Abstract:
:The effects of mesna (sodium 2-mercaptoethane-sulfonate) on the frequency of sister chromatid exchange (SCE) and chromosomal aberrations were studied in PHA-stimulated lymphocytes in vitro. Our data give no evidence for either an increase of SCE or chromosomal aberrations and, thus, do not suggest a mutagenic or cancerogenic potential of this drug, when used clinically for the reduction of urotoxicity caused by oxazaphosphorine derivatives in cancer therapy. The possibility of a radioprotective effect of mesna could not be supported by the results obtained in this test system. However, there remained a slight comutagenic effect of mesna, if used together with irradiation, which should be taken into account when this drug is administered in the preparation of patients for bone marrow transplantation.
journal_name
Oncologyjournal_title
Oncologyauthors
Becher R,Kakati S,Gibas Z,Sandberg AAdoi
10.1159/000225745subject
Has Abstractpub_date
1983-01-01 00:00:00pages
287-9issue
4eissn
0030-2414issn
1423-0232journal_volume
40pub_type
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