Abstract:
:Although the incidence of gastric cancer has been declining in Western countries, it is still a major health problem and a leading cause of cancer mortality. Surgery is the mainstay of treatment for gastric adenocarcinoma. However, even among patients undergoing gastrectomy with curative intent, 5-year survival rates are disappointing due to locoregional relapse and distant metastases. This emphasizes the importance of multidisciplinary management of patients with gastric cancer. In contrast to the preoperative approach, several phase III trials have been carried out in the adjuvant setting, but postoperative chemotherapy has not proven to be superior to surgery alone. Therefore, at present the routine use of adjuvant therapy should be regarded as an investigational approach. Improved clinical trial designs with standardized surgical techniques and the incorporation of newer active drugs are needed.
journal_name
Oncologyjournal_title
Oncologyauthors
De Vita F,Vecchione L,Galizia G,Di Martino N,Fabozzi T,Catalano G,Ciardiello F,Orditura Mdoi
10.1159/000258494subject
Has Abstractpub_date
2009-01-01 00:00:00pages
38-42eissn
0030-2414issn
1423-0232pii
000258494journal_volume
77 Suppl 1pub_type
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