Abstract:
PURPOSE:Breast cancers expressing high levels of Ki-67, a nuclear marker of cell proliferation, are associated with worse outcome. Recent data from neoadjuvant studies indicate that a single measurement of the nuclear proliferation marker Ki-67 in breast carcinoma during neoadjuvant therapy is strongly predictive of long-term outcome. Secondly, recent literature data indicate that prognostic evaluation with Ki-67 may be better after pre-surgical therapy. A retrospective study from a prospectively maintained clinical database to compare the predictive and prognostic significance of biological markers, assessed before and after neoadjuvant chemotherapy, in locally advanced breast cancer, was performed. PATIENTS AND METHODS:The following parameters were considered before and after chemotherapy for their relationship with treatment response and disease-free survival in 64 patients with locally advanced breast cancer: clinical stage, clinical and pathological lymph node involvement, Ki-67, estrogen receptor (ER), progesterone receptor (Pgr), Her2, tumor grade, clinical response, type of surgery performed, and number of chemotherapy cycles administered. The expression of Ki-67 was assessed using immunohistochemistry in pre-therapy tru-cut and post-therapy surgical excision specimens after neoadjuvant chemotherapy; only patients with breast tumors expressing high baseline Ki-67 (≥ 15%) were included in the analysis. In addition, the correlation between pre-chemotherapy biological markers and clinical and pathological response was reported. RESULTS:Post-chemotherapy Ki-67 proliferation index decrease, pre-chemotherapy ER expression and post-chemotherapy ER expression were the only significant prognostic factors adversely influencing disease-free survival in univariate analysis. Her2 overexpression was the only factor to impact on the clinical response. CONCLUSIONS:Post-treatment Ki-67 and ER status were predictors of outcome for patients with locally advanced breast cancer and a high pre-chemotherapy proliferation index.
journal_name
Oncologyjournal_title
Oncologyauthors
Miglietta L,Vanella P,Canobbio L,Naso C,Cerisola N,Meszaros P,Parodi MA,Morabito Fdoi
10.1159/000322189subject
Has Abstractpub_date
2010-01-01 00:00:00pages
255-61issue
3-4eissn
0030-2414issn
1423-0232pii
000322189journal_volume
79pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract:OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000085701
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the use of 5-fluorouracil (5-FU), leucovorin and oxaliplatin (FOLFOX) regimens in clinical practice according to their efficacy and toxicity. METHODS:Patients who received oxaliplatin-containing regimens after curative resection for colorectal carcinoma from 10 different o...
journal_title:Oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000336902
更新日期:2013-01-01 00:00:00
abstract::In pancreatic cancer (PC) accurate determination of treatment response by imaging often remains difficult. Various efforts have been undertaken to investigate new factors which may serve as more appropriate surrogate parameters of treatment efficacy. This review focuses on the role of carbohydrate antigen 19-9 (CA 19-...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000094888
更新日期:2006-01-01 00:00:00
abstract::In order to assess the feasibility of a sequential hormonal treatment after tamoxifen failure, 24 postmenopausal advanced breast cancer patients (median age 60 years; ECOG PS < or = 1) were treated with formestane (4-hydroxyandrostenedione) 250 mg i.m. fortnightly; 19 patients were estrogen receptor-positive. The site...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227510
更新日期:1995-11-01 00:00:00
abstract:PURPOSE:In order to broaden the possibility for anti-MAGE-3 immune targeting, it is important to identify HLA-A24-restricted epitopes derived from MAGE-3, since HLA-A24 is one of the most common alleles in Japanese and Asian people. In the present study, we defined a new MAGE-3 derived, HLA-A24-binding peptide presente...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000091185
更新日期:2006-01-01 00:00:00
abstract::A large number of targeted anticancer drugs are currently under development and most of them will have a companion diagnostic linked to their use. If a diagnostic assay is developed in conjunction with a targeted anticancer drug, such an assay will later end up determining the conditions for the use of the drug after ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000353454
更新日期:2013-01-01 00:00:00
abstract::Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011932
更新日期:1999-01-01 00:00:00
abstract::We have provided an in-depth, longitudinal, clinical/genetic/pathologic investigation of a family consonant with the sarcoma, breast cancer and brain tumors, lung and laryngeal cancer, leukemia, lymphoma, and adrenalcortical carcinoma syndrome. The pattern of cancer expression involves all three germinal layers with t...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226789
更新日期:1990-01-01 00:00:00
abstract::An increase in serum iron levels and a decrease in serum unsaturated iron binding capacity (uIBC) were noted following the administration of cisplatinum to 9 children with malignancies. The mean serum iron concentration increased from a pretreatment level of 75.7 +/- 30.5 micrograms/ml to a posttreatment level of 162....
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226657
更新日期:1988-01-01 00:00:00
abstract::Lymphomas, which are frequently subdivided into Hodgkin's disease and non-Hodgkin's lymphoma, represent one of the more curable cancers that present as a solid tumor. Unfortunately, most patients cannot be cured with conventional chemotherapy, therefore new techniques have been developed including high-dose chemothera...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000012100
更新日期:2000-04-01 00:00:00
abstract::Thrombopoietin (TPO) is a recently discovered hematopoietic growth factor which stimulates the production and maturation of megakaryocytes. In this study, we used a modified MTT assay to examine the in vitro growth-stimulatory effects of recombinant human (rh) TPO and recombinant human stem cell factor (rhSCF) on eigh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227600
更新日期:1996-09-01 00:00:00
abstract::The serum detection of S100B, a new melanoma marker, has shown clinical significance in early studies. The aim of our study of 1, 339 serum samples from 412 different melanoma patients and 107 control patients was to prove the prognostic value of serum S100B levels in melanoma patients at different stages of disease a...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011989
更新日期:1999-01-01 00:00:00
abstract::Although the incidence of gastric cancer has been declining in Western countries, it is still a major health problem and a leading cause of cancer mortality. Surgery is the mainstay of treatment for gastric adenocarcinoma. However, even among patients undergoing gastrectomy with curative intent, 5-year survival rates ...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000258494
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Even though the pathological background contributes to lymph node metastasis, the biological characteristics of tumors have also gained wide attention. In this study, the expression of the cadherin-catenin complex and p53 was studied in early gastric cancer. Their correlation with lymph node m...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012020
更新日期:1999-01-01 00:00:00
abstract::We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a prima...
