Abstract:
BACKGROUND:A novel oral agent that consists of trifluridine and tipiracil hydrochloride (TFTD) has been established as salvage-line treatment for metastatic colorectal cancer (mCRC). Adherence to TFTD is crucial to maintaining appropriate curative effects. This study sought to clarify adherence to TFTD and identify candidate factors deteriorating adherence at our institution. METHODS:A total of 50 consecutive mCRC patients who received TFTD monotherapy between June 1, 2014 and July 31, 2015 were analyzed in this study. Adherence to TFTD was checked by pharmacists using a self-reported treatment diary and interviewing nonadherents at a pharmaceutical outpatient clinic. The adherence rate was defined as the number of patient intakes per 20 scheduled intakes in one cycle. We retrospectively surveyed the factors from the electronic patient record associated with reduced adherence. We measured relative dose intensity, defined as the dose intensity divided by the initial dose (each in milligrams per square meter per week). RESULTS:Patient characteristics were as follows: males/females, 20/30; median age, 61 years (range, 34-83 years); performance status 0/1, 37/13. Median relative dose intensity of TFTD was 91.0%. Adherence rates were 95.0% for the first cycle of TFTD, 97.3% for the second cycle, 98.0% for the third cycle, and 98.2% for the fourth cycle. Factors associated with deteriorated adherence to TFTD were nausea/vomiting/decreased appetite (27.1%, 23 instances), pain (25.9%, 22 instances), neutropenia (11.8%, 10 instances), and missed dose (4.7%, 4 instances). Increased nonadherence to TFTD was associated with Eastern Cooperative Oncology Group performance status 1, while increased TFTD adherence in the first cycle was associated with prior regimens ≥4. CONCLUSIONS:The high frequency of treatment-related gastrointestinal disorder is the main factor affecting adherence to TFTD. Intensive supportive care in the management of these symptoms could assist adequate adherence to TFTD in mCRC patients.
journal_name
Oncologyjournal_title
Oncologyauthors
Sugita K,Kawakami K,Yokokawa T,Sugisaki T,Takiguchi T,Aoyama T,Suzuki K,Suenaga M,Yamaguchi K,Inoue A,Machida Y,Yamaguchi T,Hama Tdoi
10.1159/000448717subject
Has Abstractpub_date
2016-01-01 00:00:00pages
224-230issue
4eissn
0030-2414issn
1423-0232pii
000448717journal_volume
91pub_type
杂志文章相关文献
ONCOLOGY文献大全abstract::Growth-regulated oncogene-1 (GRO-1) is an autocrine growth factor in melanoma and is a member of the CXC family of chemokines which promote chemotaxis of granulocytes and endothelia through binding to CXC receptor 2. A previous article noted that GRO-1 was upregulated in oral cancer using a genome-wide microarray appr...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000078333
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:We recently demonstrated that papillary microcarcinomas with preoperatively detectable node metastasis in the lateral compartment on ultrasonography (clinically apparent metastasis) show worse postoperative relapse-free survival than those with no metastasis or metastasis that could not be detected preoperat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000085701
更新日期:2005-01-01 00:00:00
abstract::Various oncogenic agents were employed in tumor susceptibility studies of an inbred subline of BALB/cGn mice, BALB/cGnDu, which carries a mutant gene that results in spontaneous thymic involution in homozygous recessive individuals. Of 18 transplantable tumors, 3 in vitro transformed cell lines, 2 oncogenic papovaviru...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225643
更新日期:1982-01-01 00:00:00
abstract::The role of p53, retinoblastoma (RB) and c-erbB-2 gene proteins in the pathogenesis of anal carcinomas has been examined. A total of 97 patients were included in the study. c-erbB-2, RB and p53 proteins were abnormal in 0, 5 and 34% of the cases, respectively. No correlation was observed between p53 and age, sex, tumo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227590
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply in...
