Abstract:
:Flow cytometric (FCM) DNA studies were performed on cell suspensions obtained by endoscopic biopsy in 73 patients with gastric cancer and in 61 patients with gastric remnant. In cancer, DNA aneuploidies were detected in 49 tumors (67.1%), including 51.7% (15/29) of early gastric cancers and 77.3% (34/44) of advanced gastric cancers. Nuclear DNA content of biopsy materials had a significant correlation with that of surgically obtained ones, providing the estimation of the original ploidy pattern and DNA index (p < 0.01). The serosal invasion, lymph node metastasis, lymphatic invasion, and vascular invasion of the DNA aneuploidy were significantly higher than those of the DNA diploidy (p < 0.05). In patients with gastric remnant, 9 biopsy specimens in the anastomotic site showed DNA aneuploidy (13.9%). The DNA measurement of the endoscopically obtained specimens may provide additional preoperative information and help to identify biologic variables.
journal_name
Oncologyjournal_title
Oncologyauthors
Kimura H,Kanno M,Takamura H,Arakawa H,Maeda K,Uogishi M,Sodani H,Kawashima Tdoi
10.1159/000227389subject
Has Abstractpub_date
1994-11-01 00:00:00pages
479-84issue
6eissn
0030-2414issn
1423-0232journal_volume
51pub_type
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