journal_title:Oncology
pub_type: 杂志文章,多中心研究
doi:10.1159/000478660
更新日期:2017-01-01 00:00:00
abstract::Anticipatory nausea and vomiting (ANV) are learned responses to chemotherapy that develop in up to 25% of patients by the fourth treatment cycle. Post-treatment nausea and emesis must occur before development of ANV can take place. Certain patient characteristics and other responses to chemotherapy can also be used to...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227633
更新日期:1996-06-01 00:00:00
abstract::The prognosis of brain glioblastoma is still very poor and the median survival time is generally less than 6 months. At present, no chemotherapy has appeared to influence its prognosis. On the other hand, recent advances in brain tumor biology have suggested that brain tumor growth is at least in part under a neuroend...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227533
更新日期:1996-01-01 00:00:00
abstract::This randomised, single-blind, parallel-group study was carried out in 48 French pneumology centres to compare the anti-emetic efficacy of ondansetron and an alizapride plus methylprednisolone (ALI/MPS) combination in patients receiving high-dose cisplatin. A total of 220 patients were recruited of whom 209 were evalu...
journal_title:Oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000227061
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for patients with advanced stage (stage III or IV) head and neck squamous cell carcinoma (HNSCC) following primary radiotherapy (RT) or concomitant chemoradiotherapy. METHODS:From January 2001 to January 2003, 149 ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000086982
更新日期:2005-01-01 00:00:00
abstract::Sixteen patients with histologically confirmed inoperable hepatocellular carcinoma were treated with vindesine 3 mg/m2 i.v. weekly. Anemia, leukopenia and neuritis were documented but no severe or life-threatening toxicity was seen. There were no objective responses among the 14 evaluable patients. Eight had a no chan...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227434
更新日期:1995-01-01 00:00:00
abstract::A model system for studying some aspects of the interaction of cancer cells in tumors and their surrounding nonmalignant tissue is the co-culture of cancer cells and embryonic chick neural retinal cells in gyratory shakers. Neural retina cell aggregation, under these conditions, has been shown to be differentially inh...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225573
更新日期:1981-01-01 00:00:00
abstract::Culture-induced cytotoxic (CIC) activity developed in 7-day culture in the presence of fetal calf serum of pleural effusion lymphocytes from patients with lung cancer which initially showed markedly low or no natural killing (NK) activity against K562 cells. The development of CIC activity was proliferation-dependent....
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225637
更新日期:1982-01-01 00:00:00
abstract::Lymph node and distant metastasis were comparatively studied in 225 oral carcinomas, and factors predisposing toward metastasis were investigated using clinical and immunohistopathological approaches. Neither the sites of tumors nor T-stage was correlated with either type of metastasis. Tumor cell differentiation was ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012090
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:We assessed the prognostic value of the nuclear DNA content measured in the primary tumours of 123 patients with stage II or stage III colorectal cancer (CRC). METHODS:Isolated nuclei from paraffin sections were stained with the Feulgen reaction, and DNA was measured using a computer-assisted image analysis...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000098556
更新日期:2006-01-01 00:00:00
abstract::Endoscopic ultrasound-guided pancreatic drainage (EUS-PD) was performed in a patient with unresectable pancreatic cancer who developed pancreatitis. In this case, EUS-PD was useful as salvage therapy for pancreatitis as the transpapillary approach was difficult. ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000481238
更新日期:2017-01-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein with a molecular weight of approximately 45 kDa. It is the key mediator of angiogenesis (the formation of new blood vessels), and binds two VEGF receptors (VEGF receptor-1 and VEGF receptor-2), which are expressed on vascular endothelial cells. In...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000088478
更新日期:2005-01-01 00:00:00
abstract::67Ga-subtraction scan was found to be useful and a promising new method for the pre-treatment evaluation of the patient with Hodgkin's disease or non-Hodgkin's lymphoma. The scan appeared to be most accurate in the neck, chest, and axillary regions. It appears to offer a means of increasing the accuracy of evaluating ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225217
更新日期:1977-01-01 00:00:00
abstract::The disease provoked by injections of water and other harmless liquids or wounds without tissue loss, is characterized by the regression of certain organs, opening in the epidermis, pigmentary anomalies and malignant tumors. The very few worms which recover spontaneously, regenerate the eliminated parts or develop sup...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225055
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:This pharmacokinetic study of S-1 was conducted in patients in whom glomerular filtration rate (GFR) was directly measured to explore the possibility of adjusting the S-1 dose on the basis of GFR in patients with normal or nearly normal renal function. METHODS:S-1 was given to 12 patients twice daily for 28 ...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000337232
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages remain unclear. The latest prognostic outcomes in clinical Stage (cStage) II/III ESCC with NAC were herein elucidated. PATIENTS AND METHODS:NAC prior to curative treatmen...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000455128
更新日期:2017-01-01 00:00:00