Methyl-CCNU in malignant melanoma--a divided dose schedule of administration.

abstract：:The expression of pro-gastrin-releasing peptide (proGRP) in medullary thyroid carcinoma (MTC) and other histological types of thyroid carcinoma was studied by an immunohistochemical technique, using polyclonal anti-proGRP antiserum. Immunoreactivity for proGRP was detected exclusively in MTC (n = 7); other histologica...

journal_title：Oncology

authors： Inaji H,Komoike Y,Motomura K,Higashiyama M,Ohtsuru M,Funai H,Kasugai T,Koyama H

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVES:Superficially spreading early gastric cancer is characterized by wide horizontal extension without deep vertical invasion. This study aimed to clarify the clinicopathological characteristics and prognosis of this rare disease. METHODS:We defined superficially spreading early gastric cancer as any tumor inva...

journal_title：Oncology

authors： Kunisaki C,Akiyama H,Nomura M,Matsuda G,Otsuka Y,Ono H,Shimada H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Clear cell renal cell carcinoma (CCRCC) is a malignant neoplasm frequently associated with an increase in circulating immune complexes (CIC). Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a disease involving the chorioretinal structures of the eye, and it is commonly observe...

journal_title：Oncology

authors： Parmeggiani F,Costagliola C,D'Angelo S,Incorvaia C,Perri P,Sebastiani A

更新日期：2004-01-01 00:00:00

abstract：:C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM stagin...

journal_title：Oncology

authors： Drahovsky D,Dunzendorfer U,Ziegenhagen G,Drahovsky M,Kellen JA

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To confirm the safety and effectiveness of techniques to assist radiofrequency ablation (RFA) for difficult cases, we retrospectively evaluated successful treatment rates, early complications and local tumor progressions. PATIENTS AND METHODS:Between June 1999 and April 2009, a total of 341 patients with 535 n...

journal_title：Oncology

authors： Inoue T,Minami Y,Chung H,Hayaishi S,Ueda T,Tatsumi C,Takita M,Kitai S,Hatanaka K,Ishikawa E,Yada N,Hagiwara S,Ueshima K,Kudo M

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of lo...

journal_title：Oncology

authors： Miglietta L,Vanella P,Canobbio L,Naso C,Cerisola N,Meszaros P,Parodi MA,Morabito F

更新日期：2010-01-01 00:00:00

abstract：:Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-ph...

journal_title：Oncology

authors： Tímár J,Tóvári J,Rásó E,Mészáros L,Bereczky B,Lapis K

更新日期：2005-01-01 00:00:00

abstract：:Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40-50 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats resulted in a marked decrease in the growth rate of both tumors. Exhaustive extraction of the corn oil with water indicated that the act...

journal_title：Oncology

authors： Gilbertson JR,Gelman RA,Ove P,Coetzee ML

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC). METHODS:Nine previously reported predictive markers for liver metastasis and/or prognosis (COX-2, dysadherin, E-cadherin, beta-catenin, Ki-67, p53, laminin5gamma2, matrilysin and MUC...

journal_title：Oncology

authors： Ochiai H,Nakanishi Y,Fukasawa Y,Sato Y,Yoshimura K,Moriya Y,Kanai Y,Watanabe M,Hasegawa H,Kitagawa Y,Kitajima M,Hirohashi S

更新日期：2008-01-01 00:00:00

abstract：:We studied the chemo-radiotherapy of testicular tumors in clinical stage III. Our study involved 54 patients with lung metastases of seminoma and nonseminoma, treated with a combination of radiotherapy and chemotherapy. The results obtained have not satisfied our expectations. While in the 16 seminoma patients only 43...

journal_title：Oncology

authors： Mechl Z,Malír A

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The Oncotype DX Breast Cancer Assay is a 21-gene assay used to predict the likelihood of distant recurrence and the benefit of chemotherapy in patients with node-negative, tamoxifen-treated breast cancer. Prior studies demonstrated 7-19% discordance, or a difference between the recurrence score (RS) and tumo...