journal_title:Oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000486338
更新日期:2018-01-01 00:00:00
abstract::Twenty-two patients with metastatic breast carcinoma were treated with a combination of cisplatin (100 mg/m2 i.v. day 1) and etoposide (100 mg/m2 i.v. days 1-3). Eligible patients had measurable disease with normal organ functions, performance status < 3, age < 70 years and no previous chemotherapy for metastatic dise...
journal_title:Oncology
pub_type: 临床试验,杂志文章
doi:10.1159/000227364
更新日期:1994-07-01 00:00:00
abstract::Aberrant glycosylation of membrane components due to specific alterations of glycosyltransferase activity is a common feature of carcinoma cells and is usually associated with invasion and metastasis. In a prospective study, the enzyme activity of the sialyltransferases ST6GAL-I and ST3GAL-III was studied in gastric c...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000072339
更新日期:2003-01-01 00:00:00
abstract::Novel human estrogen receptor (ER)-beta was identified in cDNA libraries from human testis. ER-beta specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-beta might not conserve the same physiological functions as does ER-alpha. Therefore, the clinical significance of the expression of ER-...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000012121
更新日期:2000-05-01 00:00:00
abstract::Irinotecan and raltitrexed are active against advanced colorectal cancer, act through different mechanisms, and have non-overlapping toxicity profiles. In vitro studies have shown a schedule-dependent synergism between both drugs. The aim of this multicenter study was to determine the maximum tolerated dose (MTD) of t...
journal_title:Oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000065719
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS:Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, wi...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000489217
更新日期:2018-01-01 00:00:00
abstract::Studies were made of the therapeutic response of six human colorectal tumor lines serially transplanted in immunosuppressed mice. The tumors with adenomatous structure showed greater sensitivity against different cytotoxic agents than the gelatinous ones. Among the drugs, 5-FU, BCNU and MeCCNU proved to be the most ef...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225496
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Clear cell renal cell carcinoma (CCRCC) is a malignant neoplasm frequently associated with an increase in circulating immune complexes (CIC). Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a disease involving the chorioretinal structures of the eye, and it is commonly observe...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000079505
更新日期:2004-01-01 00:00:00
abstract::Primary and secondary prevention of hepatocellular carcinoma (HCC) which has become endemic worldwide in recent years are the most important issues in reducing mortality of HCC patients. Among several compounds previously reported for secondary prevention, treatment with interferon (IFN) is widely applied and shows en...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000173422
更新日期:2008-01-01 00:00:00
abstract::The Abelson-virus-induced murine lymphosarcoma cell line RAW117-P and its in vivo selected highly malignant and metastatic variant RAW117-H10 have been studied for their growth in vivo, in vitro and in semi-solid agar. The highly malignant metastatic variant RAW117-H10 cells killed syngeneic Balb/c mice rapidly and fo...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226473
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is useful for differentiating benign from malignant lesions, evaluating tumor stage, monitoring the response to therapy and detecting tumor recurrence in a variety of malignancies. Nevertheless, its use in patients with hepatocellular carcinoma (H...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000111715
更新日期:2007-01-01 00:00:00
abstract::A patient seen at presentation for Hodgkin's disease (HD) at stage IV B was successfully treated with MOPP. In remission he developed coeliac disease, controlled by dietary measures, but 26 months after the end of chemotherapy a severe dyspeptic syndrome appeared; endoscopy and barium meal suggested the presence of a ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226345
更新日期:1986-01-01 00:00:00
abstract::Rapid advances in our understanding of the biology and pathology of lymphoproliferative disorders, permitted mainly by new diagnostic tools, constantly change our approach to this heterogenous group of disorders. In this review of the more indolent subgroup of lymphoproliferative disorders, some of the recent advances...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227602
更新日期:1997-11-01 00:00:00
