents like toremifene and megestrol acetate have yielded interesting results, showing responses in hormone-receptor-negative patients and in patients progressing...

journal_title：Oncology

authors： Abrams JS,Gutheil J,Aisner J

更新日期：1992-01-01 00:00:00

abstract：:Rapid advances in our understanding of the biology and pathology of lymphoproliferative disorders, permitted mainly by new diagnostic tools, constantly change our approach to this heterogenous group of disorders. In this review of the more indolent subgroup of lymphoproliferative disorders, some of the recent advances...

journal_title：Oncology

authors： Eek R,Falkson G

更新日期：1997-11-01 00:00:00

abstract：:We examined the expression of p16, the CDKN2A gene product, in EBV-associated gastric carcinomas (EBV-GCs). EBV-GCs were identified by detecting EBV-encoded small RNA (EBER) using an in situ hybridization assay of paraffin-embedded tissue. Two non-EBV-GC cases for each EBV-GC case were selected, matched for age, sex, ...

journal_title：Oncology

authors： Koriyama C,Kitajima S,Nomoto M,Sueyoshi K,Itoh T,Eizuru Y,Yonezawa S,Akiba S

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the antitumor activity and safety of an epirubicin, cisplatin, and capecitabine (ECX) combination in patients with metastatic or advanced gastric cancer. PATIENTS AND METHODS:Patients with metastatic or advanced measurable gastric adenocarcinoma received ECX combina...

journal_title：Oncology

authors： Cho EK,Lee WK,Im SA,Lee SN,Park SH,Bang SM,Park DK,Park YH,Shin DB,Lee JH

更新日期：2005-01-01 00:00:00

abstract：:In order to determine the operative indications of three-field lymph node dissection of esophageal cancer, attempts were made to collect data concerning procedures performed between 1983 and 1989 in major institutions in Japan, and the results from institutions performing three-field or two-field lymph node dissection...

journal_title：Oncology

authors： Isono K,Sato H,Nakayama K

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:We investigated stanniocalcin 1 (STC 1) expression to assess its clinical utility as a blood marker in patients with gastric cancer and evaluated its biological impact in terms of tumor aggressiveness. METHODS:Blood specimens from 93 patients with gastric cancer and 21 normal healthy volunteers were assessed...

journal_title：Oncology

authors： Arigami T,Uenosono Y,Ishigami S,Hagihara T,Haraguchi N,Matsushita D,Yanagita S,Nakajo A,Okumura H,Hokita S,Natsugoe S

更新日期：2012-01-01 00:00:00