journal_title：Oncology

authors： Blanter J,Zimmerman B,Tharakan S,Ru M,Cascetta K,Tiersten A

更新日期：2020-01-01 00:00:00

abstract：:The registry of digestive cancer set up for the French department of Côte d'Or (455, 727) enables a morbidity study about esophageal cancer to be made among residents. The crude animal incidence rate was 16.7/100,000 for males and 1.2/100,000 for females. Corresponding age-standardized rates were 13.2 and 0.5. The sex...

journal_title：Oncology

authors： Faivre J,Milan C,Martin F,Michiels R,Cabanne F,Klepping C

更新日期：1981-01-01 00:00:00

abstract：:Surgery for hepatocellular carcinoma has improved dramatically during the last two decades, and the improvement is mainly attributable to the development of intraoperative ultrasound-guided operative procedures such as Makuuchi's segmentectomy, introduction of the intermittent vascular occlusion technique, and establi...

journal_title：Oncology

authors： Makuuchi M,Imamura H,Sugawara Y,Takayama T

更新日期：2002-01-01 00:00:00

abstract：:Thirty-five patients with metastatic breast cancer who had received one or two prior chemotherapeutic regimens were treated with elliptinium acetate at a dose of 80 mg/m2 for 3 days every 3 weeks. Of the 33 patients evaluable for response, 1 patient achieved complete remission, 4 achieved partial responses (15% overal...

journal_title：Oncology

authors： Buzdar AU,Hortobagyi GN,Esparza LT,Holmes FA,Ro JS,Fraschini G,Lichtiger B

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Suboptimal debulking (>1 cm residual tumor) results in poor survival rates for patients with an advanced stage of ovarian cancer. The purpose of this study was to develop a prediction model, based on simple preoperative parameters, for patients with an advanced stage of ovarian cancer who are at risk of subo...

journal_title：Oncology

authors： de Jong D,Eijkemans MJ,Lie Fong S,Gerestein CG,Kooi GS,Baalbergen A,van der Burg ME,Burger CW,Ansink AC

更新日期：2007-01-01 00:00:00

abstract：:The treatment of metastatic renal cell carcinoma (MRCC) has evolved from being predominantly cytokine-based to being grounded in the use of drugs targeting vascular endothelial growth factor, platelet-derived growth factor and mammalian target of rapamycin (mTOR) pathways. New agents including the small-molecule targe...

journal_title：Oncology

authors： Di Lorenzo G,Scagliarini S,Di Napoli M,Scognamiglio F,Rizzo M,Carteni' G

更新日期：2009-01-01 00:00:00

abstract：:CA 19-9 and tissue polypeptide antigen (TPA) were determined in the sera of 28 control subjects, 29 patients with pancreatic cancer, 26 with chronic pancreatitis and 62 with benign and malignant extra pancreatic diseases in order to compare their usefulness in diagnosing pancreatic cancer, to verify whether the combin...

journal_title：Oncology

authors： Basso D,Fabris C,Del Favero G,Panucci A,Plebani M,Angonese C,Leandro G,Dodi G,Burlina A,Naccarato R

更新日期：1988-01-01 00:00:00

abstract：:A demonstration multiphasic cancer screening program was conducted in a rural village in Thailand under the coordination of Bangkok's National Cancer Institute. The village's physician, mayor, and other members of the community assumed a variety of volunteer roles in order to provide logistical support. In short, this...

journal_title：Oncology

authors： Lynch HT,Pitakspraiwan P,Sombooncharoen S,Phanthumchinda P,Vechmon U,Srivanwat G,Schutz RJ,Lynch JF

更新日期：1985-01-01 00:00:00

abstract：:Male and female mice of strains C3H/eB and C57BL/6 were injected subcutaneously with methylcholanthrene (MCA) dissolved in olive oil; mice injected with olive oil served as controls. After intervals of from 2 to 13 weeks, experimental and control mice were injected intraperitoneally with 51Cr-labeled rat red cells (RR...

journal_title：Oncology

authors： Schrieber R,Stern K

更新日期：1984-01-01 00:00:00

abstract：:Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...

journal_title：Oncology

authors： Largillier R,Valenza B,Ferrero JM,Novo C,Creisson A,Lesbats G,Mari V,Hebert C,Chamorey E