abstract::Topotecan is indicated in the treatment of advanced-stage ovarian cancers refractory to prior platinum-based regimen. The aim of this study was to compare the standard therapeutic strategy with a novel strategy of weekly administration of topotecan. The primary endpoints were dose density and overall tolerance. This r...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000127384
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been reported to be a prognostic marker for several types of cancer including RCC. Exosomes or small extracellular vesicles present in body fluids have potenti...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000508688
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of this study to report on the role of laparoscopic staging in a large series of locally advanced cervical cancer (LACC) patients and its impact on prognosis. METHODS:Consecutive patients with LACC were considered for surgical staging: gynecological examination, cystoscopy and laparoscopy with...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000351995
更新日期:2013-01-01 00:00:00
abstract::The effects of theophylline treatment on mouse B-16 melanoma cell growth, metabolism, and membrane antigen expression in vitro were studied. Theophylline treatment inhibited DNA synthesis and the cell growth rate, and caused an elevation of intracellular cAMP levels. Cells treated with theophylline became elongated an...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225467
更新日期:1980-01-01 00:00:00
abstract::The present study was undertaken to detect the spontaneous mammary tumor-associated antigen ( MTAA ), and to find the cross-reacting antigen in chemically-induced mammary tumor. The antisera against spontaneous mammary tumor were raised in the WAF1 rats of the same strain and tested for the detection of tumor-associat...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225824
更新日期:1984-01-01 00:00:00
abstract::The historical aspects of drug development and evaluation are anecdotically related. Clinical trials have proven the effectiveness of animal tests in the vast majority of cases, and the effort has been well spent. Similar of more noteworthy success may be obtainable with model systems in the study of prostatic cancer....
journal_title:Oncology
pub_type: 历史文章,杂志文章
doi:10.1159/000225197
更新日期:1977-01-01 00:00:00
abstract::Cisplatin is among the most active agents available for the therapy of non-small cell lung cancer (NSCLC). Its congener, carboplatin, has been the focus of intense clinical trials over the last several years because of its improved therapeutic index. Results from randomized trials have shown that carboplatin is active...
journal_title:Oncology
pub_type: 杂志文章,评审
doi:10.1159/000227259
更新日期:1993-11-01 00:00:00
abstract::A unique case of multiple keratoacanthomas is described, with involvement of the face and lower extremities with persistent lesions clinically and histologically diagnostic of keratoacanthomas. The lower extremity lesions appear as giant keratoacanthomas, with evolution into a distinctive confluent plaque. This import...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000225359
更新日期:1979-01-01 00:00:00
abstract::38 of 306 patients survived beyond 5 years after resection of an exocrine pancreatic carcinoma during a period from 1971 to 1993. Amongst the long-term survivors there were 12 patients with ductal, 22 with ampullary, 3 with distal bile duct and 1 with duodenal cancer. An active operative strategy was employed in order...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227488
更新日期:1995-09-01 00:00:00
abstract::Originally referred to as 'lymphoepithelioma', undifferentiated and poorly differentiated nasopharyngeal carcinoma (NPC) tissues showed intense lymphoinfiltration. In a study of cryosections from 15 NPC tissues, we found that infiltrating lymphoid elements were comprised predominantly of lymphocytes, but plasma cells,...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000226945
更新日期:1991-01-01 00:00:00
abstract::The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000011850
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Previous data showed that distant metastatic breast cancer (MBC) might be curable in up to 3% of the cases in selected patients, mostly young, with good performance status and with low-volume metastatic disease, mainly by an aggressive multidisciplinary approach including aggressive combination chemotherapy ...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000500298
更新日期:2019-01-01 00:00:00
abstract::Flow cytometric (FCM) DNA studies were performed on cell suspensions obtained by endoscopic biopsy in 73 patients with gastric cancer and in 61 patients with gastric remnant. In cancer, DNA aneuploidies were detected in 49 tumors (67.1%), including 51.7% (15/29) of early gastric cancers and 77.3% (34/44) of advanced g...
journal_title:Oncology
pub_type: 杂志文章
doi:10.1159/000227389
更新日期:1994-11-01 00:00:00