Abstract:
:We have provided an in-depth, longitudinal, clinical/genetic/pathologic investigation of a family consonant with the sarcoma, breast cancer and brain tumors, lung and laryngeal cancer, leukemia, lymphoma, and adrenalcortical carcinoma syndrome. The pattern of cancer expression involves all three germinal layers with transmission through multiple generations. Segregation of these cancers occur in a manner consonant with an autosomal dominant mode of genetic transmission. It is hoped that recognition of the significance of this tumor pattern within families will provide an impetus for cancer surveillance, control, and laboratory research in the quest for clues to biomarkers which correlate with its cancer-prone genotype.
journal_name
Oncologyjournal_title
Oncologyauthors
Lynch HT,Radford B,Lynch JFdoi
10.1159/000226789subject
Has Abstractpub_date
1990-01-01 00:00:00pages
75-9issue
1eissn
0030-2414issn
1423-0232journal_volume
47pub_type
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