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate the antitumor activity and safety of an epirubicin, cisplatin, and capecitabine (ECX) combination in patients with metastatic or advanced gastric cancer. PATIENTS AND METHODS:Patients with metastatic or advanced measurable gastric adenocarcinoma received ECX combina...

journal_title：Oncology

authors： Cho EK,Lee WK,Im SA,Lee SN,Park SH,Bang SM,Park DK,Park YH,Shin DB,Lee JH

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...

journal_title：Oncology

authors： Kotsori AA,Dolly S,Sheri A,Parton M,Shaunak N,Ashley S,Walsh G,Johnston S,Smith IE

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The pretreatment neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been reported to be useful as markers for prognostic factors and metastasis in several cancers. The aim of this study was to identify the predictor of lymph node (LN) metastasis by pretreatment NLR and PLR in...

journal_title：Oncology

authors： Aoyama T,Takano M,Miyamoto M,Yoshikawa T,Kato K,Sakamoto T,Takasaki K,Matsuura H,Soyama H,Hirata J,Suzuki A,Sasa H,Tsuda H,Furuya K

更新日期：2019-01-01 00:00:00

abstract：:In squamous cell carcinoma of the head and neck (SCCHN), hypoxia is considered a crucial physiological modulator for malignant progression, wherebythe plasminogen activation system is involved in overlapping functions such as moulding of the extracellular matrix, cell proliferation and signal transduction. Little is k...

journal_title：Oncology

authors： Sprague LD,Mengele K,Schilling D,Geurts-Moespot A,Sweep FC,Stadler P,Schmitt M,Molls M

更新日期：2006-01-01 00:00:00

abstract：:The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation poten...

journal_title：Oncology

authors： Al-Awadi FM,Al-Bader AA

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Bladder cancer is the fifth most common cancer among men and the seventh among women. At diagnosis, at least 25% of bladder cancer tumors are locally or systemically advanced. Systemic chemotherapy is the only current modality for advanced or metastatic transitional cell carcinoma of the bladder. Recently, a...

journal_title：Oncology

authors： Adamo V,Magno C,Spitaleri G,Garipoli C,Maisano C,Alafaci E,Adamo B,Rossello R,Scandurra G,Scimone A

更新日期：2005-01-01 00:00:00

abstract：:This study evaluated the influence of bile acid load on the DNA distribution pattern of proliferated bile ductules and cholangiocarcinoma induced by diisopropanolnitrosamine. Ninety hamsters were separated into control, tauro- and deoxycholic acid (DCA) groups. The DNA distribution pattern of intrahepatic lesions at 1...

journal_title：Oncology

authors： Kinami Y,Miyakoshi M,Fujikawa K

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:Carcinoma of the biliary system is a rare tumor entity, and patients with advanced disease face a dismal prognosis. Because of the absence of standard chemotherapy for advanced biliary carcinoma, we have performed two consecutive studies to evaluate the clinical potential of 5-fluorouracil, leucovorin and ...

journal_title：Oncology

authors： Raderer M,Hejna MH,Valencak JB,Kornek GV,Weinländer GS,Bareck E,Lenauer J,Brodowicz T,Lang F,Scheithauer W

更新日期：1999-04-01 00:00:00

abstract：:Pancreatic intraepithelial neoplasia (PanIN) is a microscopic papillary noninvasive lesion arising from the pancreatic ductal epithelium. However, the natural history and time to progression of high-grade PanIN remain unclear. Herein, we report 2 cases of high-grade PanIN without morphological changes of the main panc...

journal_title：Oncology

authors： Yamao K,Takenaka M,Nakai A,Omoto S,Kamata K,Minaga K,Miyata T,Imai H,Sakurai T,Watanabe T,Nishida N,Matsumoto I,Takeyama Y,Chikugo T,Kudo M

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤ 1.5 × the upper limit of normal. METHODS:Documen...

journal_title：Oncology

authors： Basu B,Vitfell-Pedersen J,Moreno Garcia V,Puglisi M,Tjokrowidjaja A,Shah K,Malvankar S,Anghan B,de Bono JS,Kaye SB,Molife LR,Banerji U

更新日期：2012-01-01 00:00:00